Nautilus Biotechnology, Inc. (NAUT) Total Return Calculator with Dividends Reinvested

Nautilus Biotechnology, Inc.

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The total return for Nautilus Biotechnology, Inc. (NAUT) stock is +118.33% over the past 12 months. So far it's up 37.17% this year. The 5-year total return is -81.92%, meaning $10,000 invested in NAUT stock 5 years ago would be worth $1,808 today. Total return includes price appreciation plus reinvesting any dividends paid out.

If you invested $10,000 in NAUT 1 year ago, it would be worth $21,833 today — you'd have gained $11,833.

With Dividends Reinvested$21,833+118.33%

Price Only (No DRIP)$21,833+118.33%

Period2025-03-05 → 2026-03-04

Price

Total Return (DRIP)

S&P 500

If You Invested $10,000 in NAUT

1Y$21,833+$11,833 (+118.3%)118.3% CAGR

3Y$12,186+$2,186 (+21.9%)6.8% CAGR

5Y$1,808-$8,192 (-81.9%)-29.0% CAGR

10Y$2,510-$7,490 (-74.9%)-12.9% CAGR

15Y$2,510-$7,490 (-74.9%)-8.8% CAGR

20Y$2,510-$7,490 (-74.9%)-6.7% CAGR

30Y$2,510-$7,490 (-74.9%)-4.5% CAGR

Nautilus Biotechnology, Inc. did not pay dividends during this period. Total return = price return.

Loading NAUT total return...

As of 2026-03-05

Returns at a Glance

Period	Total Return	CAGR	Price Only	Div. Contrib.	$10K →
YTD	+37.17%	—	+37.17%	—	$13,717
1Y	+118.33%	118.33%	+118.33%	—	$21,833
3Y	+21.86%	6.81%	+21.86%	—	$12,186
5Y	-81.92%	-28.97%	-81.92%	—	$1,808
10Y	-74.90%	-12.91%	-74.90%	—	$2,510
15Y	-74.90%	-8.80%	-74.90%	—	$2,510
20Y	-74.90%	-6.68%	-74.90%	—	$2,510
30Y	-74.90%	-4.50%	-74.90%	—	$2,510

Risk & Highlights

Best Year+76.92%2023

Worst Year-66.04%2022

Max Drawdown-50.85%2025-03-07 → 2025-09-03 · Recovered 2025-10-21

Annual Returns

Year	Total Return	Price Return	Div.	S&P 500	vs S&P
2026YTD	+26.70%	+26.70%	—	+0.41%	+26.3pp
2025	+15.38%	+15.38%	—	+16.64%	-1.3pp
2024	-44.37%	-44.37%	—	+24.00%	-68.4pp
2023	+76.92%	+76.92%	—	+24.81%	+52.1pp
2022	-66.04%	-66.04%	—	-19.95%	-46.1pp

NAUT outperformed the S&P 500 by 101.65pp over the past year (+118.33% vs +16.68%).

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NAUT Peers' Total Return

Biotechnology · Top 11 by market cap

Name	Mkt Cap	30D Rtn	YTD Total Rtn	1Y Total Rtn	Div Contrib	3Y Total Rtn	5Y Total Rtn	10Y Total Rtn
NAUTNautilus Biotechnology, Inc.	$331M	+29.7%	+37.2%	+118.3%	—	+21.9%	-81.9%	-74.9%
VRTXVertex Pharmaceuticals Incorporated	$121.4B	+4.2%	+5.7%	-2.8%	—	+63.9%	+125.4%	+425.4%
REGNRegeneron Pharmaceuticals, Inc.	$108.4B	+2.7%	+1.6%	+15.1%	+0.5pp	+1.5%	+71.6%	+94.0%
PHGEBiomX Inc.	$82.8B	+38.2%	+194.4%	-48.8%	—	-93.2%	-99.5%	-99.7%
ARGXargenx SE	$46.4B	-8.6%	-10.8%	+17.8%	—	+119.3%	+158.7%	+3159.0%
ALNYAlnylam Pharmaceuticals, Inc.	$43.3B	-1.2%	-18.2%	+31.3%	—	+63.9%	+128.3%	+444.7%
CAICaris Life Sciences, Inc.	$33.2B	-6.5%	-26.4%	-29.1%	—	-29.1%	-29.1%	-29.1%
RPRXRoyalty Pharma plc	$26.8B	+7.6%	+22.7%	+43.1%	+2.7pp	+42.2%	+21.0%	+16.7%
BNTXBioNTech SE	$26.0B	-1.6%	+7.4%	-9.6%	—	-21.1%	+10.1%	+643.8%
MRNAModerna, Inc.	$22.6B	+41.4%	+87.3%	+64.2%	—	-59.9%	-56.3%	+210.8%
ROIVRoivant Sciences Ltd.	$21.4B	+39.6%	+34.6%	+175.9%	—	+275.1%	+197.6%	+183.8%

Compare:NAUT vs VRTX NAUT vs REGN NAUT vs PHGE NAUT vs VRTX vs REGN

About NAUT Dividend Returns

Nautilus Biotechnology, Inc. (NAUT) does not currently pay dividends. Many growth-focused companies reinvest profits back into the business rather than distributing them as dividends.

How We Calculate Total Return

Our total return calculator simulates dividend reinvestment (DRIP) by assuming each dividend payment is used to purchase additional shares at the closing price on the ex-dividend date. This methodology provides an accurate representation of how a dividend reinvestment plan would perform.

Frequently Asked Questions

Q1What is the total return of NAUT over the past year?

Nautilus Biotechnology, Inc. (NAUT) delivered a return of 118.33% over the past year. Since NAUT does not currently pay dividends, the total return equals the price-only return.

Q2How much would $10,000 invested in NAUT be worth today?

A $10,000 investment in Nautilus Biotechnology, Inc. one year ago would be worth $21,833 today, representing a gain of $11,833.

Q3Does NAUT pay dividends?

Nautilus Biotechnology, Inc. (NAUT) does not currently pay dividends. Many growth-focused companies reinvest profits back into the business rather than distributing them as dividends. For NAUT, the total return equals the price-only return.

Q4Did NAUT beat the S&P 500?

Yes, Nautilus Biotechnology, Inc. (NAUT) outperformed the S&P 500 by 101.65 percentage points over the past year. NAUT delivered a total return of 118.33%, compared to the S&P 500's 16.68%. This 101.65pp alpha means investors in NAUT earned more than a passive S&P 500 index fund.

Q5What is NAUT's worst drawdown?

Nautilus Biotechnology, Inc. (NAUT) experienced a maximum drawdown of -50.85% over the past year, declining from its peak on 2025-03-07 to its trough on 2025-09-03. The stock recovered to its prior peak by 2025-10-21. Maximum drawdown measures the worst peak-to-trough decline and is an important risk metric for investors.

Q6What is NAUT's long-term total return over 10, 20, or 30 years?

Nautilus Biotechnology, Inc. (NAUT) has delivered strong long-term returns with dividends reinvested. Over 10 years, the total return is -74.9% (-12.9% CAGR) — $10,000 would have grown to $2,510. Over 20 years: -74.9% total return (-6.7% CAGR) — $10,000 → $2,510. Over 30 years: -74.9% total return (-4.5% CAGR) — $10,000 → $2,510. Long-term investors benefit from compounding: dividends buy additional shares, which generate their own dividends, creating an exponential growth effect.

Q7What was NAUT's best and worst year?

Nautilus Biotechnology, Inc.'s best calendar year was 2023 with a total return of 76.9%. Its worst year was 2022 with a total return of -66.0%. This range shows the volatility investors should expect — the difference between the best and worst year is 143.0 percentage points.