Comprehensive Stock Comparison
Compare Agios Pharmaceuticals, Inc. (AGIO) vs BridgeBio Pharma, Inc. (BBIO) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Growth | BBIO | 126.3% revenue growth vs AGIO's 48.0% |
| Quality / Margins | BBIO | -145.3% net margin vs AGIO's -9.0% |
| Stability / Safety | AGIO | Beta 0.91 vs BBIO's 1.04 |
| Dividends | Tie | Neither pays a meaningful dividend |
| Momentum (1Y) | BBIO | +90.5% vs AGIO's -14.9% |
| Efficiency (ROA) | AGIO | -29.0% ROA vs BBIO's -77.9% |
Who Each Stock Is For
Income & stability
Growth exposure
Long-term compounding (10Y)
Sleep-well-at-night portfolio
Defensive / Recession hedge
Business Model
What each company does and how it makes money
Agios Pharmaceuticals is a biopharmaceutical company focused on developing treatments for rare genetic diseases related to cellular metabolism. It generates revenue primarily from sales of its lead drug PYRUKYND for pyruvate kinase deficiency — with additional income from research collaborations and milestone payments — while advancing a pipeline of other metabolic therapies. The company's competitive advantage lies in its deep expertise in cellular metabolism science and proprietary platform for targeting metabolic pathways in rare diseases.
BridgeBio Pharma is a biopharmaceutical company focused on discovering and developing precision medicines for genetic diseases. It generates revenue primarily through drug development partnerships and potential future product sales — though currently in pre-revenue stage with multiple programs in clinical trials. The company's key advantage is its efficient hub-and-spoke operating model that allows rapid development of targeted therapies for rare genetic conditions.
Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
BBIO leads in 3 of 6 categories — strongest in Financial Metrics and Valuation Metrics. 2 categories are tied.
Financial Metrics (TTM)
BBIO is the larger business by revenue, generating $502M annually — 11.2x AGIO's $45M. Profitability is closely matched — net margins range from -145.3% (BBIO) to -9.0% (AGIO). On growth, BBIO holds the edge at +25.2% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | AGIOAgios Pharmaceuti… | BBIOBridgeBio Pharma,… |
|---|---|---|
| RevenueTrailing 12 months | $45M | $502M |
| EBITDAEarnings before interest/tax | -$470M | -$560M |
| Net IncomeAfter-tax profit | -$401M | -$729M |
| Free Cash FlowCash after capex | -$414M | -$458M |
| Gross MarginGross profit ÷ Revenue | +84.4% | +94.4% |
| Operating MarginEBIT ÷ Revenue | -10.6% | -113.3% |
| Net MarginNet income ÷ Revenue | -9.0% | -145.3% |
| FCF MarginFCF ÷ Revenue | -9.2% | -91.1% |
| Rev. Growth (YoY)Latest quarter vs prior year | +43.7% | +25.2% |
| EPS Growth (YoY)Latest quarter vs prior year | -111.0% | +28.6% |
Valuation Metrics
| Metric | AGIOAgios Pharmaceuti… | BBIOBridgeBio Pharma,… |
|---|---|---|
| Market CapShares × price | $2.25T | $12.9B |
| Enterprise ValueMkt cap + debt − cash | $2.25T | $12.4B |
| Trailing P/EPrice ÷ TTM EPS | -4.25x | -17.54x |
| Forward P/EPrice ÷ next-FY EPS est. | — | — |
| PEG RatioP/E ÷ EPS growth rate | — | — |
| EV / EBITDAEnterprise value multiple | — | — |
| Price / SalesMarket cap ÷ Revenue | 9999.00x | 25.79x |
| Price / BookPrice ÷ Book value/share | 1.47x | — |
| Price / FCFMarket cap ÷ FCF | — | — |
Profitability & Efficiency
| Metric | AGIOAgios Pharmaceuti… | BBIOBridgeBio Pharma,… |
|---|---|---|
| ROE (TTM)Return on equity | -31.2% | — |
| ROA (TTM)Return on assets | -29.0% | -77.9% |
| ROICReturn on invested capital | -26.6% | — |
| ROCEReturn on capital employed | -33.8% | -80.6% |
| Piotroski ScoreFundamental quality 0–9 | 3 | 3 |
| Debt / EquityFinancial leverage | 0.03x | — |
| Net DebtTotal debt minus cash | -$49M | -$560M |
| Cash & Equiv.Liquid assets | $89M | $570M |
| Total DebtShort + long-term debt | $40M | $10M |
| Interest CoverageEBIT ÷ Interest expense | — | -6.10x |
Total Returns (with DRIP)
A $10,000 investment in BBIO five years ago would be worth $9,245 today (with dividends reinvested), compared to $6,363 for AGIO. Over the past 12 months, BBIO leads with a +90.5% total return vs AGIO's -14.9%. The 3-year compound annual growth rate (CAGR) favors BBIO at 79.9% vs AGIO's 6.1% — a key indicator of consistent wealth creation.
| Metric | AGIOAgios Pharmaceuti… | BBIOBridgeBio Pharma,… |
|---|---|---|
| YTD ReturnYear-to-date | +11.2% | -15.0% |
| 1-Year ReturnPast 12 months | -14.9% | +90.5% |
| 3-Year ReturnCumulative with dividends | +19.4% | +482.1% |
| 5-Year ReturnCumulative with dividends | -36.4% | -7.6% |
| 10-Year ReturnCumulative with dividends | -21.2% | +141.3% |
| CAGR (3Y)Annualised 3-year return | +6.1% | +79.9% |
Risk & Volatility
AGIO is the less volatile stock with a 0.91 beta — it tends to amplify market swings less than BBIO's 1.04 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. BBIO currently trades 78.3% from its 52-week high vs AGIO's 65.7% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | AGIOAgios Pharmaceuti… | BBIOBridgeBio Pharma,… |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 0.91x | 1.04x |
| 52-Week HighHighest price in past year | $46.00 | $84.94 |
| 52-Week LowLowest price in past year | $22.24 | $28.33 |
| % of 52W HighCurrent price vs 52-week peak | +65.7% | +78.3% |
| RSI (14)Momentum oscillator 0–100 | 62.3 | 39.0 |
| Avg Volume (50D)Average daily shares traded | 948K | 2.5M |
Analyst Outlook
Wall Street rates AGIO as "Buy" and BBIO as "Buy". Consensus price targets imply 48.8% upside for BBIO (target: $99) vs 37.3% for AGIO (target: $42).
| Metric | AGIOAgios Pharmaceuti… | BBIOBridgeBio Pharma,… |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | Buy |
| Price TargetConsensus 12-month target | $41.50 | $98.92 |
| # AnalystsCovering analysts | 29 | 26 |
| Dividend YieldAnnual dividend ÷ price | — | — |
| Dividend StreakConsecutive years of raises | — | 0 |
| Dividend / ShareAnnual DPS | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | +0.4% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Mar 20 | Feb 26 | Change |
|---|---|---|---|
| Agios Pharmaceutica… (AGIO) | 100 | 57.07 | -42.9% |
| BridgeBio Pharma, I… (BBIO) | 100 | 242.91 | +142.9% |
BridgeBio Pharma, I… (BBIO) returned -8% over 5 years vs Agios Pharmaceutica… (AGIO)'s -36%.
Chart 2Revenue Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Agios Pharmaceutica… (AGIO) | $70M | $54M | -22.7% |
| BridgeBio Pharma, I… (BBIO) | $0.00 | $502M | — |
Agios Pharmaceuticals, Inc.'s revenue grew from $70M (2016) to $54M (2025) — a -2.8% CAGR.
Chart 3Net Margin Trend — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Agios Pharmaceutica… (AGIO) | -2.8% | -7.6% | -169.0% |
| BridgeBio Pharma, I… (BBIO) | -6.4% | -145.3% | -2162.2% |
Agios Pharmaceuticals, Inc.'s net margin went from -3% (2016) to -8% (2025).
Chart 4EPS Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Agios Pharmaceutica… (AGIO) | -5.07 | -7.12 | -40.4% |
| BridgeBio Pharma, I… (BBIO) | -0.33 | -3.79 | -1048.5% |
Agios Pharmaceuticals, Inc.'s EPS grew from $-5.07 (2016) to $-7.12 (2025).
Chart 5Free Cash Flow — 5 Years
Agios Pharmaceuticals, Inc. generated $-377M FCF in 2025 (+9% vs 2021). BridgeBio Pharma, Inc. generated $-447M FCF in 2025 (+18% vs 2021).
AGIO vs BBIO: Frequently Asked Questions
7 questions · data-driven answers · updated daily
01Is AGIO or BBIO a better buy right now?
Analysts rate Agios Pharmaceuticals, Inc. (AGIO) a "Buy" — based on 29 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — AGIO or BBIO?
Over the past 5 years, BridgeBio Pharma, Inc. (BBIO) delivered a total return of -7.6%, compared to -36.4% for Agios Pharmaceuticals, Inc. (AGIO). A $10,000 investment in BBIO five years ago would be worth approximately $9K today (assuming dividends reinvested). Over 10 years, the gap is even starker: BBIO returned +141.3% versus AGIO's -21.2%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — AGIO or BBIO?
By beta (market sensitivity over 5 years), Agios Pharmaceuticals, Inc. (AGIO) is the lower-risk stock at 0.91β versus BridgeBio Pharma, Inc.'s 1.04β — meaning BBIO is approximately 15% more volatile than AGIO relative to the S&P 500.
04Which has better profit margins — AGIO or BBIO?
BridgeBio Pharma, Inc. (BBIO) is the more profitable company, earning -145.3% net margin versus -764.0% for Agios Pharmaceuticals, Inc. — meaning it keeps -145.3% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: BBIO leads at -113.3% versus -873.9% for AGIO. At the gross margin level — before operating expenses — BBIO leads at 94.4%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
05Which pays a better dividend — AGIO or BBIO?
None of the stocks in this comparison currently pay a material dividend. All are effectively zero-yield and should be held for capital appreciation rather than income.
06Is AGIO or BBIO better for a retirement portfolio?
For long-horizon retirement investors, Agios Pharmaceuticals, Inc. (AGIO) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.91)). Both have compounded well over 10 years (AGIO: -21.2%, BBIO: +141.3%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
07What are the main differences between AGIO and BBIO?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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