| Name | Market Cap | Current Price | P/E Ratio | Revenue Growth 1Y | Net Margin | ROE | FCF Yield | Debt/Equity |
|---|---|---|---|---|---|---|---|---|
| CORTCorcept Therapeutics Incorporated | 3.78B | 35.70 | 43.54 | 12.79% | 13.01% | 15.3% | 3.75% | 0.01 |
| BMRNBioMarin Pharmaceutical Inc. | 11.86B | 61.73 | 34.29 | 10.83% | 5.73% | 6.11% | 0.10 | |
| VRTXVertex Pharmaceuticals Incorporated | 126.19B | 496.83 | 32.43 | 8.9% | 31.35% | 21.22% | 2.53% | 0.20 |
| CPRXCatalyst Pharmaceuticals, Inc. | 2.83B | 23.08 | 13.74 | 19.78% | 36.39% | 22.46% | 7.38% | 0.00 |
| HRMYHarmony Biosciences Holdings, Inc. | 1.65B | 28.54 | 10.53 | 21.51% | 18.27% | 18.24% | 21.12% | 0.02 |
| PTCTPTC Therapeutics, Inc. | 5.45B | 68.19 | 8.76 | 114.51% | 42.25% | |||
| BCRXBioCryst Pharmaceuticals, Inc. | 1.86B | 8.75 | 7.23 | 94.1% | 30.16% | 18.63% | ||
| RAREUltragenyx Pharmaceutical Inc. | 2.26B | 23.39 | -3.72 | 29.01% | -91.95% | -35.88% | 0.15 |
Analyze head-to-head performance against top industry competitors across valuation, growth, and profitability metrics.
| Dec 2017 | Dec 2018 | Dec 2019 | Dec 2020 | Dec 2021 | Dec 2022 | Dec 2023 | Dec 2024 | Dec 2025 | |
|---|---|---|---|---|---|---|---|---|---|
| Sales/Revenue | 0 | 0 | 40.56M | 8.25M | 69.72M | 77.65M | 9.3M | 221.9M | 502.08M |
| Revenue Growth % | - | - | - | -79.66% | 745.14% | 11.38% | -88.02% | 2285.27% | 126.26% |
| Cost of Goods Sold | 260K | 0 | 2.5M | 0 | 3.11M | 3.43M | 2.45M | 3.88M | 28.27M |
| COGS % of Revenue | - | - | 6.16% | - | 4.47% | 4.42% | 26.29% | 1.75% | 5.63% |
| Gross Profit | -260K | 0 | 38.06M | 8.25M | 66.6M | 74.21M | 6.86M | 218.02M | 473.81M |
| Gross Margin % | - | - | 93.84% | 100% | 95.53% | 95.58% | 73.71% | 98.25% | 94.37% |
| Gross Profit Growth % | - | 100% | - | -78.33% | 707.39% | 11.43% | -90.76% | 3079.58% | 117.32% |
| Operating Expenses | 43.86M | 183.66M | 304.3M | 482.73M | 643.23M | 586.42M | 614.23M | 811M | 1.04B |
| OpEx % of Revenue | - | - | 750.25% | 5851.99% | 922.65% | 755.22% | 6602.46% | 365.48% | 207.72% |
| Selling, General & Admin | 13.3M | 43.59M | 94.35M | 145.68M | 192.21M | 143.19M | 150.59M | 288.93M | 555.14M |
| SG&A % of Revenue | - | - | 232.63% | 1766.08% | 275.7% | 184.41% | 1618.73% | 130.21% | 110.57% |
| Research & Development | 30.56M | 140.07M | 209.95M | 337.05M | 451.02M | 399.46M | 455.71M | 506.46M | 477.54M |
| R&D % of Revenue | - | - | 517.62% | 4085.91% | 646.94% | 514.45% | 4898.54% | 228.24% | 95.11% |
| Other Operating Expenses | 0 | 0 | 0 | 0 | 0 | 43.77M | 7.93M | 15.61M | 10.22M |
| Operating Income | -43.86M | -183.66M | -266.24M | -474.48M | -576.63M | -512.2M | -607.37M | -592.97M | -569.09M |
| Operating Margin % | - | - | -656.41% | -5751.99% | -827.12% | -659.65% | -6528.75% | -267.22% | -113.35% |
| Operating Income Growth % | - | -318.76% | -44.96% | -78.22% | -21.53% | 11.17% | -18.58% | 2.37% | 4.03% |
| EBITDA | -43.6M | -183.41M | -265.38M | -473.03M | -570.79M | -505.43M | -600.88M | -586.9M | -560.09M |
| EBITDA Margin % | - | - | -654.29% | -5734.34% | -818.73% | -650.93% | -6458.95% | -264.49% | -111.55% |
| EBITDA Growth % | - | -320.7% | -44.69% | -78.24% | -20.67% | 11.45% | -18.88% | 2.33% | 4.57% |
| D&A (Non-Cash Add-back) | 260K | 245K | 859K | 1.46M | 5.84M | 6.77M | 6.49M | 6.08M | 9M |
| EBIT | -43.82M | -183.66M | -279.82M | -468.83M | -539.68M | -404.21M | -571.96M | -442.9M | -681.88M |
| Net Interest Income | 26K | -543K | 150K | -32.64M | -45.65M | -72.9M | -63.25M | -82.04M | -33.25M |
| Interest Income | 39K | 2M | 8.91M | 4.01M | 1.13M | 7.54M | 18.04M | 17.25M | 19.85M |
| Interest Expense | 13K | 2.55M | 8.77M | 36.66M | 46.78M | 80.44M | 81.29M | 99.29M | 53.1M |
| Other Income/Expense | 26K | 14.21M | -22.34M | -31.01M | -9.82M | 27.55M | -45.88M | 50.78M | -165.9M |
| Pretax Income | -43.83M | -169.45M | -288.58M | -505.49M | -586.45M | -484.65M | -653.25M | -542.19M | -734.99M |
| Pretax Margin % | - | - | -711.5% | -6127.87% | -841.2% | -624.17% | -7021.94% | -244.34% | -146.39% |
| Income Tax | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.15M | 555K |
| Effective Tax Rate % | 69.73% | 77.16% | 90.25% | 88.77% | 95.92% | 99.28% | 98.46% | 98.81% | 99.23% |
| Net Income | -30.57M | -130.75M | -260.44M | -448.72M | -562.54M | -481.18M | -643.2M | -535.76M | -729.31M |
| Net Margin % | - | - | -642.1% | -5439.74% | -806.9% | -619.7% | -6913.92% | -241.44% | -145.26% |
| Net Income Growth % | - | -327.77% | -99.19% | -72.3% | -25.36% | 14.46% | -33.67% | 16.7% | -36.13% |
| Net Income (Continuing) | -43.83M | -169.45M | -288.58M | -505.49M | -586.45M | -484.65M | -653.25M | -543.35M | -735.54M |
| Discontinued Operations | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Minority Interest | 3.33M | 62.48M | 67.52M | 49.98M | 4.83M | 9.69M | 11.72M | 10.29M | -570K |
| EPS (Diluted) | -0.33 | -1.42 | -2.48 | -4.10 | -3.90 | -3.35 | -3.95 | -2.88 | -3.79 |
| EPS Growth % | - | -330.3% | -74.65% | -65.32% | 4.88% | 14.1% | -17.91% | 27.09% | -31.6% |
| EPS (Basic) | -0.33 | -1.42 | -2.48 | -4.10 | -3.90 | -3.35 | -3.95 | -2.88 | -3.79 |
| Diluted Shares Outstanding | 92.33M | 92.33M | 105.1M | 118M | 144.36M | 147.47M | 162.79M | 186.08M | 197.24M |
| Basic Shares Outstanding | 92.33M | 92.33M | 105.1M | 118M | 144.36M | 147.47M | 162.79M | 186.08M | 197.24M |
| Dividend Payout Ratio | - | - | - | - | - | - | - | - | - |
| Dec 2017 | Dec 2018 | Dec 2019 | Dec 2020 | Dec 2021 | Dec 2022 | Dec 2023 | Dec 2024 | Dec 2025 | |
|---|---|---|---|---|---|---|---|---|---|
| Total Current Assets | 97.13M | 445.22M | 568.62M | 642.82M | 888.86M | 548.85M | 477.59M | 720.69M | 753.68M |
| Cash & Short-Term Investments | 92M | 436.09M | 545.99M | 607.09M | 836.66M | 471.92M | 434.88M | 681.1M | 587.48M |
| Cash Only | 92M | 436.09M | 363.77M | 356.08M | 393.77M | 376.69M | 375.94M | 681.1M | 570.12M |
| Short-Term Investments | 0 | 0 | 182.22M | 251.01M | 442.89M | 95.23M | 58.95M | 0 | 587.48M |
| Accounts Receivable | 0 | 0 | 2.85M | 0 | 19.75M | 17.08M | 1.75M | 4.72M | 139.44M |
| Days Sales Outstanding | - | - | 25.6 | - | 103.4 | 80.28 | 68.7 | 7.77 | 101.37 |
| Inventory | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 26.75M |
| Days Inventory Outstanding | - | - | - | - | - | - | - | - | 345.38 |
| Other Current Assets | 889K | 0 | 0 | 139K | 177K | 37.93M | 27.65M | 3.83M | 0 |
| Total Non-Current Assets | 913K | 19.72M | 63.06M | 60.76M | 123.93M | 74.18M | 68.79M | 198.65M | 41.59M |
| Property, Plant & Equipment | 440K | 1.57M | 5.63M | 36.83M | 45.97M | 25.25M | 19.84M | 12.78M | 13.52M |
| Fixed Asset Turnover | - | - | 7.21x | 0.22x | 1.52x | 3.08x | 0.47x | 17.37x | 37.15x |
| Goodwill | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Intangible Assets | 0 | 0 | 0 | 0 | 44.93M | 28.71M | 26.32M | 23.93M | 28.08M |
| Long-Term Investments | 381K | 17.05M | 31.14M | 0 | 0 | 0 | 0 | 143.75M | 0 |
| Other Non-Current Assets | 92K | 1.09M | 26.29M | 23.93M | 33.03M | 20.22M | 22.63M | 18.2M | 0 |
| Total Assets | 98.04M | 464.94M | 631.68M | 703.59M | 1.01B | 623.04M | 546.38M | 919.34M | 936.02M |
| Asset Turnover | - | - | 0.06x | 0.01x | 0.07x | 0.12x | 0.02x | 0.24x | 0.54x |
| Asset Growth % | - | 374.22% | 35.86% | 11.38% | 43.95% | -38.48% | -12.3% | 68.26% | 1.82% |
| Total Current Liabilities | 8.55M | 32.58M | 60.38M | 95.65M | 135.07M | 121.43M | 143.84M | 154.4M | 287.97M |
| Accounts Payable | 1.89M | 13.51M | 8.85M | 8.95M | 11.88M | 11.56M | 10.65M | 9.62M | 36.23M |
| Days Payables Outstanding | 2.65K | - | 1.29K | - | 1.39K | 1.23K | 1.59K | 905.25 | 467.7 |
| Short-Term Debt | 0 | 0 | 0 | 1.46M | 0 | 0 | 0 | 0 | 6.19M |
| Deferred Revenue (Current) | 0 | 0 | 0 | 0 | 0 | 8.16M | 6.1M | 0 | 20.27M |
| Other Current Liabilities | 997K | 4.01M | 25.39M | 9.55M | 37.04M | 31.26M | 65.59M | 16.2M | 225.28M |
| Current Ratio | 11.36x | 13.67x | 9.42x | 6.72x | 6.58x | 4.52x | 3.32x | 4.67x | 2.62x |
| Quick Ratio | 11.36x | 13.67x | 9.42x | 6.72x | 6.58x | 4.52x | 3.32x | 4.67x | 2.52x |
| Cash Conversion Cycle | - | - | - | - | - | - | - | - | -20.95 |
| Total Non-Current Liabilities | 144.18M | 533.87M | 95.32M | 500.05M | 1.74B | 1.75B | 1.75B | 2.22B | 2.72B |
| Long-Term Debt | 143.87M | 54.51M | 91.79M | 475.86M | 1.7B | 1.71B | 1.73B | 1.72B | 3.81M |
| Capital Lease Obligations | 0 | 0 | 0 | 14.68M | 17.43M | 12.27M | 8.98M | 4.7M | 0 |
| Deferred Tax Liabilities | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Non-Current Liabilities | 312K | 479.36M | 3.53M | 9.52M | 22.07M | 26.64M | 9.36M | 496.47M | 2.72B |
| Total Liabilities | 152.73M | 566.44M | 155.7M | 595.7M | 1.88B | 1.87B | 1.89B | 2.38B | 3.01B |
| Total Debt | 143.87M | 54.51M | 91.79M | 495.79M | 1.73B | 1.72B | 1.74B | 1.73B | 10M |
| Net Debt | 51.87M | -381.58M | -271.98M | 139.71M | 1.33B | 1.35B | 1.36B | 1.05B | -560.12M |
| Debt / Equity | - | - | 0.19x | 4.60x | - | - | - | - | - |
| Debt / EBITDA | - | - | - | - | - | - | - | - | - |
| Net Debt / EBITDA | - | - | - | - | - | - | - | - | - |
| Interest Coverage | -3373.69x | -72.11x | -30.38x | -12.94x | -12.33x | -6.37x | -7.47x | -5.97x | -10.72x |
| Total Equity | -54.69M | -101.5M | 475.98M | 107.89M | -865.58M | -1.24B | -1.34B | -1.46B | -2.08B |
| Equity Growth % | - | -85.61% | 568.93% | -77.33% | -902.31% | -43.83% | -7.84% | -8.57% | -42.5% |
| Book Value per Share | -0.59 | -1.10 | 4.53 | 0.91 | -6.00 | -8.44 | -8.25 | -7.83 | -10.53 |
| Total Shareholders' Equity | -58.02M | -163.99M | 408.45M | 57.91M | -870.41M | -1.25B | -1.35B | -1.47B | -2.08B |
| Common Stock | 3.41M | 6.59M | 124K | 125K | 154K | 157K | 181K | 196K | 202K |
| Retained Earnings | -61.43M | -170.58M | -440.03M | -888.75M | -1.44B | -1.92B | -2.56B | -3.1B | -3.82B |
| Treasury Stock | 0 | 0 | 0 | -75M | -275M | -275M | -275M | -275M | 0 |
| Accumulated OCI | -27K | -231K | 254K | 192K | -132K | -328K | 31K | 8K | 12K |
| Minority Interest | 3.33M | 62.48M | 67.52M | 49.98M | 4.83M | 9.69M | 11.72M | 10.29M | -570K |
| Dec 2017 | Dec 2018 | Dec 2019 | Dec 2020 | Dec 2021 | Dec 2022 | Dec 2023 | Dec 2024 | Dec 2025 | |
|---|---|---|---|---|---|---|---|---|---|
| Cash from Operations | -40.49M | -136.64M | -253.59M | -399.71M | -497.93M | -419.49M | -527.72M | -520.73M | -445.91M |
| Operating CF Margin % | - | - | -625.21% | -4845.61% | -714.23% | -540.25% | -5672.58% | -234.66% | -88.81% |
| Operating CF Growth % | - | -237.49% | -85.58% | -57.62% | -24.57% | 15.75% | -25.8% | 1.33% | 14.37% |
| Net Income | -43.83M | -169.45M | -288.58M | -505.49M | -586.45M | -484.65M | -643.2M | -543.35M | -724.93M |
| Depreciation & Amortization | 260K | 245K | 859K | 3.09M | 5.84M | 6.77M | 6.49M | 6.08M | 5.97M |
| Stock-Based Compensation | 1.84M | 6.07M | 21.37M | 58.46M | 99.5M | 91.56M | 0 | 95.8M | 133.02M |
| Deferred Taxes | -260K | -14.89M | -859K | -1.87M | -30.93M | 0 | 0 | 0 | 0 |
| Other Non-Cash Items | 260K | 18.89M | 24.54M | 31.16M | 18.5M | -61.25M | 103.93M | -111.3M | 140.03M |
| Working Capital Changes | 1.24M | 22.49M | -10.91M | 14.93M | -4.4M | 28.08M | 5.06M | 32.04M | 0 |
| Change in Receivables | 0 | 0 | -2.85M | 2.85M | -19.75M | 15.17M | 15.33M | -2.97M | -134.72M |
| Change in Inventory | 0 | 0 | 2.85M | -2.85M | 19.75M | 0 | 0 | 0 | -25.31M |
| Change in Payables | 1.58M | 16.7M | -4.66M | -735K | 2.83M | -349K | 2.78M | 1.51M | 26.61M |
| Cash from Investing | -464K | -21.04M | -217.25M | -52.99M | -200.83M | 453.15M | 54.03M | 60.78M | -24.49M |
| Capital Expenditures | -464K | -18.18M | -5.14M | -7.52M | -48.25M | -4.82M | -1.31M | -933K | -1.1M |
| CapEx % of Revenue | - | - | 12.67% | 91.14% | 69.2% | 6.21% | 14.04% | 0.42% | 0.22% |
| Acquisitions | 2.84M | -2.86M | -5.49M | 21.24M | -35M | 0 | 0 | -140K | 0 |
| Investments | - | - | - | - | - | - | - | - | - |
| Other Investing | 0 | -2.86M | 784K | -21.09M | 48.65M | 118.5M | -503K | -7.97M | -6.19M |
| Cash from Financing | 112.98M | 501.55M | 398.79M | 447.19M | 736.45M | -13.13M | 451.54M | 748.46M | 359.29M |
| Debt Issued (Net) | 4.13M | 56.38M | 36.94M | 550M | 1.08B | -20.49M | 0 | 476.58M | 0 |
| Equity Issued (Net) | 1000K | 1000K | 1000K | -1000K | -1000K | 1000K | 1000K | 1000K | 0 |
| Dividends Paid | -1.15M | 0 | -997K | 0 | 0 | 0 | 0 | 0 | 0 |
| Share Repurchases | 0 | 0 | 0 | -75.71M | -204.75M | -1.56M | -6.88M | -7.53M | -48.28M |
| Other Financing | 1.83M | 14.64M | -4.38M | -27.1M | -138.49M | 4.06M | 8.61M | -35.34M | 359.29M |
| Net Change in Cash | 72.03M | 343.87M | -72.05M | -5.52M | 37.69M | 20.52M | -22.15M | 288.51M | -111.1M |
| Free Cash Flow | -40.95M | -154.82M | -258.73M | -407.23M | -546.18M | -425.81M | -529.03M | -521.66M | -447.01M |
| FCF Margin % | - | - | -637.88% | -4936.74% | -783.44% | -548.39% | -5686.62% | -235.09% | -89.03% |
| FCF Growth % | - | -278.05% | -67.11% | -57.4% | -34.12% | 22.04% | -24.24% | 1.39% | 14.31% |
| FCF per Share | -0.44 | -1.68 | -2.46 | -3.45 | -3.78 | -2.89 | -3.25 | -2.80 | -2.27 |
| FCF Conversion (FCF/Net Income) | 1.32x | 1.05x | 0.97x | 0.89x | 0.89x | 0.87x | 0.82x | 0.97x | 0.61x |
| Interest Paid | 0 | 0 | 0 | 0 | 0 | 54.44M | 61.11M | 0 | 0 |
| Taxes Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Metric | 2017 | 2018 | 2019 | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|---|---|---|---|---|
| Return on Equity (ROE) | - | - | -139.1% | -153.71% | - | - | - | - | - |
| Return on Invested Capital (ROIC) | - | - | - | -157.61% | -121.07% | -135.08% | -738.78% | - | - |
| Gross Margin | - | - | 93.84% | 100% | 95.53% | 95.58% | 73.71% | 98.25% | 94.37% |
| Net Margin | - | - | -642.1% | -5439.74% | -806.9% | -619.7% | -6913.92% | -241.44% | -145.26% |
| Debt / Equity | - | - | 0.19x | 4.60x | - | - | - | - | - |
| Interest Coverage | -3373.69x | -72.11x | -30.38x | -12.94x | -12.33x | -6.37x | -7.47x | -5.97x | -10.72x |
| FCF Conversion | 1.32x | 1.05x | 0.97x | 0.89x | 0.89x | 0.87x | 0.82x | 0.97x | 0.61x |
| Revenue Growth | - | - | - | -79.66% | 745.14% | 11.38% | -88.02% | 2285.27% | 126.26% |
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