Comprehensive Stock Comparison
Compare Azitra, Inc. (AZTR) vs Eli Lilly and Company (LLY) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Growth |  LLY | 32.0% revenue growth vs AZTR's -100.0% |
| Stability / Safety |  AZTR | Beta 0.65 vs LLY's 0.65, lower leverage |
| Dividends | LLY | 0.5% yield; 10-year raise streak; AZTR pays no meaningful dividend |
| Momentum (1Y) | LLY | +8.6% vs AZTR's -91.7% |
| Efficiency (ROA) | LLY | 16.0% ROA vs AZTR's -0.2%, ROIC 33.7% vs -0.8% |
Who Each Stock Is For
Income & stability
AZTRbeta 0.65
Growth exposure
LLYRev growth 32.0%, EPS growth 101.9%, 3Y rev CAGR 16.7%
Long-term compounding (10Y)
LLY13.2% 10Y total return vs AZTR's -100.0%
Sleep-well-at-night portfolio
AZTRLower volatility, beta 0.65, Low D/E 11.1%, current ratio 2.83x
Defensive / Recession hedge
AZTRBeta 0.65, current ratio 2.83x
Business Model
What each company does and how it makes money
Azitra is a preclinical biopharmaceutical company developing engineered bacterial therapies for rare and serious skin diseases. It aims to generate revenue through drug development partnerships and future product sales — though currently in preclinical stages without commercial revenue. The company's key advantage lies in its proprietary platform for engineering commensal skin bacteria to deliver therapeutic proteins directly to diseased skin.
Eli Lilly is a global pharmaceutical company that discovers, develops, and markets innovative medicines for serious diseases like diabetes, cancer, and autoimmune disorders. It generates revenue primarily from drug sales — with diabetes treatments like Trulicity and Mounjaro contributing over 50% of revenue — and from oncology and immunology products. The company's competitive advantage lies in its deep research and development capabilities, particularly in diabetes and obesity treatments where it has established a strong patent-protected portfolio.
Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
LLY 3AZTR 1LLY1/1 metricsAZTR2/2 metricsLLY6/9 metricsLLY6/6 metricsLLY leads in 3 of 6 categories (Financial Metrics, Profitability & Efficiency). AZTR leads in 1 (Valuation Metrics). 1 tied.
Financial Metrics (TTM)
LLY and AZTR operate at a comparable scale, with $59.4B and $0 in trailing revenue.
| Metric | AZTRAzitra, Inc. | LLYEli Lilly and Com… |
|---|---|---|
| RevenueTrailing 12 months | $0 | $59.4B |
| EBITDAEarnings before interest/tax | -$11M | $28.6B |
| Net IncomeAfter-tax profit | -$11M | $18.4B |
| Free Cash FlowCash after capex | -$86M | $9.0B |
| Gross MarginGross profit ÷ Revenue | — | +83.0% |
| Operating MarginEBIT ÷ Revenue | — | +45.0% |
| Net MarginNet income ÷ Revenue | — | +31.0% |
| FCF MarginFCF ÷ Revenue | — | +15.2% |
| Rev. Growth (YoY)Latest quarter vs prior year | — | +53.9% |
| EPS Growth (YoY)Latest quarter vs prior year | -6.9% | +4.8% |
Valuation Metrics
| Metric | AZTRAzitra, Inc. | LLYEli Lilly and Com… |
|---|---|---|
| Market CapShares × price | $2M | $898.2B |
| Enterprise ValueMkt cap + debt − cash | -$1.6B | $928.6B |
| Trailing P/EPrice ÷ TTM EPS | -0.08x | 85.70x |
| Forward P/EPrice ÷ next-FY EPS est. | — | 29.43x |
| PEG RatioP/E ÷ EPS growth rate | — | 13.94x |
| EV / EBITDAEnterprise value multiple | — | 48.19x |
| Price / SalesMarket cap ÷ Revenue | — | 19.94x |
| Price / BookPrice ÷ Book value/share | 0.00x | 63.57x |
| Price / FCFMarket cap ÷ FCF | — | 2168.03x |
Profitability & Efficiency
LLY delivers a 77.2% return on equity — every $100 of shareholder capital generates $77 in annual profit, vs $-0 for AZTR. AZTR carries lower financial leverage with a 0.11x debt-to-equity ratio, signaling a more conservative balance sheet compared to LLY's 2.36x. On the Piotroski fundamental quality scale (0–9), LLY scores 6/9 vs AZTR's 1/9, reflecting solid financial health.
| Metric | AZTRAzitra, Inc. | LLYEli Lilly and Com… |
|---|---|---|
| ROE (TTM)Return on equity | -0.3% | +77.2% |
| ROA (TTM)Return on assets | -0.2% | +16.0% |
| ROICReturn on invested capital | -0.8% | +33.7% |
| ROCEReturn on capital employed | -0.6% | +40.2% |
| Piotroski ScoreFundamental quality 0–9 | 1 | 6 |
| Debt / EquityFinancial leverage | 0.11x | 2.36x |
| Net DebtTotal debt minus cash | -$1.6B | $30.4B |
| Cash & Equiv.Liquid assets | $2.1B | $3.3B |
| Total DebtShort + long-term debt | $422M | $33.6B |
| Interest CoverageEBIT ÷ Interest expense | -13.79x | 26.09x |
Total Returns (with DRIP)
A $10,000 investment in LLY five years ago would be worth $49,693 today (with dividends reinvested), compared to $2 for AZTR. Over the past 12 months, LLY leads with a +8.6% total return vs AZTR's -91.7%. The 3-year compound annual growth rate (CAGR) favors LLY at 47.3% vs AZTR's -94.2% — a key indicator of consistent wealth creation.
| Metric | AZTRAzitra, Inc. | LLYEli Lilly and Com… |
|---|---|---|
| YTD ReturnYear-to-date | -32.1% | -6.9% |
| 1-Year ReturnPast 12 months | -91.7% | +8.6% |
| 3-Year ReturnCumulative with dividends | -100.0% | +219.8% |
| 5-Year ReturnCumulative with dividends | -100.0% | +396.9% |
| 10-Year ReturnCumulative with dividends | -100.0% | +1316.4% |
| CAGR (3Y)Annualised 3-year return | -94.2% | +47.3% |
Risk & Volatility
AZTR is the less volatile stock with a 0.65 beta — it tends to amplify market swings less than LLY's 0.65 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. LLY currently trades 88.5% from its 52-week high vs AZTR's 7.1% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | AZTRAzitra, Inc. | LLYEli Lilly and Com… |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 0.65x | 0.65x |
| 52-Week HighHighest price in past year | $2.66 | $1133.95 |
| 52-Week LowLowest price in past year | $0.15 | $623.78 |
| % of 52W HighCurrent price vs 52-week peak | +7.1% | +88.5% |
| RSI (14)Momentum oscillator 0–100 | 35.7 | 44.8 |
| Avg Volume (50D)Average daily shares traded | 1.4M | 3.0M |
Analyst Outlook
LLY is the only dividend payer here at 0.52% yield — a key consideration for income-focused portfolios.
| Metric | AZTRAzitra, Inc. | LLYEli Lilly and Com… |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | — | Buy |
| Price TargetConsensus 12-month target | — | $1214.28 |
| # AnalystsCovering analysts | — | 44 |
| Dividend YieldAnnual dividend ÷ price | — | +0.5% |
| Dividend StreakConsecutive years of raises | — | 10 |
| Dividend / ShareAnnual DPS | — | $5.18 |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | +0.3% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Jun 23 | Mar 26 | Change |
|---|---|---|---|
| Azitra, Inc. (AZTR) | 100 | 0.02 | -100.0% |
| Eli Lilly and Compa… (LLY) | 100 | 220.62 | +120.6% |
Eli Lilly and Compa… (LLY) returned +397% over 5 years vs Azitra, Inc. (AZTR)'s -100%. A $10,000 investment in LLY 5 years ago would be worth $49,693 today (including dividends reinvested).
Chart 2Revenue Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Azitra, Inc. (AZTR) | $110000.00 | $0.00 | -100.0% |
| Eli Lilly and Compa… (LLY) | $21.2B | $45.0B | +112.2% |
Chart 3Net Margin Trend — 10 Years
| Stock | 2015 | 2024 | Change |
|---|---|---|---|
| Azitra, Inc. (AZTR) | -81.3% | -119.6% | -47.1% |
| Eli Lilly and Compa… (LLY) | 12.1% | 23.5% | +94.8% |
Eli Lilly and Company's net margin went from 12% (2015) to 24% (2024).
Chart 4P/E Ratio History — 7 Years
| Stock | 2018 | 2024 | Change |
|---|---|---|---|
| Eli Lilly and Compa… (LLY) | 37 | 65.9 | +78.1% |
Eli Lilly and Company has traded in a 15x–101x P/E range over 7 years; current trailing P/E is ~86x.
Chart 5EPS Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Azitra, Inc. (AZTR) | -3.33 | -2.25 | +32.5% |
| Eli Lilly and Compa… (LLY) | 2.49 | 11.71 | +370.3% |
Chart 6Free Cash Flow — 5 Years
Azitra, Inc. generated $-11B FCF in 2025 (-128900% vs 2021). Eli Lilly and Company generated $414M FCF in 2024 (-92% vs 2021).
AZTR vs LLY: Frequently Asked Questions
7 questions · data-driven answers · updated daily
01Is AZTR or LLY a better buy right now?
Eli Lilly and Company (LLY) offers the better valuation at 85.7x trailing P/E (29.4x forward), making it the more compelling value choice. Analysts rate Eli Lilly and Company (LLY) a "Buy" — based on 44 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — AZTR or LLY?
Over the past 5 years, Eli Lilly and Company (LLY) delivered a total return of +396.9%, compared to -100.0% for Azitra, Inc. (AZTR). A $10,000 investment in LLY five years ago would be worth approximately $50K today (assuming dividends reinvested). Over 10 years, the gap is even starker: LLY returned +1316% versus AZTR's -100.0%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — AZTR or LLY?
By beta (market sensitivity over 5 years), Azitra, Inc. (AZTR) is the lower-risk stock at 0.65β versus Eli Lilly and Company's 0.65β — meaning LLY is approximately 0% more volatile than AZTR relative to the S&P 500. On balance sheet safety, Azitra, Inc. (AZTR) carries a lower debt/equity ratio of 11% versus 2% for Eli Lilly and Company — giving it more financial flexibility in a downturn.
04Which has better profit margins — AZTR or LLY?
Eli Lilly and Company (LLY) is the more profitable company, earning 23.5% net margin versus 0.0% for Azitra, Inc. — meaning it keeps 23.5% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: LLY leads at 38.9% versus 0.0% for AZTR. At the gross margin level — before operating expenses — LLY leads at 81.3%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
05Which pays a better dividend — AZTR or LLY?
In this comparison, LLY (0.5% yield) pays a dividend. AZTR does not pay a meaningful dividend and should not be held primarily for income.
06Is AZTR or LLY better for a retirement portfolio?
For long-horizon retirement investors, Eli Lilly and Company (LLY) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.65), 0.5% yield, +1316% 10Y return). Both have compounded well over 10 years (LLY: +1316%, AZTR: -100.0%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
07What are the main differences between AZTR and LLY?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. LLY pays a dividend while AZTR does not, making them suitable for different income and tax situations. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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