Comprehensive Stock Comparison
Compare Amicus Therapeutics, Inc. (FOLD) vs BridgeBio Pharma, Inc. (BBIO) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Growth | BBIO | 126.3% revenue growth vs FOLD's 32.3% |
| Quality / Margins | FOLD | -2.3% net margin vs BBIO's -145.3% |
| Stability / Safety | FOLD | Beta 0.65 vs BBIO's 1.04 |
| Dividends | Tie | Neither pays a meaningful dividend |
| Momentum (1Y) | BBIO | +90.5% vs FOLD's +51.4% |
| Efficiency (ROA) | FOLD | -1.6% ROA vs BBIO's -77.9% |
Who Each Stock Is For
Income & stability
Growth exposure
Long-term compounding (10Y)
Sleep-well-at-night portfolio
Defensive / Recession hedge
Business Model
What each company does and how it makes money
Amicus Therapeutics is a biotechnology company that develops and commercializes precision medicines for rare genetic diseases. It generates revenue primarily from sales of Galafold for Fabry disease — its only marketed product — supplemented by research collaborations and milestone payments from partners. The company's competitive advantage lies in its expertise in small molecule chaperone technology and its focused pipeline targeting high-need rare diseases with limited treatment options.
BridgeBio Pharma is a biopharmaceutical company focused on discovering and developing precision medicines for genetic diseases. It generates revenue primarily through drug development partnerships and potential future product sales — though currently in pre-revenue stage with multiple programs in clinical trials. The company's key advantage is its efficient hub-and-spoke operating model that allows rapid development of targeted therapies for rare genetic conditions.
Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
FOLD leads in 4 of 6 categories (Financial Metrics, Valuation Metrics). BBIO leads in 1 (Total Returns).
Financial Metrics (TTM)
FOLD and BBIO operate at a comparable scale, with $599M and $502M in trailing revenue. FOLD is the more profitable business, keeping -2.3% of every revenue dollar as net income compared to BBIO's -145.3%. On growth, BBIO holds the edge at +25.2% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | FOLDAmicus Therapeuti… | BBIOBridgeBio Pharma,… |
|---|---|---|
| RevenueTrailing 12 months | $599M | $502M |
| EBITDAEarnings before interest/tax | $40M | -$560M |
| Net IncomeAfter-tax profit | -$14M | -$729M |
| Free Cash FlowCash after capex | $10M | -$458M |
| Gross MarginGross profit ÷ Revenue | +89.5% | +94.4% |
| Operating MarginEBIT ÷ Revenue | +5.5% | -113.3% |
| Net MarginNet income ÷ Revenue | -2.3% | -145.3% |
| FCF MarginFCF ÷ Revenue | +1.6% | -91.1% |
| Rev. Growth (YoY)Latest quarter vs prior year | +19.5% | +25.2% |
| EPS Growth (YoY)Latest quarter vs prior year | +3.8% | +28.6% |
Valuation Metrics
| Metric | FOLDAmicus Therapeuti… | BBIOBridgeBio Pharma,… |
|---|---|---|
| Market CapShares × price | $4.4B | $12.9B |
| Enterprise ValueMkt cap + debt − cash | $4.7B | $12.4B |
| Trailing P/EPrice ÷ TTM EPS | -79.83x | -17.54x |
| Forward P/EPrice ÷ next-FY EPS est. | 47.44x | — |
| PEG RatioP/E ÷ EPS growth rate | — | — |
| EV / EBITDAEnterprise value multiple | 139.52x | — |
| Price / SalesMarket cap ÷ Revenue | 8.39x | 25.79x |
| Price / BookPrice ÷ Book value/share | 22.54x | — |
| Price / FCFMarket cap ÷ FCF | — | — |
Profitability & Efficiency
On the Piotroski fundamental quality scale (0–9), FOLD scores 5/9 vs BBIO's 3/9, reflecting solid financial health.
| Metric | FOLDAmicus Therapeuti… | BBIOBridgeBio Pharma,… |
|---|---|---|
| ROE (TTM)Return on equity | -6.1% | — |
| ROA (TTM)Return on assets | -1.6% | -77.9% |
| ROICReturn on invested capital | +4.8% | — |
| ROCEReturn on capital employed | +4.0% | -80.6% |
| Piotroski ScoreFundamental quality 0–9 | 5 | 3 |
| Debt / EquityFinancial leverage | 2.29x | — |
| Net DebtTotal debt minus cash | $230M | -$560M |
| Cash & Equiv.Liquid assets | $214M | $570M |
| Total DebtShort + long-term debt | $444M | $10M |
| Interest CoverageEBIT ÷ Interest expense | 1.11x | -6.10x |
Total Returns (with DRIP)
A $10,000 investment in FOLD five years ago would be worth $12,188 today (with dividends reinvested), compared to $9,245 for BBIO. Over the past 12 months, BBIO leads with a +90.5% total return vs FOLD's +51.4%. The 3-year compound annual growth rate (CAGR) favors BBIO at 79.9% vs FOLD's 2.9% — a key indicator of consistent wealth creation.
| Metric | FOLDAmicus Therapeuti… | BBIOBridgeBio Pharma,… |
|---|---|---|
| YTD ReturnYear-to-date | +0.7% | -15.0% |
| 1-Year ReturnPast 12 months | +51.4% | +90.5% |
| 3-Year ReturnCumulative with dividends | +8.9% | +482.1% |
| 5-Year ReturnCumulative with dividends | +21.9% | -7.6% |
| 10-Year ReturnCumulative with dividends | +133.3% | +141.3% |
| CAGR (3Y)Annualised 3-year return | +2.9% | +79.9% |
Risk & Volatility
FOLD is the less volatile stock with a 0.65 beta — it tends to amplify market swings less than BBIO's 1.04 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. FOLD currently trades 99.9% from its 52-week high vs BBIO's 78.3% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | FOLDAmicus Therapeuti… | BBIOBridgeBio Pharma,… |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 0.65x | 1.04x |
| 52-Week HighHighest price in past year | $14.38 | $84.94 |
| 52-Week LowLowest price in past year | $5.51 | $28.33 |
| % of 52W HighCurrent price vs 52-week peak | +99.9% | +78.3% |
| RSI (14)Momentum oscillator 0–100 | 72.0 | 39.0 |
| Avg Volume (50D)Average daily shares traded | 8.1M | 2.5M |
Analyst Outlook
Wall Street rates FOLD as "Buy" and BBIO as "Buy". Consensus price targets imply 48.8% upside for BBIO (target: $99) vs -0.3% for FOLD (target: $14).
| Metric | FOLDAmicus Therapeuti… | BBIOBridgeBio Pharma,… |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | Buy |
| Price TargetConsensus 12-month target | $14.33 | $98.92 |
| # AnalystsCovering analysts | 24 | 26 |
| Dividend YieldAnnual dividend ÷ price | — | — |
| Dividend StreakConsecutive years of raises | — | 0 |
| Dividend / ShareAnnual DPS | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | +0.4% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Mar 20 | Feb 26 | Change |
|---|---|---|---|
| Amicus Therapeutics… (FOLD) | 100 | 153.33 | +53.3% |
| BridgeBio Pharma, I… (BBIO) | 100 | 242.91 | +142.9% |
Amicus Therapeutics… (FOLD) returned +22% over 5 years vs BridgeBio Pharma, I… (BBIO)'s -8%. A $10,000 investment in FOLD 5 years ago would be worth $12,188 today (including dividends reinvested).
Chart 2Revenue Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Amicus Therapeutics… (FOLD) | $5M | $528M | +10555.4% |
| BridgeBio Pharma, I… (BBIO) | $0.00 | $502M | — |
Chart 3Net Margin Trend — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Amicus Therapeutics… (FOLD) | -40.3% | -10.6% | +73.7% |
| BridgeBio Pharma, I… (BBIO) | -6.4% | -145.3% | -2162.2% |
Chart 4EPS Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Amicus Therapeutics… (FOLD) | -1.49 | -0.18 | +87.9% |
| BridgeBio Pharma, I… (BBIO) | -0.33 | -3.79 | -1048.5% |
Chart 5Free Cash Flow — 5 Years
Amicus Therapeutics, Inc. generated $-37M FCF in 2024 (+82% vs 2021). BridgeBio Pharma, Inc. generated $-447M FCF in 2025 (+18% vs 2021).
FOLD vs BBIO: Frequently Asked Questions
8 questions · data-driven answers · updated daily
01Is FOLD or BBIO a better buy right now?
Analysts rate Amicus Therapeutics, Inc. (FOLD) a "Buy" — based on 24 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — FOLD or BBIO?
Over the past 5 years, Amicus Therapeutics, Inc. (FOLD) delivered a total return of +21.9%, compared to -7.6% for BridgeBio Pharma, Inc. (BBIO). A $10,000 investment in FOLD five years ago would be worth approximately $12K today (assuming dividends reinvested). Over 10 years, the gap is even starker: BBIO returned +141.3% versus FOLD's +133.3%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — FOLD or BBIO?
By beta (market sensitivity over 5 years), Amicus Therapeutics, Inc. (FOLD) is the lower-risk stock at 0.65β versus BridgeBio Pharma, Inc.'s 1.04β — meaning BBIO is approximately 59% more volatile than FOLD relative to the S&P 500.
04Which has better profit margins — FOLD or BBIO?
Amicus Therapeutics, Inc. (FOLD) is the more profitable company, earning -10.6% net margin versus -145.3% for BridgeBio Pharma, Inc. — meaning it keeps -10.6% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: FOLD leads at 4.7% versus -113.3% for BBIO. At the gross margin level — before operating expenses — BBIO leads at 94.4%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
05Is FOLD or BBIO more undervalued right now?
Analyst consensus price targets imply the most upside for BBIO: 48.8% to $98.92.
06Which pays a better dividend — FOLD or BBIO?
None of the stocks in this comparison currently pay a material dividend. All are effectively zero-yield and should be held for capital appreciation rather than income.
07Is FOLD or BBIO better for a retirement portfolio?
For long-horizon retirement investors, Amicus Therapeutics, Inc. (FOLD) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.65), +133.3% 10Y return). Both have compounded well over 10 years (FOLD: +133.3%, BBIO: +141.3%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
08What are the main differences between FOLD and BBIO?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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