Comprehensive Stock Comparison
Compare Milestone Pharmaceuticals Inc. (MIST) vs ADMA Biologics, Inc. (ADMA) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Growth | ADMA | 65.2% revenue growth vs MIST's -100.0% |
| Stability / Safety | ADMA | Beta 1.10 vs MIST's 1.32, lower leverage |
| Dividends | Tie | Neither pays a meaningful dividend |
| Momentum (1Y) | MIST | +4.9% vs ADMA's -5.0% |
| Efficiency (ROA) | ADMA | 36.8% ROA vs MIST's -66.1%, ROIC 37.7% vs -64.8% |
Who Each Stock Is For
Income & stability
Growth exposure
Long-term compounding (10Y)
Sleep-well-at-night portfolio
Defensive / Recession hedge
Business Model
What each company does and how it makes money
Milestone Pharmaceuticals is a clinical-stage biopharmaceutical company developing novel cardiovascular therapies. It generates revenue primarily through research collaborations and licensing agreements — notably with Ji Xing Pharmaceuticals for its lead candidate etripamil — while advancing toward potential drug commercialization. The company's competitive advantage lies in its proprietary etripamil formulation, a fast-acting nasal spray designed for patient self-administration during acute cardiac episodes.
ADMA Biologics is a biopharmaceutical company that develops, manufactures, and markets specialty plasma-derived biologics for treating immune deficiencies and infectious diseases. It generates revenue primarily from sales of its intravenous immune globulin products — BIVIGAM and ASCENIV — along with its Hepatitis B treatment Nabi-HB, while also operating plasma collection facilities. The company's key advantage is its integrated business model that combines plasma collection, manufacturing, and commercialization, creating a vertically controlled supply chain for plasma-derived therapies.
Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
ADMA leads in 3 of 6 categories (Profitability & Efficiency, Total Returns). MIST leads in 2 (Financial Metrics, Valuation Metrics).
Financial Metrics (TTM)
ADMA and MIST operate at a comparable scale, with $489M and $0 in trailing revenue.
| Metric | MISTMilestone Pharmac… | ADMAADMA Biologics, I… |
|---|---|---|
| RevenueTrailing 12 months | $0 | $489M |
| EBITDAEarnings before interest/tax | -$57M | $175M |
| Net IncomeAfter-tax profit | -$58M | $209M |
| Free Cash FlowCash after capex | -$43M | $41M |
| Gross MarginGross profit ÷ Revenue | — | +54.7% |
| Operating MarginEBIT ÷ Revenue | — | +34.2% |
| Net MarginNet income ÷ Revenue | — | +42.9% |
| FCF MarginFCF ÷ Revenue | — | +8.3% |
| Rev. Growth (YoY)Latest quarter vs prior year | — | +12.0% |
| EPS Growth (YoY)Latest quarter vs prior year | +14.3% | 0.0% |
Valuation Metrics
| Metric | MISTMilestone Pharmac… | ADMAADMA Biologics, I… |
|---|---|---|
| Market CapShares × price | $146M | $3.7B |
| Enterprise ValueMkt cap + debt − cash | $175M | $3.7B |
| Trailing P/EPrice ÷ TTM EPS | -2.55x | 19.22x |
| Forward P/EPrice ÷ next-FY EPS est. | — | 16.30x |
| PEG RatioP/E ÷ EPS growth rate | — | — |
| EV / EBITDAEnterprise value multiple | — | 25.10x |
| Price / SalesMarket cap ÷ Revenue | — | 8.70x |
| Price / BookPrice ÷ Book value/share | 8.09x | 10.86x |
| Price / FCFMarket cap ÷ FCF | — | 33.71x |
Profitability & Efficiency
ADMA delivers a 48.6% return on equity — every $100 of shareholder capital generates $49 in annual profit, vs $-3 for MIST. ADMA carries lower financial leverage with a 0.24x debt-to-equity ratio, signaling a more conservative balance sheet compared to MIST's 4.17x. On the Piotroski fundamental quality scale (0–9), ADMA scores 7/9 vs MIST's 2/9, reflecting strong financial health.
| Metric | MISTMilestone Pharmac… | ADMAADMA Biologics, I… |
|---|---|---|
| ROE (TTM)Return on equity | -2.8% | +48.6% |
| ROA (TTM)Return on assets | -66.1% | +36.8% |
| ROICReturn on invested capital | -64.8% | +37.7% |
| ROCEReturn on capital employed | -62.2% | +39.0% |
| Piotroski ScoreFundamental quality 0–9 | 2 | 7 |
| Debt / EquityFinancial leverage | 4.17x | 0.24x |
| Net DebtTotal debt minus cash | $29M | -$21M |
| Cash & Equiv.Liquid assets | $25M | $103M |
| Total DebtShort + long-term debt | $55M | $82M |
| Interest CoverageEBIT ÷ Interest expense | -14.42x | 19.63x |
Total Returns (with DRIP)
A $10,000 investment in ADMA five years ago would be worth $64,339 today (with dividends reinvested), compared to $2,277 for MIST. Over the past 12 months, MIST leads with a +4.9% total return vs ADMA's -5.0%. The 3-year compound annual growth rate (CAGR) favors ADMA at 63.7% vs MIST's -18.5% — a key indicator of consistent wealth creation.
| Metric | MISTMilestone Pharmac… | ADMAADMA Biologics, I… |
|---|---|---|
| YTD ReturnYear-to-date | -16.6% | -12.9% |
| 1-Year ReturnPast 12 months | +4.9% | -5.0% |
| 3-Year ReturnCumulative with dividends | -45.9% | +338.6% |
| 5-Year ReturnCumulative with dividends | -77.2% | +543.4% |
| 10-Year ReturnCumulative with dividends | -88.9% | +227.8% |
| CAGR (3Y)Annualised 3-year return | -18.5% | +63.7% |
Risk & Volatility
ADMA is the less volatile stock with a 1.10 beta — it tends to amplify market swings less than MIST's 1.32 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. ADMA currently trades 60.7% from its 52-week high vs MIST's 55.9% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | MISTMilestone Pharmac… | ADMAADMA Biologics, I… |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 1.32x | 1.10x |
| 52-Week HighHighest price in past year | $3.06 | $25.67 |
| 52-Week LowLowest price in past year | $0.63 | $13.50 |
| % of 52W HighCurrent price vs 52-week peak | +55.9% | +60.7% |
| RSI (14)Momentum oscillator 0–100 | 39.6 | 35.7 |
| Avg Volume (50D)Average daily shares traded | 2.5M | 1.8M |
Analyst Outlook
Wall Street rates MIST as "Buy" and ADMA as "Buy". Consensus price targets imply 367.8% upside for MIST (target: $8) vs 2.8% for ADMA (target: $16).
| Metric | MISTMilestone Pharmac… | ADMAADMA Biologics, I… |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | Buy |
| Price TargetConsensus 12-month target | $8.00 | $16.00 |
| # AnalystsCovering analysts | 7 | 9 |
| Dividend YieldAnnual dividend ÷ price | — | — |
| Dividend StreakConsecutive years of raises | — | 1 |
| Dividend / ShareAnnual DPS | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | 0.0% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Mar 20 | Feb 26 | Change |
|---|---|---|---|
| Milestone Pharmaceu… (MIST) | 100 | 10.44 | -89.6% |
| ADMA Biologics, Inc. (ADMA) | 100 | 589.23 | +489.2% |
ADMA Biologics, Inc. (ADMA) returned +543% over 5 years vs Milestone Pharmaceu… (MIST)'s -77%. A $10,000 investment in ADMA 5 years ago would be worth $64,339 today (including dividends reinvested).
Chart 2Revenue Growth — 10 Years
| Stock | 2015 | 2024 | Change |
|---|---|---|---|
| Milestone Pharmaceu… (MIST) | $0.00 | $0.00 | — |
| ADMA Biologics, Inc. (ADMA) | $7M | $426M | +5841.4% |
ADMA Biologics, Inc.'s revenue grew from $7M (2015) to $426M (2024) — a 57.4% CAGR.
Chart 3Net Margin Trend — 10 Years
| Stock | 2015 | 2024 | Change |
|---|---|---|---|
| Milestone Pharmaceu… (MIST) | -2.9% | -59.7% | -1989.2% |
| ADMA Biologics, Inc. (ADMA) | -2.5% | 46.4% | +1951.4% |
ADMA Biologics, Inc.'s net margin went from -3% (2015) to 46% (2024).
Chart 4EPS Growth — 10 Years
| Stock | 2015 | 2024 | Change |
|---|---|---|---|
| Milestone Pharmaceu… (MIST) | -0.34 | -0.67 | -97.1% |
| ADMA Biologics, Inc. (ADMA) | -1.73 | 0.81 | +146.8% |
ADMA Biologics, Inc.'s EPS grew from $-1.73 (2015) to $0.81 (2024).
Chart 5Free Cash Flow — 5 Years
Milestone Pharmaceuticals Inc. generated $-29M FCF in 2024 (+13% vs 2021). ADMA Biologics, Inc. generated $110M FCF in 2024 (+187% vs 2021).
MIST vs ADMA: Frequently Asked Questions
8 questions · data-driven answers · updated daily
01Is MIST or ADMA a better buy right now?
ADMA Biologics, Inc. (ADMA) offers the better valuation at 19.2x trailing P/E (16.3x forward), making it the more compelling value choice. Analysts rate Milestone Pharmaceuticals Inc. (MIST) a "Buy" — based on 7 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — MIST or ADMA?
Over the past 5 years, ADMA Biologics, Inc. (ADMA) delivered a total return of +543.4%, compared to -77.2% for Milestone Pharmaceuticals Inc. (MIST). A $10,000 investment in ADMA five years ago would be worth approximately $64K today (assuming dividends reinvested). Over 10 years, the gap is even starker: ADMA returned +227.8% versus MIST's -88.9%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — MIST or ADMA?
By beta (market sensitivity over 5 years), ADMA Biologics, Inc. (ADMA) is the lower-risk stock at 1.10β versus Milestone Pharmaceuticals Inc.'s 1.32β — meaning MIST is approximately 20% more volatile than ADMA relative to the S&P 500. On balance sheet safety, ADMA Biologics, Inc. (ADMA) carries a lower debt/equity ratio of 24% versus 4% for Milestone Pharmaceuticals Inc. — giving it more financial flexibility in a downturn.
04Which has better profit margins — MIST or ADMA?
ADMA Biologics, Inc. (ADMA) is the more profitable company, earning 46.4% net margin versus 0.0% for Milestone Pharmaceuticals Inc. — meaning it keeps 46.4% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: ADMA leads at 32.6% versus 0.0% for MIST. At the gross margin level — before operating expenses — ADMA leads at 51.5%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
05Is MIST or ADMA more undervalued right now?
Analyst consensus price targets imply the most upside for MIST: 367.8% to $8.00.
06Which pays a better dividend — MIST or ADMA?
None of the stocks in this comparison currently pay a material dividend. All are effectively zero-yield and should be held for capital appreciation rather than income.
07Is MIST or ADMA better for a retirement portfolio?
For long-horizon retirement investors, ADMA Biologics, Inc. (ADMA) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 1.10), +227.8% 10Y return). Both have compounded well over 10 years (ADMA: +227.8%, MIST: -88.9%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
08What are the main differences between MIST and ADMA?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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