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MISTMilestone Pharmaceuticals Inc.
$1.30$112M
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MIST logoMilestone Pharmaceuticals Inc.(MIST)Earnings, Financials & Key Ratios

MIST•NASDAQ
Price updated Jun 19, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryCommercial Specialty Pharma
AboutMilestone Pharmaceuticals Inc., a biopharmaceutical company, focuses on the development and commercialization of cardiovascular medicines. The company is developing etripamil, a novel channel blocker, which is in Phase III clinical trial for the treatment of paroxysmal supraventricular tachycardia in the United States and Canada; and Phase II clinical trial for the treatment of atrial fibrillation and rapid ventricular rate. It has a license and collaboration agreement with Ji Xing Pharmaceuticals to develop and commercialize etripamil prophylactic and therapeutic uses in humans. The company was incorporated in 2003 and is headquartered in Montréal, Canada.Show more
  • Revenue$2M
  • EBITDA-$62M-48.5%
  • Net Income-$63M-51.9%
  • EPS (Diluted)-0.75-11.9%
  • Gross Margin92.63%
  • EBITDA Margin-4034.35%
  • Operating Margin-4041.72%
  • Net Margin-4078.78%
  • ROE-229.65%+17.3%

MIST Key Insights

Milestone Pharmaceuticals Inc. (MIST) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

No significant strengths identified

✗Weaknesses

  • ✗Negative free cash flow
  • ✗Weak momentum: RS Rating 10 (bottom 10%)
  • ✗Shares diluted 34.8% in last year
  • ✗Trading more than 30% below 52-week high
  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

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MIST Price & Volume

Milestone Pharmaceuticals Inc. (MIST) stock price & volume — 10-year historical chart

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MIST Growth Metrics

Milestone Pharmaceuticals Inc. (MIST) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years-32.38%
TTM-

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-31.65%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM13.92%

Return on Capital

10 Years-55.41%
5 Years-65.19%
3 Years-75.56%
Last Year-74.85%

MIST Recent Earnings

Milestone Pharmaceuticals Inc. (MIST) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 7/12 qtrs (58%)●Beat Revenue 0/12 qtrs (0%)
Q2 2026Latest
May 13, 2026
Metric
Actual
Est
EPS
$0.20-433.3%
$0.06
Rev
$238,000-99.2%
$30M
Q2 2026
Mar 20, 2026
Metric
Actual
Est
EPS
$0.16+11.1%
$0.18
Rev
$2M-96.0%
$38M
Q4 2025
Nov 12, 2025
Metric
Actual
Est
EPS
$0.12+29.4%
$0.17
Rev
—
—
Q3 2025
Aug 12, 2025
Metric
Actual
Est
EPS
$0.20-11.1%
$0.18
Rev
—
—
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 13, 2026
$0.20vs $0.06-433.3%
$238,000vs $30M-99.2%
Q2 2026Mar 20, 2026
$0.16vs $0.18+11.1%
$2Mvs $38M-96.0%
Q4 2025Nov 12, 2025
$0.12vs $0.17+29.4%
—
Q3 2025Aug 12, 2025
$0.20vs $0.18-11.1%
—
Based on last 12 quarters of dataView full earnings history →

MIST Peer Comparison

Milestone Pharmaceuticals Inc. (MIST) competitors in Commercial Specialty Pharma — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
Institutional Holdings
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
ACAD logoACADACADIA Pharmaceuticals Inc.Direct Competitor3.7B21.629.4411.87%34.3%35.65%0.04
PRAX logoPRAXPraxis Precision Medicines, Inc.Direct Competitor8.15B282.31-20.94-100%-43.02%0.00
XENE logoXENEXenon Pharmaceuticals Inc.Direct Competitor4.18B52.91-12.14-49.23%0.01
INVA logoINVAInnoviva, Inc.Direct Competitor1.66B22.496.8218.52%118.91%47.59%0.23
IDYA logoIDYAIDEAYA Biosciences, Inc.Product Competitor2.74B31.23-24.4030.24%-62.17%-13.96%0.03
ARDX logoARDXArdelyx, Inc.Product Competitor1.48B6.05-23.2722.09%-13.58%-38.11%1.27
LXRX logoLXRXLexicon Pharmaceuticals, Inc.Product Competitor892.83M2.01-14.3660.24%-37.46%-18.64%0.58
FLGT logoFLGTFulgent Genetics, Inc.Product Competitor535.45M18.00-9.1413.83%-18.75%-5.42%0.00

Compare MIST vs Peers

Milestone Pharmaceuticals Inc. (MIST) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs ACAD

Most directly comparable listed peer for MIST.

Scale Benchmark

vs MRK

Larger-name benchmark to compare MIST against a more recognizable public peer.

Peer Set

Compare Top 5

vs ACAD, PRAX, XENE, INVA

MIST Income Statement

Milestone Pharmaceuticals Inc. (MIST) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Sales/Revenue
000015M5M1M01.55M1.78M
Revenue Growth %
------66.67%-80%-100%--
Cost of Goods Sold
8K10K000000114K95K
COGS % of Revenue
--------7.37%-
Gross Profit
-8K▲ 0%
-10K▼ 25.0%
0▲ 100.0%
0▲ 0%
15M▲ 0%
5M▼ 66.7%
1M▼ 80.0%
0▼ 100.0%
1.43M▲ 0%
1.69M▲ 0%
Gross Margin %
----100%100%100%-92.63%94.67%
Gross Profit Growth %
--25%100%---66.67%-80%-100%--
Operating Expenses
8.27M23.82M57.88M50.71M58.07M64.64M62.1M42.1M63.92M67.15M
OpEx % of Revenue
----387.15%1292.84%6209.8%-4134.35%-
Selling, General & Admin
2.63M6.97M15.62M15.9M19.4M24.81M31.05M27.75M17.27M34.83M
SG&A % of Revenue
----129.35%496.26%3104.6%-1117.34%-
Research & Development
5.64M16.85M42.38M34.86M38.67M39.83M31.05M14.36M18.11M16.56M
R&D % of Revenue
----257.81%796.58%3105.2%-1171.28%-
Other Operating Expenses
00-115K-55K000028.54M1000K
Operating Income
-8.27M▲ 0%
-23.82M▼ 188.1%
-57.88M▼ 143.0%
-50.71M▲ 12.4%
-43.07M▲ 15.1%
-59.64M▼ 38.5%
-61.1M▼ 2.4%
-42.1M▲ 31.1%
-62.48M▼ 48.4%
-65.46M▲ 0%
Operating Margin %
-----287.15%-1192.84%-6109.8%--4041.72%-3669.39%
Operating Income Growth %
--188.12%-142.97%12.39%15.06%-38.47%-2.44%31.09%-48.41%-
EBITDA
-8.26M-23.81M-57.84M-50.61M-42.98M-59.55M-61.01M-42M-62.37M-65.32M
EBITDA Margin %
-----286.53%-1191.06%-6100.6%--4034.35%-3661.38%
EBITDA Growth %
--188.28%-142.92%12.5%15.08%-38.56%-2.44%31.16%-48.51%-25.5%
D&A (Non-Cash Add-back)
8K10K38K97K93K89K92K105K114K143K
EBIT
-8.27M-23.37M-57.88M-50.71M-43.07M-58.39M-57.13M-37.94M-62.48M-63.24M
Net Interest Income
0000220K1.25M1.41M7.75M-918K-3.08M
Interest Income
186K711K2.6M726K220K1.25M3.97M4.16M2.92M3.96M
Interest Expense
002.6M726K002.55M-3.58M3.84M7.04M
Other Income/Expense
186K711K2.6M726K220K1.25M1.41M583K-918K-3.08M
Pretax Income
-8.08M▲ 0%
-23.11M▼ 186.0%
55.28M▲ 339.2%
-49.98M▼ 190.4%
-42.85M▲ 14.3%
-58.39M▼ 36.3%
-59.69M▼ 2.2%
-41.52M▲ 30.4%
-63.4M▼ 52.7%
-68.55M▲ 0%
Pretax Margin %
-----285.69%-1167.76%-5968.5%--4101.1%-3842.21%
Income Tax
4K74K56K-17K0000-345K-182K
Effective Tax Rate %
-0.05%-0.32%0.1%0.03%0%0%0%0%0.54%0.27%
Net Income
-8.09M▲ 0%
-23.18M▼ 186.7%
-55.23M▼ 138.2%
-49.97M▲ 9.5%
-42.85M▲ 14.2%
-58.39M▼ 36.3%
-59.69M▼ 2.2%
-41.52M▲ 30.4%
-63.06M▼ 51.9%
-68.36M▲ 0%
Net Margin %
-----285.69%-1167.76%-5968.5%--4078.78%-3832.01%
Net Income Growth %
--186.73%-138.21%9.53%14.24%-36.25%-2.22%30.44%-51.88%-31.65%
Net Income (Continuing)
-8.09M-23.18M-55.23M-49.97M-42.85M-58.39M-59.69M-41.52M-63.06M-68.36M
Discontinued Operations
0000000000
Minority Interest
0000000000
EPS (Diluted)
-0.34▲ 0%
-0.98▼ 188.2%
-3.50▼ 257.1%
-1.70▲ 51.4%
-1.02▲ 40.0%
-1.35▼ 32.4%
-1.39▼ 3.0%
-0.67▲ 51.8%
-0.75▼ 11.9%
-0.52▲ 0%
EPS Growth %
--188.24%-257.14%51.43%40%-32.35%-2.96%51.8%-11.94%13.92%
EPS (Basic)
-0.34-0.98-3.50-1.70-1.02-1.35-1.39-0.67-0.75-
Diluted Shares Outstanding
23.65M23.65M15.78M29.34M41.83M42.45M42.96M62.21M83.88M130.29M
Basic Shares Outstanding
23.65M23.65M15.78M29.34M41.83M42.45M42.96M62.21M83.88M130.29M
Dividend Payout Ratio
----------

MIST Balance Sheet

Milestone Pharmaceuticals Inc. (MIST) balance sheet — assets, liabilities & shareholders' equity

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Total Current Assets
27.55M88.05M122.5M148.69M118.92M71.8M73.03M73.93M111.92M192.25M
Cash & Short-Term Investments
26.91M85.98M119.82M142.31M114.14M64.58M66M69.69M105.96M184.22M
Cash Only
10.88M85.95M119.82M72.31M114.14M7.64M13.76M25.31M73.05M71.32M
Short-Term Investments
16.03M29K070M056.95M52.24M44.38M32.91M112.9M
Accounts Receivable
543K677K00483K1.21M3.85M2.39M3.51M5M
Days Sales Outstanding
----11.7588.551.41K-828.21614.81
Inventory
00000000648K1.83M
Days Inventory Outstanding
--------2.07K2.38K
Other Current Assets
00836K948K000000
Total Non-Current Assets
35K30K929K1.29M926K2.68M2.19M1.57M1.64M1.48M
Property, Plant & Equipment
35K30K929K1.29M926K2.68M2.19M1.57M1.64M1.48M
Fixed Asset Turnover
----16.20x1.87x0.46x-0.94x1.31x
Goodwill
0000000000
Intangible Assets
0000000000
Long-Term Investments
0000000000
Other Non-Current Assets
0000000000
Total Assets
27.59M▲ 0%
88.08M▲ 219.2%
123.43M▲ 40.1%
149.97M▲ 21.5%
119.85M▼ 20.1%
74.48M▼ 37.9%
75.23M▲ 1.0%
75.5M▲ 0.4%
113.56M▲ 50.4%
193.73M▲ 0%
Asset Turnover
----0.13x0.07x0.01x-0.01x0.02x
Asset Growth %
-219.25%40.13%21.51%-20.09%-37.85%1%0.36%50.41%222.71%
Total Current Liabilities
1.6M4.53M8.33M6.16M6.78M6.14M7.23M8.13M13.98M20.94M
Accounts Payable
4K2.6M4.38M4.64M4.38M2.26M3.98M1.93M5.64M10.02M
Days Payables Outstanding
182.595.01K------18.07K20.92K
Short-Term Debt
0000224K495K00647K659K
Deferred Revenue (Current)
000000000416K
Other Current Liabilities
1.11M56K00709K808K1.99M07.69M8.69M
Current Ratio
17.17x19.42x14.71x24.14x17.55x11.70x10.11x9.10x8.01x9.18x
Quick Ratio
17.17x19.42x14.71x24.14x17.55x11.70x10.11x9.10x7.96x9.09x
Cash Conversion Cycle
---------15.17K-17.93K
Total Non-Current Liabilities
59.1M138.76M184K696K474K2M51.23M54.23M57.81M136.74M
Long-Term Debt
00000049.77M53.35M57.19M136.3M
Capital Lease Obligations
00184K696K474K2M1.46M874K539K2.06M
Deferred Tax Liabilities
0000000000
Other Non-Current Liabilities
59.1M138.76M00000083K72K
Total Liabilities
60.71M143.29M8.51M6.86M7.25M8.13M58.45M62.35M71.79M157.69M
Total Debt
00514K941K698K2.49M51.77M54.8M58.38M137.33M
Net Debt
-10.88M-85.95M-119.3M-71.37M-113.44M-5.14M38.02M29.48M-14.67M66.01M
Debt / Equity
--0.00x0.01x0.01x0.04x3.09x4.17x1.40x3.81x
Debt / EBITDA
----------2.10x
Net Debt / EBITDA
----------1.01x
Interest Coverage
---22.30x-69.85x---22.37x-10.59x-16.28x-8.99x
Total Equity
-33.12M▲ 0%
-55.21M▼ 66.7%
114.92M▲ 308.1%
143.12M▲ 24.5%
112.6M▼ 21.3%
66.35M▼ 41.1%
16.77M▼ 74.7%
13.15M▼ 21.6%
41.77M▲ 217.7%
36.05M▲ 0%
Equity Growth %
--66.7%308.15%24.54%-21.32%-41.08%-74.72%-21.61%217.71%736.34%
Book Value per Share
-1.40-2.337.284.882.691.560.390.210.500.28
Total Shareholders' Equity
-33.12M-55.21M114.92M143.12M112.6M66.35M16.77M13.15M41.77M36.05M
Common Stock
1.23M2.04M226.25M251.68M251.9M273.9M260.5M288.05M352.62M373.7M
Retained Earnings
-35.09M-58.27M-113.5M-163.47M-206.32M-266.34M-326.03M-367.55M-430.6M-456.67M
Treasury Stock
0000000000
Accumulated OCI
-1.63M-1.63M-1.63M46.37M51.31M34.35M48.46M53.08M55.65M55.65M
Minority Interest
0000000000

MIST Cash Flow Statement

Milestone Pharmaceuticals Inc. (MIST) cash flow — operating, investing & free cash flow history

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Cash from Operations
-8.05M-21.05M-51.15M-50.73M-33.22M-52.47M-46.42M-28.85M-49.04M-51.21M
Operating CF Margin %
-----221.49%-1049.38%-4642.4%--3172.12%-
Operating CF Growth %
--161.38%-143.05%0.82%34.51%-57.93%11.52%37.86%-70%-249.21%
Net Income
-8.09M-23.18M-55.23M-49.97M-42.85M-58.39M-59.69M-41.52M-63.06M-68.36M
Depreciation & Amortization
8K10K38K97K93K89K92K105K114K143K
Stock-Based Compensation
190K633K1.19M4.95M7.28M9.05M9.53M5.78M7.46M6.14M
Deferred Taxes
00-1.63M0000000
Other Non-Cash Items
59K787K1.63M0044K2.39M3.13M3.76M8.26M
Working Capital Changes
-164K1.5M2.85M-5.81M2.26M-3.26M1.24M3.66M2.68M2.6M
Change in Receivables
147K-134K-169K-112K465K-730K-2.64M1.46M-1.12M-2.85M
Change in Inventory
00169K00000-648K-1.18M
Change in Payables
-222K2.88M3.52M-2.08M00004.43M7.58M
Cash from Investing
-16.02M16M-384K-70M70M-57.12M4.76M8.28M11.25M-103.03M
Capital Expenditures
-36K-5K-413K00-272K-112K-33K-302K-74.98K
CapEx % of Revenue
-----5.44%11.2%-19.53%4.2%
Acquisitions
0035.41M0000000
Investments
----------
Other Investing
-15.99M16M-35.41M000000-46.36M
Cash from Financing
30.72M80.11M85.41M73.22M5.05M3.09M47.79M32.12M85.53M180.48M
Debt Issued (Net)
00000050M0075M
Equity Issued (Net)
31M79.65M85.36M24.92M02.63M027.26M85.53M104.89M
Dividends Paid
0000000000
Share Repurchases
0000000000
Other Financing
-278K461K44K48.31M5.05M458K-2.21M4.86M0599.2K
Net Change in Cash
6.65M▲ 0%
75.07M▲ 1029.3%
33.87M▼ 54.9%
-47.51M▼ 240.3%
41.83M▲ 188.1%
-106.5M▼ 354.6%
6.12M▲ 105.7%
11.55M▲ 88.7%
47.73M▲ 313.1%
26.23M▲ 0%
Free Cash Flow
-8.09M▲ 0%
-21.05M▼ 160.3%
-51.56M▼ 145.0%
-50.73M▲ 1.6%
-33.22M▲ 34.5%
-52.74M▼ 58.7%
-46.54M▲ 11.8%
-28.88M▲ 37.9%
-49.34M▼ 70.8%
-51.23M▲ 0%
FCF Margin %
-----221.49%-1054.82%-4653.6%--3191.66%-2871.85%
FCF Growth %
--160.27%-144.95%1.62%34.51%-58.74%11.77%37.94%-70.85%-51.11%
FCF per Share
-0.34-0.89-3.27-1.73-0.79-1.24-1.08-0.46-0.59-0.39
FCF Conversion (FCF/Net Income)
1.00x0.91x0.93x1.02x0.78x0.90x0.78x0.69x0.78x0.75x
Interest Paid
0000000000
Taxes Paid
0000000000

MIST Key Ratios

Milestone Pharmaceuticals Inc. (MIST) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric20182019202020212022202320242025TTM
Return on Equity (ROE)
--185%-38.73%-33.52%-65.26%-143.61%-277.55%-229.65%-339.38%
Return on Invested Capital (ROIC)
---112.92%-91.12%-148.22%-79.01%-64.83%-134.41%-125.62%
Gross Margin
---100%100%100%-92.63%94.67%
Net Margin
----285.69%-1167.76%-5968.5%--4078.78%-3832.01%
Debt / Equity
-0.00x0.01x0.01x0.04x3.09x4.17x1.40x3.81x
Interest Coverage
--22.30x-69.85x---22.37x-10.59x-16.28x-8.99x
FCF Conversion
0.91x0.93x1.02x0.78x0.90x0.78x0.69x0.78x0.75x
Revenue Growth
-----66.67%-80%-100%--
Related:MIST Dividend History·MIST Revenue History·MIST Price History·MIST P/E History·MIST Financial Ratios·MIST Institutional Holders

MIST SEC Filings & Documents

Milestone Pharmaceuticals Inc. (MIST) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 13, 2026·SEC

Material company update

Mar 20, 2026·SEC

Material company update

Jan 26, 2026·SEC

10-K Annual Reports

3
FY 2026

Mar 20, 2026·SEC

FY 2025

Mar 13, 2025·SEC

FY 2024

Mar 21, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

May 13, 2026·SEC

FY 2025

Nov 12, 2025·SEC

FY 2025

Aug 12, 2025·SEC

MIST Frequently Asked Questions

Milestone Pharmaceuticals Inc. (MIST) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Milestone Pharmaceuticals Inc. (MIST) reported $1.8M in revenue for fiscal year 2025.

Milestone Pharmaceuticals Inc. (MIST) grew revenue by 0.0% over the past year. Growth has been modest.

Milestone Pharmaceuticals Inc. (MIST) reported a net loss of $68.4M for fiscal year 2025.

Dividend & Returns

Milestone Pharmaceuticals Inc. (MIST) has a return on equity (ROE) of -229.7%. Negative ROE indicates the company is unprofitable.

Milestone Pharmaceuticals Inc. (MIST) had negative free cash flow of $51.2M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in MIST back in 2017?

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