Comprehensive Stock Comparison
Compare PTC Therapeutics, Inc. (PTCT) vs BridgeBio Pharma, Inc. (BBIO) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Growth | BBIO | 126.3% revenue growth vs PTCT's 114.5% |
| Quality / Margins | PTCT | 42.3% net margin vs BBIO's -145.3% |
| Stability / Safety | PTCT | Beta 0.91 vs BBIO's 1.04 |
| Dividends | Tie | Neither pays a meaningful dividend |
| Momentum (1Y) | BBIO | +90.5% vs PTCT's +23.4% |
| Efficiency (ROA) | PTCT | 28.4% ROA vs BBIO's -77.9% |
Who Each Stock Is For
Income & stability
Growth exposure
Long-term compounding (10Y)
Sleep-well-at-night portfolio
Defensive / Recession hedge
Business Model
What each company does and how it makes money
PTC Therapeutics is a biopharmaceutical company that develops and commercializes treatments for rare genetic disorders. It generates revenue primarily from sales of its approved therapies for Duchenne muscular dystrophy and spinal muscular atrophy — with additional income from collaborations and licensing agreements. The company's competitive advantage lies in its proprietary RNA-targeting and splicing technologies that enable it to address previously untreatable genetic mutations.
BridgeBio Pharma is a biopharmaceutical company focused on discovering and developing precision medicines for genetic diseases. It generates revenue primarily through drug development partnerships and potential future product sales — though currently in pre-revenue stage with multiple programs in clinical trials. The company's key advantage is its efficient hub-and-spoke operating model that allows rapid development of targeted therapies for rare genetic conditions.
Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
PTCT leads in 2 of 6 categories — strongest in Financial Metrics and Profitability & Efficiency. 3 categories are tied.
Financial Metrics (TTM)
PTCT is the larger business by revenue, generating $1.8B annually — 3.5x BBIO's $502M. PTCT is the more profitable business, keeping 42.3% of every revenue dollar as net income compared to BBIO's -145.3%. On growth, BBIO holds the edge at +25.2% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | PTCTPTC Therapeutics,… | BBIOBridgeBio Pharma,… |
|---|---|---|
| RevenueTrailing 12 months | $1.8B | $502M |
| EBITDAEarnings before interest/tax | $809M | -$560M |
| Net IncomeAfter-tax profit | $752M | -$729M |
| Free Cash FlowCash after capex | $699M | -$458M |
| Gross MarginGross profit ÷ Revenue | +91.2% | +94.4% |
| Operating MarginEBIT ÷ Revenue | +43.6% | -113.3% |
| Net MarginNet income ÷ Revenue | +42.3% | -145.3% |
| FCF MarginFCF ÷ Revenue | +39.3% | -91.1% |
| Rev. Growth (YoY)Latest quarter vs prior year | +7.2% | +25.2% |
| EPS Growth (YoY)Latest quarter vs prior year | +114.4% | +28.6% |
Valuation Metrics
| Metric | PTCTPTC Therapeutics,… | BBIOBridgeBio Pharma,… |
|---|---|---|
| Market CapShares × price | $5.5B | $12.9B |
| Enterprise ValueMkt cap + debt − cash | $4.9B | $12.4B |
| Trailing P/EPrice ÷ TTM EPS | 8.76x | -17.54x |
| Forward P/EPrice ÷ next-FY EPS est. | — | — |
| PEG RatioP/E ÷ EPS growth rate | — | — |
| EV / EBITDAEnterprise value multiple | 5.61x | — |
| Price / SalesMarket cap ÷ Revenue | 3.15x | 25.79x |
| Price / BookPrice ÷ Book value/share | — | — |
| Price / FCFMarket cap ÷ FCF | — | — |
Profitability & Efficiency
On the Piotroski fundamental quality scale (0–9), PTCT scores 4/9 vs BBIO's 3/9, reflecting mixed financial health.
| Metric | PTCTPTC Therapeutics,… | BBIOBridgeBio Pharma,… |
|---|---|---|
| ROE (TTM)Return on equity | — | — |
| ROA (TTM)Return on assets | +28.4% | -77.9% |
| ROICReturn on invested capital | — | — |
| ROCEReturn on capital employed | +56.8% | -80.6% |
| Piotroski ScoreFundamental quality 0–9 | 4 | 3 |
| Debt / EquityFinancial leverage | — | — |
| Net DebtTotal debt minus cash | -$586M | -$560M |
| Cash & Equiv.Liquid assets | $985M | $570M |
| Total DebtShort + long-term debt | $399M | $10M |
| Interest CoverageEBIT ÷ Interest expense | 6.37x | -6.10x |
Total Returns (with DRIP)
A $10,000 investment in PTCT five years ago would be worth $11,725 today (with dividends reinvested), compared to $9,245 for BBIO. Over the past 12 months, BBIO leads with a +90.5% total return vs PTCT's +23.4%. The 3-year compound annual growth rate (CAGR) favors BBIO at 79.9% vs PTCT's 16.0% — a key indicator of consistent wealth creation.
| Metric | PTCTPTC Therapeutics,… | BBIOBridgeBio Pharma,… |
|---|---|---|
| YTD ReturnYear-to-date | -11.1% | -15.0% |
| 1-Year ReturnPast 12 months | +23.4% | +90.5% |
| 3-Year ReturnCumulative with dividends | +56.1% | +482.1% |
| 5-Year ReturnCumulative with dividends | +17.2% | -7.6% |
| 10-Year ReturnCumulative with dividends | +754.5% | +141.3% |
| CAGR (3Y)Annualised 3-year return | +16.0% | +79.9% |
Risk & Volatility
PTCT is the less volatile stock with a 0.91 beta — it tends to amplify market swings less than BBIO's 1.04 beta. A beta below 1.0 means the stock typically moves less than the S&P 500.
| Metric | PTCTPTC Therapeutics,… | BBIOBridgeBio Pharma,… |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 0.91x | 1.04x |
| 52-Week HighHighest price in past year | $87.50 | $84.94 |
| 52-Week LowLowest price in past year | $35.95 | $28.33 |
| % of 52W HighCurrent price vs 52-week peak | +77.9% | +78.3% |
| RSI (14)Momentum oscillator 0–100 | 35.0 | 39.0 |
| Avg Volume (50D)Average daily shares traded | 994K | 2.5M |
Analyst Outlook
Wall Street rates PTCT as "Buy" and BBIO as "Buy". Consensus price targets imply 48.8% upside for BBIO (target: $99) vs 23.9% for PTCT (target: $85).
| Metric | PTCTPTC Therapeutics,… | BBIOBridgeBio Pharma,… |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | Buy |
| Price TargetConsensus 12-month target | $84.50 | $98.92 |
| # AnalystsCovering analysts | 26 | 26 |
| Dividend YieldAnnual dividend ÷ price | — | — |
| Dividend StreakConsecutive years of raises | — | 0 |
| Dividend / ShareAnnual DPS | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | +0.4% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Mar 20 | Feb 26 | Change |
|---|---|---|---|
| PTC Therapeutics, I… (PTCT) | 100 | 136.32 | +36.3% |
| BridgeBio Pharma, I… (BBIO) | 100 | 242.91 | +142.9% |
PTC Therapeutics, I… (PTCT) returned +17% over 5 years vs BridgeBio Pharma, I… (BBIO)'s -8%. A $10,000 investment in PTCT 5 years ago would be worth $11,725 today (including dividends reinvested).
Chart 2Revenue Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| PTC Therapeutics, I… (PTCT) | $83M | $1.7B | +1992.6% |
| BridgeBio Pharma, I… (BBIO) | $0.00 | $502M | — |
PTC Therapeutics, Inc.'s revenue grew from $83M (2016) to $1.7B (2025) — a 40.2% CAGR.
Chart 3Net Margin Trend — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| PTC Therapeutics, I… (PTCT) | -171.8% | 39.4% | +123.0% |
| BridgeBio Pharma, I… (BBIO) | -6.4% | -145.3% | -2162.2% |
PTC Therapeutics, Inc.'s net margin went from -172% (2016) to 39% (2025).
Chart 4EPS Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| PTC Therapeutics, I… (PTCT) | -4.17 | 7.78 | +286.6% |
| BridgeBio Pharma, I… (BBIO) | -0.33 | -3.79 | -1048.5% |
PTC Therapeutics, Inc.'s EPS grew from $-4.17 (2016) to $7.78 (2025).
Chart 5Free Cash Flow — 5 Years
PTC Therapeutics, Inc. generated $0M FCF in 2025 (+100% vs 2021). BridgeBio Pharma, Inc. generated $-447M FCF in 2025 (+18% vs 2021).
PTCT vs BBIO: Frequently Asked Questions
7 questions · data-driven answers · updated daily
01Is PTCT or BBIO a better buy right now?
PTC Therapeutics, Inc. (PTCT) offers the better valuation at 8.8x trailing P/E, making it the more compelling value choice. Analysts rate PTC Therapeutics, Inc. (PTCT) a "Buy" — based on 26 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — PTCT or BBIO?
Over the past 5 years, PTC Therapeutics, Inc. (PTCT) delivered a total return of +17.2%, compared to -7.6% for BridgeBio Pharma, Inc. (BBIO). A $10,000 investment in PTCT five years ago would be worth approximately $12K today (assuming dividends reinvested). Over 10 years, the gap is even starker: PTCT returned +754.5% versus BBIO's +141.3%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — PTCT or BBIO?
By beta (market sensitivity over 5 years), PTC Therapeutics, Inc. (PTCT) is the lower-risk stock at 0.91β versus BridgeBio Pharma, Inc.'s 1.04β — meaning BBIO is approximately 14% more volatile than PTCT relative to the S&P 500.
04Which has better profit margins — PTCT or BBIO?
PTC Therapeutics, Inc. (PTCT) is the more profitable company, earning 39.4% net margin versus -145.3% for BridgeBio Pharma, Inc. — meaning it keeps 39.4% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: PTCT leads at 50.1% versus -113.3% for BBIO. At the gross margin level — before operating expenses — BBIO leads at 94.4%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
05Which pays a better dividend — PTCT or BBIO?
None of the stocks in this comparison currently pay a material dividend. All are effectively zero-yield and should be held for capital appreciation rather than income.
06Is PTCT or BBIO better for a retirement portfolio?
For long-horizon retirement investors, PTC Therapeutics, Inc. (PTCT) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.91), +754.5% 10Y return). Both have compounded well over 10 years (PTCT: +754.5%, BBIO: +141.3%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
07What are the main differences between PTCT and BBIO?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. In terms of investment character: PTCT is a small-cap deep-value stock; BBIO is a mid-cap quality compounder stock. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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