| Name | Market Cap | Current Price | P/E Ratio | Revenue Growth 1Y | Net Margin | ROE | FCF Yield | Debt/Equity |
|---|---|---|---|---|---|---|---|---|
| CORTCorcept Therapeutics Incorporated | 3.78B | 35.70 | 43.54 | 12.79% | 13.01% | 15.3% | 3.75% | 0.01 |
| BMRNBioMarin Pharmaceutical Inc. | 11.86B | 61.73 | 34.29 | 10.83% | 5.73% | 6.11% | 0.10 | |
| VRTXVertex Pharmaceuticals Incorporated | 126.19B | 496.83 | 32.43 | 8.9% | 31.35% | 21.22% | 2.53% | 0.20 |
| CPRXCatalyst Pharmaceuticals, Inc. | 2.83B | 23.08 | 13.74 | 19.78% | 36.39% | 22.46% | 7.38% | 0.00 |
| HRMYHarmony Biosciences Holdings, Inc. | 1.65B | 28.54 | 10.53 | 21.51% | 18.27% | 18.24% | 21.12% | 0.02 |
| PTCTPTC Therapeutics, Inc. | 5.45B | 68.19 | 8.76 | 114.51% | 42.25% | |||
| BCRXBioCryst Pharmaceuticals, Inc. | 1.86B | 8.75 | 7.23 | 94.1% | 30.16% | 18.63% | ||
| RAREUltragenyx Pharmaceutical Inc. | 2.26B | 23.39 | -3.72 | 29.01% | -91.95% | -35.88% | 0.15 |
Analyze head-to-head performance against top industry competitors across valuation, growth, and profitability metrics.
| Dec 2016 | Dec 2017 | Dec 2018 | Dec 2019 | Dec 2020 | Dec 2021 | Dec 2022 | Dec 2023 | Dec 2024 | Dec 2025 | |
|---|---|---|---|---|---|---|---|---|---|---|
| Sales/Revenue | 82.7M | 194.39M | 264.73M | 306.98M | 380.77M | 538.59M | 698.8M | 937.82M | 806.78M | 1.73B |
| Revenue Growth % | 124.95% | 135.04% | 36.19% | 15.96% | 24.04% | 41.45% | 29.75% | 34.2% | -13.97% | 114.51% |
| Cost of Goods Sold | 117.63M | 4.58M | 12.67M | 12.13M | 18.94M | 32.33M | 44.68M | 65.49M | 57.4M | 0 |
| COGS % of Revenue | 142.23% | 2.35% | 4.79% | 3.95% | 4.97% | 6% | 6.39% | 6.98% | 7.11% | - |
| Gross Profit | -34.93M | 189.81M | 252.06M | 294.85M | 361.82M | 506.26M | 654.12M | 872.34M | 749.38M | 0 |
| Gross Margin % | -42.23% | 97.65% | 95.21% | 96.05% | 95.03% | 94% | 93.61% | 93.02% | 92.89% | - |
| Gross Profit Growth % | 58.93% | 643.45% | 32.79% | 16.97% | 22.72% | 39.92% | 29.21% | 33.36% | -14.09% | -100% |
| Operating Expenses | 214.76M | 254.11M | 348.41M | 536M | 793.59M | 880.71M | 1.1B | 1.31B | 1.05B | 863.72M |
| OpEx % of Revenue | 259.67% | 130.72% | 131.61% | 174.61% | 208.42% | 163.52% | 157.63% | 139.88% | 130.39% | 49.91% |
| Selling, General & Admin | 97.13M | 121.27M | 153.55M | 202.54M | 245.16M | 285.77M | 326M | 332.54M | 300.91M | 347.14M |
| SG&A % of Revenue | 117.44% | 62.38% | 58% | 65.98% | 64.39% | 53.06% | 46.65% | 35.46% | 37.3% | 20.06% |
| Research & Development | 117.63M | 117.46M | 171.98M | 257.45M | 477.64M | 540.68M | 651.5M | 666.56M | 534.48M | 455.25M |
| R&D % of Revenue | 142.23% | 60.42% | 64.96% | 83.87% | 125.44% | 100.39% | 93.23% | 71.08% | 66.25% | 26.3% |
| Other Operating Expenses | -1.21M | -1.28M | 129K | 76.01M | 70.78M | 54.25M | 124.04M | 312.74M | 216.56M | 61.33M |
| Operating Income | -132.06M | -64.29M | -115.69M | -241.16M | -431.77M | -374.44M | -447.41M | -439.5M | -302.57M | 866.93M |
| Operating Margin % | -159.67% | -33.07% | -43.7% | -78.56% | -113.39% | -69.52% | -64.03% | -46.86% | -37.5% | 50.09% |
| Operating Income Growth % | 20.98% | 51.32% | -79.94% | -108.46% | -79.04% | 13.28% | -19.49% | 1.77% | 31.16% | 386.52% |
| EBITDA | -128.77M | -46.61M | -89.6M | -208.98M | -388.28M | -310.31M | -318.57M | -202.91M | -226.91M | 866.93M |
| EBITDA Margin % | -155.7% | -23.98% | -33.84% | -68.08% | -101.97% | -57.61% | -45.59% | -21.64% | -28.13% | 50.09% |
| EBITDA Growth % | 21.6% | 63.8% | -92.23% | -133.24% | -85.8% | 20.08% | -2.66% | 36.31% | -11.83% | 482.07% |
| D&A (Non-Cash Add-back) | 3.29M | 17.68M | 26.09M | 32.18M | 43.49M | 64.13M | 128.84M | 236.59M | 75.66M | 0 |
| EBIT | -132.06M | -64.29M | -115.56M | -227.44M | -346.58M | -432.32M | -496.62M | -566.93M | -196.13M | 0 |
| Net Interest Income | -8.28M | -12.09M | -12.55M | -12.49M | -56.35M | -86.02M | -90.87M | -129.18M | -166.99M | 0 |
| Interest Income | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Interest Expense | 8.28M | 12.09M | 12.55M | 12.49M | 56.35M | 86.02M | 90.87M | 129.18M | 166.99M | -152.23M |
| Other Income/Expense | -9.48M | -13.37M | -12.43M | 1.23M | 28.84M | -143.9M | -140.08M | -256.61M | -60.55M | -170.32M |
| Pretax Income | -141.54M | -77.67M | -128.11M | -239.93M | -402.93M | -518.34M | -587.49M | -696.11M | -363.12M | 696.62M |
| Pretax Margin % | -171.14% | -39.95% | -48.39% | -78.16% | -105.82% | -96.24% | -84.07% | -74.23% | -45.01% | 40.25% |
| Income Tax | 569K | 1.33M | -29K | 11.65M | 35.23M | 5.56M | -28.47M | -69.51M | 176K | -13.97M |
| Effective Tax Rate % | 100.4% | 101.72% | 99.98% | 104.86% | 108.74% | 101.07% | 95.15% | 90.02% | 100.05% | 97.99% |
| Net Income | -142.11M | -79M | -128.08M | -251.58M | -438.16M | -523.9M | -559.02M | -626.6M | -363.3M | 682.64M |
| Net Margin % | -171.83% | -40.64% | -48.38% | -81.95% | -115.07% | -97.27% | -80% | -66.81% | -45.03% | 39.44% |
| Net Income Growth % | 16.63% | 44.41% | -62.13% | -96.42% | -74.17% | -19.57% | -6.7% | -12.09% | 42.02% | 287.9% |
| Net Income (Continuing) | -142.11M | -79M | -128.08M | -251.58M | -438.16M | -523.9M | -559.02M | -626.6M | -363.3M | 682.64M |
| Discontinued Operations | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Minority Interest | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| EPS (Diluted) | -4.17 | -2.02 | -2.75 | -4.27 | -6.64 | -7.43 | -7.79 | -8.37 | -4.73 | 7.78 |
| EPS Growth % | 17.75% | 51.56% | -36.14% | -55.27% | -55.5% | -11.9% | -4.85% | -7.45% | 43.49% | 264.48% |
| EPS (Basic) | -4.17 | -2.02 | -2.75 | -4.27 | -6.64 | -7.43 | -7.79 | -8.37 | -4.73 | 8.58 |
| Diluted Shares Outstanding | 34.04M | 39.18M | 46.58M | 58.86M | 66.03M | 70.47M | 71.73M | 74.84M | 76.85M | 88.31M |
| Basic Shares Outstanding | 34.04M | 39.11M | 46.58M | 58.86M | 66.03M | 70.47M | 71.73M | 74.84M | 76.85M | 79.53M |
| Dividend Payout Ratio | - | - | - | - | - | - | - | - | - | - |
| Dec 2016 | Dec 2017 | Dec 2018 | Dec 2019 | Dec 2020 | Dec 2021 | Dec 2022 | Dec 2023 | Dec 2024 | Dec 2025 | |
|---|---|---|---|---|---|---|---|---|---|---|
| Total Current Assets | 261.29M | 249.06M | 320.86M | 779.28M | 1.23B | 954.37M | 693.78M | 1.22B | 1.37B | 2.27B |
| Cash & Short-Term Investments | 231.67M | 191.25M | 227.59M | 686.56M | 1.1B | 773.38M | 410.7M | 876.74M | 1.14B | 1.95B |
| Cash Only | 231.67M | 191.25M | 227.59M | 288.03M | 208.81M | 189.72M | 279.83M | 594M | 779.71M | 984.65M |
| Short-Term Investments | 0 | 0 | 0 | 398.54M | 894.84M | 583.66M | 130.87M | 282.74M | 359.99M | 960.72M |
| Accounts Receivable | 24.93M | 40.39M | 67.91M | 55.54M | 69.93M | 110.45M | 155.61M | 160.82M | 158.55M | 181.62M |
| Days Sales Outstanding | 110.02 | 75.85 | 93.63 | 66.03 | 67.03 | 74.85 | 81.28 | 62.59 | 71.73 | 38.3 |
| Inventory | 0 | 10.75M | 16.12M | 19.29M | 18.7M | 15.86M | 21.81M | 30.58M | 23.19M | 79.65M |
| Days Inventory Outstanding | - | 857.59 | 464.3 | 580.06 | 360.28 | 179.02 | 178.16 | 170.43 | 147.49 | - |
| Other Current Assets | 4.69M | 6.67M | 9.25M | 0 | 0 | 0 | 105.66M | 150.49M | 44.09M | 67.31M |
| Total Non-Current Assets | 8.06M | 142.59M | 798.37M | 844.5M | 976.53M | 983.69M | 1.01B | 677.07M | 339.49M | 624.82M |
| Property, Plant & Equipment | 7.43M | 8.38M | 12.69M | 35.24M | 118.24M | 130.01M | 175.02M | 178.99M | 117.66M | 135.42M |
| Fixed Asset Turnover | 11.13x | 23.21x | 20.86x | 8.71x | 3.22x | 4.14x | 3.99x | 5.24x | 6.86x | 12.78x |
| Goodwill | 0 | 0 | 82.34M | 82.34M | 82.34M | 82.34M | 82.34M | 82.34M | 82.34M | 82.34M |
| Intangible Assets | 0 | 132.99M | 701.03M | 710.5M | 715.33M | 724.84M | 705.89M | 379.5M | 118.79M | 388.75M |
| Long-Term Investments | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Non-Current Assets | 630K | 1.22M | 2.3M | 16.41M | 60.62M | 46.5M | 48.58M | 36.25M | 20.7M | 18.3M |
| Total Assets | 269.35M | 391.65M | 1.12B | 1.62B | 2.21B | 1.94B | 1.71B | 1.9B | 1.71B | 2.9B |
| Asset Turnover | 0.31x | 0.50x | 0.24x | 0.19x | 0.17x | 0.28x | 0.41x | 0.49x | 0.47x | 0.60x |
| Asset Growth % | -26.82% | 45.41% | 185.77% | 45.08% | 36% | -12.24% | -11.99% | 11.14% | -10.06% | 70.01% |
| Total Current Liabilities | 49.62M | 82.05M | 166.8M | 235.86M | 277.33M | 509.35M | 406.24M | 603.1M | 580.98M | 968.43M |
| Accounts Payable | 6.3M | 15.28M | 6M | 10.32M | 18.66M | 23.03M | 27.27M | 6.04M | 17.27M | 0 |
| Days Payables Outstanding | 19.54 | 1.22K | 172.88 | 310.53 | 359.66 | 260.05 | 222.77 | 33.69 | 109.85 | - |
| Short-Term Debt | 0 | 0 | 11.67M | 20M | 0 | 208.83M | 72.15M | 194.31M | 257.82M | 302.12M |
| Deferred Revenue (Current) | 1.59M | 3.94M | 3.72M | 8.24M | 4.15M | 0 | 1.35M | 801K | 5.5M | 2.04M |
| Other Current Liabilities | 29.68M | 45.12M | 117.78M | 120.16M | 129.89M | 118.86M | 126.46M | 139.82M | 120.22M | 664.27M |
| Current Ratio | 5.27x | 3.04x | 1.92x | 3.30x | 4.44x | 1.87x | 1.71x | 2.02x | 2.35x | 2.35x |
| Quick Ratio | 5.27x | 2.90x | 1.83x | 3.22x | 4.37x | 1.84x | 1.65x | 1.97x | 2.31x | 2.27x |
| Cash Conversion Cycle | - | -285.25 | 385.05 | 335.57 | 67.65 | -6.18 | 36.67 | 199.33 | 109.38 | - |
| Total Non-Current Liabilities | 100.14M | 153.17M | 601.7M | 793.6M | 1.45B | 1.43B | 1.65B | 2.11B | 2.22B | 2.14B |
| Long-Term Debt | 98.22M | 144.97M | 141.35M | 293.86M | 309.14M | 956.59M | 1.26B | 1.9B | 2.11B | 96.58M |
| Capital Lease Obligations | 0 | 0 | 0 | 9.02M | 102.55M | 93.67M | 119.53M | 114.81M | 90.52M | 0 |
| Deferred Tax Liabilities | 0 | -3.94M | 122.03M | 130.86M | 136.74M | 137.11M | 102.83M | 55.91M | 0 | 0 |
| Other Non-Current Liabilities | 335K | 243K | 328.6M | 356.44M | 900.53M | 239.9M | 166.64M | 36.44M | 22.23M | 2.04B |
| Total Liabilities | 149.76M | 235.22M | 768.5M | 1.03B | 1.73B | 1.94B | 2.05B | 2.71B | 2.8B | 3.1B |
| Total Debt | 98.22M | 144.97M | 153.01M | 328.03M | 420.44M | 1.27B | 1.46B | 2.23B | 2.47B | 398.7M |
| Net Debt | -133.45M | -46.27M | -74.57M | 40M | 211.63M | 1.08B | 1.18B | 1.64B | 1.69B | -585.95M |
| Debt / Equity | 0.82x | 0.93x | 0.44x | 0.55x | 0.87x | 882.73x | - | - | - | - |
| Debt / EBITDA | - | - | - | - | - | - | - | - | - | 0.46x |
| Net Debt / EBITDA | - | - | - | - | - | - | - | - | - | -0.68x |
| Interest Coverage | -15.96x | -5.32x | -9.21x | -19.31x | -7.66x | -4.35x | -4.92x | -3.40x | -1.81x | - |
| Total Equity | 119.58M | 156.44M | 350.73M | 594.33M | 481.98M | 1.44M | -347.09M | -818.55M | -1.1B | -205.31M |
| Equity Growth % | -59.93% | 30.82% | 124.2% | 69.46% | -18.9% | -99.7% | -24236.72% | -135.84% | -34.15% | 81.3% |
| Book Value per Share | 3.51 | 3.99 | 7.53 | 10.10 | 7.30 | 0.02 | -4.84 | -10.94 | -14.29 | -2.32 |
| Total Shareholders' Equity | 119.58M | 156.44M | 350.73M | 594.33M | 481.98M | 1.44M | -347.09M | -818.55M | -1.1B | -205.31M |
| Common Stock | 34K | 42K | 51K | 62K | 70K | 71K | 72K | 75K | 77K | 80K |
| Retained Earnings | -735.11M | -814.11M | -938.92M | -1.19B | -1.63B | -2.1B | -2.66B | -3.28B | -3.65B | -2.96B |
| Treasury Stock | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Accumulated OCI | -1.49M | 3.97M | 1.46M | -10.58M | -60.96M | -24.28M | 4.8M | -1.28M | -25.89M | 10.5M |
| Minority Interest | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Dec 2016 | Dec 2017 | Dec 2018 | Dec 2019 | Dec 2020 | Dec 2021 | Dec 2022 | Dec 2023 | Dec 2024 | Dec 2025 | |
|---|---|---|---|---|---|---|---|---|---|---|
| Cash from Operations | -103.57M | -10.06M | -27.64M | -98.64M | -194.07M | -251.33M | -356.65M | -158.42M | -107.69M | 0 |
| Operating CF Margin % | -125.22% | -5.18% | -10.44% | -32.13% | -50.97% | -46.66% | -51.04% | -16.89% | -13.35% | - |
| Operating CF Growth % | 16.71% | 90.28% | -174.68% | -256.86% | -96.75% | -29.51% | -41.91% | 55.58% | 32.02% | 100% |
| Net Income | -142.11M | -79M | -128.08M | -251.58M | -438.16M | -523.9M | -559.02M | -626.6M | -363.3M | 0 |
| Depreciation & Amortization | 3.29M | 17.68M | 26.09M | 32.18M | 84.87M | 64.13M | 128.84M | 236.59M | 75.66M | 0 |
| Stock-Based Compensation | 35.01M | 30.56M | 33.25M | 42.13M | 70.33M | 103.51M | 110.33M | 131.21M | 74.61M | 73.74M |
| Deferred Taxes | -199K | 199K | -490K | 8.83M | 5.87M | 377K | -34.28M | -46.93M | -55.91M | 0 |
| Other Non-Cash Items | 9.41M | 7.27M | 27.38M | 49.37M | 46.11M | 128.33M | 82.81M | 151.32M | 58.7M | -73.74M |
| Working Capital Changes | -8.96M | 13.23M | 14.21M | 20.43M | 36.91M | -23.79M | -85.33M | -4M | 102.54M | 0 |
| Change in Receivables | -14.84M | -12.2M | -29.59M | 11.53M | -10.48M | -44.99M | -48.47M | -1.54M | 1.73M | 0 |
| Change in Inventory | 893K | -6.45M | -5.82M | -3.46M | 1.84M | 1.8M | -6.67M | -8.18M | 6.16M | 0 |
| Change in Payables | 4.26M | 24.01M | 43.11M | 13.75M | 53.59M | 23.41M | 27.54M | 0 | 0 | 45.49M |
| Cash from Investing | 104.48M | 13.12M | -42.61M | -387.24M | -561.55M | 219.18M | 290.18M | -176.74M | 44.18M | 0 |
| Capital Expenditures | -1.78M | -3.1M | -15.53M | -45.44M | -55.98M | -85.33M | -152.46M | -28.44M | -6.5M | 0 |
| CapEx % of Revenue | 2.15% | 1.6% | 5.87% | 14.8% | 14.7% | 15.84% | 21.82% | 3.03% | 0.81% | - |
| Acquisitions | 0 | -77.16M | -48.89M | -4M | 38.13M | 57.12M | 128.44M | 0 | 0 | 0 |
| Investments | - | - | - | - | - | - | - | - | - | - |
| Other Investing | 106.26M | 16.22M | 13.38M | 0 | -38.13M | -57.12M | -128.44M | -92.18M | 110.31M | 0 |
| Cash from Financing | 968K | 44.22M | 131.57M | 613.21M | 668.72M | 20.88M | 167.95M | 646.4M | 255.87M | 0 |
| Debt Issued (Net) | 0 | 40M | 0 | 267.6M | -46.16M | -2.22M | 148.72M | -301.38M | -1.49M | 0 |
| Equity Issued (Net) | 0 | 0 | 1000K | 1000K | 1000K | 1000K | 1000K | 0 | 0 | 0 |
| Dividends Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Share Repurchases | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Financing | 968K | 4.22M | 13.65M | 21.85M | 686.78M | 0 | -30.77M | 947.78M | 257.36M | 0 |
| Net Change in Cash | 299K | 53.47M | 57.71M | 126.03M | -79.22M | -19.09M | 98.71M | 314.36M | 185.03M | 0 |
| Free Cash Flow | -105.34M | -13.16M | -43.17M | -144.08M | -250.05M | -336.66M | -509.11M | -279.04M | -181.94M | 0 |
| FCF Margin % | -127.37% | -6.77% | -16.31% | -46.93% | -65.67% | -62.51% | -72.86% | -29.75% | -22.55% | - |
| FCF Growth % | 17.09% | 87.5% | -227.95% | -233.74% | -73.55% | -34.64% | -51.22% | 45.19% | 34.8% | 100% |
| FCF per Share | -3.09 | -0.34 | -0.93 | -2.45 | -3.79 | -4.78 | -7.10 | -3.73 | -2.37 | - |
| FCF Conversion (FCF/Net Income) | 0.73x | 0.13x | 0.22x | 0.39x | 0.44x | 0.48x | 0.64x | 0.25x | 0.30x | - |
| Interest Paid | 4.51M | 6.27M | 7.77M | 7.69M | 9.8M | 9.59M | 18.46M | 36.13M | 5.82M | 0 |
| Taxes Paid | 943K | 1.1M | 1.58M | 2.11M | 26.4M | 7.71M | 4.92M | 14.15M | 17.55M | 0 |
| Metric | 2016 | 2017 | 2018 | 2019 | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|---|---|---|---|---|---|
| Return on Equity (ROE) | -67.99% | -57.24% | -50.51% | -53.24% | -81.42% | -216.75% | - | - | - | - |
| Return on Invested Capital (ROIC) | -491.74% | -100.15% | -44.92% | -39.73% | -48.77% | -31.65% | -35.03% | -39.93% | -32.19% | - |
| Gross Margin | -42.23% | 97.65% | 95.21% | 96.05% | 95.03% | 94% | 93.61% | 93.02% | 92.89% | - |
| Net Margin | -171.83% | -40.64% | -48.38% | -81.95% | -115.07% | -97.27% | -80% | -66.81% | -45.03% | 39.44% |
| Debt / Equity | 0.82x | 0.93x | 0.44x | 0.55x | 0.87x | 882.73x | - | - | - | - |
| Interest Coverage | -15.96x | -5.32x | -9.21x | -19.31x | -7.66x | -4.35x | -4.92x | -3.40x | -1.81x | - |
| FCF Conversion | 0.73x | 0.13x | 0.22x | 0.39x | 0.44x | 0.48x | 0.64x | 0.25x | 0.30x | - |
| Revenue Growth | 124.95% | 135.04% | 36.19% | 15.96% | 24.04% | 41.45% | 29.75% | 34.2% | -13.97% | 114.51% |
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