Comprehensive Stock Comparison
Compare United Therapeutics Corporation (UTHR) vs Zai Lab Limited (ZLAB) vs Amarin Corporation plc (AMRN) vs Alkermes plc (ALKS) vs ADMA Biologics, Inc. (ADMA) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Growth | ADMA | 65.2% revenue growth vs AMRN's -25.5% |
| Value | ADMA | Lower P/E (16.3x vs 32.0x) |
| Quality / Margins | ADMA | 42.9% net margin vs ZLAB's -38.1% |
| Stability / Safety | UTHR | Beta 0.43 vs ADMA's 1.10 |
| Dividends | Tie | Neither pays a meaningful dividend |
| Momentum (1Y) | UTHR | +57.4% vs ZLAB's -44.5% |
| Efficiency (ROA) | ADMA | 36.8% ROA vs ZLAB's -15.0%, ROIC 37.7% vs -42.8% |
Who Each Stock Is For
Income & stability
Growth exposure
Long-term compounding (10Y)
Sleep-well-at-night portfolio
Defensive / Recession hedge
Business Model
What each company does and how it makes money
United Therapeutics is a biotechnology company focused on developing and commercializing therapies for pulmonary arterial hypertension and other rare diseases. It generates revenue primarily from its portfolio of PAH treatments — including Remodulin, Tyvaso, and Orenitram — which account for the vast majority of its sales. The company's competitive advantage lies in its deep expertise in prostacyclin therapies and its vertically integrated manufacturing capabilities for complex drug delivery systems.
Zai Lab is a biopharmaceutical company that licenses, develops, and commercializes innovative therapies for oncology, autoimmune disorders, and infectious diseases primarily in Greater China. It generates revenue through product sales of its commercialized drugs — like Zejula for ovarian cancer and NUZYRA for bacterial infections — supplemented by milestone payments and royalties from its extensive partnership network. The company's key advantage lies in its strategic licensing model that gives it exclusive rights to promising late-stage and commercial-stage therapies for the Greater China market, allowing it to build a diversified portfolio without bearing full R&D costs.
Amarin Corporation is a pharmaceutical company focused on developing and commercializing cardiovascular therapeutics. It generates nearly all its revenue from VASCEPA — a prescription omega-3 fatty acid product for reducing triglyceride levels — sold primarily to wholesalers and specialty pharmacies. Its key advantage is patent protection and regulatory exclusivity for VASCEPA, though this moat faces challenges from generic competition.
Alkermes is a biopharmaceutical company that develops and commercializes medicines for central nervous system disorders and other serious conditions. It generates revenue primarily from product sales of its proprietary drugs like VIVITROL and ARISTADA — which treat addiction and schizophrenia — along with royalties from partnered products and manufacturing services. The company's competitive advantage lies in its specialized drug delivery technologies that enable long-acting injectable formulations, creating significant barriers to entry for competitors.
ADMA Biologics is a biopharmaceutical company that develops, manufactures, and markets specialty plasma-derived biologics for treating immune deficiencies and infectious diseases. It generates revenue primarily from sales of its intravenous immune globulin products — BIVIGAM and ASCENIV — along with its Hepatitis B treatment Nabi-HB, while also operating plasma collection facilities. The company's key advantage is its integrated business model that combines plasma collection, manufacturing, and commercialization, creating a vertically controlled supply chain for plasma-derived therapies.
Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Financial Metrics Comparison
Side-by-side fundamentals across 5 stocks. BestLagging
Financial Scorecard
UTHR leads in 3 of 6 categories (Financial Metrics, Valuation Metrics). ADMA leads in 2 (Profitability & Efficiency, Total Returns). 1 tied.
Financial Metrics (TTM)
UTHR is the larger business by revenue, generating $3.2B annually — 14.0x AMRN's $227M. ADMA is the more profitable business, keeping 42.9% of every revenue dollar as net income compared to ZLAB's -38.1%. On growth, AMRN holds the edge at +17.4% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | UTHRUnited Therapeuti… | ZLABZai Lab Limited | AMRNAmarin Corporatio… | ALKSAlkermes plc | ADMAADMA Biologics, I… |
|---|---|---|---|---|---|
| RevenueTrailing 12 months | $3.2B | $460M | $227M | $1.5B | $489M |
| EBITDAEarnings before interest/tax | $1.6B | -$218M | -$93M | $281M | $175M |
| Net IncomeAfter-tax profit | $1.3B | -$176M | -$86M | $242M | $209M |
| Free Cash FlowCash after capex | $1.0B | -$159M | -$22M | $520,800 | $41M |
| Gross MarginGross profit ÷ Revenue | +87.9% | +58.6% | +38.9% | +86.3% | +54.7% |
| Operating MarginEBIT ÷ Revenue | +46.9% | -49.9% | -42.5% | +17.2% | +34.2% |
| Net MarginNet income ÷ Revenue | +41.9% | -38.1% | -38.0% | +16.4% | +42.9% |
| FCF MarginFCF ÷ Revenue | +32.7% | -34.5% | -9.6% | +0.0% | +8.3% |
| Rev. Growth (YoY)Latest quarter vs prior year | +7.4% | +17.0% | +17.4% | -10.6% | +12.0% |
| EPS Growth (YoY)Latest quarter vs prior year | +23.7% | +43.8% | +69.7% | -67.0% | 0.0% |
Valuation Metrics
At 18.1x trailing earnings, UTHR trades at a 14% valuation discount to ALKS's 21.0x P/E. On an enterprise value basis, UTHR's 12.9x EV/EBITDA is more attractive than ADMA's 25.1x.
| Metric | UTHRUnited Therapeuti… | ZLABZai Lab Limited | AMRNAmarin Corporatio… | ALKSAlkermes plc | ADMAADMA Biologics, I… |
|---|---|---|---|---|---|
| Market CapShares × price | $22.0B | $21.3B | $5.7B | $5.0B | $3.7B |
| Enterprise ValueMkt cap + debt − cash | $20.4B | $20.8B | $5.6B | $4.5B | $3.7B |
| Trailing P/EPrice ÷ TTM EPS | 18.09x | -12.01x | -3.45x | 21.05x | 19.22x |
| Forward P/EPrice ÷ next-FY EPS est. | 16.90x | — | — | 32.04x | 16.30x |
| PEG RatioP/E ÷ EPS growth rate | 0.94x | — | — | — | — |
| EV / EBITDAEnterprise value multiple | 12.95x | — | — | 15.89x | 25.10x |
| Price / SalesMarket cap ÷ Revenue | 6.91x | 46.21x | 25.11x | 3.38x | 8.70x |
| Price / BookPrice ÷ Book value/share | 3.40x | 2.94x | 0.58x | 2.79x | 10.86x |
| Price / FCFMarket cap ÷ FCF | 21.13x | — | — | 9571.39x | 33.71x |
Profitability & Efficiency
ADMA delivers a 48.6% return on equity — every $100 of shareholder capital generates $49 in annual profit, vs $-25 for ZLAB. AMRN carries lower financial leverage with a 0.02x debt-to-equity ratio, signaling a more conservative balance sheet compared to ZLAB's 0.31x. On the Piotroski fundamental quality scale (0–9), UTHR scores 7/9 vs AMRN's 2/9, reflecting strong financial health.
| Metric | UTHRUnited Therapeuti… | ZLABZai Lab Limited | AMRNAmarin Corporatio… | ALKSAlkermes plc | ADMAADMA Biologics, I… |
|---|---|---|---|---|---|
| ROE (TTM)Return on equity | +18.8% | -24.5% | -18.8% | +13.3% | +48.6% |
| ROA (TTM)Return on assets | +16.9% | -15.0% | -13.1% | +9.7% | +36.8% |
| ROICReturn on invested capital | +21.1% | -42.8% | -18.7% | +14.9% | +37.7% |
| ROCEReturn on capital employed | +21.4% | -27.9% | -17.0% | +14.4% | +39.0% |
| Piotroski ScoreFundamental quality 0–9 | 7 | 3 | 2 | 5 | 7 |
| Debt / EquityFinancial leverage | — | 0.31x | 0.02x | 0.04x | 0.24x |
| Net DebtTotal debt minus cash | -$1.6B | -$455M | -$113M | -$518M | -$21M |
| Cash & Equiv.Liquid assets | $1.6B | $680M | $121M | $588M | $103M |
| Total DebtShort + long-term debt | $0 | $224M | $8M | $70M | $82M |
| Interest CoverageEBIT ÷ Interest expense | 88.89x | -48.75x | -7085.14x | 23.55x | 19.63x |
Total Returns (with DRIP)
A $10,000 investment in ADMA five years ago would be worth $64,339 today (with dividends reinvested), compared to $1,115 for AMRN. Over the past 12 months, UTHR leads with a +57.4% total return vs ZLAB's -44.5%. The 3-year compound annual growth rate (CAGR) favors ADMA at 63.7% vs AMRN's -30.2% — a key indicator of consistent wealth creation.
| Metric | UTHRUnited Therapeuti… | ZLABZai Lab Limited | AMRNAmarin Corporatio… | ALKSAlkermes plc | ADMAADMA Biologics, I… |
|---|---|---|---|---|---|
| YTD ReturnYear-to-date | +1.4% | +10.9% | +0.6% | +6.5% | -12.9% |
| 1-Year ReturnPast 12 months | +57.4% | -44.5% | +27.3% | -12.3% | -5.0% |
| 3-Year ReturnCumulative with dividends | +104.8% | -48.3% | -66.0% | +12.6% | +338.6% |
| 5-Year ReturnCumulative with dividends | +194.2% | -88.1% | -88.9% | +56.8% | +543.4% |
| 10-Year ReturnCumulative with dividends | +313.2% | -31.2% | -52.7% | -6.7% | +227.8% |
| CAGR (3Y)Annualised 3-year return | +27.0% | -19.7% | -30.2% | +4.0% | +63.7% |
Risk & Volatility
UTHR is the less volatile stock with a 0.43 beta — it tends to amplify market swings less than ADMA's 1.10 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. UTHR currently trades 93.8% from its 52-week high vs ZLAB's 43.3% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | UTHRUnited Therapeuti… | ZLABZai Lab Limited | AMRNAmarin Corporatio… | ALKSAlkermes plc | ADMAADMA Biologics, I… |
|---|---|---|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 0.43x | 0.99x | 0.84x | 0.61x | 1.10x |
| 52-Week HighHighest price in past year | $537.00 | $44.34 | $20.90 | $36.32 | $25.67 |
| 52-Week LowLowest price in past year | $266.98 | $15.96 | $7.08 | $25.17 | $13.50 |
| % of 52W HighCurrent price vs 52-week peak | +93.8% | +43.3% | +66.0% | +82.9% | +60.7% |
| RSI (14)Momentum oscillator 0–100 | 58.6 | 57.7 | 40.0 | 39.0 | 35.7 |
| Avg Volume (50D)Average daily shares traded | 274K | 622K | 76K | 1.6M | 1.8M |
Analyst Outlook
Analyst consensus: UTHR as "Buy", ZLAB as "Buy", AMRN as "Hold", ALKS as "Buy", ADMA as "Buy". Consensus price targets imply 82.1% upside for ZLAB (target: $35) vs -84.3% for AMRN (target: $2).
| Metric | UTHRUnited Therapeuti… | ZLABZai Lab Limited | AMRNAmarin Corporatio… | ALKSAlkermes plc | ADMAADMA Biologics, I… |
|---|---|---|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | Buy | Hold | Buy | Buy |
| Price TargetConsensus 12-month target | $563.17 | $35.00 | $2.17 | $46.00 | $16.00 |
| # AnalystsCovering analysts | 30 | 11 | 18 | 28 | 9 |
| Dividend YieldAnnual dividend ÷ price | — | — | — | — | — |
| Dividend StreakConsecutive years of raises | 1 | — | — | 0 | 1 |
| Dividend / ShareAnnual DPS | — | — | — | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | +4.5% | 0.0% | 0.0% | 0.0% | 0.0% |
Historical Charts
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Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Feb 20 | Feb 26 | Change |
|---|---|---|---|
| United Therapeutics… (UTHR) | 100 | 461.34 | +361.3% |
| Zai Lab Limited (ZLAB) | 100 | 29.65 | -70.3% |
| Amarin Corporation … (AMRN) | 100 | 5.11 | -94.9% |
| Alkermes plc (ALKS) | 100 | 167.75 | +67.8% |
| ADMA Biologics, Inc. (ADMA) | 100 | 599.32 | +499.3% |
ADMA Biologics, Inc. (ADMA) returned +543% over 5 years vs Amarin Corporation … (AMRN)'s -89%. A $10,000 investment in ADMA 5 years ago would be worth $64,339 today (including dividends reinvested).
Chart 2Revenue Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| United Therapeutics… (UTHR) | $1.6B | $3.2B | +99.1% |
| Zai Lab Limited (ZLAB) | $0.00 | $460M | — |
| Amarin Corporation … (AMRN) | $130M | $229M | +75.7% |
| Alkermes plc (ALKS) | $746M | $1.5B | +97.9% |
| ADMA Biologics, Inc. (ADMA) | $11M | $426M | +3900.1% |
United Therapeutics Corporation's revenue grew from $1.6B (2016) to $3.2B (2025) — a 7.9% CAGR. Zai Lab Limited's revenue grew from $0M (2016) to $460M (2025) — a 0.0% CAGR.
Chart 3Net Margin Trend — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| United Therapeutics… (UTHR) | 44.6% | 41.9% | -6.1% |
| Zai Lab Limited (ZLAB) | -1074.3% | -38.1% | +96.4% |
| Amarin Corporation … (AMRN) | -66.4% | -35.9% | +45.8% |
| Alkermes plc (ALKS) | -28.0% | 16.4% | +158.6% |
| ADMA Biologics, Inc. (ADMA) | -183.1% | 46.4% | +125.3% |
United Therapeutics Corporation's net margin went from 45% (2016) to 42% (2025).
Chart 4P/E Ratio History — 8 Years
| Stock | 2017 | 2025 | Change |
|---|---|---|---|
| United Therapeutics… (UTHR) | 15.9 | 17.5 | +10.1% |
| Alkermes plc (ALKS) | 13.2 | 19.6 | +48.5% |
United Therapeutics Corporation has traded in a 8x–22x P/E range over 8 years; current trailing P/E is ~18x. Alkermes plc has traded in a 13x–20x P/E range over 3 years; current trailing P/E is ~21x.
Chart 5EPS Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| United Therapeutics… (UTHR) | 15.25 | 27.86 | +82.7% |
| Zai Lab Limited (ZLAB) | -39.7 | -1.6 | +96.0% |
| Amarin Corporation … (AMRN) | -8.2 | -4 | +51.2% |
| Alkermes plc (ALKS) | -1.38 | 1.43 | +203.6% |
| ADMA Biologics, Inc. (ADMA) | -1.61 | 0.81 | +150.3% |
United Therapeutics Corporation's EPS grew from $15.25 (2016) to $27.86 (2025) — a 7% CAGR. Zai Lab Limited's EPS grew from $-39.70 (2016) to $-1.60 (2025).
Chart 6Free Cash Flow — 5 Years
United Therapeutics Corporation generated $1B FCF in 2025 (+118% vs 2021). Zai Lab Limited generated $-159M FCF in 2025 (+72% vs 2021).
UTHR vs ZLAB vs AMRN vs ALKS vs ADMA: Key Questions Answered
9 questions · data-driven answers · updated daily
01Is UTHR or ZLAB or AMRN or ALKS or ADMA a better buy right now?
United Therapeutics Corporation (UTHR) offers the better valuation at 18.1x trailing P/E (16.9x forward), making it the more compelling value choice. Analysts rate United Therapeutics Corporation (UTHR) a "Buy" — based on 30 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which has the better valuation — UTHR or ZLAB or AMRN or ALKS or ADMA?
On trailing P/E, United Therapeutics Corporation (UTHR) is the cheapest at 18.1x versus Alkermes plc at 21.0x. On forward P/E, ADMA Biologics, Inc. is actually cheaper at 16.3x — notably different from the trailing picture, reflecting expected earnings growth.
03Which is the better long-term investment — UTHR or ZLAB or AMRN or ALKS or ADMA?
Over the past 5 years, ADMA Biologics, Inc. (ADMA) delivered a total return of +543.4%, compared to -88.9% for Amarin Corporation plc (AMRN). A $10,000 investment in ADMA five years ago would be worth approximately $64K today (assuming dividends reinvested). Over 10 years, the gap is even starker: UTHR returned +313.2% versus AMRN's -52.7%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
04Which is safer — UTHR or ZLAB or AMRN or ALKS or ADMA?
By beta (market sensitivity over 5 years), United Therapeutics Corporation (UTHR) is the lower-risk stock at 0.43β versus ADMA Biologics, Inc.'s 1.10β — meaning ADMA is approximately 154% more volatile than UTHR relative to the S&P 500. On balance sheet safety, Amarin Corporation plc (AMRN) carries a lower debt/equity ratio of 2% versus 31% for Zai Lab Limited — giving it more financial flexibility in a downturn.
05Which has better profit margins — UTHR or ZLAB or AMRN or ALKS or ADMA?
ADMA Biologics, Inc. (ADMA) is the more profitable company, earning 46.4% net margin versus -38.1% for Zai Lab Limited — meaning it keeps 46.4% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: UTHR leads at 46.9% versus -49.9% for ZLAB. At the gross margin level — before operating expenses — UTHR leads at 87.9%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
06Is UTHR or ZLAB or AMRN or ALKS or ADMA more undervalued right now?
On forward earnings alone, ADMA Biologics, Inc. (ADMA) trades at 16.3x forward P/E versus 32.0x for Alkermes plc — 15.7x cheaper on a one-year earnings basis. Analyst consensus price targets imply the most upside for ZLAB: 82.1% to $35.00.
07Which pays a better dividend — UTHR or ZLAB or AMRN or ALKS or ADMA?
None of the stocks in this comparison currently pay a material dividend. All are effectively zero-yield and should be held for capital appreciation rather than income.
08Is UTHR or ZLAB or AMRN or ALKS or ADMA better for a retirement portfolio?
For long-horizon retirement investors, United Therapeutics Corporation (UTHR) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.43), +313.2% 10Y return). Both have compounded well over 10 years (UTHR: +313.2%, ZLAB: -31.2%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
09What are the main differences between UTHR and ZLAB and AMRN and ALKS and ADMA?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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