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APLS logoApellis Pharmaceuticals, Inc.(APLS)Earnings, Financials & Key Ratios

APLS•NASDAQ
$41.12
$5.26B mkt cap·228.4× P/E·Price updated May 6, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryImmunology and Inflammation Therapies
AboutApellis Pharmaceuticals, Inc., a commercial-stage biopharmaceutical company, focuses on the discovery, development, and commercialization of therapeutic compounds through the inhibition of the complement system for autoimmune and inflammatory diseases. The company's lead product candidate is pegcetacoplan that is in Phase III clinical trials for the treatment of geographic atrophy (GA) in age-related macular degeneration and paroxysmal nocturnal hemoglobinuria (PNH) diseases. It also develops EMPAVELI (systemic pegcetacoplan) for the treatment of cold agglutinin disease (CAD), and hematopoietic stem cell transplantation-associated thrombotic microangiopathy (HSCT-TMA) in hematology; C3 glomerulopathy (C3G), and immune complex membranoproliferative glomerulonephritis (IC-MPGN) in nephrology; and amyotrophic lateral sclerosis (ALS) in neurology. In addition, the company develops APL-2006, a bispecific C3 and VEGF inhibitor for treating complement-mediated disorders; APL-1030, a C3 inhibitor for the treatment of multiple neurodegenerative diseases; and the combination of EMPAVELI and a small interfering RNA, or siRNA for reducing the production of C3 proteins by the liver. It has a collaboration and license agreement with Swedish Orphan Biovitrum AB (publ) to co-develop pegcetacoplan; and a research collaboration with Beam Therapeutics Inc. focused on the use of Beam's base editing technology to discover new treatments for complement-driven diseases. Apellis Pharmaceuticals, Inc. was incorporated in 2009 and is based in Waltham, Massachusetts.Show more
  • Revenue$1B+28.5%
  • EBITDA$57M+134.9%
  • Net Income$22M+111.3%
  • EPS (Diluted)0.18+111.3%
  • Gross Margin89.81%+5.7%
  • EBITDA Margin5.68%+127.2%
  • Operating Margin5.52%+126.2%
  • Net Margin2.23%+108.8%
  • ROE7.48%+108.0%
  • ROIC12.3%+112.0%
  • Debt/Equity1.31-36.1%
  • Interest Coverage1.54+139.9%
Technical→

APLS Key Insights

Apellis Pharmaceuticals, Inc. (APLS) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Strong Piotroski F-Score: 7/9
  • ✓Momentum leader: RS Rating 93 (top 7%)
  • ✓High quality earnings: Operating CF exceeds net income
  • ✓Strong 5Y sales CAGR of 32.0%
  • ✓Trading near 52-week high

✗Weaknesses

  • ✗Expensive at 14.0x book value

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

APLS Price & Volume

Apellis Pharmaceuticals, Inc. (APLS) stock price & volume — 10-year historical chart

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APLS Growth Metrics

Apellis Pharmaceuticals, Inc. (APLS) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years31.98%
3 Years136.98%
TTM28.46%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM111.31%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM110.69%

Return on Capital

10 Years-63.09%
5 Years-53.31%
3 Years-36.73%
Last Year7.64%

APLS Recent Earnings

Apellis Pharmaceuticals, Inc. (APLS) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 5/12 qtrs (42%)●Beat Revenue 9/12 qtrs (75%)
Q1 2026Latest
Feb 24, 2026
EPS
$0.47
Est $0.39
-20.5%
Revenue
$200M
Est $199M
+0.3%
Q4 2025
Oct 30, 2025
EPS
$1.67
Est $1.03
+62.1%
Revenue
$459M
Est $199M
+130.1%
Q3 2025
Jul 31, 2025
EPS
$0.33
Est $0.44
+25.0%
Revenue
$178M
Est $372M
-52.0%
Q2 2025
May 7, 2025
EPS
$0.74
Est $0.36
-105.6%
Revenue
$167M
Est $209M
-20.3%
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q1 2026LatestFeb 24, 2026
$0.47vs $0.39-20.5%
$200Mvs $199M+0.3%
Q4 2025Oct 30, 2025
$1.67vs $1.03+62.1%
$459Mvs $199M+130.1%
Q3 2025Jul 31, 2025
$0.33vs $0.44+25.0%
$178Mvs $372M-52.0%
Q2 2025May 7, 2025
$0.74vs $0.36-105.6%
$167Mvs $209M-20.3%
Based on last 12 quarters of dataView full earnings history →

APLS Peer Comparison

Apellis Pharmaceuticals, Inc. (APLS) competitors in Immunology and Inflammation Therapies — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
RARE logoRAREUltragenyx Pharmaceutical Inc.Direct Competitor2.55B25.93-4.4520.13%-91.03%-6.08%
BEAM logoBEAMBeam Therapeutics Inc.Direct Competitor3.32B32.33-39.92120.01%-57.24%-7.31%0.24
AKRO logoAKROAkero Therapeutics, Inc.Direct Competitor4.5B54.65-14.57-30.58%0.05
INVA logoINVAInnoviva, Inc.Direct Competitor1.91B22.526.8218.52%118.91%46.47%0.23
BCAB logoBCABBioAtla, Inc.Direct Competitor5.29M4.50-0.09-81.82%-29.8%
REGN logoREGNRegeneron Pharmaceuticals, Inc.Product Competitor74.89B720.7817.380.99%29.65%14.32%0.09
BIIB logoBIIBBiogen Inc.Product Competitor28.15B190.6821.591.39%13.92%7.55%0.38
IONS logoIONSIonis Pharmaceuticals, Inc.Product Competitor12.7B76.85-32.2933.87%-30.87%-58.57%5.35

Compare APLS vs Peers

Apellis Pharmaceuticals, Inc. (APLS) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs RARE

Most directly comparable listed peer for APLS.

Scale Benchmark

vs ABBV

Larger-name benchmark to compare APLS against a more recognizable public peer.

Peer Set

Compare Top 5

vs RARE, BEAM, AKRO, INVA

APLS Income Statement

Apellis Pharmaceuticals, Inc. (APLS) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Sales/Revenue000250.65M66.56M75.42M396.59M781.37M1B
Revenue Growth %-----73.44%13.31%425.83%97.02%28.46%
Cost of Goods Sold0127.92M595.45K25.05M5.2M5.64M58.51M117.72M102.24M
COGS % of Revenue---9.99%7.81%7.47%14.75%15.07%10.19%
Gross Profit
-50.77M▲ 0%
-127.92M▼ 152.0%
-595.45K▲ 99.5%
225.6M▲ 37986.7%
61.36M▼ 72.8%
69.79M▲ 13.7%
338.08M▲ 384.5%
663.64M▲ 96.3%
901.55M▲ 35.8%
Gross Margin %---90.01%92.19%92.53%85.25%84.93%89.81%
Gross Profit Growth %--151.98%99.53%37986.7%-72.8%13.73%384.45%96.3%35.85%
Operating Expenses50.77M127.92M287.42M439.32M597.64M664.4M855.2M828.62M846.12M
OpEx % of Revenue---175.28%897.86%880.91%215.64%106.05%84.29%
Selling, General & Admin10.46M22.64M66.45M139.4M176.77M277.16M500.81M501.05M550.26M
SG&A % of Revenue---55.62%265.57%367.48%126.28%64.13%54.82%
Research & Development40.3M105.29M220.97M299.92M420.87M387.24M354.39M327.57M295.85M
R&D % of Revenue---119.66%632.29%513.43%89.36%41.92%29.47%
Other Operating Expenses11.54K-111K0-501K1.36M-288K000
Operating Income
-50.77M▲ 0%
-127.92M▼ 152.0%
-288.02M▼ 125.1%
-213.73M▲ 25.8%
-536.28M▼ 150.9%
-594.61M▼ 10.9%
-517.12M▲ 13.0%
-164.98M▲ 68.1%
55.43M▲ 133.6%
Operating Margin %----85.27%-805.67%-788.38%-130.39%-21.11%5.52%
Operating Income Growth %-86.08%-151.98%-125.14%25.79%-150.92%-10.88%13.03%68.1%133.6%
EBITDA-50.76M0-287.42M-212.87M-534.78M-593.13M-515.42M-163.18M56.98M
EBITDA Margin %----84.93%-803.43%-786.41%-129.96%-20.88%5.68%
EBITDA Growth %-100%-25.94%-151.23%-10.91%13.1%68.34%134.92%
D&A (Non-Cash Add-back)11.94K127.92M595.45K859K1.49M1.49M1.7M1.8M1.56M
EBIT-50.91M-124.99M-299.42M-313.09M-732.76M-618.88M-496.92M-156.32M68.44M
Net Interest Income-96.92K447.81K-176K-25.77M-12.82M-23.71M-8.65M-27.62M-31.18M
Interest Income02.96M5.11M4.16M418K8.91M20.93M12.77M13.14M
Interest Expense96.92K2.51M5.29M29.94M13.24M32.63M29.58M40.39M44.33M
Other Income/Expense-239K422.81K-16.69M-129.3M-209.72M-56.89M-9.38M-31.74M-31.32M
Pretax Income
-51.01M▲ 0%
-127.5M▼ 150.0%
-304.71M▼ 139.0%
-343.03M▼ 12.6%
-746M▼ 117.5%
-651.5M▲ 12.7%
-526.5M▲ 19.2%
-196.72M▲ 62.6%
24.11M▲ 112.3%
Pretax Margin %----136.86%-1120.75%-863.81%-132.76%-25.18%2.4%
Income Tax250.61K-533K01.84M352K669K2.13M1.16M1.72M
Effective Tax Rate %-0.49%0.42%0%-0.54%-0.05%-0.1%-0.4%-0.59%7.14%
Net Income
-51.01M▲ 0%
-127.5M▼ 150.0%
-304.71M▼ 139.0%
-344.87M▼ 13.2%
-746.35M▼ 116.4%
-652.17M▲ 12.6%
-528.63M▲ 18.9%
-197.88M▲ 62.6%
22.39M▲ 111.3%
Net Margin %----137.59%-1121.27%-864.7%-133.29%-25.32%2.23%
Net Income Growth %-88.04%-149.97%-138.98%-13.18%-116.41%12.62%18.94%62.57%111.31%
Net Income (Continuing)-51.01M-127.5M-304.71M-344.87M-746.35M-652.17M-528.63M-197.88M22.39M
Discontinued Operations000000000
Minority Interest000000000
EPS (Diluted)
-1.49▲ 0%
-2.34▼ 57.0%
-4.98▼ 112.8%
-4.59▲ 7.8%
-8.84▼ 92.6%
-6.15▲ 30.4%
-4.45▲ 27.6%
-1.60▲ 64.0%
0.18▲ 111.3%
EPS Growth %0.67%-57.05%-112.82%7.83%-92.59%30.43%27.64%64.04%111.25%
EPS (Basic)-1.49-2.34-4.98-4.59-8.84-6.15-4.45-1.600.18
Diluted Shares Outstanding34.22M54.4M62.23M75.16M84.42M106.11M118.68M123.91M126.02M
Basic Shares Outstanding34.22M54.4M62.23M75.16M84.42M106.11M118.68M123.91M126.02M
Dividend Payout Ratio---------

APLS Balance Sheet

Apellis Pharmaceuticals, Inc. (APLS) balance sheet — assets, liabilities & shareholders' equity

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Total Current Assets182.02M202.44M373.09M917.19M824.05M719.52M766.33M788.95M1.01B
Cash & Short-Term Investments175.64M176.27M351.99M877.65M701.23M551.8M352.3M416.14M467.76M
Cash Only175.64M176.27M351.99M565.78M640.19M551.8M351.19M411.29M467.76M
Short-Term Investments000311.87M61.03M01.11M4.85M0
Accounts Receivable00025M80.1M7.73M206.44M271.72M366.22M
Days Sales Outstanding---36.41439.2537.39190126.93133.17
Inventory000024M85.71M146.36M82.48M142.56M
Days Inventory Outstanding----1.68K5.55K913.04255.74508.95
Other Current Assets1.31M1.84M1.31M11.14M13.54M36.66M22.41M9.1M0
Total Non-Current Assets116.15K1.09M16.15M43.38M57.72M40.69M22.4M96.1M60.42M
Property, Plant & Equipment0977.92K15.77M24.52M26.08M24.89M21.09M19.04M19.9M
Fixed Asset Turnover---10.22x2.55x3.03x18.80x41.05x50.43x
Goodwill000000000
Intangible Assets000000000
Long-Term Investments0000003.24M00
Other Non-Current Assets116.15K116.42K385.09K18.86M31.64M15.8M-1.93M77.06M40.51M
Total Assets
182.13M▲ 0%
203.53M▲ 11.8%
389.24M▲ 91.2%
960.57M▲ 146.8%
881.76M▼ 8.2%
760.22M▼ 13.8%
788.73M▲ 3.8%
885.05M▲ 12.2%
1.08B▲ 21.5%
Asset Turnover---0.26x0.08x0.10x0.50x0.88x0.93x
Asset Growth %563.91%11.75%91.24%146.78%-8.2%-13.78%3.75%12.21%21.49%
Total Current Liabilities6.55M17.02M65.75M128.33M131.85M167.61M247.59M185.51M323.6M
Accounts Payable3.66M10.25M8.36M8.48M16.91M37.34M37.52M38.57M56.8M
Days Payables Outstanding-29.265.12K123.521.19K2.42K234.03119.59202.78
Short-Term Debt01.67M2.61M00000100.75M
Deferred Revenue (Current)000000000
Other Current Liabilities0043.34M4.23M7.58M81.43M75.83M0127.55M
Current Ratio27.77x11.89x5.67x7.15x6.25x4.29x3.10x4.25x3.14x
Quick Ratio27.77x11.89x5.67x7.15x6.07x3.78x2.50x3.81x2.70x
Cash Conversion Cycle----937.193.17K869.01263.08439.34
Total Non-Current Liabilities26.63M25.54M289.26M627.68M551.26M422.74M346.62M471M381.51M
Long-Term Debt26.39M25.38M142.57M358.83M189.02M92.74M93.03M452.83M373.61M
Capital Lease Obligations0011.86M15.22M17.08M14.35M11.45M10.2M11.95M
Deferred Tax Liabilities000000000
Other Non-Current Liabilities244.29K158.78K134.84M253.64M345.15M315.65M242.13M7.97M-4.04M
Total Liabilities33.19M42.56M355.02M756.01M683.1M590.35M594.21M656.51M705.11M
Total Debt26.39M27.04M157.03M377.73M210.22M112.71M110.93M469.78M486.31M
Net Debt-149.25M-149.22M-194.95M-188.05M-429.97M-439.09M-240.26M58.49M18.55M
Debt / Equity0.18x0.17x4.59x1.85x1.06x0.66x0.57x2.06x1.31x
Debt / EBITDA--------8.53x
Net Debt / EBITDA--------0.33x
Interest Coverage-525.30x-49.74x-56.66x-10.46x-55.34x-18.97x-16.80x-3.87x1.54x
Total Equity
148.94M▲ 0%
160.97M▲ 8.1%
34.23M▼ 78.7%
204.56M▲ 497.6%
198.66M▼ 2.9%
169.87M▼ 14.5%
194.52M▲ 14.5%
228.54M▲ 17.5%
370.15M▲ 62.0%
Equity Growth %525.96%8.08%-78.74%497.6%-2.88%-14.49%14.51%17.49%61.96%
Book Value per Share4.352.960.552.722.351.601.641.842.94
Total Shareholders' Equity148.94M160.97M34.23M204.56M198.66M169.87M194.52M228.54M370.15M
Common Stock5.03K5.63K6.39K8K10K11K12K12K12K
Retained Earnings-149.26M-276.77M-581.47M-926.35M-1.66B-2.31B-2.84B-3.04B-3.01B
Treasury Stock000000000
Accumulated OCI0-122.81K-153.78K-117K-2.09M-875K-3.54M-3.31M-2.1M
Minority Interest000000000

APLS Cash Flow Statement

Apellis Pharmaceuticals, Inc. (APLS) cash flow — operating, investing & free cash flow history

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Cash from Operations-46.6M-131.24M-211.13M-160.49M-563.13M-513.75M-594.74M-87.87M45.33M
Operating CF Margin %----64.03%-846%-681.16%-149.96%-11.25%4.52%
Operating CF Growth %-79.19%-181.66%-60.88%23.99%-250.88%8.77%-15.76%85.23%151.59%
Net Income-51.01M-127.5M-304.71M-344.87M-746.35M-652.17M-528.63M-197.88M22.39M
Depreciation & Amortization11.94K0596K859K1.49M1.49M1.7M1.8M0
Stock-Based Compensation5.42M7.73M21.14M45.38M70.67M91.08M105.94M114.13M0
Deferred Taxes153.69K000198.26M0000
Other Non-Cash Items13.56K568.33K18.52M118.56M6.33M61.55M26.41M12.44M108.06M
Working Capital Changes-1.19M-12.04M53.31M19.59M-93.52M-15.7M-200.17M-18.36M-85.12M
Change in Receivables0000-10.1M2.38M0-58.48M-101.28M
Change in Inventory0000-16.32M-69.4M0-10.76M-15.27M
Change in Payables932.3K6.59M-1.64M-54K10.49M18.69M170K1.09M18.22M
Cash from Investing00-1.69M-316.99M247.62M59.89M-674K-403K-313K
Capital Expenditures00-1.69M-5.42M-1.1M-1.52M-773K-403K-313K
CapEx % of Revenue---2.16%1.66%2.02%0.19%0.05%0.03%
Acquisitions0000-248.72M-61.42M000
Investments---------
Other Investing0000248.72M61.42M99K00
Cash from Financing197.38M131.9M388.54M692.18M392.24M365.66M394.5M149.24M8.88M
Debt Issued (Net)26.36M0184.21M322.87M000365.45M0
Equity Issued (Net)169.81M131.19M109.58M381.42M380.36M380.12M384.39M18.83M8.89M
Dividends Paid000000000
Share Repurchases000000000
Other Financing1.2M709.36K94.75M-12.12M11.87M-14.46M10.11M-235.04M-11K
Net Change in Cash
150.78M▲ 0%
624.14K▼ 99.6%
175.72M▲ 28053.6%
215.06M▲ 22.4%
74.71M▼ 65.3%
-88.68M▼ 218.7%
-200.78M▼ 126.4%
60.31M▲ 130.0%
55.15M▼ 8.6%
Free Cash Flow
-46.6M▲ 0%
-131.24M▼ 181.7%
-212.83M▼ 62.2%
-165.91M▲ 22.0%
-564.23M▼ 240.1%
-515.27M▲ 8.7%
-595.51M▼ 15.6%
-88.27M▲ 85.2%
45.01M▲ 151.0%
FCF Margin %----66.19%-847.66%-683.18%-150.16%-11.3%4.48%
FCF Growth %-79.19%-181.66%-62.17%22.05%-240.08%8.68%-15.57%85.18%151%
FCF per Share-1.36-2.41-3.42-2.21-6.68-4.86-5.02-0.710.36
FCF Conversion (FCF/Net Income)0.91x1.03x0.69x0.47x0.75x0.79x1.13x0.44x2.02x
Interest Paid00987K12.93M10.27M5M029.37M0
Taxes Paid000049K4.92M01.65M0

APLS Key Ratios

Apellis Pharmaceuticals, Inc. (APLS) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric2016201720182019202020212022202320242025
Return on Equity (ROE)-92.31%-59.06%-82.28%-312.2%-288.86%-370.2%-353.93%-290.14%-93.55%7.48%
Return on Invested Capital (ROIC)---1677.51%--970.89%----102.56%12.3%
Gross Margin----90.01%92.19%92.53%85.25%84.93%89.81%
Net Margin-----137.59%-1121.27%-864.7%-133.29%-25.32%2.23%
Debt / Equity-0.18x0.17x4.59x1.85x1.06x0.66x0.57x2.06x1.31x
Interest Coverage--525.30x-49.74x-56.66x-10.46x-55.34x-18.97x-16.80x-3.87x1.54x
FCF Conversion0.96x0.91x1.03x0.69x0.47x0.75x0.79x1.13x0.44x2.02x
Revenue Growth------73.44%13.31%425.83%97.02%28.46%

APLS SEC Filings & Documents

Apellis Pharmaceuticals, Inc. (APLS) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 4, 2026·SEC

Material company update

Mar 31, 2026·SEC

Material company update

Mar 2, 2026·SEC

10-K Annual Reports

2
FY 2026

Feb 24, 2026·SEC

FY 2025

Feb 28, 2025·SEC

10-Q Quarterly Reports

6
FY 2025

Oct 30, 2025·SEC

FY 2025

Jul 31, 2025·SEC

FY 2025

May 7, 2025·SEC

APLS Frequently Asked Questions

Apellis Pharmaceuticals, Inc. (APLS) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Apellis Pharmaceuticals, Inc. (APLS) reported $1.00B in revenue for fiscal year 2025.

Apellis Pharmaceuticals, Inc. (APLS) grew revenue by 28.5% over the past year. This is strong growth.

Yes, Apellis Pharmaceuticals, Inc. (APLS) is profitable, generating $22.4M in net income for fiscal year 2025 (2.2% net margin).

Dividend & Returns

Apellis Pharmaceuticals, Inc. (APLS) has a return on equity (ROE) of 7.5%. This is below average, suggesting room for improvement.

Apellis Pharmaceuticals, Inc. (APLS) generated $45.3M in free cash flow for fiscal year 2025. Positive FCF indicates the company can fund dividends, buybacks, or reinvestment.

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Apellis Pharmaceuticals, Inc. (APLS) financial analysis — history, returns, DCA and operating performance tools

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Dividend History

Yield, growth, payout safety & DRIP

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Earnings History

EPS trends, net income & profitability

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Price History

Long-term charts & historical price data

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Revenue History

Sales growth patterns & revenue breakdown

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Financial Ratios

30 years of market, efficiency and balance-sheet ratios

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Valuation

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