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6May 4, 2026·SEC
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Apellis Pharmaceuticals, Inc. (APLS) fundamental analysis — strengths, weaknesses & financial health based on data analysis
* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.
Apellis Pharmaceuticals, Inc. (APLS) stock price & volume — 10-year historical chart
Apellis Pharmaceuticals, Inc. (APLS) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR
Apellis Pharmaceuticals, Inc. (APLS) EPS & revenue vs analyst estimates — last 4 quarters
| Quarter | Date | EPS (Act vs Est) | Revenue (Act vs Est) |
|---|---|---|---|
| Q1 2026Latest | Feb 24, 2026 | $0.47vs $0.39-20.5% | $200Mvs $199M+0.3% |
| Q4 2025 | Oct 30, 2025 | $1.67vs $1.03+62.1% | $459Mvs $199M+130.1% |
| Q3 2025 | Jul 31, 2025 | $0.33vs $0.44+25.0% | $178Mvs $372M-52.0% |
| Q2 2025 | May 7, 2025 | $0.74vs $0.36-105.6% | $167Mvs $209M-20.3% |
Apellis Pharmaceuticals, Inc. (APLS) competitors in Immunology and Inflammation Therapies — business model, growth, and fundamentals comparison
Apellis Pharmaceuticals, Inc. (APLS) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.
Apellis Pharmaceuticals, Inc. (APLS) annual income statement — 10-year revenue, gross profit & net income history
| Line item | Dec'17 | Dec'18 | Dec'19 | Dec'20 | Dec'21 | Dec'22 | Dec'23 | Dec'24 | Dec'25 |
|---|---|---|---|---|---|---|---|---|---|
| Sales/Revenue | 0 | 0 | 0 | 250.65M | 66.56M | 75.42M | 396.59M | 781.37M | 1B |
| Revenue Growth % | - | - | - | - | -73.44% | 13.31% | 425.83% | 97.02% | 28.46% |
| Cost of Goods Sold | 0 | 127.92M | 595.45K | 25.05M | 5.2M | 5.64M | 58.51M | 117.72M | 102.24M |
| COGS % of Revenue | - | - | - | 9.99% | 7.81% | 7.47% | 14.75% | 15.07% | 10.19% |
| Gross Profit | -50.77M▲ 0% | -127.92M▼ 152.0% | -595.45K▲ 99.5% | 225.6M▲ 37986.7% | 61.36M▼ 72.8% | 69.79M▲ 13.7% | 338.08M▲ 384.5% | 663.64M▲ 96.3% | 901.55M▲ 35.8% |
| Gross Margin % | - | - | - | 90.01% | 92.19% | 92.53% | 85.25% | 84.93% | 89.81% |
| Gross Profit Growth % | - | -151.98% | 99.53% | 37986.7% | -72.8% | 13.73% | 384.45% | 96.3% | 35.85% |
| Operating Expenses | 50.77M | 127.92M | 287.42M | 439.32M | 597.64M | 664.4M | 855.2M | 828.62M | 846.12M |
| OpEx % of Revenue | - | - | - | 175.28% | 897.86% | 880.91% | 215.64% | 106.05% | 84.29% |
| Selling, General & Admin | 10.46M | 22.64M | 66.45M | 139.4M | 176.77M | 277.16M | 500.81M | 501.05M | 550.26M |
| SG&A % of Revenue | - | - | - | 55.62% | 265.57% | 367.48% | 126.28% | 64.13% | 54.82% |
| Research & Development | 40.3M | 105.29M | 220.97M | 299.92M | 420.87M | 387.24M | 354.39M | 327.57M | 295.85M |
| R&D % of Revenue | - | - | - | 119.66% | 632.29% | 513.43% | 89.36% | 41.92% | 29.47% |
| Other Operating Expenses | 11.54K | -111K | 0 | -501K | 1.36M | -288K | 0 | 0 | 0 |
| Operating Income | -50.77M▲ 0% | -127.92M▼ 152.0% | -288.02M▼ 125.1% | -213.73M▲ 25.8% | -536.28M▼ 150.9% | -594.61M▼ 10.9% | -517.12M▲ 13.0% | -164.98M▲ 68.1% | 55.43M▲ 133.6% |
| Operating Margin % | - | - | - | -85.27% | -805.67% | -788.38% | -130.39% | -21.11% | 5.52% |
| Operating Income Growth % | -86.08% | -151.98% | -125.14% | 25.79% | -150.92% | -10.88% | 13.03% | 68.1% | 133.6% |
| EBITDA | -50.76M | 0 | -287.42M | -212.87M | -534.78M | -593.13M | -515.42M | -163.18M | 56.98M |
| EBITDA Margin % | - | - | - | -84.93% | -803.43% | -786.41% | -129.96% | -20.88% | 5.68% |
| EBITDA Growth % | - | 100% | - | 25.94% | -151.23% | -10.91% | 13.1% | 68.34% | 134.92% |
| D&A (Non-Cash Add-back) | 11.94K | 127.92M | 595.45K | 859K | 1.49M | 1.49M | 1.7M | 1.8M | 1.56M |
| EBIT | -50.91M | -124.99M | -299.42M | -313.09M | -732.76M | -618.88M | -496.92M | -156.32M | 68.44M |
| Net Interest Income | -96.92K | 447.81K | -176K | -25.77M | -12.82M | -23.71M | -8.65M | -27.62M | -31.18M |
| Interest Income | 0 | 2.96M | 5.11M | 4.16M | 418K | 8.91M | 20.93M | 12.77M | 13.14M |
| Interest Expense | 96.92K | 2.51M | 5.29M | 29.94M | 13.24M | 32.63M | 29.58M | 40.39M | 44.33M |
| Other Income/Expense | -239K | 422.81K | -16.69M | -129.3M | -209.72M | -56.89M | -9.38M | -31.74M | -31.32M |
| Pretax Income | -51.01M▲ 0% | -127.5M▼ 150.0% | -304.71M▼ 139.0% | -343.03M▼ 12.6% | -746M▼ 117.5% | -651.5M▲ 12.7% | -526.5M▲ 19.2% | -196.72M▲ 62.6% | 24.11M▲ 112.3% |
| Pretax Margin % | - | - | - | -136.86% | -1120.75% | -863.81% | -132.76% | -25.18% | 2.4% |
| Income Tax | 250.61K | -533K | 0 | 1.84M | 352K | 669K | 2.13M | 1.16M | 1.72M |
| Effective Tax Rate % | -0.49% | 0.42% | 0% | -0.54% | -0.05% | -0.1% | -0.4% | -0.59% | 7.14% |
| Net Income | -51.01M▲ 0% | -127.5M▼ 150.0% | -304.71M▼ 139.0% | -344.87M▼ 13.2% | -746.35M▼ 116.4% | -652.17M▲ 12.6% | -528.63M▲ 18.9% | -197.88M▲ 62.6% | 22.39M▲ 111.3% |
| Net Margin % | - | - | - | -137.59% | -1121.27% | -864.7% | -133.29% | -25.32% | 2.23% |
| Net Income Growth % | -88.04% | -149.97% | -138.98% | -13.18% | -116.41% | 12.62% | 18.94% | 62.57% | 111.31% |
| Net Income (Continuing) | -51.01M | -127.5M | -304.71M | -344.87M | -746.35M | -652.17M | -528.63M | -197.88M | 22.39M |
| Discontinued Operations | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Minority Interest | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| EPS (Diluted) | -1.49▲ 0% | -2.34▼ 57.0% | -4.98▼ 112.8% | -4.59▲ 7.8% | -8.84▼ 92.6% | -6.15▲ 30.4% | -4.45▲ 27.6% | -1.60▲ 64.0% | 0.18▲ 111.3% |
| EPS Growth % | 0.67% | -57.05% | -112.82% | 7.83% | -92.59% | 30.43% | 27.64% | 64.04% | 111.25% |
| EPS (Basic) | -1.49 | -2.34 | -4.98 | -4.59 | -8.84 | -6.15 | -4.45 | -1.60 | 0.18 |
| Diluted Shares Outstanding | 34.22M | 54.4M | 62.23M | 75.16M | 84.42M | 106.11M | 118.68M | 123.91M | 126.02M |
| Basic Shares Outstanding | 34.22M | 54.4M | 62.23M | 75.16M | 84.42M | 106.11M | 118.68M | 123.91M | 126.02M |
| Dividend Payout Ratio | - | - | - | - | - | - | - | - | - |
Apellis Pharmaceuticals, Inc. (APLS) balance sheet — assets, liabilities & shareholders' equity
| Line item | Dec'17 | Dec'18 | Dec'19 | Dec'20 | Dec'21 | Dec'22 | Dec'23 | Dec'24 | Dec'25 |
|---|---|---|---|---|---|---|---|---|---|
| Total Current Assets | 182.02M | 202.44M | 373.09M | 917.19M | 824.05M | 719.52M | 766.33M | 788.95M | 1.01B |
| Cash & Short-Term Investments | 175.64M | 176.27M | 351.99M | 877.65M | 701.23M | 551.8M | 352.3M | 416.14M | 467.76M |
| Cash Only | 175.64M | 176.27M | 351.99M | 565.78M | 640.19M | 551.8M | 351.19M | 411.29M | 467.76M |
| Short-Term Investments | 0 | 0 | 0 | 311.87M | 61.03M | 0 | 1.11M | 4.85M | 0 |
| Accounts Receivable | 0 | 0 | 0 | 25M | 80.1M | 7.73M | 206.44M | 271.72M | 366.22M |
| Days Sales Outstanding | - | - | - | 36.41 | 439.25 | 37.39 | 190 | 126.93 | 133.17 |
| Inventory | 0 | 0 | 0 | 0 | 24M | 85.71M | 146.36M | 82.48M | 142.56M |
| Days Inventory Outstanding | - | - | - | - | 1.68K | 5.55K | 913.04 | 255.74 | 508.95 |
| Other Current Assets | 1.31M | 1.84M | 1.31M | 11.14M | 13.54M | 36.66M | 22.41M | 9.1M | 0 |
| Total Non-Current Assets | 116.15K | 1.09M | 16.15M | 43.38M | 57.72M | 40.69M | 22.4M | 96.1M | 60.42M |
| Property, Plant & Equipment | 0 | 977.92K | 15.77M | 24.52M | 26.08M | 24.89M | 21.09M | 19.04M | 19.9M |
| Fixed Asset Turnover | - | - | - | 10.22x | 2.55x | 3.03x | 18.80x | 41.05x | 50.43x |
| Goodwill | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Intangible Assets | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Long-Term Investments | 0 | 0 | 0 | 0 | 0 | 0 | 3.24M | 0 | 0 |
| Other Non-Current Assets | 116.15K | 116.42K | 385.09K | 18.86M | 31.64M | 15.8M | -1.93M | 77.06M | 40.51M |
| Total Assets | 182.13M▲ 0% | 203.53M▲ 11.8% | 389.24M▲ 91.2% | 960.57M▲ 146.8% | 881.76M▼ 8.2% | 760.22M▼ 13.8% | 788.73M▲ 3.8% | 885.05M▲ 12.2% | 1.08B▲ 21.5% |
| Asset Turnover | - | - | - | 0.26x | 0.08x | 0.10x | 0.50x | 0.88x | 0.93x |
| Asset Growth % | 563.91% | 11.75% | 91.24% | 146.78% | -8.2% | -13.78% | 3.75% | 12.21% | 21.49% |
| Total Current Liabilities | 6.55M | 17.02M | 65.75M | 128.33M | 131.85M | 167.61M | 247.59M | 185.51M | 323.6M |
| Accounts Payable | 3.66M | 10.25M | 8.36M | 8.48M | 16.91M | 37.34M | 37.52M | 38.57M | 56.8M |
| Days Payables Outstanding | - | 29.26 | 5.12K | 123.52 | 1.19K | 2.42K | 234.03 | 119.59 | 202.78 |
| Short-Term Debt | 0 | 1.67M | 2.61M | 0 | 0 | 0 | 0 | 0 | 100.75M |
| Deferred Revenue (Current) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Current Liabilities | 0 | 0 | 43.34M | 4.23M | 7.58M | 81.43M | 75.83M | 0 | 127.55M |
| Current Ratio | 27.77x | 11.89x | 5.67x | 7.15x | 6.25x | 4.29x | 3.10x | 4.25x | 3.14x |
| Quick Ratio | 27.77x | 11.89x | 5.67x | 7.15x | 6.07x | 3.78x | 2.50x | 3.81x | 2.70x |
| Cash Conversion Cycle | - | - | - | - | 937.19 | 3.17K | 869.01 | 263.08 | 439.34 |
| Total Non-Current Liabilities | 26.63M | 25.54M | 289.26M | 627.68M | 551.26M | 422.74M | 346.62M | 471M | 381.51M |
| Long-Term Debt | 26.39M | 25.38M | 142.57M | 358.83M | 189.02M | 92.74M | 93.03M | 452.83M | 373.61M |
| Capital Lease Obligations | 0 | 0 | 11.86M | 15.22M | 17.08M | 14.35M | 11.45M | 10.2M | 11.95M |
| Deferred Tax Liabilities | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Non-Current Liabilities | 244.29K | 158.78K | 134.84M | 253.64M | 345.15M | 315.65M | 242.13M | 7.97M | -4.04M |
| Total Liabilities | 33.19M | 42.56M | 355.02M | 756.01M | 683.1M | 590.35M | 594.21M | 656.51M | 705.11M |
| Total Debt | 26.39M | 27.04M | 157.03M | 377.73M | 210.22M | 112.71M | 110.93M | 469.78M | 486.31M |
| Net Debt | -149.25M | -149.22M | -194.95M | -188.05M | -429.97M | -439.09M | -240.26M | 58.49M | 18.55M |
| Debt / Equity | 0.18x | 0.17x | 4.59x | 1.85x | 1.06x | 0.66x | 0.57x | 2.06x | 1.31x |
| Debt / EBITDA | - | - | - | - | - | - | - | - | 8.53x |
| Net Debt / EBITDA | - | - | - | - | - | - | - | - | 0.33x |
| Interest Coverage | -525.30x | -49.74x | -56.66x | -10.46x | -55.34x | -18.97x | -16.80x | -3.87x | 1.54x |
| Total Equity | 148.94M▲ 0% | 160.97M▲ 8.1% | 34.23M▼ 78.7% | 204.56M▲ 497.6% | 198.66M▼ 2.9% | 169.87M▼ 14.5% | 194.52M▲ 14.5% | 228.54M▲ 17.5% | 370.15M▲ 62.0% |
| Equity Growth % | 525.96% | 8.08% | -78.74% | 497.6% | -2.88% | -14.49% | 14.51% | 17.49% | 61.96% |
| Book Value per Share | 4.35 | 2.96 | 0.55 | 2.72 | 2.35 | 1.60 | 1.64 | 1.84 | 2.94 |
| Total Shareholders' Equity | 148.94M | 160.97M | 34.23M | 204.56M | 198.66M | 169.87M | 194.52M | 228.54M | 370.15M |
| Common Stock | 5.03K | 5.63K | 6.39K | 8K | 10K | 11K | 12K | 12K | 12K |
| Retained Earnings | -149.26M | -276.77M | -581.47M | -926.35M | -1.66B | -2.31B | -2.84B | -3.04B | -3.01B |
| Treasury Stock | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Accumulated OCI | 0 | -122.81K | -153.78K | -117K | -2.09M | -875K | -3.54M | -3.31M | -2.1M |
| Minority Interest | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Apellis Pharmaceuticals, Inc. (APLS) cash flow — operating, investing & free cash flow history
| Line item | Dec'17 | Dec'18 | Dec'19 | Dec'20 | Dec'21 | Dec'22 | Dec'23 | Dec'24 | Dec'25 |
|---|---|---|---|---|---|---|---|---|---|
| Cash from Operations | -46.6M | -131.24M | -211.13M | -160.49M | -563.13M | -513.75M | -594.74M | -87.87M | 45.33M |
| Operating CF Margin % | - | - | - | -64.03% | -846% | -681.16% | -149.96% | -11.25% | 4.52% |
| Operating CF Growth % | -79.19% | -181.66% | -60.88% | 23.99% | -250.88% | 8.77% | -15.76% | 85.23% | 151.59% |
| Net Income | -51.01M | -127.5M | -304.71M | -344.87M | -746.35M | -652.17M | -528.63M | -197.88M | 22.39M |
| Depreciation & Amortization | 11.94K | 0 | 596K | 859K | 1.49M | 1.49M | 1.7M | 1.8M | 0 |
| Stock-Based Compensation | 5.42M | 7.73M | 21.14M | 45.38M | 70.67M | 91.08M | 105.94M | 114.13M | 0 |
| Deferred Taxes | 153.69K | 0 | 0 | 0 | 198.26M | 0 | 0 | 0 | 0 |
| Other Non-Cash Items | 13.56K | 568.33K | 18.52M | 118.56M | 6.33M | 61.55M | 26.41M | 12.44M | 108.06M |
| Working Capital Changes | -1.19M | -12.04M | 53.31M | 19.59M | -93.52M | -15.7M | -200.17M | -18.36M | -85.12M |
| Change in Receivables | 0 | 0 | 0 | 0 | -10.1M | 2.38M | 0 | -58.48M | -101.28M |
| Change in Inventory | 0 | 0 | 0 | 0 | -16.32M | -69.4M | 0 | -10.76M | -15.27M |
| Change in Payables | 932.3K | 6.59M | -1.64M | -54K | 10.49M | 18.69M | 170K | 1.09M | 18.22M |
| Cash from Investing | 0 | 0 | -1.69M | -316.99M | 247.62M | 59.89M | -674K | -403K | -313K |
| Capital Expenditures | 0 | 0 | -1.69M | -5.42M | -1.1M | -1.52M | -773K | -403K | -313K |
| CapEx % of Revenue | - | - | - | 2.16% | 1.66% | 2.02% | 0.19% | 0.05% | 0.03% |
| Acquisitions | 0 | 0 | 0 | 0 | -248.72M | -61.42M | 0 | 0 | 0 |
| Investments | - | - | - | - | - | - | - | - | - |
| Other Investing | 0 | 0 | 0 | 0 | 248.72M | 61.42M | 99K | 0 | 0 |
| Cash from Financing | 197.38M | 131.9M | 388.54M | 692.18M | 392.24M | 365.66M | 394.5M | 149.24M | 8.88M |
| Debt Issued (Net) | 26.36M | 0 | 184.21M | 322.87M | 0 | 0 | 0 | 365.45M | 0 |
| Equity Issued (Net) | 169.81M | 131.19M | 109.58M | 381.42M | 380.36M | 380.12M | 384.39M | 18.83M | 8.89M |
| Dividends Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Share Repurchases | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Financing | 1.2M | 709.36K | 94.75M | -12.12M | 11.87M | -14.46M | 10.11M | -235.04M | -11K |
| Net Change in Cash | 150.78M▲ 0% | 624.14K▼ 99.6% | 175.72M▲ 28053.6% | 215.06M▲ 22.4% | 74.71M▼ 65.3% | -88.68M▼ 218.7% | -200.78M▼ 126.4% | 60.31M▲ 130.0% | 55.15M▼ 8.6% |
| Free Cash Flow | -46.6M▲ 0% | -131.24M▼ 181.7% | -212.83M▼ 62.2% | -165.91M▲ 22.0% | -564.23M▼ 240.1% | -515.27M▲ 8.7% | -595.51M▼ 15.6% | -88.27M▲ 85.2% | 45.01M▲ 151.0% |
| FCF Margin % | - | - | - | -66.19% | -847.66% | -683.18% | -150.16% | -11.3% | 4.48% |
| FCF Growth % | -79.19% | -181.66% | -62.17% | 22.05% | -240.08% | 8.68% | -15.57% | 85.18% | 151% |
| FCF per Share | -1.36 | -2.41 | -3.42 | -2.21 | -6.68 | -4.86 | -5.02 | -0.71 | 0.36 |
| FCF Conversion (FCF/Net Income) | 0.91x | 1.03x | 0.69x | 0.47x | 0.75x | 0.79x | 1.13x | 0.44x | 2.02x |
| Interest Paid | 0 | 0 | 987K | 12.93M | 10.27M | 5M | 0 | 29.37M | 0 |
| Taxes Paid | 0 | 0 | 0 | 0 | 49K | 4.92M | 0 | 1.65M | 0 |
Apellis Pharmaceuticals, Inc. (APLS) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios
| Metric | 2016 | 2017 | 2018 | 2019 | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|---|---|---|---|---|---|
| Return on Equity (ROE) | -92.31% | -59.06% | -82.28% | -312.2% | -288.86% | -370.2% | -353.93% | -290.14% | -93.55% | 7.48% |
| Return on Invested Capital (ROIC) | - | - | -1677.51% | - | -970.89% | - | - | - | -102.56% | 12.3% |
| Gross Margin | - | - | - | - | 90.01% | 92.19% | 92.53% | 85.25% | 84.93% | 89.81% |
| Net Margin | - | - | - | - | -137.59% | -1121.27% | -864.7% | -133.29% | -25.32% | 2.23% |
| Debt / Equity | - | 0.18x | 0.17x | 4.59x | 1.85x | 1.06x | 0.66x | 0.57x | 2.06x | 1.31x |
| Interest Coverage | - | -525.30x | -49.74x | -56.66x | -10.46x | -55.34x | -18.97x | -16.80x | -3.87x | 1.54x |
| FCF Conversion | 0.96x | 0.91x | 1.03x | 0.69x | 0.47x | 0.75x | 0.79x | 1.13x | 0.44x | 2.02x |
| Revenue Growth | - | - | - | - | - | -73.44% | 13.31% | 425.83% | 97.02% | 28.46% |
Apellis Pharmaceuticals, Inc. (APLS) SEC filings — annual & quarterly reports (10-K, 10-Q)
May 4, 2026·SEC
Mar 31, 2026·SEC
Mar 2, 2026·SEC
Apellis Pharmaceuticals, Inc. (APLS) stock FAQ — growth, dividends, profitability & financials explained
Apellis Pharmaceuticals, Inc. (APLS) reported $1.00B in revenue for fiscal year 2025.
Apellis Pharmaceuticals, Inc. (APLS) grew revenue by 28.5% over the past year. This is strong growth.
Yes, Apellis Pharmaceuticals, Inc. (APLS) is profitable, generating $22.4M in net income for fiscal year 2025 (2.2% net margin).
Apellis Pharmaceuticals, Inc. (APLS) has a return on equity (ROE) of 7.5%. This is below average, suggesting room for improvement.
Apellis Pharmaceuticals, Inc. (APLS) generated $45.3M in free cash flow for fiscal year 2025. Positive FCF indicates the company can fund dividends, buybacks, or reinvestment.
Apellis Pharmaceuticals, Inc. (APLS) financial analysis — history, returns, DCA and operating performance tools
Historical returns with dividends reinvested
Dollar cost averaging vs lump sum
Yield, growth, payout safety & DRIP
EPS trends, net income & profitability
Long-term charts & historical price data
Sales growth patterns & revenue breakdown
30 years of market, efficiency and balance-sheet ratios
DCF intrinsic value, peer multiples & estimates