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APLS logoApellis Pharmaceuticals, Inc.(APLS)Earnings, Financials & Key Ratios

APLS•NASDAQ
227.9× P/E·Price updated May 29, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryImmunology and Inflammation Therapies
AboutApellis Pharmaceuticals, Inc., a commercial-stage biopharmaceutical company, focuses on the discovery, development, and commercialization of therapeutic compounds through the inhibition of the complement system for autoimmune and inflammatory diseases. The company's lead product candidate is pegcetacoplan that is in Phase III clinical trials for the treatment of geographic atrophy (GA) in age-related macular degeneration and paroxysmal nocturnal hemoglobinuria (PNH) diseases. It also develops EMPAVELI (systemic pegcetacoplan) for the treatment of cold agglutinin disease (CAD), and hematopoietic stem cell transplantation-associated thrombotic microangiopathy (HSCT-TMA) in hematology; C3 glomerulopathy (C3G), and immune complex membranoproliferative glomerulonephritis (IC-MPGN) in nephrology; and amyotrophic lateral sclerosis (ALS) in neurology. In addition, the company develops APL-2006, a bispecific C3 and VEGF inhibitor for treating complement-mediated disorders; APL-1030, a C3 inhibitor for the treatment of multiple neurodegenerative diseases; and the combination of EMPAVELI and a small interfering RNA, or siRNA for reducing the production of C3 proteins by the liver. It has a collaboration and license agreement with Swedish Orphan Biovitrum AB (publ) to co-develop pegcetacoplan; and a research collaboration with Beam Therapeutics Inc. focused on the use of Beam's base editing technology to discover new treatments for complement-driven diseases. Apellis Pharmaceuticals, Inc. was incorporated in 2009 and is based in Waltham, Massachusetts.Show more
  • Revenue$1B+28.5%
  • EBITDA$57M+134.9%
  • Net Income$22M+111.3%
  • EPS (Diluted)0.18+111.3%
  • Gross Margin89.81%+5.7%
  • EBITDA Margin5.68%+127.2%
  • Operating Margin5.52%+126.2%
  • Net Margin2.23%+108.8%
  • ROE7.48%+108.0%

APLS Key Insights

Apellis Pharmaceuticals, Inc. (APLS) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Strong Piotroski F-Score: 7/9
  • ✓Momentum leader: RS Rating 95 (top 5%)
  • ✓High quality earnings: Operating CF exceeds net income
  • ✓Strong 5Y sales CAGR of 32.0%
  • ✓Trading near 52-week high

✗Weaknesses

  • ✗Expensive at 14.0x book value

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

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APLS Price & Volume

Apellis Pharmaceuticals, Inc. (APLS) stock price & volume — 10-year historical chart

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APLS Growth Metrics

Apellis Pharmaceuticals, Inc. (APLS) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years31.98%
3 Years136.98%
TTM32.63%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM159.58%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM150.84%

Return on Capital

10 Years-63.09%
5 Years-53.31%
3 Years-36.73%
Last Year7.64%

APLS Recent Earnings

Apellis Pharmaceuticals, Inc. (APLS) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 6/12 qtrs (50%)●Beat Revenue 9/12 qtrs (75%)
Q2 2026Latest
May 7, 2026
Metric
Actual
Est
EPS
$0.15+139.5%
$0.38
Rev
$268M+27.5%
$210M
Q1 2026
Feb 24, 2026
Metric
Actual
Est
EPS
$0.47-20.5%
$0.39
Rev
$200M+0.3%
$199M
Q4 2025
Oct 30, 2025
Metric
Actual
Est
EPS
$1.67+62.1%
$1.03
Rev
$459M+130.1%
$199M
Q3 2025
Jul 31, 2025
Metric
Actual
Est
EPS
$0.33+25.0%
$0.44
Rev
$178M-52.0%
$372M
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 7, 2026
$0.15vs $0.38+139.5%
$268Mvs $210M+27.5%
Q1 2026Feb 24, 2026
$0.47vs $0.39-20.5%
$200Mvs $199M+0.3%
Q4 2025Oct 30, 2025
$1.67vs $1.03+62.1%
$459Mvs $199M+130.1%
Q3 2025Jul 31, 2025
$0.33vs $0.44+25.0%
$178Mvs $372M-52.0%
Based on last 12 quarters of dataView full earnings history →

APLS Peer Comparison

Apellis Pharmaceuticals, Inc. (APLS) competitors in Immunology and Inflammation Therapies — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
Institutional Holdings
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
RARE logoRAREUltragenyx Pharmaceutical Inc.Direct Competitor2.7B27.44-4.7120.13%-91.03%-6.08%
BEAM logoBEAMBeam Therapeutics Inc.Direct Competitor3.51B34.14-42.15120.01%-49.17%-5.89%0.24
AKRO logoAKROAkero Therapeutics, Inc.Direct Competitor4.5B54.65-14.57-30.58%0.05
INVA logoINVAInnoviva, Inc.Direct Competitor1.66B22.496.8218.52%118.91%47.59%0.23
BCAB logoBCABBioAtla, Inc.Direct Competitor4.61M3.66-0.07-81.82%-25.31%
REGN logoREGNRegeneron Pharmaceuticals, Inc.Product Competitor63.37B609.9414.700.99%29.65%14.32%0.09
BIIB logoBIIBBiogen Inc.Product Competitor29.02B196.5822.261.39%13.92%7.55%0.38
IONS logoIONSIonis Pharmaceuticals, Inc.Product Competitor12.25B74.12-31.1433.87%-30.87%-58.57%5.35

Compare APLS vs Peers

Apellis Pharmaceuticals, Inc. (APLS) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs RARE

Most directly comparable listed peer for APLS.

Scale Benchmark

vs ABBV

Larger-name benchmark to compare APLS against a more recognizable public peer.

Peer Set

Compare Top 5

vs RARE, BEAM, AKRO, INVA

APLS Income Statement

Apellis Pharmaceuticals, Inc. (APLS) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Sales/Revenue
000250.65M66.56M75.42M396.59M781.37M1B1.03B
Revenue Growth %
-----73.44%13.31%425.83%97.02%28.46%32.63%
Cost of Goods Sold
0127.92M595.45K25.05M5.2M5.64M58.51M117.72M102.24M108.87M
COGS % of Revenue
---9.99%7.81%7.47%14.75%15.07%10.19%-
Gross Profit
-50.77M▲ 0%
-127.92M▼ 152.0%
-595.45K▲ 99.5%
225.6M▲ 37986.7%
61.36M▼ 72.8%
69.79M▲ 13.7%
338.08M▲ 384.5%
663.64M▲ 96.3%
901.55M▲ 35.8%
920.13M▲ 0%
Gross Margin %
---90.01%92.19%92.53%85.25%84.93%89.81%89.42%
Gross Profit Growth %
--151.98%99.53%37986.7%-72.8%13.73%384.45%96.3%35.85%-
Operating Expenses
50.77M127.92M287.42M439.32M597.64M664.4M855.2M828.62M846.12M831.19M
OpEx % of Revenue
---175.28%897.86%880.91%215.64%106.05%84.29%-
Selling, General & Admin
10.46M22.64M66.45M139.4M176.77M277.16M500.81M501.05M550.26M544.8M
SG&A % of Revenue
---55.62%265.57%367.48%126.28%64.13%54.82%-
Research & Development
40.3M105.29M220.97M299.92M420.87M387.24M354.39M327.57M295.85M286.39M
R&D % of Revenue
---119.66%632.29%513.43%89.36%41.92%29.47%-
Other Operating Expenses
11.54K-111K0-501K1.36M-288K0000
Operating Income
-50.77M▲ 0%
-127.92M▼ 152.0%
-288.02M▼ 125.1%
-213.73M▲ 25.8%
-536.28M▼ 150.9%
-594.61M▼ 10.9%
-517.12M▲ 13.0%
-164.98M▲ 68.1%
55.43M▲ 133.6%
165.22M▲ 0%
Operating Margin %
----85.27%-805.67%-788.38%-130.39%-21.11%5.52%16.06%
Operating Income Growth %
-86.08%-151.98%-125.14%25.79%-150.92%-10.88%13.03%68.1%133.6%-
EBITDA
-50.76M0-287.42M-212.87M-534.78M-593.13M-515.42M-163.18M56.98M166.33M
EBITDA Margin %
----84.93%-803.43%-786.41%-129.96%-20.88%5.68%16.16%
EBITDA Growth %
-100%-25.94%-151.23%-10.91%13.1%68.34%134.92%190.19%
D&A (Non-Cash Add-back)
11.94K127.92M595.45K859K1.49M1.49M1.7M1.8M1.56M1.11M
EBIT
-50.91M-124.99M-299.42M-313.09M-732.76M-618.88M-496.92M-156.32M68.44M149.27M
Net Interest Income
-96.92K447.81K-176K-25.77M-12.82M-23.71M-8.65M-27.62M-31.18M-22.79M
Interest Income
02.96M5.11M4.16M418K8.91M20.93M12.77M13.14M13.4M
Interest Expense
96.92K2.51M5.29M29.94M13.24M32.63M29.58M40.39M44.33M22.96M
Other Income/Expense
-239K422.81K-16.69M-129.3M-209.72M-56.89M-9.38M-31.74M-31.32M-30.08M
Pretax Income
-51.01M▲ 0%
-127.5M▼ 150.0%
-304.71M▼ 139.0%
-343.03M▼ 12.6%
-746M▼ 117.5%
-651.5M▲ 12.7%
-526.5M▲ 19.2%
-196.72M▲ 62.6%
24.11M▲ 112.3%
135.15M▲ 0%
Pretax Margin %
----136.86%-1120.75%-863.81%-132.76%-25.18%2.4%13.13%
Income Tax
250.61K-533K01.84M352K669K2.13M1.16M1.72M1.88M
Effective Tax Rate %
-0.49%0.42%0%-0.54%-0.05%-0.1%-0.4%-0.59%7.14%1.39%
Net Income
-51.01M▲ 0%
-127.5M▼ 150.0%
-304.71M▼ 139.0%
-344.87M▼ 13.2%
-746.35M▼ 116.4%
-652.17M▲ 12.6%
-528.63M▲ 18.9%
-197.88M▲ 62.6%
22.39M▲ 111.3%
133.27M▲ 0%
Net Margin %
----137.59%-1121.27%-864.7%-133.29%-25.32%2.23%12.95%
Net Income Growth %
-88.04%-149.97%-138.98%-13.18%-116.41%12.62%18.94%62.57%111.31%159.58%
Net Income (Continuing)
-51.01M-127.5M-304.71M-344.87M-746.35M-652.17M-528.63M-197.88M22.39M133.27M
Discontinued Operations
0000000000
Minority Interest
0000000000
EPS (Diluted)
-1.49▲ 0%
-2.34▼ 57.0%
-4.98▼ 112.8%
-4.59▲ 7.8%
-8.84▼ 92.6%
-6.15▲ 30.4%
-4.45▲ 27.6%
-1.60▲ 64.0%
0.18▲ 111.3%
-▲ 0%
EPS Growth %
0.67%-57.05%-112.82%7.83%-92.59%30.43%27.64%64.04%111.25%150.84%
EPS (Basic)
-1.49-2.34-4.98-4.59-8.84-6.15-4.45-1.600.18-
Diluted Shares Outstanding
34.22M54.4M62.23M75.16M84.42M106.11M118.68M123.91M126.02M0
Basic Shares Outstanding
34.22M54.4M62.23M75.16M84.42M106.11M118.68M123.91M126.02M0
Dividend Payout Ratio
----------

APLS Balance Sheet

Apellis Pharmaceuticals, Inc. (APLS) balance sheet — assets, liabilities & shareholders' equity

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Total Current Assets
182.02M202.44M373.09M917.19M824.05M719.52M766.33M788.95M1.01B1.03B
Cash & Short-Term Investments
175.64M176.27M351.99M877.65M701.23M551.8M352.3M416.14M467.76M405.21M
Cash Only
175.64M176.27M351.99M565.78M640.19M551.8M351.19M411.29M467.76M405.21M
Short-Term Investments
000311.87M61.03M01.11M4.85M00
Accounts Receivable
00025M80.1M7.73M206.44M271.72M366.22M440.3M
Days Sales Outstanding
---36.41439.2537.39190126.93133.17123.3
Inventory
000024M85.71M146.36M82.48M142.56M131.41M
Days Inventory Outstanding
----1.68K5.55K913.04255.74508.95433.99
Other Current Assets
1.31M1.84M1.31M11.14M13.54M36.66M22.41M9.1M051.11M
Total Non-Current Assets
116.15K1.09M16.15M43.38M57.72M40.69M22.4M96.1M60.42M54.51M
Property, Plant & Equipment
0977.92K15.77M24.52M26.08M24.89M21.09M19.04M19.9M20.36M
Fixed Asset Turnover
---10.22x2.55x3.03x18.80x41.05x50.43x52.32x
Goodwill
0000000000
Intangible Assets
0000000000
Long-Term Investments
0000003.24M000
Other Non-Current Assets
116.15K116.42K385.09K18.86M31.64M15.8M-1.93M77.06M40.51M34.15M
Total Assets
182.13M▲ 0%
203.53M▲ 11.8%
389.24M▲ 91.2%
960.57M▲ 146.8%
881.76M▼ 8.2%
760.22M▼ 13.8%
788.73M▲ 3.8%
885.05M▲ 12.2%
1.08B▲ 21.5%
1.08B▲ 0%
Asset Turnover
---0.26x0.08x0.10x0.50x0.88x0.93x1.02x
Asset Growth %
563.91%11.75%91.24%146.78%-8.2%-13.78%3.75%12.21%21.49%63.79%
Total Current Liabilities
6.55M17.02M65.75M128.33M131.85M167.61M247.59M185.51M323.6M283.45M
Accounts Payable
3.66M10.25M8.36M8.48M16.91M37.34M37.52M38.57M56.8M49.05M
Days Payables Outstanding
-29.265.12K123.521.19K2.42K234.03119.59202.78166.53
Short-Term Debt
01.67M2.61M00000100.75M6.96M
Deferred Revenue (Current)
0000000000
Other Current Liabilities
0043.34M4.23M7.58M81.43M75.83M0127.55M227.44M
Current Ratio
27.77x11.89x5.67x7.15x6.25x4.29x3.10x4.25x3.14x3.63x
Quick Ratio
27.77x11.89x5.67x7.15x6.07x3.78x2.50x3.81x2.70x3.16x
Cash Conversion Cycle
----937.193.17K869.01263.08439.34390.75
Total Non-Current Liabilities
26.63M25.54M289.26M627.68M551.26M422.74M346.62M471M381.51M384.16M
Long-Term Debt
26.39M25.38M142.57M358.83M189.02M92.74M93.03M452.83M373.61M106.55M
Capital Lease Obligations
0011.86M15.22M17.08M14.35M11.45M10.2M11.95M33.94M
Deferred Tax Liabilities
0000000000
Other Non-Current Liabilities
244.29K158.78K134.84M253.64M345.15M315.65M242.13M7.97M-4.04M277.61M
Total Liabilities
33.19M42.56M355.02M756.01M683.1M590.35M594.21M656.51M705.11M667.61M
Total Debt
26.39M27.04M157.03M377.73M210.22M112.71M110.93M469.78M486.31M113.51M
Net Debt
-149.25M-149.22M-194.95M-188.05M-429.97M-439.09M-240.26M58.49M18.55M-291.69M
Debt / Equity
0.18x0.17x4.59x1.85x1.06x0.66x0.57x2.06x1.31x0.27x
Debt / EBITDA
--------8.53x0.68x
Net Debt / EBITDA
--------0.33x-1.75x
Interest Coverage
-525.30x-49.74x-56.66x-10.46x-55.34x-18.97x-16.80x-3.87x1.54x6.50x
Total Equity
148.94M▲ 0%
160.97M▲ 8.1%
34.23M▼ 78.7%
204.56M▲ 497.6%
198.66M▼ 2.9%
169.87M▼ 14.5%
194.52M▲ 14.5%
228.54M▲ 17.5%
370.15M▲ 62.0%
414.92M▲ 0%
Equity Growth %
525.96%8.08%-78.74%497.6%-2.88%-14.49%14.51%17.49%61.96%242.95%
Book Value per Share
4.352.960.552.722.351.601.641.842.943.24
Total Shareholders' Equity
148.94M160.97M34.23M204.56M198.66M169.87M194.52M228.54M370.15M414.92M
Common Stock
5.03K5.63K6.39K8K10K11K12K12K12K13K
Retained Earnings
-149.26M-276.77M-581.47M-926.35M-1.66B-2.31B-2.84B-3.04B-3.01B-2.99B
Treasury Stock
0000000000
Accumulated OCI
0-122.81K-153.78K-117K-2.09M-875K-3.54M-3.31M-2.1M-2.41M
Minority Interest
0000000000

APLS Cash Flow Statement

Apellis Pharmaceuticals, Inc. (APLS) cash flow — operating, investing & free cash flow history

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Cash from Operations
-46.6M-131.24M-211.13M-160.49M-563.13M-513.75M-594.74M-87.87M45.33M37.77M
Operating CF Margin %
----64.03%-846%-681.16%-149.96%-11.25%4.52%-
Operating CF Growth %
-79.19%-181.66%-60.88%23.99%-250.88%8.77%-15.76%85.23%151.59%184.06%
Net Income
-51.01M-127.5M-304.71M-344.87M-746.35M-652.17M-528.63M-197.88M22.39M133.27M
Depreciation & Amortization
11.94K0596K859K1.49M1.49M1.7M1.8M0-155K
Stock-Based Compensation
5.42M7.73M21.14M45.38M70.67M91.08M105.94M114.13M0-27.37M
Deferred Taxes
153.69K000198.26M00000
Other Non-Cash Items
13.56K568.33K18.52M118.56M6.33M61.55M26.41M12.44M108.06M155.69M
Working Capital Changes
-1.19M-12.04M53.31M19.59M-93.52M-15.7M-200.17M-18.36M-85.12M-201.27M
Change in Receivables
0000-10.1M2.38M0-58.48M-101.28M-205.03M
Change in Inventory
0000-16.32M-69.4M0-10.76M-15.27M-10.46M
Change in Payables
932.3K6.59M-1.64M-54K10.49M18.69M170K1.09M18.22M-6.23M
Cash from Investing
00-1.69M-316.99M247.62M59.89M-674K-403K-313K-305K
Capital Expenditures
00-1.69M-5.42M-1.1M-1.52M-773K-403K-313K8K
CapEx % of Revenue
---2.16%1.66%2.02%0.19%0.05%0.03%0%
Acquisitions
0000-248.72M-61.42M0000
Investments
----------
Other Investing
0000248.72M61.42M99K00-313K
Cash from Financing
197.38M131.9M388.54M692.18M392.24M365.66M394.5M149.24M8.88M8.67M
Debt Issued (Net)
26.36M0184.21M322.87M000365.45M00
Equity Issued (Net)
169.81M131.19M109.58M381.42M380.36M380.12M384.39M18.83M8.89M8.7M
Dividends Paid
0000000000
Share Repurchases
0000000000
Other Financing
1.2M709.36K94.75M-12.12M11.87M-14.46M10.11M-235.04M-11K-26K
Net Change in Cash
150.78M▲ 0%
624.14K▼ 99.6%
175.72M▲ 28053.6%
215.06M▲ 22.4%
74.71M▼ 65.3%
-88.68M▼ 218.7%
-200.78M▼ 126.4%
60.31M▲ 130.0%
55.15M▼ 8.6%
46.9M▲ 0%
Free Cash Flow
-46.6M▲ 0%
-131.24M▼ 181.7%
-212.83M▼ 62.2%
-165.91M▲ 22.0%
-564.23M▼ 240.1%
-515.27M▲ 8.7%
-595.51M▼ 15.6%
-88.27M▲ 85.2%
45.01M▲ 151.0%
37.78M▲ 0%
FCF Margin %
----66.19%-847.66%-683.18%-150.16%-11.3%4.48%3.67%
FCF Growth %
-79.19%-181.66%-62.17%22.05%-240.08%8.68%-15.57%85.18%151%549.16%
FCF per Share
-1.36-2.41-3.42-2.21-6.68-4.86-5.02-0.710.36-
FCF Conversion (FCF/Net Income)
0.91x1.03x0.69x0.47x0.75x0.79x1.13x0.44x2.02x0.28x
Interest Paid
00987K12.93M10.27M5M029.37M00
Taxes Paid
000049K4.92M01.65M0666K

APLS Key Ratios

Apellis Pharmaceuticals, Inc. (APLS) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric201720182019202020212022202320242025TTM
Return on Equity (ROE)
-59.06%-82.28%-312.2%-288.86%-370.2%-353.93%-290.14%-93.55%7.48%39.71%
Return on Invested Capital (ROIC)
--1677.51%--970.89%----102.56%12.3%42.59%
Gross Margin
---90.01%92.19%92.53%85.25%84.93%89.81%89.42%
Net Margin
----137.59%-1121.27%-864.7%-133.29%-25.32%2.23%12.95%
Debt / Equity
0.18x0.17x4.59x1.85x1.06x0.66x0.57x2.06x1.31x0.27x
Interest Coverage
-525.30x-49.74x-56.66x-10.46x-55.34x-18.97x-16.80x-3.87x1.54x6.50x
FCF Conversion
0.91x1.03x0.69x0.47x0.75x0.79x1.13x0.44x2.02x0.28x
Revenue Growth
-----73.44%13.31%425.83%97.02%28.46%32.63%
Related:APLS Dividend History·APLS Revenue History·APLS Price History·APLS P/E History·APLS Financial Ratios·APLS Institutional Holders

APLS SEC Filings & Documents

Apellis Pharmaceuticals, Inc. (APLS) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 4, 2026·SEC

Material company update

Mar 31, 2026·SEC

Material company update

Mar 2, 2026·SEC

10-K Annual Reports

2
FY 2026

Feb 24, 2026·SEC

FY 2025

Feb 28, 2025·SEC

10-Q Quarterly Reports

6
FY 2026

May 7, 2026·SEC

FY 2025

Oct 30, 2025·SEC

FY 2025

Jul 31, 2025·SEC

APLS Frequently Asked Questions

Apellis Pharmaceuticals, Inc. (APLS) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Apellis Pharmaceuticals, Inc. (APLS) reported $1.03B in revenue for fiscal year 2025.

Apellis Pharmaceuticals, Inc. (APLS) grew revenue by 28.5% over the past year. This is strong growth.

Yes, Apellis Pharmaceuticals, Inc. (APLS) is profitable, generating $133.3M in net income for fiscal year 2025 (2.2% net margin).

Dividend & Returns

Apellis Pharmaceuticals, Inc. (APLS) has a return on equity (ROE) of 7.5%. This is below average, suggesting room for improvement.

Apellis Pharmaceuticals, Inc. (APLS) generated $37.8M in free cash flow for fiscal year 2025. Positive FCF indicates the company can fund dividends, buybacks, or reinvestment.

What if you invested $1,000 in APLS back in 2013?

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