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CRNXCrinetics Pharmaceuticals, Inc.
$84.95$9.0B
Overview & Tools
OverviewChart Terminal ↗Visualize
Valuation & Forecasts
Valuation ModelsEstimatesDCF Model
Price & Analyst Data
Analyst TargetsPrice History
Financial Statements
Income StatementBalance SheetCash FlowRatios & Margins
Performance
P/E HistoryRevenue HistoryEarnings HistoryDividend HistoryTotal Return
Discovery & Screens
Live BreakoutsStock ScreenerOwnership
CRNX logo

Crinetics Pharmaceuticals, Inc.

CRNX
NASDAQ · Biotechnology
$84.95
At close - Sep 15, 4:00 PM EDT - USD
Market Cap$9B
P/E-17.2x
52W High$85.03
Volume2.89M
OverviewTerminalAnalysisFinancialsValuationEarningsBreakoutsOwnership
VCP Research Verdict2026Q2

Milestone Revenue Spike Masks Accelerating Cash Burn

Crinetics is a clinical-stage biotech whose positive PATHFNDR-1 Phase 3 data for paltusotine has triggered milestone-driven revenue (Q2 2026 revenue of $25.1M, up 23.4% QoQ) but also a step-up in R&D investment, with operating losses deepening to -$132.5M in Q...

GrowthMixed
ProfitabilityNegative
ValuationReview
TechnicalsStrong
Explore valuation models
MARKET ACTION

CRNX price & volume

Price trend, volume and key moving averages

Launch Terminal
Loading chart...
Decision Checklist4 Core Signals

What matters now

The signals most likely to change the investment case.

01

Earnings momentum

3/12 Beats

EPS beat 3 of last 12 quarters

02

Valuation risk

-162% Peers

P/E is 162% below peer median

03

Market leadership

RS 96 · Leader

High momentum (Outperforming 96% of market)

04

Strong Uptrend

Strong Trend

Price > 20DMA > 50DMA > 200DMA

Next CatalystConfirmed earnings · Nov 5

Market performance

Price History →

Trailing total returns as of 9/23/2026, which may include dividends or other distributions. Benchmark is S&P 500 (^GSPC).

YTD Return
CRNX+81.79%
S&P 500 (^GSPC)+13.20%
1-Year Return
CRNX+151.93%
S&P 500 (^GSPC)+15.98%
3-Year Return
CRNX+194.76%
S&P 500 (^GSPC)+82.25%
5-Year Return
CRNX+308.41%
S&P 500 (^GSPC)+77.83%
02

Test the fundamentals

Check whether operating performance supports the current valuation.

VALUATION & INTRINSIC VALUE

Valuation Scenarios

Valuation Analysis
Trailing P/E
-17.2x
Forward P/E
N/A
EV/EBITDA
N/A
FCF YieldCash Flow
N/A

Valuation vs 5-Year History

Multiple Range
Metric
Current
5Y Median
Historical Range
Percentile
P/E
-17.2x
N/A
N/A
EV/EBITDA
N/A
N/A
N/A
Price/FCF
N/A
N/A
N/A
Current Multiple
5Y Median (50th %ile)

Intrinsic Value Scenarios

DCF Projection
Bear$0.94-98.9%
Base (Fair)$59.83-29.6%
Bull$1.27-98.5%
$0.94 Bear$59.83 Base$1.27 Bull
Current Market Price: $84.95
Trades at a 42.0% premium to Base DCF ($59.83)
Open DCF & Valuation Models →Chart Terminal ↗

Growth & profitability

Annual revenue & EPS trend
Revenue
$8M+640.7% YoY
Net income
-$465M-55.9% YoY
Free cash flow
-$384M-67.0% YoY
Operating margin
-6714.8%+25898.7 pts YoY
ROIC (TTM)-37.8%
Avg ROIC 5Y-
ROE (TTM)-40.2%
Piotroski Score2 / 9
Financial Statements →
03

Monitor what changed

Recent results and news deserve attention only when they alter the forward view.

OPERATING RESULTS

Recent Earnings

Earnings History
EPS Beat Rate3/12 (25%)
Revenue Beat Rate7/12 (78%)
QuarterEPS (Act vs Est)Revenue (Act vs Est)
Q3 2026Latest
Aug 3, 2026
-$1.14+3.4%
vs -$1.18
$25M+69.2%
vs $15M
Q2 2026
May 7, 2026
-$1.23-0.8%
vs -$1.22
$11M+26.1%
vs $9M
Q1 2026
Feb 26, 2026
-$1.29+5.8%
vs -$1.37
$6M+37.2%
vs $4M
Q4 2025
Nov 6, 2025
-$1.38-8.7%
vs -$1.27
$143,000-96.7%
vs $4M
Historical baseline: 12 quarters analyzedGAAP / Adjusted
MARKET COVERAGE

Latest News

5 Stories
Defense World·2d ago
Financial Comparison: Crinetics Pharmaceuticals (NASDAQ:CRNX) and Lyra Therapeutics (OTCMKTS:LYRA)

Crinetics Pharmaceuticals (NASDAQ: CRNX - Get Free Report) and Lyra Therapeutics (OTCMKTS:LYRA - Get Free Report) are both healthcare companies, but which is the better business? We will contrast the two companies based on the strength of their institutional ownership, analyst recommendations, profitability, valuation, earnings, risk and dividends. Analyst Ratings This is a summary of current

Fool - Investing News·Sep 10, 2026
Which Healthcare ETF Is the Better Buy: Fidelity's Broad FHLC or State Street's Pharma-Focused XPH?

FHLC captures the whole healthcare opportunity at rock-bottom cost. XPH narrows the bet to pharmaceuticals and charges significantly more for it.

Business Wire·Sep 1, 2026
Vertex Completes Acquisition of Crinetics Pharmaceuticals and Announces Expansion of Executive Leadership Team

BOSTON--(BUSINESS WIRE)--Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX) today announced the successful completion of the acquisition of Crinetics Pharmaceuticals, Inc. (Nasdaq: CRNX), a global pharmaceutical company focused on the discovery, development and commercialization of novel therapeutics for endocrine diseases. Vertex also announced the expansion of its executive leadership team, in support of the Company's continued growth and diversification. Completion of Acquisition of Crinetic.

Defense World·Aug 26, 2026
BlackRock Inc. Purchases New Position in Crinetics Pharmaceuticals, Inc. $CRNX

BlackRock Inc. purchased a new position in shares of Crinetics Pharmaceuticals, Inc. (NASDAQ: CRNX) during the second quarter, according to the company in its most recent filing with the Securities and Exchange Commission. The institutional investor purchased 9,758,938 shares of the company's stock, valued at approximately $365,179,000. BlackRock Inc. owned approximately 9.20% of

Filtered for Crinetics Pharmaceuticals, Inc.More Headlines
04

Compare before deciding

Benchmark CRNX against direct peers instead of judging its metrics in isolation.

Peers Comparison

Key metrics vs top competitors for Crinetics Pharmaceuticals, Inc. (CRNX)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
CRNX logoCRNXCrinetics Pharmaceuticals, Inc.Current
$84.95$9B-17.16640.71%-6046.22%-40.17%—
RCUS logoRCUSArcus Biosciences, Inc.
$26.87$3.38B-8.17-4.26%-386.32%-87.98%—
CHRS logoCHRSCoherus Oncology, Inc.
$1.30$159.13M-0.90-84.2%-257.1%-181.73%—
ACVA logoACVAACV Auctions Inc.
$10.45$1.82B-26.7919.22%-7.88%-14.99%—
ACAD logoACADACADIA Pharmaceuticals Inc.
$26.41$4.52B11.5311.87%33.42%32.39%—
NVAX logoNVAXNovavax, Inc.
$10.83$1.78B4.2664.69%-59.87%——

Compare CRNX vs Peers

Crinetics Pharmaceuticals, Inc. (CRNX) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs RCUS

Most directly comparable listed peer for CRNX.

Scale Benchmark

vs NVS

Larger-name benchmark to compare CRNX against a more recognizable public peer.

Peer Set

Compare Top 5

vs RCUS, CHRS, ACVA, ACAD

05

Keep researching

Verify the primary filings, follow material updates, and answer the remaining questions.

CRNX SEC Filings & Documents

Crinetics Pharmaceuticals, Inc. (CRNX) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Aug 3, 2026·SEC

Material company update

Jul 10, 2026·SEC

Material company update

Jul 6, 2026·SEC

10-K Annual Reports

2
FY 2026

Feb 26, 2026·SEC

FY 2025

Feb 27, 2025·SEC

10-Q Quarterly Reports

6
FY 2026

Aug 3, 2026·SEC

FY 2026

May 7, 2026·SEC

FY 2025

Nov 6, 2025·SEC

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CRNX Frequently Asked Questions

Crinetics Pharmaceuticals, Inc. (CRNX) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
What is Crinetics Pharmaceuticals, Inc.'s revenue?

Crinetics Pharmaceuticals, Inc. (CRNX) reported $42.2M in revenue for fiscal year 2025. This represents a 7057% increase from $0.6M in 2016.

How fast is Crinetics Pharmaceuticals, Inc. growing?

Crinetics Pharmaceuticals, Inc. (CRNX) grew revenue by 640.7% over the past year. This is strong growth.

Is CRNX profitable?

Crinetics Pharmaceuticals, Inc. (CRNX) reported a net loss of $501.6M for fiscal year 2025.

Dividend & Returns
What is CRNX's return on equity?

Crinetics Pharmaceuticals, Inc. (CRNX) has a return on equity (ROE) of -40.2%. Negative ROE indicates the company is unprofitable.

What is Crinetics Pharmaceuticals, Inc.'s free cash flow?

Crinetics Pharmaceuticals, Inc. (CRNX) had negative free cash flow of $425.2M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in CRNX back in 2016?

Total return calculator · dividends reinvested · 10+ years of data

See returns →