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SLNO logoSoleno Therapeutics, Inc.(SLNO)Earnings, Financials & Key Ratios

SLNO•NASDAQ
$52.95
$2.76B mkt cap·135.8× P/E·Price updated May 7, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryCommercial Rare Disease Biopharma
AboutSoleno Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on the development and commercialization of novel therapeutics for the treatment of rare diseases. Its lead candidate is Diazoxide Choline Controlled-Release, a once-daily oral tablet for the treatment of Prader-Willi Syndrome, which is being evaluated in an ongoing Phase III clinical development program. The company was formerly known as Capnia, Inc. and changed its name to Soleno Therapeutics, Inc. in May 2017. Soleno Therapeutics, Inc. was incorporated in 1999 and is based in Redwood City, California.Show more
  • Revenue$190M
  • EBITDA$17M+109.1%
  • Net Income$21M+111.9%
  • EPS (Diluted)0.39+108.9%
  • Gross Margin98.58%
  • EBITDA Margin8.91%
  • Operating Margin7.85%
  • Net Margin10.97%
  • ROE6.01%+106.9%
  • ROIC3.78%+102.7%
  • Debt/Equity0.01-97.2%
  • Interest Coverage4.81+100.6%
Technical→

SLNO Key Insights

Soleno Therapeutics, Inc. (SLNO) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Company is almost debt free
  • ✓Strong Piotroski F-Score: 7/9
  • ✓FCF machine: 24.5% free cash flow margin
  • ✓High quality earnings: Operating CF exceeds net income
  • ✓Healthy 5Y average net margin of 11.0%

✗Weaknesses

  • ✗Shares diluted 35.2% in last year
  • ✗Trading more than 30% below 52-week high

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

SLNO Price & Volume

Soleno Therapeutics, Inc. (SLNO) stock price & volume — 10-year historical chart

Loading chart...

SLNO Growth Metrics

Soleno Therapeutics, Inc. (SLNO) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years85.84%
5 Years-
3 Years-
TTM-

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM111.88%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM105.32%

Return on Capital

10 Years-83.4%
5 Years-59.56%
3 Years-39.41%
Last Year3.67%

SLNO Recent Earnings

Soleno Therapeutics, Inc. (SLNO) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 5/12 qtrs (42%)●Beat Revenue 1/12 qtrs (33%)
Q1 2026Latest
Feb 25, 2026
EPS
$0.80
Est $0.64
+25.0%
Revenue
$92M
Est $89M
+3.4%
Q4 2025
Nov 4, 2025
EPS
$0.47
Est $0.06
+717.4%
Revenue
$66M
Est $89M
-25.4%
Q3 2025
Aug 6, 2025
EPS
$0.09
Est $0.53
+83.0%
Revenue
$33M
Est $39M
-17.0%
Q2 2025
May 7, 2025
EPS
$0.95
Est $1.14
+16.7%
Revenue
—
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q1 2026LatestFeb 25, 2026
$0.80vs $0.64+25.0%
$92Mvs $89M+3.4%
Q4 2025Nov 4, 2025
$0.47vs $0.06+717.4%
$66Mvs $89M-25.4%
Q3 2025Aug 6, 2025
$0.09vs $0.53+83.0%
$33Mvs $39M-17.0%
Q2 2025May 7, 2025
$0.95vs $1.14+16.7%
—
Based on last 12 quarters of dataView full earnings history →

SLNO Peer Comparison

Soleno Therapeutics, Inc. (SLNO) competitors in Commercial Rare Disease Biopharma — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
RARE logoRAREUltragenyx Pharmaceutical Inc.Direct Competitor2.57B26.13-4.4820.13%-91.03%-6.08%
ACAD logoACADACADIA Pharmaceuticals Inc.Direct Competitor3.86B22.579.8511.87%34.3%35.65%0.04
RYTM logoRYTMRhythm Pharmaceuticals, Inc.Direct Competitor6.59B96.23-30.9445.83%-93.84%-204.35%1.77
MDGL logoMDGLMadrigal Pharmaceuticals, Inc.Direct Competitor12.27B534.86-41.62432.05%-27.32%-50.15%0.59
PTCT logoPTCTPTC Therapeutics, Inc.Direct Competitor5.35B64.498.29114.51%-22.58%
ANAB logoANABAnaptysBio, Inc.Product Competitor2.89B66.96-145.57157.01%-5.64%-24.49%0.38
FOLD logoFOLDAmicus Therapeutics, Inc.Product Competitor4.55B14.49-164.8520.05%-4.27%-12.02%1.76
KRYS logoKRYSKrystal Biotech, Inc.Product Competitor8.75B296.7043.3833.94%53.92%19.25%0.01

Compare SLNO vs Peers

Soleno Therapeutics, Inc. (SLNO) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs RARE

Most directly comparable listed peer for SLNO.

Scale Benchmark

vs ABBV

Larger-name benchmark to compare SLNO against a more recognizable public peer.

Peer Set

Compare Top 5

vs RARE, ACAD, RYTM, MDGL

SLNO Income Statement

Soleno Therapeutics, Inc. (SLNO) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Sales/Revenue-1.55B0000000190.41M
Revenue Growth %-107145.41%100%-------
Cost of Goods Sold1.61M1.92M2.3M2.19M00002.7M
COGS % of Revenue-0.1%-------1.42%
Gross Profit
-1.55B▲ 0%
-1.92M▲ 99.9%
-2.3M▼ 19.7%
-2.19M▲ 4.5%
0▲ 100.0%
0▲ 0%
0▲ 0%
0▲ 0%
187.71M▲ 0%
Gross Margin %100.1%-------98.58%
Gross Profit Growth %-2656540.69%99.88%-19.7%4.48%100%----
Operating Expenses9.68M13.73M20.9M29.75M31.53M24.4M41.38M187.67M172.75M
OpEx % of Revenue-0.62%-------90.73%
Selling, General & Admin6.61M6.56M4.63M6.56M10.81M9.84M13.48M105.86M132.13M
SG&A % of Revenue-0.43%-------69.39%
Research & Development3.07M7.18M16.27M23.19M21.45M15.27M25.19M78.57M40.63M
R&D % of Revenue-0.2%-------21.34%
Other Operating Expenses-585.95K6K00-731K-712K2.71M3.24M0
Operating Income
-12.17M▲ 0%
-14.3M▼ 17.5%
-23.2M▼ 62.2%
-31.95M▼ 37.7%
-31.53M▲ 1.3%
-24.4M▲ 22.6%
-41.38M▼ 69.6%
-187.67M▼ 353.5%
14.95M▲ 108.0%
Operating Margin %0.78%-------7.85%
Operating Income Growth %10.57%-17.5%-62.21%-37.73%1.32%22.62%-69.63%-353.49%107.97%
EBITDA-10.56M-12.38M-20.9M-29.75M-29.57M-22.43M-39.43M-185.68M16.97M
EBITDA Margin %0.68%-------8.91%
EBITDA Growth %22.3%-17.25%-68.79%-42.37%0.64%24.12%-75.75%-370.97%109.14%
D&A (Non-Cash Add-back)1.61M1.92M2.3M2.19M1.96M1.96M1.96M1.99M2.02M
EBIT-13.44M-13.73M-30.77M-24.64M-32.26M-24.07M-38.99M-175.62M26.37M
Net Interest Income00154K13K110K300K2.58M11.82M11.48M
Interest Income00154K13K110K300K2.58M12.05M16.95M
Interest Expense062K00000231K5.48M
Other Income/Expense-1.27M2.46M-7.58M7.31M618K330K2.4M11.82M5.94M
Pretax Income
-13.72M▲ 0%
-11.84M▲ 13.7%
-30.77M▼ 159.9%
-24.64M▲ 19.9%
-30.91M▼ 25.5%
-24.07M▲ 22.1%
-38.99M▼ 62.0%
-175.85M▼ 351.0%
20.89M▲ 111.9%
Pretax Margin %0.88%-------10.97%
Income Tax-1.65M00000000
Effective Tax Rate %12.03%0%0%0%0%0%0%0%0%
Net Income
-15.67M▲ 0%
-13.34M▲ 14.9%
-30.77M▼ 130.8%
-24.64M▲ 19.9%
-30.91M▼ 25.5%
-24.07M▲ 22.1%
-38.99M▼ 62.0%
-175.85M▼ 351.0%
20.89M▲ 111.9%
Net Margin %1.01%-------10.97%
Net Income Growth %-29.86%14.89%-130.78%19.94%-25.45%22.14%-62%-351.04%111.88%
Net Income (Continuing)-11.79M-11.84M-30.77M-24.64M-30.91M-24.07M-38.99M-175.85M20.89M
Discontinued Operations-3.59M-1.49M0000000
Minority Interest000000000
EPS (Diluted)
-26.18▲ 0%
-9.54▲ 63.6%
-15.78▼ 65.4%
-3.68▲ 76.7%
-5.81▼ 57.9%
-2.87▲ 50.6%
-2.36▲ 17.8%
-4.38▼ 85.6%
0.39▲ 108.9%
EPS Growth %55.13%63.56%-65.41%76.68%-57.88%50.6%17.77%-85.59%108.9%
EPS (Basic)-26.18-9.54-15.78-3.68-5.81-2.87-2.36-4.380.41
Diluted Shares Outstanding598.52K1.4M2.28M4.17M5.32M8.4M16.49M40.18M54.33M
Basic Shares Outstanding598.52K1.4M2.28M4.17M5.32M8.4M16.49M40.18M53.18M
Dividend Payout Ratio---------

SLNO Balance Sheet

Soleno Therapeutics, Inc. (SLNO) balance sheet — assets, liabilities & shareholders' equity

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Total Current Assets17.99M24.67M21.14M50.24M22.42M15.65M171.36M293.89M355.81M
Cash & Short-Term Investments17.1M24.08M20.73M49.22M21.3M14.6M169.68M291.44M305.47M
Cash Only17.1M23.1M20.73M49.22M21.3M14.6M169.68M87.93M70.11M
Short-Term Investments0978K00000203.51M235.37M
Accounts Receivable064K00000028.21M
Days Sales Outstanding--------54.07
Inventory0000000015.02M
Days Inventory Outstanding--------2.03K
Other Current Assets551K00001.04M1.68M2.45M7.11M
Total Non-Current Assets21.03M18.48M17.03M14.74M13.13M10.85M9.33M37.08M208.02M
Property, Plant & Equipment22.89K12K444K158K454K157K419K2.98M2.38M
Fixed Asset Turnover-67861.13x-------80.14x
Goodwill125.53K00000000
Intangible Assets20.41M18.47M16.52M14.58M12.64M10.69M8.75M6.8M4.86M
Long-Term Investments000000027.21M0
Other Non-Current Assets591.92K059K040K0165K83K200.78M
Total Assets
39.02M▲ 0%
43.15M▲ 10.6%
38.17M▼ 11.5%
64.98M▲ 70.2%
35.55M▼ 45.3%
26.5M▼ 25.5%
180.69M▲ 581.9%
330.97M▲ 83.2%
563.83M▲ 70.4%
Asset Turnover-39.80x-------0.34x
Asset Growth %601.22%10.58%-11.54%70.23%-45.29%-25.47%581.93%83.17%70.36%
Total Current Liabilities1.73M1.88M4.96M8.62M8.01M7.31M11.51M18.75M61.36M
Accounts Payable633K934K2M3.49M3.25M1.78M3.15M8.88M12.44M
Days Payables Outstanding143.42177.65317.01580.44----1.68K
Short-Term Debt00000000726K
Deferred Revenue (Current)000000000
Other Current Liabilities127K623K665K1.2M1.05M2.16M4.95M9.34M48.2M
Current Ratio10.38x13.14x4.26x5.83x2.80x2.14x14.89x15.68x5.80x
Quick Ratio10.38x13.14x4.26x5.83x2.80x2.14x14.89x15.68x5.55x
Cash Conversion Cycle--------404.07
Total Non-Current Liabilities10.75M10.86M18.26M10.82M9.75M8.84M11.68M67.11M52.35M
Long-Term Debt000000049.83M1.96M
Capital Lease Obligations0000175K0130K2.47M0
Deferred Tax Liabilities000000000
Other Non-Current Liabilities10.47M10.86M18.26M10.82M9.58M8.84M11.55M14.81M50.39M
Total Liabilities12.49M12.74M23.23M19.43M17.76M16.15M23.18M85.86M113.72M
Total Debt00305K139K457K155K403K52.83M2.69M
Net Debt-17.1M-23.1M-20.43M-49.09M-20.85M-14.45M-169.28M-35.1M-67.42M
Debt / Equity--0.02x0.00x0.03x0.01x0.00x0.22x0.01x
Debt / EBITDA--------0.16x
Net Debt / EBITDA---------3.97x
Interest Coverage--221.52x------760.26x4.81x
Total Equity
26.53M▲ 0%
30.41M▲ 14.6%
14.95M▼ 50.9%
45.55M▲ 204.7%
17.79M▼ 60.9%
10.35M▼ 41.8%
157.51M▲ 1422.1%
245.11M▲ 55.6%
450.12M▲ 83.6%
Equity Growth %672.44%14.62%-50.85%204.72%-60.93%-41.84%1422.1%55.62%83.64%
Book Value per Share44.3321.756.5710.913.351.239.556.108.28
Total Shareholders' Equity26.53M30.41M14.95M45.55M17.79M10.35M157.51M245.11M450.12M
Common Stock19.24K32K45K80K80K8K32K46K52K
Retained Earnings-113.98M-127.03M-157.81M-182.44M-213.35M-237.42M-276.41M-452.26M-431.37M
Treasury Stock000000000
Accumulated OCI-73.65K-93K00000361K415K
Minority Interest000000000

SLNO Cash Flow Statement

Soleno Therapeutics, Inc. (SLNO) cash flow — operating, investing & free cash flow history

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Cash from Operations-9.95M-11.68M-17.38M-25.22M-27.77M-20.78M-24.94M-69.1M46.8M
Operating CF Margin %0.64%-------24.58%
Operating CF Growth %26.29%-17.42%-48.72%-45.17%-10.09%25.17%-20.01%-177.05%167.73%
Net Income-12.07M-11.84M-30.77M-24.64M-30.91M-24.07M-38.99M-175.85M20.89M
Depreciation & Amortization1.61M1.96M1.96M1.95M1.96M1.96M1.96M1.99M2.02M
Stock-Based Compensation880.03K988K825K1.5M3.28M2.53M5.95M99.96M45.85M
Deferred Taxes-1.65M-3.88M6.96M-11.64M00000
Other Non-Cash Items1.31M1M1.15M4.62M-951K-452K3.22M-1.21M2.68M
Working Capital Changes-24.07K82K2.5M2.98M-1.15M-756K2.93M6.02M-24.63M
Change in Receivables0-64K64K00000-28.21M
Change in Inventory00-64K00000-14.03M
Change in Payables190.63K249K1.06M1.49M-235K-1.48M1.37M5.67M3.61M
Cash from Investing378.78K-180K528K-7K-22K-13K0-225.68M-201.78M
Capital Expenditures-2.57K-8K-21K-7K-22K-13K0-218K-73K
CapEx % of Revenue-0%-------0.04%
Acquisitions-572.59K0500K000000
Investments---------
Other Investing953.94K-172K49K000000
Cash from Financing23.94M17.83M14.48M53.72M-128K14.09M180.02M213.03M137.16M
Debt Issued (Net)00-2K-17K-8K0049.89M0
Equity Issued (Net)25.01M16.3M14.48M53.72M014.11M137.86M148.96M137.96M
Dividends Paid000000000
Share Repurchases00000000-100.15M
Other Financing-838K1.52M017K-120K-16K42.16M14.18M-803K
Net Change in Cash
14.37M▲ 0%
5.96M▼ 58.5%
-2.37M▼ 139.7%
28.49M▲ 1304.2%
-27.92M▼ 198.0%
-6.7M▲ 76.0%
155.08M▲ 2413.9%
-81.75M▼ 152.7%
-17.82M▲ 78.2%
Free Cash Flow
-9.95M▲ 0%
-11.69M▼ 17.5%
-17.4M▼ 48.8%
-25.23M▼ 45.0%
-27.79M▼ 10.2%
-20.79M▲ 25.2%
-24.94M▼ 19.9%
-69.31M▼ 177.9%
46.73M▲ 167.4%
FCF Margin %0.64%-------24.54%
FCF Growth %26.48%-17.47%-48.8%-45.04%-10.15%25.18%-19.94%-177.92%167.41%
FCF per Share-16.63-8.36-7.64-6.04-5.23-2.48-1.51-1.730.86
FCF Conversion (FCF/Net Income)0.64x0.88x0.56x1.02x0.90x0.86x0.64x0.39x2.24x
Interest Paid000000000
Taxes Paid80000000000

SLNO Key Ratios

Soleno Therapeutics, Inc. (SLNO) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric2016201720182019202020212022202320242025
Return on Equity (ROE)-362.37%-104.55%-46.83%-135.69%-81.46%-97.6%-171.05%-46.45%-87.35%6.01%
Return on Invested Capital (ROIC)-1439.31%-179.97%-128.07%-1898.28%-----142%3.78%
Gross Margin-4.03%100.1%-------98.58%
Net Margin-831.63%1.01%-------10.97%
Debt / Equity---0.02x0.00x0.03x0.01x0.00x0.22x0.01x
Interest Coverage---221.52x------760.26x4.81x
FCF Conversion1.12x0.64x0.88x0.56x1.02x0.90x0.86x0.64x0.39x2.24x
Revenue Growth274.34%-107145.41%100%-------

SLNO SEC Filings & Documents

Soleno Therapeutics, Inc. (SLNO) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Apr 7, 2026·SEC

Material company update

Apr 6, 2026·SEC

Material company update

Mar 16, 2026·SEC

10-K Annual Reports

3
FY 2026

Feb 25, 2026·SEC

FY 2025

Feb 28, 2025·SEC

FY 2024

Mar 7, 2024·SEC

10-Q Quarterly Reports

6
FY 2025

Nov 4, 2025·SEC

FY 2025

Aug 6, 2025·SEC

FY 2025

May 7, 2025·SEC

SLNO Frequently Asked Questions

Soleno Therapeutics, Inc. (SLNO) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Soleno Therapeutics, Inc. (SLNO) reported $190.4M in revenue for fiscal year 2025.

Soleno Therapeutics, Inc. (SLNO) grew revenue by 0.0% over the past year. Growth has been modest.

Yes, Soleno Therapeutics, Inc. (SLNO) is profitable, generating $20.9M in net income for fiscal year 2025 (11.0% net margin).

Dividend & Returns

Soleno Therapeutics, Inc. (SLNO) has a return on equity (ROE) of 6.0%. This is below average, suggesting room for improvement.

Soleno Therapeutics, Inc. (SLNO) generated $46.9M in free cash flow for fiscal year 2025. Positive FCF indicates the company can fund dividends, buybacks, or reinvestment.

Explore More SLNO

Soleno Therapeutics, Inc. (SLNO) financial analysis — history, returns, DCA and operating performance tools

Total Return Calculator

Historical returns with dividends reinvested

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DCA Calculator

Dollar cost averaging vs lump sum

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Dividend History

Yield, growth, payout safety & DRIP

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Earnings History

EPS trends, net income & profitability

→

Price History

Long-term charts & historical price data

→

Revenue History

Sales growth patterns & revenue breakdown

→

Financial Ratios

30 years of market, efficiency and balance-sheet ratios

→

Valuation

DCF intrinsic value, peer multiples & estimates

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