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KPTIKaryopharm Therapeutics Inc.
$0.05$1M
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KPTI logo

Karyopharm Therapeutics Inc.

KPTI
NASDAQ · Oncology Biotech
$0.05
At close - Nov 6, 4:00 PM EST - USD
Market Cap$1M
P/E-0.0x
52W High$10.99
Volume103.55M
OverviewTerminalAnalysisFinancialsValuationEarningsBreakoutsOwnership
VCP Research Verdict2026Q1

Persistent Operating Deficits Challenge Capital Structure Stability

Karyopharm faces a precarious financial outlook characterized by a persistent disconnect between its 96.1% gross margins and deeply negative operating margins of -76.3%.

GrowthMixed
ProfitabilityNegative
ValuationReview
TechnicalsWeak
Explore valuation models
MARKET ACTION

KPTI price & volume

Price trend, volume and key moving averages

Launch Terminal
Loading chart...
Decision Checklist4 Core Signals

What matters now

The signals most likely to change the investment case.

01

Earnings momentum

7/12 Beats

EPS beat 7 of last 12 quarters

02

Valuation risk

-100% Peers

P/E is 100% below peer median

03

Market leadership

N/A

RS data unavailable

04

Weak Trend

Below 200DMA

Price < 200DMA

Next CatalystEstimated earnings · Nov 13

Market performance

Price History →

Trailing total returns as of 11/8/2026, which may include dividends or other distributions. Benchmark is S&P 500 (^GSPC).

YTD Return
KPTI-99.24%
S&P 500 (^GSPC)+7.63%
1-Year Return
KPTI-98.95%
S&P 500 (^GSPC)+9.69%
3-Year Return
KPTI-99.58%
S&P 500 (^GSPC)+66.68%
5-Year Return
KPTI-99.96%
S&P 500 (^GSPC)+53.98%

Growth & profitability

Annual revenue & EPS trend
Revenue FY25
$146M+0.6% YoY
Net income FY25
-$196M-156.5% YoY
Free cash flow FY25
-$75M+40.9% YoY
Operating margin FY25
-62.1%+20.1 pts YoY
ROIC (FY25)-
Avg ROIC 5Y-1332.3%
ROE (FY25)-
Piotroski Score3 / 9
Financial Statements →
03

Monitor what changed

Recent results and news deserve attention only when they alter the forward view.

OPERATING RESULTS

Recent Earnings

Earnings History
EPS Beat Rate7/12 (58%)
Revenue Beat Rate5/12 (42%)
QuarterEPS (Act vs Est)Revenue (Act vs Est)
Q3 2026Latest
Aug 13, 2026
-$2.32-69.3%
vs -$1.37
$33M+3.8%
vs $32M
Q2 2026
May 14, 2026
-$1.24+14.5%
vs -$1.45
$35M+11.7%
vs $31M
Q1 2026
Feb 12, 2026
-$2.23+1.3%
vs -$2.26
$34M-2.9%
vs $35M
Q4 2025
Nov 3, 2025
-$3.82-10.1%
vs -$3.47
$44M+4.7%
vs $42M
Historical baseline: 12 quarters analyzedGAAP / Adjusted
MARKET COVERAGE

Latest News

4 Stories
PRNewsWire·4d ago
Karyopharm to Present Selinexor Data in Patients with Myelofibrosis and Multiple Myeloma at the 68th American Society of Hematology Annual Meeting and Exposition (ASH)

– Week 48 Data from the Phase 3 SENTRY Trial Selected for Oral Presentation – – Data from the Phase 2 SENTRY-2 Trial Selected for Oral Presentation – NEWTON, Mass., Nov. 4, 2026 /PRNewswire/ -- Karyopharm Therapeutics Inc. (Nasdaq: KPTI) ("Karyopharm" or the "Company"), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today announced that abstracts from two of its clinical trials evaluating selinexor in patients with myelofibrosis were selected for oral presentations at ASH 2026.

PRNewsWire·6d ago
Karyopharm Therapeutics Inc. Announces Planned Merger with Ayrmid Ltd. to Strengthen Company for the Future

– The Company Remains Focused on Supporting Patients and Advancing its Programs in Multiple Myeloma and Myelofibrosis – – Ayrmid will Serve as Lead Bidder in Court-Supervised Sale Process to Maximize Business Value for all Stakeholders – – The Company Receives a Commitment of $55 Million in Additional Financing and Ongoing Operations Are Expected to be Uninterrupted During Sale Process – NEWTON, Mass., Nov. 2, 2026 /PRNewswire/ -- Karyopharm Therapeutics Inc. (Nasdaq: KPTI) ("Karyopharm" or the "Company"), a commercial-stage pharmaceutical company pioneering novel cancer therapies, announced today it has entered into a Restructuring Support Agreement with its existing lenders and noteholders and other key stakeholders, which provides for a merger between Ayrmid Ltd.

PRNewsWire·Oct 1, 2026
Karyopharm Therapeutics Reports Inducement Grant Under Nasdaq Listing Rule 5635(c)(4)

NEWTON, Mass., Oct. 1, 2026 /PRNewswire/ -- Karyopharm Therapeutics Inc. (Nasdaq: KPTI), a commercial-stage pharmaceutical company pioneering novel cancer therapies, today announced that the Company granted 333 restricted stock units (RSUs) to one newly-hired employee.

Defense World·Sep 30, 2026
Reviewing Alpha Cognition (NASDAQ:ACOG) & Karyopharm Therapeutics (NASDAQ:KPTI)

Karyopharm Therapeutics (NASDAQ: KPTI - Get Free Report) and Alpha Cognition (NASDAQ: ACOG - Get Free Report) are both small-cap healthcare companies, but which is the better business? We will contrast the two companies based on the strength of their institutional ownership, earnings, valuation, profitability, dividends, risk and analyst recommendations. Analyst Ratings This is a breakdown of

Filtered for Karyopharm Therapeutics Inc.More Headlines
04

Compare before deciding

Benchmark KPTI against direct peers instead of judging its metrics in isolation.

Peers Comparison

Key metrics vs top competitors for Karyopharm Therapeutics Inc. (KPTI)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
KPTI logoKPTIKaryopharm Therapeutics Inc.Current
$0.05$1.24M-0.010.57%-153.28%——
PTCT logoPTCTPTC Therapeutics, Inc.
$65.44$5.43B-51.55114.51%-9.17%——
MGNX logoMGNXMacroGenics, Inc.
$2.33$148.1M-10.150.78%-8.7%-31.27%—
ADMA logoADMAADMA Biologics, Inc.
$12.73$2.95B15.7619.63%35.14%42.56%—
TGTX logoTGTXTG Therapeutics, Inc.
$59.83$9.16B21.3187.32%55.22%72.3%—
PRTA logoPRTAProthena Corporation plc
$7.97$417.26M-17.11-92.84%-45.43%-8.34%—

Compare KPTI vs Peers

Karyopharm Therapeutics Inc. (KPTI) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs PTCT

Most directly comparable listed peer for KPTI.

Scale Benchmark

vs JNJ

Larger-name benchmark to compare KPTI against a more recognizable public peer.

Peer Set

Compare Top 5

vs PTCT, MGNX, ADMA, TGTX

05

Keep researching

Verify the primary filings, follow material updates, and answer the remaining questions.

KPTI SEC Filings & Documents

Karyopharm Therapeutics Inc. (KPTI) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Aug 31, 2026·SEC

Material company update

Aug 13, 2026·SEC

Material company update

Jul 31, 2026·SEC

10-K Annual Reports

2
FY 2026

Feb 13, 2026·SEC

FY 2025

Feb 19, 2025·SEC

10-Q Quarterly Reports

6
FY 2026

Aug 13, 2026·SEC

FY 2026

May 14, 2026·SEC

FY 2025

Nov 3, 2025·SEC

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KPTI Frequently Asked Questions

Karyopharm Therapeutics Inc. (KPTI) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
What is Karyopharm Therapeutics Inc.'s revenue?

Karyopharm Therapeutics Inc. (KPTI) reported $146.1M in revenue in fiscal year 2025, which is also its trailing twelve months. That is 95997% more than the $0.2M of fiscal year 2011.

How fast is Karyopharm Therapeutics Inc. growing?

Karyopharm Therapeutics Inc. (KPTI) grew revenue by 6.8% over the trailing twelve months, compared with the twelve months before.

Is KPTI profitable?

No. Karyopharm Therapeutics Inc. (KPTI) reported a net loss of $224.7M over the trailing twelve months.

Dividend & Returns
What is Karyopharm Therapeutics Inc.'s free cash flow?

Karyopharm Therapeutics Inc. (KPTI) had negative free cash flow of $65.3M over the trailing twelve months.

What if you invested $1,000 in KPTI back in 2011?

Total return calculator · dividends reinvested · 15+ years of data

See returns →