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Septerna, Inc. (SEPN) 10-Year Financial Performance & Capital Metrics

SEPN • • Industrial / General
HealthcareBiotechnologyMetabolic & Liver DiseasesObesity & Metabolic Disorders
AboutSepterna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products candidates for the treatment of endocrinology, immunology and inflammation, and metabolic diseases. The company develops SEP-786, an oral small molecule PTH1R agonist for hypoparathyroidism; SEP-631, an oral small molecule MRGPRX2 NAM for chronic spontaneous urticaria and other mast cell diseases; TSHR Program, an oral small molecule TSHR NAM for Graves' disease and thyroid eye disease. It also develops oral small molecule single- and multi-incretin receptor agonists for metabolic disorders including obesity and type 2 diabetes. Septerna, Inc. was formerly known as GPCR NewCo, Inc. and changed its name to Septerna Inc. in June 2021. The company was incorporated in 2019 and is headquartered in South San Francisco, California.Show more
  • Revenue $1M +611.9%
  • EBITDA -$79M -2817.1%
  • Net Income -$72M -1817.7%
  • EPS (Diluted) -7.26 -25048.5%
  • Gross Margin 100%
  • EBITDA Margin -7388.09% -481.7%
  • Operating Margin -7518.42% -647.1%
  • Net Margin -6678.88% -341.3%
  • ROE -37.62%
  • ROIC -130.31%
  • Debt/Equity 0.06
  • Interest Coverage -
Technical Analysis

Key Insights

Based on financial data analysis

✓Strengths

  • ✓Company is almost debt free
  • ✓Momentum leader: RS Rating 95 (top 5%)
  • ✓Share count reduced 49.3% through buybacks
  • ✓Trading at only 0.6x book value

✗Weaknesses

  • ✗Negative free cash flow
  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

Price & Volume

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Growth Metrics

Revenue CAGR

10Y-
5Y-
3Y-
TTM-

Profit (Net Income) CAGR

10Y-
5Y-
3Y-
TTM-

EPS CAGR

10Y-
5Y-
3Y-
TTM-

ROCE

10Y Avg-39.09%
5Y Avg-39.09%
3Y Avg-39.09%
Latest-28.48%

Peer Comparison

Obesity & Metabolic Disorders
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Sector-Specific
NameMarket CapCurrent PriceP/E RatioRevenue Growth 1YNet MarginROEFCF YieldDebt/Equity
MNKDMannKind Corporation1.77B5.7759.3643.5%9.32%1.85%
CORTCorcept Therapeutics Incorporated3.93B37.3630.3739.94%14.19%16.65%4.98%0.01
GUTSFractyl Health, Inc. Common Stock306.74M2.00-1.23-22.5%-40732.33%-241.68%2.20
LXRXLexicon Pharmaceuticals, Inc.428.81M1.18-1.8724.81%-96.77%-57.07%0.74
RZLTRezolute, Inc.232.75M2.51-2.56-52.45%0.01
BIOABioAge Labs, Inc.640.01M17.85-2.69-12.81%-27.32%0.03
MISTMilestone Pharmaceuticals Inc.166.93M1.96-2.93-100%-282.97%4.17
ALTAltimmune, Inc.422.59M4.05-3.02-95.31%-4195.75%-45.21%0.01

Profit & Loss

Dec 2022Dec 2023Dec 2024
Sales/Revenue+0151K1.07M
Revenue Growth %--6.12%
Cost of Goods Sold+000
COGS % of Revenue---
Gross Profit+0151K1.07M
Gross Margin %-1%1%
Gross Profit Growth %--6.12%
Operating Expenses+27.97M-1.92M81.9M
OpEx % of Revenue--12.74%76.18%
Selling, General & Admin5.92M9.72M16.56M
SG&A % of Revenue-64.38%15.41%
Research & Development22.04M35.98M65.34M
R&D % of Revenue-238.27%60.78%
Other Operating Expenses0-47.63M0
Operating Income+-27.97M2.08M-80.82M
Operating Margin %-13.74%-75.18%
Operating Income Growth %-1.07%-39.95%
EBITDA+-27.39M2.92M-79.42M
EBITDA Margin %-19.36%-73.88%
EBITDA Growth %-1.11%-28.17%
D&A (Non-Cash Add-back)577K848K1.4M
EBIT-27.97M-45.55M-80.82M
Net Interest Income+291K2.79M8.62M
Interest Income291K2.79M8.62M
Interest Expense000
Other Income/Expense291K2.8M8.53M
Pretax Income+-27.68M4.87M-72.3M
Pretax Margin %-32.26%-67.25%
Income Tax+0691K-498K
Effective Tax Rate %1%0.86%0.99%
Net Income+-27.68M4.18M-71.8M
Net Margin %-27.68%-66.79%
Net Income Growth %-1.15%-18.18%
Net Income (Continuing)-27.68M4.18M-71.8M
Discontinued Operations000
Minority Interest000
EPS (Diluted)+-1.420.03-7.26
EPS Growth %-1.02%-250.48%
EPS (Basic)-1.420.03-7.26
Diluted Shares Outstanding19.5M19.5M9.89M
Basic Shares Outstanding19.5M19.5M9.89M
Dividend Payout Ratio---

Balance Sheet

Dec 2022Dec 2023Dec 2024
Total Current Assets+31.89M112.68M356.82M
Cash & Short-Term Investments30.61M88.48M350.92M
Cash Only30.61M88.48M238.2M
Short-Term Investments00112.73M
Accounts Receivable022.78M1.12M
Days Sales Outstanding-55.05K381.64
Inventory000
Days Inventory Outstanding---
Other Current Assets204K92K200K
Total Non-Current Assets+4.23M18.19M99.73M
Property, Plant & Equipment3.1M17.19M28.69M
Fixed Asset Turnover-0.01x0.04x
Goodwill000
Intangible Assets000
Long-Term Investments0069.87M
Other Non-Current Assets1.12M1M1.17M
Total Assets+36.12M130.87M456.55M
Asset Turnover-0.00x0.00x
Asset Growth %-2.62%2.49%
Total Current Liabilities+5.54M6.91M12.85M
Accounts Payable3.07M2.64M3.2M
Days Payables Outstanding---
Short-Term Debt000
Deferred Revenue (Current)000
Other Current Liabilities1.76M3.04M4.21M
Current Ratio5.75x16.30x27.77x
Quick Ratio5.75x16.30x27.77x
Cash Conversion Cycle---
Total Non-Current Liabilities+74.78M162.33M23.66M
Long-Term Debt000
Capital Lease Obligations012.57M23.63M
Deferred Tax Liabilities000
Other Non-Current Liabilities74.78M149.76M33K
Total Liabilities80.32M169.24M36.51M
Total Debt+710K12.57M25.48M
Net Debt-29.9M-75.92M-212.72M
Debt / Equity--0.06x
Debt / EBITDA-4.30x-
Net Debt / EBITDA--25.97x-
Interest Coverage---
Total Equity+-44.2M-38.37M420.05M
Equity Growth %-0.13%11.95%
Book Value per Share-2.27-1.9742.47
Total Shareholders' Equity-44.2M-38.37M420.05M
Common Stock3K3K44K
Retained Earnings-50.76M-46.58M-118.37M
Treasury Stock000
Accumulated OCI0056K
Minority Interest000

Cash Flow

Dec 2022Dec 2023Dec 2024
Cash from Operations+-23.3M-38.72M-67.47M
Operating CF Margin %--256.44%-62.76%
Operating CF Growth %--0.66%-0.74%
Net Income-27.68M4.18M-71.8M
Depreciation & Amortization577K848K1.4M
Stock-Based Compensation1.52M1.62M3.15M
Deferred Taxes0491K-491K
Other Non-Cash Items530K-46.79M18K
Working Capital Changes1.75M926K248K
Change in Receivables0-151K-20K
Change in Inventory000
Change in Payables1.73M-653K723K
Cash from Investing+-1.29M22.12M-160.6M
Capital Expenditures-1.29M-2.88M-2.1M
CapEx % of Revenue-19.06%1.96%
Acquisitions---
Investments---
Other Investing025M22.63M
Cash from Financing+30.05M74.52M377.78M
Debt Issued (Net)---
Equity Issued (Net)---
Dividends Paid000
Share Repurchases---
Other Financing82K052K
Net Change in Cash---
Free Cash Flow+-24.59M-41.6M-69.57M
FCF Margin %--275.5%-64.72%
FCF Growth %--0.69%-0.67%
FCF per Share-1.26-2.13-7.03
FCF Conversion (FCF/Net Income)0.84x-9.26x0.94x
Interest Paid000
Taxes Paid075K232K

Key Ratios

Metric202220232024
Return on Equity (ROE)---37.62%
Return on Invested Capital (ROIC)---130.31%
Gross Margin-100%100%
Net Margin-2768.21%-6678.88%
Debt / Equity--0.06x
FCF Conversion0.84x-9.26x0.94x
Revenue Growth--611.92%

Frequently Asked Questions

Growth & Financials

Septerna, Inc. (SEPN) reported $22.0M in revenue for fiscal year 2024.

Septerna, Inc. (SEPN) grew revenue by 611.9% over the past year. This is strong growth.

Septerna, Inc. (SEPN) reported a net loss of $58.8M for fiscal year 2024.

Dividend & Returns

Septerna, Inc. (SEPN) has a return on equity (ROE) of -37.6%. Negative ROE indicates the company is unprofitable.

Septerna, Inc. (SEPN) generated $103.2M in free cash flow for fiscal year 2024. Positive FCF indicates the company can fund dividends, buybacks, or reinvestment.

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