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Septerna, Inc.(SEPN)Earnings, Financials & Key Ratios
SEPN•NASDAQ
$23.98
$1.07B mkt cap·Price updated May 7, 2026
AboutSepterna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products candidates for the treatment of endocrinology, immunology and inflammation, and metabolic diseases. The company develops SEP-786, an oral small molecule PTH1R agonist for hypoparathyroidism; SEP-631, an oral small molecule MRGPRX2 NAM for chronic spontaneous urticaria and other mast cell diseases; TSHR Program, an oral small molecule TSHR NAM for Graves' disease and thyroid eye disease. It also develops oral small molecule single- and multi-incretin receptor agonists for metabolic disorders including obesity and type 2 diabetes. Septerna, Inc. was formerly known as GPCR NewCo, Inc. and changed its name to Septerna Inc. in June 2021. The company was incorporated in 2019 and is headquartered in South San Francisco, California.Show more
- Revenue$46M+4174.5%
- EBITDA-$68M+14.0%
- Net Income-$49M+31.9%
- EPS (Diluted)-1.10+84.8%
- EBITDA Margin-148.63%+98.0%
- Operating Margin-148.63%+98.0%
- Net Margin-106.37%+98.4%
- ROE-12.19%+67.6%
- ROIC-20.82%+84.0%
- Debt/Equity0.06+2.0%
SEPN Key Insights
Septerna, Inc. (SEPN) fundamental analysis — strengths, weaknesses & financial health based on data analysis
✓Strengths
- ✓Company is almost debt free
- ✓FCF machine: 238.7% free cash flow margin
✗Weaknesses
- ✗Shares diluted 100.0% in last year
- ✗Low asset turnover indicates capital-intensive operations
* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.
SEPN Price & Volume
Septerna, Inc. (SEPN) stock price & volume — 10-year historical chart
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SEPN Growth Metrics
Septerna, Inc. (SEPN) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR
Revenue CAGR
10 Years-
5 Years-
3 Years-
TTM-
Profit CAGR
10 Years-
5 Years-
3 Years-
TTM-
EPS CAGR
10 Years-
5 Years-
3 Years-
TTM-
Return on Capital
10 Years-32.9%
5 Years-32.9%
3 Years-13.37%
Last Year-14.33%
SEPN Recent Earnings
Septerna, Inc. (SEPN) EPS & revenue vs analyst estimates — last 4 quarters
●Beat EPS 1/8 qtrs (17%)●Beat Revenue 2/8 qtrs (50%)
Q2 2026Latest
Mar 9, 2026EPS
$0.24
Est $0.23
-4.3%
Revenue
$24M
Est $18M
+32.5%
Q4 2025
Nov 10, 2025EPS
$0.09
Est $0.19
-147.4%
Revenue
$21M
Est $17M
+24.5%
Q3 2025
Aug 11, 2025EPS
$0.56
Est $0.05
-1020.0%
Revenue
$119,000
Est $5M
-97.6%
Q2 2025
May 15, 2025EPS
$0.49
Est $0.38
-28.9%
Revenue
$219,000
Est $30M
-99.3%
| Quarter | Date | EPS (Act vs Est) | Revenue (Act vs Est) |
|---|---|---|---|
| Q2 2026Latest | Mar 9, 2026 | $0.24vs $0.23-4.3% | $24Mvs $18M+32.5% |
| Q4 2025 | Nov 10, 2025 | $0.09vs $0.19-147.4% | $21Mvs $17M+24.5% |
| Q3 2025 | Aug 11, 2025 | $0.56vs $0.05-1020.0% | $119,000vs $5M-97.6% |
| Q2 2025 | May 15, 2025 | $0.49vs $0.38-28.9% | $219,000vs $30M-99.3% |
Based on last 8 quarters of dataView full earnings history →
SEPN Peer Comparison
Septerna, Inc. (SEPN) competitors in Metabolic and Obesity Therapies — business model, growth, and fundamentals comparison
| Company | Market Cap | Stock Price | P/E Ratio (TTM) | Revenue Growth 1Y | Net Margin | Return on Equity (ROE) | FCF Yield | Debt / Equity |
|---|---|---|---|---|---|---|---|---|
 KYMR | 6.91B | 84.63 | -22.94 | -16.72% | -6.12% | -25.02% | 0.05 | |
 RXRX | 1.46B | 3.27 | -2.27 | 26.92% | -8.44% | -54.32% | 0.07 | |
 VKTX | 3.66B | 31.58 | -9.90 | -71.31% | 0.00 | |||
 GPCR | 2.25B | 39.15 | -16.31 | -15.12% | 0.00 | |||
 ACLX | 6.73B | 115.07 | -28.27 | -79.35% | -10.27% | -55.42% | 0.24 | |
 TPVG | 242.54M | 5.99 | 4.91 | 36.55% | -3.39% | 1.33 | ||
 ARWR | 10.92B | 77.95 | -6389.34 | 232.58% | -48.38% | -55.47% | 0.73 | |
 PRAX | 9.63B | 333.28 | -24.72 | -100% | -43.02% | 0.00 |
Compare SEPN vs Peers
Septerna, Inc. (SEPN) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.
SEPN Income Statement
Septerna, Inc. (SEPN) annual income statement — 10-year revenue, gross profit & net income history
10Y historyFree accessUpdated daily
| Line item | Dec'22 | Dec'23 | Dec'24 | Dec'25 |
|---|---|---|---|---|
| Sales/Revenue | 0 | 151K | 1.07M | 45.95M |
| Revenue Growth % | - | - | 611.92% | 4174.51% |
| Cost of Goods Sold | 0 | 0 | 0 | 0 |
| COGS % of Revenue | - | - | - | - |
| Gross Profit | 0▲ 0% | 151K▲ 0% | 1.07M▲ 611.9% | 0▼ 100.0% |
| Gross Margin % | - | 100% | 100% | - |
| Gross Profit Growth % | - | - | 611.92% | -100% |
| Operating Expenses | 27.97M | -1.92M | 81.9M | 126.75M |
| OpEx % of Revenue | - | -1274.17% | 7618.42% | 275.83% |
| Selling, General & Admin | 5.92M | 9.72M | 16.56M | 29.16M |
| SG&A % of Revenue | - | 6438.41% | 1540.56% | 63.47% |
| Research & Development | 22.04M | 35.98M | 65.34M | 97.58M |
| R&D % of Revenue | - | 23827.15% | 6077.86% | 212.37% |
| Other Operating Expenses | 0 | -47.63M | 0 | 0 |
| Operating Income | -27.97M▲ 0% | 2.08M▲ 107.4% | -80.82M▼ 3995.1% | -68.3M▲ 15.5% |
| Operating Margin % | - | 1374.17% | -7518.42% | -148.63% |
| Operating Income Growth % | - | 107.42% | -3995.08% | 15.5% |
| EBITDA | -27.39M | 2.92M | -79.42M | -68.3M |
| EBITDA Margin % | - | 1935.76% | -7388.09% | -148.63% |
| EBITDA Growth % | - | 110.67% | -2817.14% | 14.01% |
| D&A (Non-Cash Add-back) | 577K | 848K | 1.4M | 0 |
| EBIT | -27.97M | -45.55M | -80.82M | 0 |
| Net Interest Income | 291K | 2.79M | 8.62M | 0 |
| Interest Income | 291K | 2.79M | 8.62M | 19.53M |
| Interest Expense | 0 | 0 | 0 | 0 |
| Other Income/Expense | 291K | 2.8M | 8.53M | 19.43M |
| Pretax Income | -27.68M▲ 0% | 4.87M▲ 117.6% | -72.3M▼ 1584.2% | -48.87M▲ 32.4% |
| Pretax Margin % | - | 3225.83% | -6725.21% | -106.35% |
| Income Tax | 0 | 691K | -498K | 12K |
| Effective Tax Rate % | 0% | 14.19% | 0.69% | -0.02% |
| Net Income | -27.68M▲ 0% | 4.18M▲ 115.1% | -71.8M▼ 1817.7% | -48.88M▲ 31.9% |
| Net Margin % | - | 2768.21% | -6678.88% | -106.37% |
| Net Income Growth % | - | 115.1% | -1817.66% | 31.92% |
| Net Income (Continuing) | -27.68M | 4.18M | -71.8M | -48.88M |
| Discontinued Operations | 0 | 0 | 0 | 0 |
| Minority Interest | 0 | 0 | 0 | 0 |
| EPS (Diluted) | -1.42▲ 0% | 0.03▲ 102.0% | -7.26▼ 25048.5% | -1.10▲ 84.8% |
| EPS Growth % | - | 102.05% | -25048.45% | 84.85% |
| EPS (Basic) | -1.42 | 0.03 | -7.26 | -1.10 |
| Diluted Shares Outstanding | 19.5M | 19.5M | 9.89M | 44.26M |
| Basic Shares Outstanding | 19.5M | 19.5M | 9.89M | 44.26M |
| Dividend Payout Ratio | - | - | - | - |
SEPN Balance Sheet
Septerna, Inc. (SEPN) balance sheet — assets, liabilities & shareholders' equity
| Line item | Dec'22 | Dec'23 | Dec'24 | Dec'25 |
|---|---|---|---|---|
| Total Current Assets | 31.89M | 112.68M | 356.82M | 410.96M |
| Cash & Short-Term Investments | 30.61M | 88.48M | 350.92M | 391.09M |
| Cash Only | 30.61M | 88.48M | 238.2M | 120.72M |
| Short-Term Investments | 0 | 0 | 112.73M | 270.37M |
| Accounts Receivable | 0 | 22.78M | 1.12M | 10.36M |
| Days Sales Outstanding | - | 55.05K | 381.64 | 82.26 |
| Inventory | 0 | 0 | 0 | 0 |
| Days Inventory Outstanding | - | - | - | - |
| Other Current Assets | 204K | 92K | 200K | 9.52M |
| Total Non-Current Assets | 4.23M | 18.19M | 99.73M | 185.22M |
| Property, Plant & Equipment | 3.1M | 17.19M | 28.69M | 25.93M |
| Fixed Asset Turnover | - | 0.01x | 0.04x | 1.77x |
| Goodwill | 0 | 0 | 0 | 0 |
| Intangible Assets | 0 | 0 | 0 | 0 |
| Long-Term Investments | 0 | 0 | 69.87M | 0 |
| Other Non-Current Assets | 1.12M | 1M | 1.17M | 159.29M |
| Total Assets | 36.12M▲ 0% | 130.87M▲ 262.3% | 456.55M▲ 248.9% | 596.19M▲ 30.6% |
| Asset Turnover | - | 0.00x | 0.00x | 0.08x |
| Asset Growth % | - | 262.32% | 248.87% | 30.58% |
| Total Current Liabilities | 5.54M | 6.91M | 12.85M | 86.93M |
| Accounts Payable | 3.07M | 2.64M | 3.2M | 10.28M |
| Days Payables Outstanding | - | - | - | - |
| Short-Term Debt | 0 | 0 | 0 | 2.21M |
| Deferred Revenue (Current) | 0 | 0 | 0 | 62.27M |
| Other Current Liabilities | 1.76M | 3.04M | 4.21M | 22.45M |
| Current Ratio | 5.75x | 16.30x | 27.77x | 4.73x |
| Quick Ratio | 5.75x | 16.30x | 27.77x | 4.73x |
| Cash Conversion Cycle | - | - | - | - |
| Total Non-Current Liabilities | 74.78M | 162.33M | 23.66M | 127.33M |
| Long-Term Debt | 0 | 0 | 0 | 21.41M |
| Capital Lease Obligations | 0 | 12.57M | 23.63M | 0 |
| Deferred Tax Liabilities | 0 | 0 | 0 | 0 |
| Other Non-Current Liabilities | 74.78M | 149.76M | 33K | 105.92M |
| Total Liabilities | 80.32M | 169.24M | 36.51M | 214.26M |
| Total Debt | 710K | 12.57M | 25.48M | 23.63M |
| Net Debt | -29.9M | -75.92M | -212.72M | -97.1M |
| Debt / Equity | - | - | 0.06x | 0.06x |
| Debt / EBITDA | - | 4.30x | - | - |
| Net Debt / EBITDA | - | -25.97x | - | - |
| Interest Coverage | - | - | - | - |
| Total Equity | -44.2M▲ 0% | -38.37M▲ 13.2% | 420.05M▲ 1194.6% | 381.93M▼ 9.1% |
| Equity Growth % | - | 13.18% | 1194.61% | -9.08% |
| Book Value per Share | -2.27 | -1.97 | 42.47 | 8.63 |
| Total Shareholders' Equity | -44.2M | -38.37M | 420.05M | 381.93M |
| Common Stock | 3K | 3K | 44K | 45K |
| Retained Earnings | -50.76M | -46.58M | -118.37M | -167.25M |
| Treasury Stock | 0 | 0 | 0 | 0 |
| Accumulated OCI | 0 | 0 | 56K | 617K |
| Minority Interest | 0 | 0 | 0 | 0 |
SEPN Cash Flow Statement
Septerna, Inc. (SEPN) cash flow — operating, investing & free cash flow history
| Line item | Dec'22 | Dec'23 | Dec'24 | Dec'25 |
|---|---|---|---|---|
| Cash from Operations | -23.3M | -38.72M | -67.47M | 110.19M |
| Operating CF Margin % | - | -25644.37% | -6276.28% | 239.8% |
| Operating CF Growth % | - | -66.17% | -74.24% | 263.32% |
| Net Income | -27.68M | 4.18M | -71.8M | -48.88M |
| Depreciation & Amortization | 577K | 848K | 1.4M | 1.6M |
| Stock-Based Compensation | 1.52M | 1.62M | 3.15M | 8.48M |
| Deferred Taxes | 0 | 491K | -491K | 0 |
| Other Non-Cash Items | 530K | -46.79M | 18K | 148.99M |
| Working Capital Changes | 1.75M | 926K | 248K | 0 |
| Change in Receivables | 0 | -151K | -20K | -10.19M |
| Change in Inventory | 0 | 0 | 0 | 0 |
| Change in Payables | 1.73M | -653K | 723K | 6.6M |
| Cash from Investing | -1.29M | 22.12M | -160.6M | -229.35M |
| Capital Expenditures | -1.29M | -2.88M | -2.1M | -518K |
| CapEx % of Revenue | - | 1905.96% | 195.63% | 1.13% |
| Acquisitions | 0 | 0 | 0 | 0 |
| Investments | - | - | - | - |
| Other Investing | 0 | 25M | 22.63M | 12.5M |
| Cash from Financing | 30.05M | 74.52M | 377.78M | 1.69M |
| Debt Issued (Net) | 0 | 0 | 0 | 0 |
| Equity Issued (Net) | 1000K | 1000K | 1000K | 0 |
| Dividends Paid | 0 | 0 | 0 | 0 |
| Share Repurchases | 0 | -1K | -1K | -1K |
| Other Financing | 82K | 0 | 52K | 1.69M |
| Net Change in Cash | 5.46M▲ 0% | 57.92M▲ 961.0% | 149.71M▲ 158.5% | -117.47M▼ 178.5% |
| Free Cash Flow | -24.59M▲ 0% | -41.6M▼ 69.2% | -69.57M▼ 67.2% | 109.67M▲ 257.6% |
| FCF Margin % | - | -27550.33% | -6471.91% | 238.67% |
| FCF Growth % | - | -69.16% | -67.24% | 257.63% |
| FCF per Share | -1.26 | -2.13 | -7.03 | 2.48 |
| FCF Conversion (FCF/Net Income) | 0.84x | -9.26x | 0.94x | -2.25x |
| Interest Paid | 0 | 0 | 0 | 0 |
| Taxes Paid | 0 | 75K | 232K | 0 |
SEPN Key Ratios
Septerna, Inc. (SEPN) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios
| Metric | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|
| Return on Equity (ROE) | - | - | -37.62% | -12.19% |
| Return on Invested Capital (ROIC) | - | - | -130.31% | -20.82% |
| Gross Margin | - | 100% | 100% | - |
| Net Margin | - | 2768.21% | -6678.88% | -106.37% |
| Debt / Equity | - | - | 0.06x | 0.06x |
| FCF Conversion | 0.84x | -9.26x | 0.94x | -2.25x |
| Revenue Growth | - | - | 611.92% | 4174.51% |
SEPN SEC Filings & Documents
Septerna, Inc. (SEPN) SEC filings — annual & quarterly reports (10-K, 10-Q)
SEPN Frequently Asked Questions
Septerna, Inc. (SEPN) stock FAQ — growth, dividends, profitability & financials explained
Growth & Financials
Septerna, Inc. (SEPN) reported $46.0M in revenue for fiscal year 2025.
Septerna, Inc. (SEPN) grew revenue by 4174.5% over the past year. This is strong growth.
Septerna, Inc. (SEPN) reported a net loss of $48.9M for fiscal year 2025.
Dividend & Returns
Septerna, Inc. (SEPN) has a return on equity (ROE) of -12.2%. Negative ROE indicates the company is unprofitable.
Septerna, Inc. (SEPN) generated $109.7M in free cash flow for fiscal year 2025. Positive FCF indicates the company can fund dividends, buybacks, or reinvestment.
Explore More SEPN
Septerna, Inc. (SEPN) financial analysis — history, returns, DCA and operating performance tools
Total Return Calculator
Historical returns with dividends reinvested
DCA Calculator
Dollar cost averaging vs lump sum
Dividend History
Yield, growth, payout safety & DRIP
Earnings History
EPS trends, net income & profitability
Price History
Long-term charts & historical price data
Revenue History
Sales growth patterns & revenue breakdown
Financial Ratios
30 years of market, efficiency and balance-sheet ratios
Valuation
DCF intrinsic value, peer multiples & estimates