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SYRS logoSyros Pharmaceuticals, Inc.(SYRS)Earnings, Financials & Key Ratios

SYRS•NASDAQ
Price updated Jun 19, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryOncology Therapeutics Developers
AboutSyros Pharmaceuticals, Inc., a biopharmaceutical company, focuses on the development of treatments for cancer and monogenic diseases, and building a pipeline of gene control medicines. The company's lead product candidates are Tamibarotene, a selective retinoic acid receptor alpha agonist, which is in Phase III clinical trial for genomically defined subset of patients with myelodysplastic syndrome and Phase II clinical trial for patients with acute myeloid leukemia; SY-2101, a novel oral form of arsenic trioxide for treating patients with acute promyelocytic leukemia; and SY-5609, a cyclin-dependent kinase 7 inhibitor, which is in a Phase I clinical trial in patients with select advanced solid tumors. It has target discovery, research collaboration, and option agreement with Incyte Corporation to identify therapeutic targets with a focus on myeloproliferative neoplasms; and a license agreement with TMRC Co. Ltd. for the development and commercialization of tamibarotene. The company was formerly known as LS22, Inc. and changed its name to Syros Pharmaceuticals, Inc. in August 2012. Syros Pharmaceuticals, Inc. was incorporated in 2011 and is headquartered in Cambridge, Massachusetts.Show more
  • Revenue$10M-33.2%
  • EBITDA-$127M+4.6%
  • Net Income-$165M-73.9%
  • EPS (Diluted)-5.81+22.4%
  • Gross Margin77.33%-3.4%
  • EBITDA Margin-1275.52%-42.8%
  • Operating Margin-1298.19%-42.2%
  • Net Margin-1656.34%-160.4%
  • ROE-227.95%-156.4%

SYRS Key Insights

Syros Pharmaceuticals, Inc. (SYRS) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Momentum leader: RS Rating 88 (top 12%)
  • ✓Strong 5Y sales CAGR of 37.1%
  • ✓Trading at only 0.0x book value

✗Weaknesses

  • ✗High debt to equity ratio of 3.7x
  • ✗Profits declining 21.5% over 5 years
  • ✗Weak Piotroski F-Score: 1/9
  • ✗Negative free cash flow
  • ✗Shares diluted 100.0% in last year
  • ✗Trading more than 30% below 52-week high

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

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SYRS Price & Volume

Syros Pharmaceuticals, Inc. (SYRS) stock price & volume — 10-year historical chart

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SYRS Growth Metrics

Syros Pharmaceuticals, Inc. (SYRS) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years37.12%
3 Years-13.01%
TTM-90.54%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-53.44%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM-32.68%

Return on Capital

10 Years-67.75%
5 Years-66.8%
3 Years-69.44%
Last Year-74.73%

SYRS Peer Comparison

Syros Pharmaceuticals, Inc. (SYRS) competitors in Oncology Therapeutics Developers — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
Institutional Holdings
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
KYMR logoKYMRKymera Therapeutics, Inc.Direct Competitor7.38B90.43-24.51-16.72%-6.12%-25.02%0.05
ARVN logoARVNArvinas, Inc.Direct Competitor494.88M7.67-5.99-0.3%-247.54%-44.39%0.02
IMVT logoIMVTImmunovant, Inc.Direct Competitor7.26B35.34-12.76-68.16%0.00
TNGX logoTNGXTango Therapeutics, Inc.Direct Competitor3.25B27.97-32.1548.29%-188.15%-41.54%0.10
PRAX logoPRAXPraxis Precision Medicines, Inc.Direct Competitor8.15B282.31-20.94-100%-43.02%0.00
RVMD logoRVMDRevolution Medicines, Inc.Direct Competitor34.65B162.99-27.39-83.22%0.10
BEAM logoBEAMBeam Therapeutics Inc.Product Competitor3.51B34.14-42.15120.01%-49.17%-5.89%0.24
EDIT logoEDITEditas Medicine, Inc.Product Competitor263.37M2.69-1.4925.39%-281.59%-6.77%2.81

Compare SYRS vs Peers

Syros Pharmaceuticals, Inc. (SYRS) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs KYMR

Most directly comparable listed peer for SYRS.

Scale Benchmark

vs TMO

Larger-name benchmark to compare SYRS against a more recognizable public peer.

Peer Set

Compare Top 5

vs KYMR, ARVN, IMVT, TNGX

SYRS Income Statement

Syros Pharmaceuticals, Inc. (SYRS) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
MetricDec'15Dec'16Dec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23TTM
Sales/Revenue
317K317K1.1M2.05M1.98M15.09M23.49M14.88M9.94M386K
Revenue Growth %
-0%247.32%86.19%-3.32%661.5%55.62%-36.65%-33.23%-90.54%
Cost of Goods Sold
602K01.53M00002.97M2.25M1.27M
COGS % of Revenue
189.91%-138.69%----19.94%22.67%-
Gross Profit
-285K▲ 0%
317K▲ 211.2%
-426K▼ 234.4%
2.05M▲ 581.2%
1.98M▼ 3.3%
15.09M▲ 661.5%
23.49M▲ 55.6%
11.91M▼ 49.3%
7.68M▼ 35.5%
-883K▲ 0%
Gross Margin %
-89.91%100%-38.69%100%100%100%100%80.06%77.33%-228.76%
Gross Profit Growth %
-211.23%-234.38%581.22%-3.32%661.5%55.62%-49.28%-35.5%-
Operating Expenses
30.14M48.28M55.79M66.35M79.72M97.39M122.91M38.81M30.77M111.3M
OpEx % of Revenue
9506.94%15230.28%5066.94%3236.39%4022.35%645.27%523.28%260.81%309.69%-
Selling, General & Admin
5.73M10.46M13.89M16.16M21.48M21.32M23.04M29.3M28.28M23.27M
SG&A % of Revenue
1807.26%3300.63%1261.67%788.49%1083.65%141.29%98.08%196.9%284.64%-
Research & Development
24.41M37.82M41.9M50.18M58.24M76.06M99.87M111.94M108.15M88.03M
R&D % of Revenue
7699.68%11929.65%3805.27%2447.9%2938.7%503.98%425.2%752.31%1088.5%-
Other Operating Expenses
2K220K676K0000-102.43M-105.66M0
Operating Income
-29.82M▲ 0%
-47.96M▼ 60.8%
-54.69M▼ 14.0%
-64.3M▼ 17.6%
-77.74M▼ 20.9%
-82.3M▼ 5.9%
-99.42M▼ 20.8%
-135.87M▼ 36.7%
-128.99M▲ 5.1%
-111.52M▲ 0%
Operating Margin %
-9406.94%-15130.28%-4966.94%-3136.39%-3922.35%-545.27%-423.28%-913.13%-1298.19%-28892.23%
Operating Income Growth %
-121.96%-60.84%-14.02%-17.57%-20.91%-5.86%-20.81%-36.67%5.07%-
EBITDA
-29.22M-46.69M-53.16M-62.69M-75.02M-79.26M-96.4M-132.91M-126.74M-110.25M
EBITDA Margin %
-9217.03%-14728.71%-4828.25%-3058.15%-3785.02%-525.16%-410.43%-893.19%-1275.52%-28563.47%
EBITDA Growth %
-121.73%-59.8%-13.86%-17.93%-19.66%-5.66%-21.62%-37.87%4.64%18.39%
D&A (Non-Cash Add-back)
602K1.27M1.53M1.6M2.72M3.04M3.02M2.97M2.25M1.27M
EBIT
-29.82M-47.96M-54.69M-62.28M-75.44M-82.25M-82.65M-90.52M-159.45M-92.48M
Net Interest Income
0002.02M2.3M-1.37M-3.82M-2M1.69M-623K
Interest Income
0002.02M2.3M426K87K2.13M6.82M4.71M
Interest Expense
0001K01.79M3.91M4.13M5.13M5.33M
Other Income/Expense
2K220K676K2.02M2.3M-1.74M12.86M41.22M-35.59M13.84M
Pretax Income
-29.82M▲ 0%
-47.74M▼ 60.1%
-54.01M▼ 13.1%
-62.28M▼ 15.3%
-75.44M▼ 21.1%
-84.04M▼ 11.4%
-86.56M▼ 3.0%
-94.65M▼ 9.4%
-164.57M▼ 73.9%
-97.81M▲ 0%
Pretax Margin %
-9406.31%-15060.88%-4905.54%-3038%-3806.16%-556.8%-368.52%-636.12%-1656.34%-25340.67%
Income Tax
0000000000
Effective Tax Rate %
0%0%0%0%0%0%0%0%0%0%
Net Income
-29.82M▲ 0%
-47.74M▼ 60.1%
-54.01M▼ 13.1%
-62.28M▼ 15.3%
-75.44M▼ 21.1%
-84.04M▼ 11.4%
-86.56M▼ 3.0%
-94.65M▼ 9.4%
-164.57M▼ 73.9%
-97.81M▲ 0%
Net Margin %
-9406.31%-15060.88%-4905.54%-3038%-3806.16%-556.8%-368.52%-636.12%-1656.34%-25340.67%
Net Income Growth %
-122.01%-60.11%-13.13%-15.31%-21.13%-11.4%-3%-9.35%-73.87%-53.44%
Net Income (Continuing)
-29.82M-47.74M-54.01M-62.28M-75.44M-84.04M-86.56M-94.65M-164.57M-97.81M
Discontinued Operations
0000000000
Minority Interest
0000000000
EPS (Diluted)
-120.45▲ 0%
-37.60▲ 68.8%
-21.26▲ 43.5%
-19.07▲ 10.3%
-18.76▲ 1.6%
-18.25▲ 2.7%
-13.84▲ 24.2%
-7.49▲ 45.9%
-5.81▲ 22.4%
-2.49▲ 0%
EPS Growth %
-122.03%68.78%43.46%10.3%1.63%2.72%24.16%45.88%22.43%-32.68%
EPS (Basic)
-120.45-37.60-21.26-19.07-18.76-18.25-13.84-7.49-5.81-
Diluted Shares Outstanding
247.56K1.27M2.54M3.27M4.02M4.61M6.25M12.63M28.33M39.34M
Basic Shares Outstanding
247.56K1.27M2.54M3.27M4.02M4.61M6.25M12.63M28.33M39.27M
Dividend Payout Ratio
----------

SYRS Balance Sheet

Syros Pharmaceuticals, Inc. (SYRS) balance sheet — assets, liabilities & shareholders' equity

MetricDec'15Dec'16Dec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23TTM
Total Current Assets
36.45M85.51M73.16M101.73M114.51M178.56M136.59M211.39M144.98M63.93M
Cash & Short-Term Investments
35.91M83.59M72.05M99.68M91.42M173.98M130.37M202.3M139.53M58.27M
Cash Only
35.91M58.59M32.2M49.89M41.44M173.98M92.3M167.47M139.53M58.27M
Short-Term Investments
025M39.84M49.79M49.98M038.07M34.84M00
Accounts Receivable
0867K0020.16M2.33M2.98M1.69M00
Days Sales Outstanding
-998.28--3.71K56.3746.2941.55--
Inventory
0000290K00000
Days Inventory Outstanding
----------
Other Current Assets
01.05M193K638K0007.39M5.45M5.66M
Total Non-Current Assets
7.18M5.82M5.33M5.03M35.47M34.69M46.35M33.09M23.19M21.06M
Property, Plant & Equipment
4.8M4.85M3.94M3.86M31.89M29.64M27.29M24.66M19.48M17.58M
Fixed Asset Turnover
0.07x0.07x0.28x0.53x0.06x0.51x0.86x0.60x0.51x0.02x
Goodwill
0000000000
Intangible Assets
0000000000
Long-Term Investments
483K483K290K290K3.09M3.09M13.04M3.09M2.12M8.48M
Other Non-Current Assets
1.9M482K1.1M881K490K1.97M6.03M5.35M1.59M1.37M
Total Assets
43.63M▲ 0%
91.32M▲ 109.3%
78.49M▼ 14.1%
106.77M▲ 36.0%
149.98M▲ 40.5%
213.25M▲ 42.2%
182.94M▼ 14.2%
244.49M▲ 33.6%
168.17M▼ 31.2%
85M▲ 0%
Asset Turnover
0.01x0.00x0.01x0.02x0.01x0.07x0.13x0.06x0.06x0.00x
Asset Growth %
-29.05%109.31%-14.05%36.03%40.47%42.19%-14.22%33.65%-31.21%-149.12%
Total Current Liabilities
7.96M9.57M12.41M19.53M23.52M28.62M31.51M30.78M36.68M28.39M
Accounts Payable
5.04M2.42M2.28M3.31M5.85M3.6M3.69M6.41M11.54M9.65M
Days Payables Outstanding
3.05K-545.71----788.681.87K2.88K
Short-Term Debt
0168K47K9K1.28M1.73M006.67M0
Deferred Revenue (Current)
0550K355K1.93M5.74M12.21M10.18M4.33M00
Other Current Liabilities
284K4.36M7.54M11.29M5.19M3.99M9.28M9.44M6.99M0
Current Ratio
4.58x8.94x5.89x5.21x4.87x6.24x4.33x6.87x3.95x2.25x
Quick Ratio
4.58x8.94x5.89x5.21x4.86x6.24x4.33x6.87x3.95x2.25x
Cash Conversion Cycle
----------
Total Non-Current Liabilities
1.63M1.15M751K8.65M47.28M94.07M66.21M85.97M114.83M67.73M
Long-Term Debt
0000039.55M40.26M40.65M34.56M41.08M
Capital Lease Obligations
206K53K6K22K24.64M24.93M22.92M20.85M18.53M70.21M
Deferred Tax Liabilities
000-22K000000
Other Non-Current Liabilities
1.42M1.1M745K353K019.71M3.03M24.47M61.75M10.08M
Total Liabilities
9.58M10.72M13.16M28.18M70.79M122.7M97.72M116.75M151.51M96.12M
Total Debt
339K221K53K31K25.92M66.21M65.19M63.57M62.08M60.23M
Net Debt
-35.57M-58.37M-32.15M-49.85M-15.52M-107.77M-27.11M-103.9M-77.45M1.95M
Debt / Equity
0.01x0.00x0.00x0.00x0.33x0.73x0.76x0.50x3.73x-5.41x
Debt / EBITDA
----------0.55x
Net Debt / EBITDA
----------0.02x
Interest Coverage
----62279.00x--45.90x-21.15x-21.90x-31.10x-17.35x
Total Equity
34.05M▲ 0%
80.6M▲ 136.7%
65.32M▼ 19.0%
78.59M▲ 20.3%
79.18M▲ 0.8%
90.55M▲ 14.4%
85.22M▼ 5.9%
127.74M▲ 49.9%
16.66M▼ 87.0%
-11.12M▲ 0%
Equity Growth %
-43.48%136.72%-18.95%20.3%0.76%14.36%-5.89%49.89%-86.96%-412.16%
Book Value per Share
137.5463.4825.7124.0619.6919.6613.6310.110.59-0.28
Total Shareholders' Equity
34.05M80.6M65.32M78.59M79.18M90.55M85.22M127.74M16.66M-11.12M
Common Stock
2K23K26K34K43K56K61K20K26K27K
Retained Earnings
-53.51M-101.26M-155.27M-217.54M-292.98M-377.02M-463.58M-558.23M-722.81M-756.24M
Treasury Stock
0000000000
Accumulated OCI
-931K-9K-42K-3K24K0-79K102K00
Minority Interest
0000000000

SYRS Cash Flow Statement

Syros Pharmaceuticals, Inc. (SYRS) cash flow — operating, investing & free cash flow history

MetricDec'15Dec'16Dec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23TTM
Cash from Operations
-23.03M-40.54M-44.73M-40.31M-60.25M-57.36M-99.54M-123.06M-109.71M-100.02M
Operating CF Margin %
-7264.98%-12787.38%-4062.58%-1966.59%-3040.01%-380.07%-423.79%-827.05%-1104.14%-
Operating CF Growth %
-92.41%-76.01%-10.34%9.87%-49.46%4.79%-73.52%-23.63%10.85%58.53%
Net Income
-29.82M-47.74M-54.01M-62.28M-75.44M-84.04M-86.56M-94.65M-164.57M-97.81M
Depreciation & Amortization
602K1.27M1.53M1.6M2.72M3.04M3.02M2.97M2.25M1.27M
Stock-Based Compensation
3.23M4.23M4.42M6.61M9.84M10.94M10.35M11.41M10.43M7.25M
Deferred Taxes
0000-1.13M326K-16.46M008.08M
Other Non-Cash Items
17K10K-102K-642K7.24M2.32M706K-37.27M37.13M-22.18M
Working Capital Changes
2.94M1.69M3.44M14.39M-3.48M10.05M-10.6M-5.52M5.05M3.38M
Change in Receivables
0-317K867K0-20.16M19.99M7K1.28M1.69M1.67M
Change in Inventory
02.69M3.3M0-4.36M-2.53M1.98M-1.28M029K
Change in Payables
2.02M-404K141K888K1.49M-1.06M48K2.77M5.13M6.79M
Cash from Investing
-1.18M-27.34M-15.59M-10.64M-11.73M46.66M-52.65M67.19M37.34M1.95M
Capital Expenditures
-1.18M-2.32M-821K-1.38M-12.64M-3.34M-1.25M-1.24M-272K-67K
CapEx % of Revenue
370.98%732.49%74.57%67.51%637.64%22.1%5.3%8.34%2.74%17.36%
Acquisitions
0009K110K00001.46M
Investments
----------
Other Investing
0-25.02M-14.77M9K00001.56M25.22M
Cash from Financing
-278K90.56M33.94M69.08M65.99M142.95M70.51M131.04M43.46M43.16M
Debt Issued (Net)
-50K-135K-168K-50K-205K39.38M-265K-291K-65K-3K
Equity Issued (Net)
-228K90.3M32.31M68.51M65.82M102.27M70.34M119.68M43.27M43.27M
Dividends Paid
0000000000
Share Repurchases
-620K000000-81K0115K
Other Financing
0395K1.8M626K374K1.3M439K11.66M257K-111K
Net Change in Cash
-24.48M▲ 0%
22.68M▲ 192.6%
-26.38M▼ 216.3%
18.13M▲ 168.7%
-6M▼ 133.1%
132.25M▲ 2305.3%
-81.68M▼ 161.8%
75.17M▲ 192.0%
-28.91M▼ 138.5%
-53.94M▲ 0%
Free Cash Flow
-24.21M▲ 0%
-42.86M▼ 77.1%
-45.55M▼ 6.3%
-41.7M▲ 8.5%
-72.89M▼ 74.8%
-60.7M▲ 16.7%
-100.78M▼ 66.0%
-124.31M▼ 23.3%
-109.98M▲ 11.5%
-100.06M▲ 0%
FCF Margin %
-7635.96%-13519.87%-4137.15%-2034.1%-3677.65%-402.17%-429.09%-835.39%-1106.87%-25921.5%
FCF Growth %
-98.9%-77.06%-6.28%8.45%-74.8%16.73%-66.04%-23.34%11.53%18.74%
FCF per Share
-97.78-33.76-17.93-12.77-18.12-13.18-16.12-9.84-3.88-2.54
FCF Conversion (FCF/Net Income)
0.77x0.85x0.83x0.65x0.80x0.68x1.15x1.30x0.67x1.02x
Interest Paid
0002K72K1.5M0000
Taxes Paid
0007K29K7K0000

SYRS Key Ratios

Syros Pharmaceuticals, Inc. (SYRS) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric201520162017201820192020202120222023TTM
Return on Equity (ROE)
-63.25%-83.28%-74.02%-86.55%-95.63%-99.02%-98.49%-88.9%-227.95%-2746.84%
Return on Invested Capital (ROIC)
--347.32%-148.05%-155.8%-126.22%-265.81%-364.72%-248.71%-329.92%
Gross Margin
-89.91%100%-38.69%100%100%100%100%80.06%77.33%-228.76%
Net Margin
-9406.31%-15060.88%-4905.54%-3038%-3806.16%-556.8%-368.52%-636.12%-1656.34%-25340.67%
Debt / Equity
0.01x0.00x0.00x0.00x0.33x0.73x0.76x0.50x3.73x-5.41x
Interest Coverage
----62279.00x--45.90x-21.15x-21.90x-31.10x-17.35x
FCF Conversion
0.77x0.85x0.83x0.65x0.80x0.68x1.15x1.30x0.67x1.02x
Revenue Growth
-0%247.32%86.19%-3.32%661.5%55.62%-36.65%-33.23%-90.54%
Related:SYRS Dividend History·SYRS Revenue History·SYRS Price History·SYRS P/E History·SYRS Financial Ratios·SYRS Institutional Holders

SYRS SEC Filings & Documents

Syros Pharmaceuticals, Inc. (SYRS) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Mar 4, 2025·SEC

Material company update

Feb 28, 2025·SEC

Material company update

Jan 8, 2025·SEC

10-K Annual Reports

2
FY 2024

Mar 27, 2024·SEC

FY 2023

Mar 2, 2023·SEC

10-Q Quarterly Reports

6
FY 2024

Oct 31, 2024·SEC

FY 2024

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SYRS Frequently Asked Questions

Syros Pharmaceuticals, Inc. (SYRS) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Syros Pharmaceuticals, Inc. (SYRS) reported $0.4M in revenue for fiscal year 2023.

Syros Pharmaceuticals, Inc. (SYRS) saw revenue decline by 33.2% over the past year.

Syros Pharmaceuticals, Inc. (SYRS) reported a net loss of $97.8M for fiscal year 2023.

Dividend & Returns

Syros Pharmaceuticals, Inc. (SYRS) has a return on equity (ROE) of -227.9%. Negative ROE indicates the company is unprofitable.

Syros Pharmaceuticals, Inc. (SYRS) had negative free cash flow of $100.1M in fiscal year 2023, likely due to heavy capital investments.

What if you invested $1,000 in SYRS back in 2013?

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How much would $100/month in SYRS be worth today?

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