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XBIO logoXenetic Biosciences, Inc.(XBIO)Earnings, Financials & Key Ratios

XBIO•NASDAQ
Price updated Jun 19, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryCell and Gene Therapy Developers
AboutXenetic Biosciences, Inc., a biopharmaceutical company, focuses on advancing XCART, a personalized chimeric antigen receptor T cell (CAR T) platform technology engineered to target patient-specific tumor neoantigens. The company engages in the discovery, research, and development of biologic drugs and oncology therapeutics. It advances cell-based therapeutics targeting the B-cell receptor on the surface of an individual patient's malignant tumor cells for the treatment of B-cell lymphomas. It is also leveraging PolyXen, its proprietary drug delivery platform, by partnering with biotechnology and pharmaceutical companies. It has collaboration agreements with Takeda Pharmaceutical Co. Ltd., Serum Institute of India Limited, PJSC Pharmsynthez, and SynBio LLC. Xenetic Biosciences, Inc. is headquartered in Framingham, Massachusetts.Show more
  • Revenue$3M+19.0%
  • EBITDA-$3M+30.0%
  • Net Income-$3M+32.3%
  • EPS (Diluted)-1.58+38.5%
  • Gross Margin100%
  • EBITDA Margin-95.23%+41.2%
  • Operating Margin-95.23%+43.4%
  • Net Margin-90.07%+43.1%
  • ROE-40%+20.2%

XBIO Key Insights

Xenetic Biosciences, Inc. (XBIO) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Strong 5Y profit CAGR of 24.5%
  • ✓Strong 5Y sales CAGR of 46.8%
  • ✓Trading at only 0.6x book value

✗Weaknesses

  • ✗Weak Piotroski F-Score: 3/9
  • ✗Negative free cash flow
  • ✗Shares diluted 10.4% in last year
  • ✗Trading more than 30% below 52-week high

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

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XBIO Price & Volume

Xenetic Biosciences, Inc. (XBIO) stock price & volume — 10-year historical chart

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XBIO Growth Metrics

Xenetic Biosciences, Inc. (XBIO) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years46.78%
3 Years20.36%
TTM23.52%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM39.1%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM48.32%

Return on Capital

10 Years-77.67%
5 Years-42.7%
3 Years-44.68%
Last Year-42.3%

XBIO Recent Earnings

Xenetic Biosciences, Inc. (XBIO) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 9/12 qtrs (82%)●Beat Revenue 7/12 qtrs (64%)
Q2 2026Latest
May 12, 2026
Metric
Actual
Est
EPS
$0.20
—
Rev
$806,923
—
Q2 2026
Mar 12, 2026
Metric
Actual
Est
EPS
$0.22+57.7%
$0.52
Rev
$766,296+11.1%
$690,000
Q4 2025
Nov 12, 2025
Metric
Actual
Est
EPS
$0.33+32.7%
$0.49
Rev
$1M+63.0%
$630,000
Q3 2025
Aug 12, 2025
Metric
Actual
Est
EPS
$0.45+29.7%
$0.64
Rev
$589,897+23.2%
$479,000
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 12, 2026
$0.20
$806,923
Q2 2026Mar 12, 2026
$0.22vs $0.52+57.7%
$766,296vs $690,000+11.1%
Q4 2025Nov 12, 2025
$0.33vs $0.49+32.7%
$1Mvs $630,000+63.0%
Q3 2025Aug 12, 2025
$0.45vs $0.64+29.7%
$589,897vs $479,000+23.2%
Based on last 12 quarters of dataView full earnings history →

XBIO Peer Comparison

Xenetic Biosciences, Inc. (XBIO) competitors in Cell and Gene Therapy Developers — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
Institutional Holdings
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
HALO logoHALOHalozyme Therapeutics, Inc.Direct Competitor8.13B68.5526.7837.55%23.13%126.27%43.89
ADMA logoADMAADMA Biologics, Inc.Direct Competitor1.93B8.3113.8519.63%32.43%38.97%0.17
IMUX logoIMUXImmunic, Inc.Direct Competitor140.13M14.20-2.28-220.75%
AGEN logoAGENAgenus Inc.Direct Competitor124.93M3.00-882.3510.37%52.16%
CRIS logoCRISCuris, Inc.Direct Competitor81.52M0.42-0.73-13.43%-299.66%-138.81%0.30
PRTA logoPRTAProthena Corporation plcProduct Competitor467.51M8.93-1.97-92.84%-260.92%-49.88%0.05
ALNY logoALNYAlnylam Pharmaceuticals, Inc.Product Competitor37.1B278.09119.3565.19%13.46%98.29%1.62
ARWR logoARWRArrowhead Pharmaceuticals, Inc.Product Competitor11.52B81.82-6706.56232.58%-48.38%-55.09%0.73

Compare XBIO vs Peers

Xenetic Biosciences, Inc. (XBIO) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs HALO

Most directly comparable listed peer for XBIO.

Scale Benchmark

vs MRK

Larger-name benchmark to compare XBIO against a more recognizable public peer.

Peer Set

Compare Top 5

vs HALO, ADMA, IMUX, AGEN

XBIO Income Statement

Xenetic Biosciences, Inc. (XBIO) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Sales/Revenue
7.58M017.07K436.94K1.16M1.71M2.54M2.5M2.98M3.19M
Revenue Growth %
152.83%-100%-2460.31%165.64%47.06%48.8%-1.56%19.04%23.52%
Cost of Goods Sold
156.12K15.83K00000000
COGS % of Revenue
2.06%---------
Gross Profit
7.43M▲ 0%
-15.83K▼ 100.2%
17.07K▲ 207.8%
436.94K▲ 2460.3%
1.16M▲ 165.6%
1.71M▲ 47.1%
2.54M▲ 48.8%
2.5M▼ 1.6%
2.98M▲ 19.0%
2.38M▲ 0%
Gross Margin %
97.94%-100%100%100%100%100%100%100%74.71%
Gross Profit Growth %
150.68%-100.21%207.83%2460.31%165.64%47.06%48.8%-1.56%19.04%-
Operating Expenses
11M7.28M12.9M14.37M6.91M8.42M7.06M6.7M5.81M5.58M
OpEx % of Revenue
144.99%-75611.71%3289.82%595.12%493.57%277.78%268.16%195.23%-
Selling, General & Admin
6.94M4.39M4.73M3.4M3.74M3.65M3.56M3.42M2.75M2.74M
SG&A % of Revenue
91.47%-27722.82%778.15%322.56%214.07%140.2%136.64%92.24%-
Research & Development
4.06M2.88M4.89M1.73M3.16M4.77M3.49M3.29M3.07M2.85M
R&D % of Revenue
53.53%-28649.6%396.26%272.55%279.5%137.59%131.52%102.99%-
Other Operating Expenses
-41.1K-24.64K3.28M9.24M000000
Operating Income
-3.57M▲ 0%
-7.28M▼ 103.9%
-12.89M▼ 77.1%
-13.94M▼ 8.2%
-5.75M▲ 58.8%
-6.72M▼ 16.9%
-4.52M▲ 32.8%
-4.2M▲ 6.9%
-2.83M▲ 32.6%
-2.39M▲ 0%
Operating Margin %
-47.05%--75511.71%-3189.82%-495.12%-393.57%-177.78%-168.16%-95.23%-75.05%
Operating Income Growth %
92.48%-103.89%-77.11%-8.15%58.77%-16.9%32.78%6.89%32.58%-
EBITDA
-3.54M-7.26M-12.86M-13.91M-5.71M-6.69M-4.52M-4.05M-2.83M-2.41M
EBITDA Margin %
-46.74%--75350.65%-3183.22%-492.06%-391.98%-177.78%-162.03%-95.23%-75.47%
EBITDA Growth %
92.52%-104.81%-77.11%-8.16%58.94%-17.15%32.51%10.29%30.03%37.93%
D&A (Non-Cash Add-back)
23.78K15.83K27.49K28.84K35.48K27.04K0153.34K0-13.24K
EBIT
-3.59M-7.28M-9.6M-4.69M-5.75M-6.72M-4.52M-4.2M-2.83M-2.36M
Net Interest Income
14.73K0108.49K126.17K100.47K167.15K355.76K249.86K148K154.56K
Interest Income
16.54K0108.49K126.17K100.47K167.15K355.76K249.86K148K154.56K
Interest Expense
1.82K24.13K00000000
Other Income/Expense
-26.37K-24.13K111.8K125.68K101.59K165.56K381.14K244.15K153.72K160.19K
Pretax Income
-3.6M▲ 0%
-7.3M▼ 103.1%
-12.78M▼ 75.0%
-13.81M▼ 8.1%
-5.65M▲ 59.1%
-6.55M▼ 16.1%
-4.13M▲ 36.9%
-3.96M▲ 4.2%
-2.68M▲ 32.3%
-2.23M▲ 0%
Pretax Margin %
-47.4%--74856.59%-3161.06%-486.36%-383.87%-162.78%-158.39%-90.07%-70.03%
Income Tax
26.37K24.13K0-2.92M000000
Effective Tax Rate %
-0.73%-0.33%0%21.13%0%0%0%0%0%0%
Net Income
-3.6M▲ 0%
-7.3M▼ 103.1%
-12.78M▼ 75.0%
-10.89M▲ 14.7%
-5.65M▲ 48.2%
-6.55M▼ 16.1%
-4.13M▲ 36.9%
-3.96M▲ 4.2%
-2.68M▲ 32.3%
-2.23M▲ 0%
Net Margin %
-47.4%--74856.59%-2493.11%-486.36%-383.87%-162.78%-158.39%-90.07%-70.03%
Net Income Growth %
93.37%-103.07%-74.99%14.73%48.18%-16.07%36.9%4.22%32.31%39.1%
Net Income (Continuing)
-3.6M-7.3M-12.78M-10.89M-5.65M-6.55M-4.13M-3.96M-2.68M-2.23M
Discontinued Operations
0000000000
Minority Interest
0000000000
EPS (Diluted)
-49.78▲ 0%
-96.57▼ 94.0%
-55.92▲ 42.1%
-17.04▲ 69.5%
-5.39▲ 68.4%
-4.49▲ 16.7%
-2.71▲ 39.6%
-2.57▲ 5.2%
-1.58▲ 38.5%
-0.98▲ 0%
EPS Growth %
94.31%-93.99%42.09%69.53%68.37%16.7%39.64%5.17%38.52%48.32%
EPS (Basic)
-49.78-96.58-55.92-17.04-5.39-4.49-2.71-2.57-1.58-
Diluted Shares Outstanding
72.21K75.6K285.25K639.24K1.03M1.42M1.53M1.54M1.7M2.29M
Basic Shares Outstanding
72.21K75.59K285.25K639.24K1.03M1.42M1.53M1.54M1.7M2.29M
Dividend Payout Ratio
----------

XBIO Balance Sheet

Xenetic Biosciences, Inc. (XBIO) balance sheet — assets, liabilities & shareholders' equity

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Total Current Assets
5.88M1.19M11.09M12.37M18.72M13.65M9.59M6.59M8.05M7.6M
Cash & Short-Term Investments
5.53M571.61K10.37M11.53M18.24M13.1M8.98M6.17M7.88M7.35M
Cash Only
5.53M571.61K10.37M11.53M18.24M13.1M8.98M6.17M7.88M7.35M
Short-Term Investments
0000000000
Accounts Receivable
0000000000
Days Sales Outstanding
----------
Inventory
0000000000
Days Inventory Outstanding
----------
Other Current Assets
99.51K66.51K527.08K0227.04K0603.83K0166.29K247.81K
Total Non-Current Assets
13.28M13.24M10.46M809.99K1.09M1.07M1.02M313.92K313.92K313.92K
Property, Plant & Equipment
27.85K4.96K20.8K27.04K000000
Fixed Asset Turnover
272.39x-0.82x16.16x------
Goodwill
3.28M3.28M00000000
Intangible Assets
9.24M9.24M9.24M0000000
Long-Term Investments
0000000000
Other Non-Current Assets
724.71K705.66K1.19M782.94K1.09M1.07M1.02M313.92K313.92K313.92K
Total Assets
19.16M▲ 0%
14.43M▼ 24.7%
21.55M▲ 49.3%
13.18M▼ 38.8%
19.82M▲ 50.3%
14.72M▼ 25.7%
10.61M▼ 28.0%
6.9M▼ 34.9%
8.36M▲ 21.2%
7.91M▲ 0%
Asset Turnover
0.40x-0.00x0.03x0.06x0.12x0.24x0.36x0.36x0.48x
Asset Growth %
-8.63%-24.7%49.31%-38.83%50.35%-25.71%-27.96%-34.92%21.19%-19.99%
Total Current Liabilities
1.94M1.6M1.42M936.93K1.42M1.07M809.59K894.26K968.02K958.24K
Accounts Payable
786.78K934.15K931.13K327.4K362.47K287.36K240.83K283.62K258.11K558.81K
Days Payables Outstanding
1.84K21.54K--------
Short-Term Debt
0020.04K0000000
Deferred Revenue (Current)
0000000000
Other Current Liabilities
44.31K218.03K463.99K0039.95K48.26K34.2K709.92K399.43K
Current Ratio
3.03x0.75x7.84x13.20x13.18x12.72x11.84x7.37x8.32x7.93x
Quick Ratio
3.03x0.75x7.84x13.20x13.18x12.72x11.84x7.37x8.32x7.93x
Cash Conversion Cycle
----------
Total Non-Current Liabilities
2.92M2.92M2.92M27.04K000000
Long-Term Debt
0000000000
Capital Lease Obligations
00027.04K000000
Deferred Tax Liabilities
2.92M2.92M2.92M0000000
Other Non-Current Liabilities
0000000000
Total Liabilities
4.86M4.52M4.33M963.97K1.42M1.07M809.59K894.26K968.02K958.24K
Total Debt
0020.04K62.52K27.04K00000
Net Debt
-5.53M-571.61K-10.35M-11.47M-18.22M-13.1M-8.98M-6.17M-7.88M-7.35M
Debt / Equity
--0.00x0.01x0.00x----0.00x
Debt / EBITDA
----------0.00x
Net Debt / EBITDA
---------3.05x
Interest Coverage
-1976.52x-301.53x--------
Total Equity
14.3M▲ 0%
9.91M▼ 30.7%
17.21M▲ 73.6%
12.22M▼ 29.0%
18.39M▲ 50.6%
13.65M▼ 25.8%
9.8M▼ 28.2%
6.01M▼ 38.7%
7.4M▲ 23.1%
6.95M▲ 0%
Equity Growth %
-11.55%-30.69%73.65%-29.03%50.58%-25.81%-28.22%-38.67%23.12%-25.22%
Book Value per Share
198.04131.1260.3519.1117.899.596.413.904.353.03
Total Shareholders' Equity
14.3M9.91M17.21M12.22M18.39M13.65M9.8M6.01M7.4M6.95M
Common Stock
9.04K9.73K6.09K8.77K13.46K1.52K1.54K1.54K2.29K2.29K
Retained Earnings
-145.93M-153.23M-166.01M-176.9M-182.55M-189.1M-193.23M-197.19M-199.88M-200.33M
Treasury Stock
-5.28M-5.28M-5.28M-5.28M-5.28M-5.28M-5.28M-5.28M-5.28M-5.28M
Accumulated OCI
253.73K253.73K253.73K253.73K253.73K253.73K253.73K253.73K253.73K253.73K
Minority Interest
0000000000

XBIO Cash Flow Statement

Xenetic Biosciences, Inc. (XBIO) cash flow — operating, investing & free cash flow history

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Cash from Operations
1.49M-6.46M-6.4M-4.27M-4.74M-4.65M-4.11M-2.82M-2.29M-1.82M
Operating CF Margin %
19.7%--37497.97%-976.6%-408.21%-272.23%-161.98%-112.69%-76.83%-
Operating CF Growth %
117%-532.6%1%33.32%-11.03%1.93%11.46%31.52%18.84%93.96%
Net Income
-3.6M-7.3M-12.78M-10.89M-5.65M-6.55M-4.13M-3.96M-2.68M-2.23M
Depreciation & Amortization
23.78K15.83K27.49K28.84K35.48K27.04K0000
Stock-Based Compensation
1.92M1.42M853.52K468.91K410.44K511.48K283.08K171.81K64.79K29.68K
Deferred Taxes
000-2.92M-24.27K00000
Other Non-Cash Items
-126.32K-5.23K6.38M9.1M24.27K1.79M00027.17K
Working Capital Changes
3.27M-595.68K-881.52K-52.45K461.19K-426.69K-262.73K970.98K329.42K356.12K
Change in Receivables
3M000000000
Change in Inventory
8.18K000000000
Change in Payables
-8.18K-343.88K-227.96K-378.11K457.13K-347.95K-263.57K84.68K73.76K290.31K
Cash from Investing
-9.26K22.5K2K00-500K0000
Capital Expenditures
-9.26K0000-500K0000
CapEx % of Revenue
0.12%----29.29%0%--0%
Acquisitions
022.5K00000000
Investments
----------
Other Investing
022.5K2K0000000
Cash from Financing
1251.48M16.13M5.43M11.45M0004M4M
Debt Issued (Net)
0000000000
Equity Issued (Net)
0016.12M5.43M11.45M0004M4M
Dividends Paid
0000000000
Share Repurchases
0000000000
Other Financing
-1251.48M6.21K03.68K00000
Net Change in Cash
1.48M▲ 0%
-4.96M▼ 434.1%
9.73M▲ 296.1%
1.16M▼ 88.1%
6.72M▲ 479.2%
-5.15M▼ 176.6%
-4.11M▲ 20.1%
-2.82M▲ 31.5%
1.72M▲ 161.0%
2.18M▲ 0%
Free Cash Flow
1.48M▲ 0%
-6.46M▼ 535.3%
-6.4M▲ 1.0%
-4.27M▲ 33.3%
-4.74M▼ 11.0%
-5.15M▼ 8.6%
-4.11M▲ 20.1%
-2.82M▲ 31.5%
-2.29M▲ 18.8%
-1.82M▲ 0%
FCF Margin %
19.58%--37497.97%-976.6%-408.21%-301.52%-161.98%-112.69%-76.83%-57.09%
FCF Growth %
116.87%-535.3%1%33.32%-11.03%-8.63%20.06%31.52%18.84%31.54%
FCF per Share
20.56-85.50-22.43-6.68-4.61-3.62-2.69-1.83-1.34-0.79
FCF Conversion (FCF/Net Income)
-0.42x0.89x0.50x0.39x0.84x0.71x1.00x0.71x0.85x0.82x
Interest Paid
0080000000
Taxes Paid
0000000000

XBIO Key Ratios

Xenetic Biosciences, Inc. (XBIO) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric201720182019202020212022202320242025TTM
Return on Equity (ROE)
-23.6%-60.3%-94.19%-74.03%-36.88%-40.9%-35.27%-50.12%-40%-39.28%
Return on Invested Capital (ROIC)
-25.63%-60.27%-119.27%-274.51%-929.13%-1385.82%-497.16%-964.01%-520.76%
Gross Margin
97.94%-100%100%100%100%100%100%100%74.71%
Net Margin
-47.4%--74856.59%-2493.11%-486.36%-383.87%-162.78%-158.39%-90.07%-70.03%
Debt / Equity
--0.00x0.01x0.00x----0.00x
Interest Coverage
-1976.52x-301.53x--------
FCF Conversion
-0.42x0.89x0.50x0.39x0.84x0.71x1.00x0.71x0.85x0.82x
Revenue Growth
152.83%-100%-2460.31%165.64%47.06%48.8%-1.56%19.04%23.52%
Related:XBIO Dividend History·XBIO Revenue History·XBIO Price History·XBIO P/E History·XBIO Financial Ratios·XBIO Institutional Holders

XBIO SEC Filings & Documents

Xenetic Biosciences, Inc. (XBIO) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 13, 2026·SEC

Material company update

Apr 24, 2026·SEC

Material company update

Mar 13, 2026·SEC

10-K Annual Reports

4
FY 2026

Mar 12, 2026·SEC

FY 2025

Mar 18, 2025·SEC

FY 2024

Mar 21, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

May 12, 2026·SEC

FY 2025

Nov 12, 2025·SEC

FY 2025

Aug 12, 2025·SEC

XBIO Frequently Asked Questions

Xenetic Biosciences, Inc. (XBIO) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Xenetic Biosciences, Inc. (XBIO) reported $3.2M in revenue for fiscal year 2025. This represents a 987% increase from $0.3M in 2012.

Xenetic Biosciences, Inc. (XBIO) grew revenue by 19.0% over the past year. This is strong growth.

Xenetic Biosciences, Inc. (XBIO) reported a net loss of $2.2M for fiscal year 2025.

Dividend & Returns

Xenetic Biosciences, Inc. (XBIO) has a return on equity (ROE) of -40.0%. Negative ROE indicates the company is unprofitable.

Xenetic Biosciences, Inc. (XBIO) had negative free cash flow of $1.8M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in XBIO back in 2012?

Total return calculator · dividends reinvested · 14+ years of data

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How much would $100/month in XBIO be worth today?

Dollar cost averaging calculator · DCA vs lump sum

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