Comprehensive Stock Comparison
Compare Crinetics Pharmaceuticals, Inc. (CRNX) vs Regeneron Pharmaceuticals, Inc. (REGN) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Growth | CRNX | 421.7% revenue growth vs REGN's 1.0% |
| Quality / Margins | REGN | 31.4% net margin vs CRNX's -85.9% |
| Stability / Safety | REGN | Beta 0.58 vs CRNX's 1.05 |
| Dividends | REGN | 0.4% yield; 1-year raise streak; CRNX pays no meaningful dividend |
| Momentum (1Y) | CRNX | +14.9% vs REGN's +12.4% |
| Efficiency (ROA) | REGN | 11.1% ROA vs CRNX's -41.3%, ROIC 12.4% vs -37.8% |
Who Each Stock Is For
Income & stability
Growth exposure
Long-term compounding (10Y)
Sleep-well-at-night portfolio
Defensive / Recession hedge
Business Model
What each company does and how it makes money
Crinetics Pharmaceuticals is a clinical-stage biopharmaceutical company developing oral therapies for rare endocrine diseases and endocrine-related tumors. It currently generates no revenue from product sales—funding comes from equity offerings and collaborations—but aims to commercialize its lead candidate paltusotine for acromegaly pending regulatory approval. The company's moat lies in its specialized expertise in nonpeptide somatostatin receptor pharmacology and a pipeline targeting underserved endocrine disorders with high unmet medical need.
Regeneron Pharmaceuticals is a biotechnology company that discovers, develops, and commercializes innovative medicines for serious diseases. It generates revenue primarily from sales of its flagship products — EYLEA for eye diseases (~60% of revenue) and Dupixent for inflammatory conditions (~30%) — with additional income from collaborations and royalties. The company's competitive advantage lies in its proprietary VelocImmune technology platform for creating human antibodies and its deep expertise in genetic research, which enables rapid drug discovery and development.
Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
REGN leads in 4 of 6 categories (Financial Metrics, Valuation Metrics). CRNX leads in 1 (Total Returns).
Financial Metrics (TTM)
REGN is the larger business by revenue, generating $14.3B annually — 2646.3x CRNX's $5M. REGN is the more profitable business, keeping 31.4% of every revenue dollar as net income compared to CRNX's -85.9%.
| Metric | CRNXCrinetics Pharmac… | REGNRegeneron Pharmac… |
|---|---|---|
| RevenueTrailing 12 months | $5M | $14.3B |
| EBITDAEarnings before interest/tax | -$514M | $4.2B |
| Net IncomeAfter-tax profit | -$465M | $4.5B |
| Free Cash FlowCash after capex | -$384M | $3.2B |
| Gross MarginGross profit ÷ Revenue | +108.5% | +86.3% |
| Operating MarginEBIT ÷ Revenue | -95.3% | +25.7% |
| Net MarginNet income ÷ Revenue | -85.9% | +31.4% |
| FCF MarginFCF ÷ Revenue | -70.8% | +22.0% |
| Rev. Growth (YoY)Latest quarter vs prior year | — | +2.5% |
| EPS Growth (YoY)Latest quarter vs prior year | -47.7% | -2.5% |
Valuation Metrics
| Metric | CRNXCrinetics Pharmac… | REGNRegeneron Pharmac… |
|---|---|---|
| Market CapShares × price | $3.9B | $107.6B |
| Enterprise ValueMkt cap + debt − cash | $3.9B | $91.4B |
| Trailing P/EPrice ÷ TTM EPS | -8.30x | 18.84x |
| Forward P/EPrice ÷ next-FY EPS est. | — | 17.25x |
| PEG RatioP/E ÷ EPS growth rate | — | 2.98x |
| EV / EBITDAEnterprise value multiple | — | 21.64x |
| Price / SalesMarket cap ÷ Revenue | 724.75x | 7.50x |
| Price / BookPrice ÷ Book value/share | 3.90x | 2.72x |
| Price / FCFMarket cap ÷ FCF | — | 26.36x |
Profitability & Efficiency
REGN delivers a 14.4% return on equity — every $100 of shareholder capital generates $14 in annual profit, vs $-47 for CRNX. CRNX carries lower financial leverage with a 0.05x debt-to-equity ratio, signaling a more conservative balance sheet compared to REGN's 0.09x. On the Piotroski fundamental quality scale (0–9), REGN scores 7/9 vs CRNX's 2/9, reflecting strong financial health.
| Metric | CRNXCrinetics Pharmac… | REGNRegeneron Pharmac… |
|---|---|---|
| ROE (TTM)Return on equity | -46.9% | +14.4% |
| ROA (TTM)Return on assets | -41.3% | +11.1% |
| ROICReturn on invested capital | -37.8% | +12.4% |
| ROCEReturn on capital employed | -42.8% | +10.8% |
| Piotroski ScoreFundamental quality 0–9 | 2 | 7 |
| Debt / EquityFinancial leverage | 0.05x | 0.09x |
| Net DebtTotal debt minus cash | -$53M | -$16.2B |
| Cash & Equiv.Liquid assets | $102M | $18.9B |
| Total DebtShort + long-term debt | $49M | $2.7B |
| Interest CoverageEBIT ÷ Interest expense | — | 120.42x |
Total Returns (with DRIP)
A $10,000 investment in CRNX five years ago would be worth $26,195 today (with dividends reinvested), compared to $16,977 for REGN. Over the past 12 months, CRNX leads with a +14.9% total return vs REGN's +12.4%. The 3-year compound annual growth rate (CAGR) favors CRNX at 27.9% vs REGN's 1.1% — a key indicator of consistent wealth creation.
| Metric | CRNXCrinetics Pharmac… | REGNRegeneron Pharmac… |
|---|---|---|
| YTD ReturnYear-to-date | -12.0% | +0.8% |
| 1-Year ReturnPast 12 months | +14.9% | +12.4% |
| 3-Year ReturnCumulative with dividends | +109.3% | +3.4% |
| 5-Year ReturnCumulative with dividends | +162.0% | +69.8% |
| 10-Year ReturnCumulative with dividends | +67.7% | +104.7% |
| CAGR (3Y)Annualised 3-year return | +27.9% | +1.1% |
Risk & Volatility
REGN is the less volatile stock with a 0.58 beta — it tends to amplify market swings less than CRNX's 1.05 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. REGN currently trades 95.2% from its 52-week high vs CRNX's 70.9% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | CRNXCrinetics Pharmac… | REGNRegeneron Pharmac… |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 1.05x | 0.58x |
| 52-Week HighHighest price in past year | $57.99 | $821.11 |
| 52-Week LowLowest price in past year | $24.10 | $476.49 |
| % of 52W HighCurrent price vs 52-week peak | +70.9% | +95.2% |
| RSI (14)Momentum oscillator 0–100 | 39.0 | 49.1 |
| Avg Volume (50D)Average daily shares traded | 1.1M | 687K |
Analyst Outlook
Wall Street rates CRNX as "Buy" and REGN as "Buy". Consensus price targets imply 130.4% upside for CRNX (target: $95) vs 9.7% for REGN (target: $857). REGN is the only dividend payer here at 0.44% yield — a key consideration for income-focused portfolios.
| Metric | CRNXCrinetics Pharmac… | REGNRegeneron Pharmac… |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | Buy |
| Price TargetConsensus 12-month target | $94.71 | $857.17 |
| # AnalystsCovering analysts | 18 | 48 |
| Dividend YieldAnnual dividend ÷ price | — | +0.4% |
| Dividend StreakConsecutive years of raises | — | 1 |
| Dividend / ShareAnnual DPS | — | $3.41 |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | +3.2% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Mar 20 | Feb 26 | Change |
|---|---|---|---|
| Crinetics Pharmaceu… (CRNX) | 100 | 239.21 | +139.2% |
| Regeneron Pharmaceu… (REGN) | 100 | 162.46 | +62.5% |
Crinetics Pharmaceu… (CRNX) returned +162% over 5 years vs Regeneron Pharmaceu… (REGN)'s +70%. A $10,000 investment in CRNX 5 years ago would be worth $26,195 today (including dividends reinvested).
Chart 2Revenue Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Crinetics Pharmaceu… (CRNX) | $589000.00 | $5M | +820.2% |
| Regeneron Pharmaceu… (REGN) | $4.9B | $14.3B | +195.1% |
Crinetics Pharmaceuticals, Inc.'s revenue grew from $1M (2016) to $5M (2025) — a 28.0% CAGR. Regeneron Pharmaceuticals, Inc.'s revenue grew from $4.9B (2016) to $14.3B (2025) — a 12.8% CAGR.
Chart 3Net Margin Trend — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Crinetics Pharmaceu… (CRNX) | -10.2% | -85.9% | -740.1% |
| Regeneron Pharmaceu… (REGN) | 18.4% | 31.4% | +70.5% |
Crinetics Pharmaceuticals, Inc.'s net margin went from -10% (2016) to -86% (2025). Regeneron Pharmaceuticals, Inc.'s net margin went from 18% (2016) to 31% (2025).
Chart 4P/E Ratio History — 9 Years
| Stock | 2017 | 2025 | Change |
|---|---|---|---|
| Regeneron Pharmaceu… (REGN) | 36.4 | 18.6 | -48.9% |
Regeneron Pharmaceuticals, Inc. has traded in a 9x–36x P/E range over 9 years; current trailing P/E is ~19x.
Chart 5EPS Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Crinetics Pharmaceu… (CRNX) | -0.43 | -4.95 | -1051.2% |
| Regeneron Pharmaceu… (REGN) | 7.7 | 41.48 | +438.7% |
Crinetics Pharmaceuticals, Inc.'s EPS grew from $-0.43 (2016) to $-4.95 (2025). Regeneron Pharmaceuticals, Inc.'s EPS grew from $7.70 (2016) to $41.48 (2025) — a 21% CAGR.
Chart 6Free Cash Flow — 5 Years
Crinetics Pharmaceuticals, Inc. generated $-384M FCF in 2025 (-331% vs 2021). Regeneron Pharmaceuticals, Inc. generated $4B FCF in 2025 (-38% vs 2021).
CRNX vs REGN: Frequently Asked Questions
8 questions · data-driven answers · updated daily
01Is CRNX or REGN a better buy right now?
Regeneron Pharmaceuticals, Inc. (REGN) offers the better valuation at 18.8x trailing P/E (17.3x forward), making it the more compelling value choice. Analysts rate Crinetics Pharmaceuticals, Inc. (CRNX) a "Buy" — based on 18 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — CRNX or REGN?
Over the past 5 years, Crinetics Pharmaceuticals, Inc. (CRNX) delivered a total return of +162.0%, compared to +69.8% for Regeneron Pharmaceuticals, Inc. (REGN). A $10,000 investment in CRNX five years ago would be worth approximately $26K today (assuming dividends reinvested). Over 10 years, the gap is even starker: REGN returned +104.7% versus CRNX's +67.7%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — CRNX or REGN?
By beta (market sensitivity over 5 years), Regeneron Pharmaceuticals, Inc. (REGN) is the lower-risk stock at 0.58β versus Crinetics Pharmaceuticals, Inc.'s 1.05β — meaning CRNX is approximately 81% more volatile than REGN relative to the S&P 500. On balance sheet safety, Crinetics Pharmaceuticals, Inc. (CRNX) carries a lower debt/equity ratio of 5% versus 9% for Regeneron Pharmaceuticals, Inc. — giving it more financial flexibility in a downturn.
04Which has better profit margins — CRNX or REGN?
Regeneron Pharmaceuticals, Inc. (REGN) is the more profitable company, earning 31.4% net margin versus -85.9% for Crinetics Pharmaceuticals, Inc. — meaning it keeps 31.4% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: REGN leads at 25.7% versus -95.3% for CRNX. At the gross margin level — before operating expenses — REGN leads at 86.3%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
05Is CRNX or REGN more undervalued right now?
Analyst consensus price targets imply the most upside for CRNX: 130.4% to $94.71.
06Which pays a better dividend — CRNX or REGN?
In this comparison, REGN (0.4% yield) pays a dividend. CRNX does not pay a meaningful dividend and should not be held primarily for income.
07Is CRNX or REGN better for a retirement portfolio?
For long-horizon retirement investors, Regeneron Pharmaceuticals, Inc. (REGN) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.58), +104.7% 10Y return). Both have compounded well over 10 years (REGN: +104.7%, CRNX: +67.7%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
08What are the main differences between CRNX and REGN?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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