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CRNXCrinetics Pharmaceuticals, Inc.
$35.38$3.7B
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CRNX logoCrinetics Pharmaceuticals, Inc.(CRNX)Earnings, Financials & Key Ratios

CRNX•NASDAQ
Price updated Jun 19, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryCommercial Rare Disease Biopharma
AboutCrinetics Pharmaceuticals, Inc., a clinical stage pharmaceutical company, focuses on the discovery, development, and commercialization of therapeutics for rare endocrine diseases and endocrine-related tumors. Its lead product candidate is Paltusotine, an oral selective nonpeptide somatostatin receptor type 2 agonist that has completed phase III clinical trial for the treatment of acromegaly, as well as completed phase II clinical trial to treat carcinoid syndrome and nonfunctional neuroendocrine tumors (NETs). The company is also developing CRN04777, an oral selective nonpeptide somatostatin type 5 receptor agonist, which is in phase I clinical trial for the treatment of congenital hyperinsulinism; and CRN04894, an oral adrenocorticotrophic hormone antagonist that is in phase I clinical trial for the treatment of Cushing's and congenital adrenal hyperplasia diseases. Crinetics Pharmaceuticals, Inc. was incorporated in 2008 and is headquartered in San Diego, California.Show more
  • Revenue$8M+640.7%
  • EBITDA-$513M-52.6%
  • Net Income-$465M-55.9%
  • EPS (Diluted)-4.95-34.1%
  • Gross Margin86.02%-14.0%
  • EBITDA Margin-6664.23%+79.4%
  • Operating Margin-6714.77%+79.4%
  • Net Margin-6046.22%+78.9%
  • ROE-40.17%-25.4%

CRNX Key Insights

Crinetics Pharmaceuticals, Inc. (CRNX) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Company is almost debt free
  • ✓Strong 5Y sales CAGR of 155.3%

✗Weaknesses

  • ✗Profits declining 44.5% over 5 years
  • ✗Weak Piotroski F-Score: 2/9
  • ✗Negative free cash flow
  • ✗Shares diluted 16.4% in last year
  • ✗Trading more than 30% below 52-week high
  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

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CRNX Price & Volume

Crinetics Pharmaceuticals, Inc. (CRNX) stock price & volume — 10-year historical chart

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CRNX Growth Metrics

Crinetics Pharmaceuticals, Inc. (CRNX) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years155.27%
3 Years17.56%
TTM2277.5%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-51.22%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM-34.55%

Return on Capital

10 Years-46.05%
5 Years-43.8%
3 Years-41.9%
Last Year-42.61%

CRNX Recent Earnings

Crinetics Pharmaceuticals, Inc. (CRNX) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 2/12 qtrs (17%)●Beat Revenue 7/12 qtrs (78%)
Q2 2026Latest
May 7, 2026
Metric
Actual
Est
EPS
$1.23-0.8%
$1.22
Rev
$11M+26.1%
$9M
Q1 2026
Feb 26, 2026
Metric
Actual
Est
EPS
$1.29+5.8%
$1.37
Rev
$6M+37.2%
$4M
Q4 2025
Nov 6, 2025
Metric
Actual
Est
EPS
$1.38-8.7%
$1.27
Rev
$143,000-96.7%
$4M
Q3 2025
Aug 7, 2025
Metric
Actual
Est
EPS
$1.23-8.8%
$1.13
Rev
$1M+161.7%
$394,000
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 7, 2026
$1.23vs $1.22-0.8%
$11Mvs $9M+26.1%
Q1 2026Feb 26, 2026
$1.29vs $1.37+5.8%
$6Mvs $4M+37.2%
Q4 2025Nov 6, 2025
$1.38vs $1.27-8.7%
$143,000vs $4M-96.7%
Q3 2025Aug 7, 2025
$1.23vs $1.13-8.8%
$1Mvs $394,000+161.7%
Based on last 12 quarters of dataView full earnings history →

CRNX Peer Comparison

Crinetics Pharmaceuticals, Inc. (CRNX) competitors in Commercial Rare Disease Biopharma — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
Institutional Holdings
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
RCUS logoRCUSArcus Biosciences, Inc.Direct Competitor2.45B24.31-7.39-4.26%-156.36%-68.97%0.16
CHRS logoCHRSCoherus Oncology, Inc.Direct Competitor181.17M1.48-1.02-84.2%-323.49%-174.71%0.66
ACVA logoACVAACV Auctions Inc.Direct Competitor1.13B6.48-16.6219.22%-7.97%-14.27%0.44
ACAD logoACADACADIA Pharmaceuticals Inc.Direct Competitor3.7B21.629.4411.87%34.3%35.65%0.04
NVAX logoNVAXNovavax, Inc.Product Competitor1.5B9.133.5964.69%-14.73%
ESPR logoESPREsperion Therapeutics, Inc.Product Competitor654.91M3.15-28.6421.31%-1.77%
XNCR logoXNCRXencor, Inc.Product Competitor927M12.64-10.1913.65%-185.71%-28.77%0.30
PTCT logoPTCTPTC Therapeutics, Inc.Product Competitor6.55B78.9810.15114.51%-22.58%

Compare CRNX vs Peers

Crinetics Pharmaceuticals, Inc. (CRNX) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs RCUS

Most directly comparable listed peer for CRNX.

Scale Benchmark

vs NVS

Larger-name benchmark to compare CRNX against a more recognizable public peer.

Peer Set

Compare Top 5

vs RCUS, CHRS, ACVA, ACAD

CRNX Income Statement

Crinetics Pharmaceuticals, Inc. (CRNX) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Sales/Revenue
2.04M2.43M1.19M71K1.08M4.74M4.01M1.04M7.7M18.07M
Revenue Growth %
247.2%18.73%-50.86%-94.05%1418.31%339.42%-15.28%-74.11%640.71%2277.5%
Cost of Goods Sold
9.23M24.48M1.11M57M00001.08M200K
COGS % of Revenue
451.49%1008.2%93.29%80278.87%----13.98%-
Gross Profit
-7.19M▲ 0%
-22.05M▼ 206.8%
80K▲ 100.4%
-56.93M▼ 71258.8%
1.08M▲ 101.9%
4.74M▲ 339.4%
4.01M▼ 15.3%
1.04M▼ 74.1%
6.62M▲ 537.2%
17.87M▲ 0%
Gross Margin %
-351.49%-908.2%6.71%-80178.87%100%100%100%100%86.02%98.89%
Gross Profit Growth %
-59.34%-206.78%100.36%-71258.75%101.89%339.42%-15.28%-74.11%537.15%-
Operating Expenses
9.13M28.71M53.83M18.03M108.78M172.62M226.62M339.89M523.39M563.61M
OpEx % of Revenue
446.31%1182.45%4512.32%25388.73%10090.91%3644.06%5647.17%32713.47%6800.79%-
Selling, General & Admin
1.94M6.66M13.52M18.03M24.52M42.39M58.09M99.74M191.33M206.64M
SG&A % of Revenue
94.82%274.26%1133.19%25388.73%2275.05%894.95%1447.65%9599.33%2486.11%-
Research & Development
9.23M24.48M41.51M57.6M84.25M130.22M168.53M240.16M332.06M355.9M
R&D % of Revenue
451.49%1008.2%3479.13%81123.94%7815.86%2749.1%4199.53%23114.15%4314.68%-
Other Operating Expenses
-48K1.59M-1.19M-57.6M000001000K
Operating Income
-9.13M▲ 0%
-28.71M▼ 214.6%
-53.83M▼ 87.5%
-74.95M▼ 39.2%
-107.7M▼ 43.7%
-167.88M▼ 55.9%
-222.61M▼ 32.6%
-338.85M▼ 52.2%
-516.77M▼ 52.5%
-545.74M▲ 0%
Operating Margin %
-446.31%-1182.45%-4512.32%-105567.61%-9990.91%-3544.06%-5547.17%-32613.47%-6714.77%-3020.32%
Operating Income Growth %
-51.01%-214.56%-87.5%-39.23%-43.69%-55.88%-32.6%-52.22%-52.5%-
EBITDA
-9M-28.24M-52.72M-74M-106.78M-166.9M-221.51M-336.07M-512.88M-541.62M
EBITDA Margin %
-440.05%-1163.06%-4419.03%-104232.39%-9905.38%-3523.31%-5519.81%-32345.43%-6664.23%-2997.49%
EBITDA Growth %
-51.19%-213.8%-86.69%-40.38%-44.29%-56.3%-32.72%-51.72%-52.61%-45.01%
D&A (Non-Cash Add-back)
128K471K1.11M948K922K983K1.1M2.79M3.89M4.13M
EBIT
-9.15M-27.11M-53.83M-74.95M-107.7M-167.88M-222.61M-338.85M-516.77M-545.74M
Net Interest Income
18K03.46M991K157K4.32M13.44M41.44M51.99M49.82M
Interest Income
26K1.75M3.46M991K157K4.32M13.44M41.44M51.99M49.82M
Interest Expense
8K000000000
Other Income/Expense
-30K1.59M3.41M1.14M61K3.96M8.08M40.45M51.63M49.53M
Pretax Income
-9.16M▲ 0%
-27.11M▼ 196.1%
-50.42M▼ 86.0%
-73.81M▼ 46.4%
-107.64M▼ 45.8%
-163.92M▼ 52.3%
-214.53M▼ 30.9%
-298.41M▼ 39.1%
-465.14M▼ 55.9%
-496.21M▲ 0%
Pretax Margin %
-447.78%-1116.76%-4226.49%-103960.56%-9985.25%-3460.38%-5345.85%-28720.69%-6043.88%-2746.18%
Income Tax
-40K0000000180K180K
Effective Tax Rate %
0.44%0%0%0%0%0%0%0%-0.04%-0.04%
Net Income
-9.16M▲ 0%
-27.11M▼ 196.1%
-49.53M▼ 82.7%
-73.81M▼ 49.0%
-107.64M▼ 45.8%
-163.92M▼ 52.3%
-214.53M▼ 30.9%
-298.41M▼ 39.1%
-465.32M▼ 55.9%
-496.39M▲ 0%
Net Margin %
-447.78%-1116.76%-4152.14%-103960.56%-9985.25%-3460.38%-5345.85%-28720.69%-6046.22%-2747.18%
Net Income Growth %
-52.13%-196.11%-82.68%-49.01%-45.83%-52.28%-30.88%-39.1%-55.93%-51.22%
Net Income (Continuing)
-9.16M-27.11M-50.42M-73.81M-107.64M-163.92M-214.53M-298.41M-465.32M-496.39M
Discontinued Operations
0000000000
Minority Interest
0000000000
EPS (Diluted)
-0.66▲ 0%
-2.23▼ 237.9%
-2.05▲ 8.1%
-2.42▼ 18.0%
-2.80▼ 15.7%
-3.15▼ 12.5%
-3.69▼ 17.1%
-3.69▲ 0.0%
-4.95▼ 34.1%
-4.77▲ 0%
EPS Growth %
-53.49%-237.88%8.07%-18.05%-15.7%-12.5%-17.14%0%-34.15%-34.55%
EPS (Basic)
-0.66-2.23-2.05-2.42-2.80-3.15-3.69-3.69-4.95-
Diluted Shares Outstanding
13.88M12.14M24.18M30.45M38.44M51.98M58.07M80.78M94.06M104.1M
Basic Shares Outstanding
13.88M12.14M24.18M30.45M38.44M51.98M58.07M80.78M94.06M104.1M
Dividend Payout Ratio
----------

CRNX Balance Sheet

Crinetics Pharmaceuticals, Inc. (CRNX) balance sheet — assets, liabilities & shareholders' equity

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Total Current Assets
15.16M166.68M123.34M177.49M344.72M345.18M574.15M1.38B1.05B1.32B
Cash & Short-Term Investments
14.19M163.88M118.39M170.88M333.71M334.43M558.55M1.35B1.03B1.29B
Cash Only
14.19M44.97M40.33M93.09M200.69M32.67M54.9M264.55M101.54M114.34M
Short-Term Investments
0118.9M78.07M77.79M133.01M301.75M503.66M1.09B926.35M1.18B
Accounts Receivable
734K01.38M1.83M2.03M2.42M9.35M8.47M592K5.68M
Days Sales Outstanding
131.01-421.69.42K687186.85850.512.98K28.0831.69
Inventory
141K00000002.02M3.06M
Days Inventory Outstanding
5.57-------685.92.32K
Other Current Assets
001.09M1.02M02.54M1.58M1.71M17.84M22.36M
Total Non-Current Assets
433K4.73M7.04M5.95M6.29M6.99M61.2M59.2M87.15M78.91M
Property, Plant & Equipment
400K4.23M6.46M5.41M4.72M4.99M57.43M55.58M54.79M53.29M
Fixed Asset Turnover
5.11x0.57x0.18x0.01x0.23x0.95x0.07x0.02x0.14x0.33x
Goodwill
0000000000
Intangible Assets
0000000000
Long-Term Investments
0500K500K01.01M1.97M1.77M800K800K2.4M
Other Non-Current Assets
33K082K540K568K37K2M2.83M22.33M24.82M
Total Assets
15.6M▲ 0%
171.41M▲ 999.0%
130.38M▼ 23.9%
183.44M▲ 40.7%
351.01M▲ 91.3%
352.18M▲ 0.3%
635.35M▲ 80.4%
1.43B▲ 125.8%
1.14B▼ 20.8%
1.4B▲ 0%
Asset Turnover
0.13x0.01x0.01x0.00x0.00x0.01x0.01x0.00x0.01x0.01x
Asset Growth %
23.8%998.95%-23.94%40.7%91.35%0.33%80.41%125.79%-20.85%47.53%
Total Current Liabilities
897K7.92M8.34M10.49M15.99M27.72M43.94M59.68M85.07M71.09M
Accounts Payable
403K1.46M2.7M3.49M3.42M6.88M6.55M5.85M22.61M12.88M
Days Payables Outstanding
15.9321.71884.7922.34----7.67K24.15K
Short-Term Debt
00724K001.05M4.17M06.49M6.54M
Deferred Revenue (Current)
000002.24M2.06M2.18M1.24M4.41M
Other Current Liabilities
0590K2.8M4.9M7.53M8.47M16.65M10K19.16M24.61M
Current Ratio
16.91x21.03x14.79x16.92x21.55x12.45x13.07x23.04x12.32x18.60x
Quick Ratio
16.75x21.03x14.79x16.92x21.55x12.45x13.07x23.04x12.30x18.56x
Cash Conversion Cycle
120.65--------6.96K-21.79K
Total Non-Current Liabilities
29.72M3.27M4.9M4.04M3.08M8.13M52.3M50.1M58.34M49.59M
Long-Term Debt
0000000000
Capital Lease Obligations
004.85M4.01M3.07M2.02M47.55M44.57M42.05M169.4M
Deferred Tax Liabilities
000000009.24M9.24M
Other Non-Current Liabilities
29.72M3.27M49K23K2K00829K3.24M4.93M
Total Liabilities
30.62M11.19M13.24M14.53M19.07M35.85M96.25M109.79M143.41M120.68M
Total Debt
005.57M4.01M3.07M3.08M51.73M51.72M48.54M47.85M
Net Debt
-14.19M-44.97M-34.75M-89.07M-197.62M-29.6M-3.17M-212.82M-52.99M-66.49M
Debt / Equity
--0.05x0.02x0.01x0.01x0.10x0.04x0.05x0.04x
Debt / EBITDA
----------0.09x
Net Debt / EBITDA
---------0.12x
Interest Coverage
-1143.63x---------
Total Equity
-15.02M▲ 0%
-43.38M▼ 188.8%
117.14M▲ 370.0%
168.92M▲ 44.2%
331.94M▲ 96.5%
316.33M▼ 4.7%
539.11M▲ 70.4%
1.32B▲ 145.7%
992.08M▼ 25.1%
1.28B▲ 0%
Equity Growth %
-142.13%-188.78%370.03%44.2%96.51%-4.7%70.43%145.74%-25.11%46.74%
Book Value per Share
-1.08-3.574.855.558.646.099.2816.4010.5512.30
Total Shareholders' Equity
-15.02M-43.38M117.14M168.92M331.94M316.33M539.11M1.32B992.08M1.28B
Common Stock
1K24K210.79M336.51M607.58M759.43M1.19B2.28B2.41B2.83B
Retained Earnings
-16.27M-43.38M-93.8M-167.61M-275.25M-439.17M-653.7M-952.11M-1.42B-1.55B
Treasury Stock
0-374.94M00000000
Accumulated OCI
-304K61K148K25K-382K-3.93M977K963K1.75M-2.29M
Minority Interest
0000000000

CRNX Cash Flow Statement

Crinetics Pharmaceuticals, Inc. (CRNX) cash flow — operating, investing & free cash flow history

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Cash from Operations
-9.48M-19.46M-46.38M-62.03M-88.59M-115.2M-166.31M-225.97M-377.92M-414.17M
Operating CF Margin %
-463.52%-801.44%-3887.76%-87361.97%-8217.81%-2432.02%-4144.21%-21748.8%-4910.63%-
Operating CF Growth %
-73.35%-105.29%-138.35%-33.73%-42.82%-30.05%-44.36%-35.88%-67.24%-246.94%
Net Income
-9.16M-27.11M-50.42M-73.81M-107.64M-163.92M-214.53M-298.41M-465.32M-496.39M
Depreciation & Amortization
128K471K887K948K922K983K1.1M2.79M3.89M4.13M
Stock-Based Compensation
271K2.32M6.29M10.43M17.35M28.27M40.94M69.39M91.02M100.23M
Deferred Taxes
00-1.23M-227K422K00000
Other Non-Cash Items
480K-433K222K261K-739K850K-1.86M-11.37M-12.36M-10.31M
Working Capital Changes
-721K5.3M-2.13M376K1.1M18.61M8.04M11.63M4.84M-11.82M
Change in Receivables
0002.72M6.29M10.99M14.65M17.54M-592K-5.09M
Change in Inventory
000-2.72M-6.29M000-2.02M-909K
Change in Payables
47K7.36M696K2.72M6.29M00028.98M18.27M
Cash from Investing
-304K-119.46M41.67M217K-56.48M-173.98M-200.41M-574.82M173.91M7.51M
Capital Expenditures
-304K-1.06M-492K-186K-436K-1.66M-4.69M-3.84M-5.76M-5.34M
CapEx % of Revenue
14.87%43.62%41.24%261.97%40.45%34.96%116.82%369.97%74.87%29.57%
Acquisitions
00-1.23M-227K422K00000
Investments
----------
Other Investing
0-118.4M1.23M227K-422K00015.43M578K
Cash from Financing
11.82M170.2M67K114.57M252.68M121.96M388.94M1.01B40.61M426.05M
Debt Issued (Net)
-212K000000000
Equity Issued (Net)
11.97M169.75M-59K114.28M249.54M117.24M369.02M970.05M40.61M426.05M
Dividends Paid
0000000000
Share Repurchases
00-59K0000000
Other Financing
66K451K126K288K3.14M4.72M19.93M40.39M00
Net Change in Cash
2.04M▲ 0%
31.28M▲ 1433.4%
-4.65M▼ 114.9%
52.76M▲ 1235.4%
107.61M▲ 104.0%
-167.22M▼ 255.4%
22.22M▲ 113.3%
209.65M▲ 843.3%
-163.51M▼ 178.0%
19.27M▲ 0%
Free Cash Flow
-9.78M▲ 0%
-20.52M▼ 109.7%
-46.87M▼ 128.4%
-62.21M▼ 32.7%
-89.02M▼ 43.1%
-116.86M▼ 31.3%
-171M▼ 46.3%
-229.81M▼ 34.4%
-383.68M▼ 67.0%
-419.52M▲ 0%
FCF Margin %
-478.39%-845.06%-3929%-87623.94%-8258.26%-2466.98%-4261.03%-22118.77%-4985.5%-2321.74%
FCF Growth %
-72.91%-109.73%-128.45%-32.73%-43.1%-31.27%-46.32%-34.4%-66.95%-58.12%
FCF per Share
-0.70-1.69-1.94-2.04-2.32-2.25-2.94-2.84-4.08-4.03
FCF Conversion (FCF/Net Income)
1.04x0.72x0.94x0.84x0.82x0.70x0.78x0.76x0.81x0.85x
Interest Paid
0000000000
Taxes Paid
0000000000

CRNX Key Ratios

Crinetics Pharmaceuticals, Inc. (CRNX) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric201720182019202020212022202320242025TTM
Return on Equity (ROE)
---134.32%-51.61%-42.98%-50.57%-50.16%-32.02%-40.17%-43.96%
Return on Invested Capital (ROIC)
----69.3%-75.43%-59.81%-40.59%-30.84%-37.79%-37.8%
Gross Margin
-351.49%-908.2%6.71%-80178.87%100%100%100%100%86.02%98.89%
Net Margin
-447.78%-1116.76%-4152.14%-103960.56%-9985.25%-3460.38%-5345.85%-28720.69%-6046.22%-2747.18%
Debt / Equity
--0.05x0.02x0.01x0.01x0.10x0.04x0.05x0.04x
Interest Coverage
-1143.63x---------
FCF Conversion
1.04x0.72x0.94x0.84x0.82x0.70x0.78x0.76x0.81x0.85x
Revenue Growth
247.2%18.73%-50.86%-94.05%1418.31%339.42%-15.28%-74.11%640.71%2277.5%
Related:CRNX Dividend History·CRNX Revenue History·CRNX Price History·CRNX P/E History·CRNX Financial Ratios·CRNX Institutional Holders

CRNX SEC Filings & Documents

Crinetics Pharmaceuticals, Inc. (CRNX) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 7, 2026·SEC

Material company update

Apr 10, 2026·SEC

Material company update

Mar 23, 2026·SEC

10-K Annual Reports

2
FY 2026

Feb 26, 2026·SEC

FY 2025

Feb 27, 2025·SEC

10-Q Quarterly Reports

6
FY 2026

May 7, 2026·SEC

FY 2025

Nov 6, 2025·SEC

FY 2025

Aug 7, 2025·SEC

CRNX Frequently Asked Questions

Crinetics Pharmaceuticals, Inc. (CRNX) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Crinetics Pharmaceuticals, Inc. (CRNX) reported $18.1M in revenue for fiscal year 2025. This represents a 2968% increase from $0.6M in 2016.

Crinetics Pharmaceuticals, Inc. (CRNX) grew revenue by 640.7% over the past year. This is strong growth.

Crinetics Pharmaceuticals, Inc. (CRNX) reported a net loss of $496.4M for fiscal year 2025.

Dividend & Returns

Crinetics Pharmaceuticals, Inc. (CRNX) has a return on equity (ROE) of -40.2%. Negative ROE indicates the company is unprofitable.

Crinetics Pharmaceuticals, Inc. (CRNX) had negative free cash flow of $419.5M in fiscal year 2025, likely due to heavy capital investments.

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