Comprehensive Stock Comparison
Compare Cardio Diagnostics Holdings, Inc. (CDIO) vs Nautilus Biotechnology, Inc. (NAUT) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Stability / Safety |  NAUT | Beta 1.71 vs CDIO's 2.02 |
| Dividends | Tie | Neither pays a meaningful dividend |
| Momentum (1Y) | NAUT | +118.3% vs CDIO's -62.1% |
| Efficiency (ROA) | NAUT | -31.3% ROA vs CDIO's -74.5% |
Who Each Stock Is For
Income & stability
NAUTbeta 1.71
Growth exposure
CDIORev growth 104.5%, EPS growth 53.0%, 3Y rev CAGR 238.3%
Long-term compounding (10Y)
NAUT-74.9% 10Y total return vs CDIO's -98.2%
Sleep-well-at-night portfolio
CDIOLower volatility, beta 2.02, Low D/E 10.1%, current ratio 13.92x
Defensive / Recession hedge
NAUTBeta 1.71, current ratio 13.33x
Business Model
What each company does and how it makes money
Cardio Diagnostics develops and commercializes epigenetics-based clinical tests for cardiovascular disease risk assessment. It generates revenue primarily from sales of its Epi+Gen CHD test—a three-year symptomatic coronary heart disease risk assessment—to healthcare providers and through laboratory services. The company's moat lies in its proprietary epigenetic technology platform that offers more personalized cardiovascular risk prediction than traditional methods.
Nautilus Biotechnology is a life sciences company developing a proteomics platform to analyze proteins at unprecedented scale and depth. It aims to generate revenue through sales of its integrated platform — including instruments, consumables, and software — though it remains pre-revenue as it develops its technology. The company's potential moat lies in its proprietary single-molecule protein analysis technology, which could enable comprehensive proteome mapping that existing methods cannot achieve.
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
NAUT 4CDIO 1NAUT1/1 metricsNAUT2/2 metricsCDIO4/6 metricsNAUT5/6 metricsNAUT2/2 metricsNAUT leads in 4 of 6 categories (Financial Metrics, Valuation Metrics). CDIO leads in 1 (Profitability & Efficiency).
Financial Metrics (TTM)
CDIO and NAUT operate at a comparable scale, with $15,782 and $0 in trailing revenue.
| Metric | CDIOCardio Diagnostic… | NAUTNautilus Biotechn… |
|---|---|---|
| RevenueTrailing 12 months | $15,782 | $0 |
| EBITDAEarnings before interest/tax | -$6M | -$60M |
| Net IncomeAfter-tax profit | -$7M | -$63M |
| Free Cash FlowCash after capex | -$6M | -$54M |
| Gross MarginGross profit ÷ Revenue | -10.3% | — |
| Operating MarginEBIT ÷ Revenue | -414.2% | — |
| Net MarginNet income ÷ Revenue | -415.2% | — |
| FCF MarginFCF ÷ Revenue | -379.5% | — |
| Rev. Growth (YoY)Latest quarter vs prior year | -56.6% | — |
| EPS Growth (YoY)Latest quarter vs prior year | -15.3% | +15.4% |
Valuation Metrics
| Metric | CDIOCardio Diagnostic… | NAUTNautilus Biotechn… |
|---|---|---|
| Market CapShares × price | $9M | $331M |
| Enterprise ValueMkt cap + debt − cash | $2M | $349M |
| Trailing P/EPrice ÷ TTM EPS | -0.57x | -5.57x |
| Forward P/EPrice ÷ next-FY EPS est. | — | — |
| PEG RatioP/E ÷ EPS growth rate | — | — |
| EV / EBITDAEnterprise value multiple | — | — |
| Price / SalesMarket cap ÷ Revenue | 266.33x | — |
| Price / BookPrice ÷ Book value/share | 14.80x | 2.11x |
| Price / FCFMarket cap ÷ FCF | — | — |
Profitability & Efficiency
NAUT delivers a -37.1% return on equity — every $100 of shareholder capital generates $-37 in annual profit, vs $-80 for CDIO. CDIO carries lower financial leverage with a 0.10x debt-to-equity ratio, signaling a more conservative balance sheet compared to NAUT's 0.19x. On the Piotroski fundamental quality scale (0–9), CDIO scores 4/9 vs NAUT's 1/9, reflecting mixed financial health.
| Metric | CDIOCardio Diagnostic… | NAUTNautilus Biotechn… |
|---|---|---|
| ROE (TTM)Return on equity | -80.4% | -37.1% |
| ROA (TTM)Return on assets | -74.5% | -31.3% |
| ROICReturn on invested capital | -2.2% | — |
| ROCEReturn on capital employed | -123.0% | — |
| Piotroski ScoreFundamental quality 0–9 | 4 | 1 |
| Debt / EquityFinancial leverage | 0.10x | 0.19x |
| Net DebtTotal debt minus cash | -$7M | $18M |
| Cash & Equiv.Liquid assets | $8M | $12M |
| Total DebtShort + long-term debt | $969,863 | $30M |
| Interest CoverageEBIT ÷ Interest expense | -418.04x | — |
Total Returns (with DRIP)
A $10,000 investment in NAUT five years ago would be worth $1,808 today (with dividends reinvested), compared to $179 for CDIO. Over the past 12 months, NAUT leads with a +118.3% total return vs CDIO's -62.1%. The 3-year compound annual growth rate (CAGR) favors NAUT at 6.8% vs CDIO's -68.0% — a key indicator of consistent wealth creation.
| Metric | CDIOCardio Diagnostic… | NAUTNautilus Biotechn… |
|---|---|---|
| YTD ReturnYear-to-date | +85.2% | +37.2% |
| 1-Year ReturnPast 12 months | -62.1% | +118.3% |
| 3-Year ReturnCumulative with dividends | -96.7% | +21.9% |
| 5-Year ReturnCumulative with dividends | -98.2% | -81.9% |
| 10-Year ReturnCumulative with dividends | -98.2% | -74.9% |
| CAGR (3Y)Annualised 3-year return | -68.0% | +6.8% |
Risk & Volatility
NAUT is the less volatile stock with a 1.71 beta — it tends to amplify market swings less than CDIO's 2.02 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. NAUT currently trades 85.1% from its 52-week high vs CDIO's 30.2% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | CDIOCardio Diagnostic… | NAUTNautilus Biotechn… |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 2.02x | 1.71x |
| 52-Week HighHighest price in past year | $17.39 | $3.08 |
| 52-Week LowLowest price in past year | $0.97 | $0.62 |
| % of 52W HighCurrent price vs 52-week peak | +30.2% | +85.1% |
| RSI (14)Momentum oscillator 0–100 | — | — |
| Avg Volume (50D)Average daily shares traded | 2.1M | 161K |
Analyst Outlook
| Metric | CDIOCardio Diagnostic… | NAUTNautilus Biotechn… |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | — | Buy |
| Price TargetConsensus 12-month target | — | $2.50 |
| # AnalystsCovering analysts | — | 5 |
| Dividend YieldAnnual dividend ÷ price | — | — |
| Dividend StreakConsecutive years of raises | — | — |
| Dividend / ShareAnnual DPS | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | +0.0% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Jan 22 | Mar 26 | Change |
|---|---|---|---|
| Cardio Diagnostics … (CDIO) | 100 | 1.77 | -98.2% |
| Nautilus Biotechnol… (NAUT) | 100 | 48.79 | -51.2% |
Nautilus Biotechnol… (NAUT) returned -82% over 5 years vs Cardio Diagnostics … (CDIO)'s -98%.
Chart 2Revenue Growth — 10 Years
| Stock | 2018 | 2025 | Change |
|---|---|---|---|
| Cardio Diagnostics … (CDIO) | $0.00 | $34890.00 | — |
| Nautilus Biotechnol… (NAUT) | $0.00 | $0.00 | — |
Nautilus Biotechnology, Inc.'s revenue grew from $0M (2018) to $0M (2025) — a 0.0% CAGR.
Chart 3EPS Growth — 10 Years
| Stock | 2018 | 2025 | Change |
|---|---|---|---|
| Cardio Diagnostics … (CDIO) | -0.06 | -9.3 | -14522.6% |
| Nautilus Biotechnol… (NAUT) | 87.18 | -0.47 | -100.5% |
Nautilus Biotechnology, Inc.'s EPS grew from $87.18 (2018) to $-0.47 (2025) — a NaN% CAGR.
Chart 4Free Cash Flow — 5 Years
Cardio Diagnostics Holdings, Inc. generated $-5M FCF in 2024 (-672% vs 2021). Nautilus Biotechnology, Inc. generated $-52M FCF in 2025 (-25% vs 2021).
CDIO vs NAUT: Frequently Asked Questions
7 questions · data-driven answers · updated daily
01Is CDIO or NAUT a better buy right now?
Analysts rate Nautilus Biotechnology, Inc. (NAUT) a "Buy" — based on 5 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — CDIO or NAUT?
Over the past 5 years, Nautilus Biotechnology, Inc. (NAUT) delivered a total return of -81.9%, compared to -98.2% for Cardio Diagnostics Holdings, Inc. (CDIO). A $10,000 investment in NAUT five years ago would be worth approximately $2K today (assuming dividends reinvested). Over 10 years, the gap is even starker: NAUT returned -74.9% versus CDIO's -98.2%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — CDIO or NAUT?
By beta (market sensitivity over 5 years), Nautilus Biotechnology, Inc. (NAUT) is the lower-risk stock at 1.71β versus Cardio Diagnostics Holdings, Inc.'s 2.02β — meaning CDIO is approximately 18% more volatile than NAUT relative to the S&P 500. On balance sheet safety, Cardio Diagnostics Holdings, Inc. (CDIO) carries a lower debt/equity ratio of 10% versus 19% for Nautilus Biotechnology, Inc. — giving it more financial flexibility in a downturn.
04Which has better profit margins — CDIO or NAUT?
Nautilus Biotechnology, Inc. (NAUT) is the more profitable company, earning 0.0% net margin versus -240.3% for Cardio Diagnostics Holdings, Inc. — meaning it keeps 0.0% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: NAUT leads at 0.0% versus -239.8% for CDIO. At the gross margin level — before operating expenses — CDIO leads at 100.0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
05Which pays a better dividend — CDIO or NAUT?
None of the stocks in this comparison currently pay a material dividend. All are effectively zero-yield and should be held for capital appreciation rather than income.
06Is CDIO or NAUT better for a retirement portfolio?
For long-horizon retirement investors, Nautilus Biotechnology, Inc. (NAUT) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding. Cardio Diagnostics Holdings, Inc. (CDIO) carries a higher beta of 2.02 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (NAUT: -74.9%, CDIO: -98.2%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
07What are the main differences between CDIO and NAUT?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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