Biotechnology
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KZIA vs NKTR vs IMVT vs RCUS
Revenue, margins, valuation, and 5-year total return — side by side.
Biotechnology
Biotechnology
Biotechnology
KZIA vs NKTR vs IMVT vs RCUS — Key Financials
Market cap, revenue, margins, and valuation side-by-side.
| Company Snapshot | ||||
|---|---|---|---|---|
| Industry | Biotechnology | Biotechnology | Biotechnology | Biotechnology |
| Market Cap | $16M | $1.16B | $6.90B | $2.40B |
| Revenue (TTM) | $3M | $56M | $0.00 | $236M |
| Net Income (TTM) | $-47M | $-158M | $-506M | $-369M |
| Gross Margin | 100.0% | 99.4% | — | 90.7% |
| Operating Margin | -16.9% | -224.9% | — | -168.6% |
| Total Debt | $396K | $149M | $72K | $99M |
| Cash & Equiv. | $4M | $15M | $902M | $222M |
KZIA vs NKTR vs IMVT vs RCUS — Long-Term Stock Performance
Price return indexed to 100 at period start. Dividends excluded.
| Stock | Jun 20 | Jun 26 | Return |
|---|---|---|---|
| Kazia Therapeutics … (KZIA) | 100 | 8.4 | -91.6% |
| Nektar Therapeutics (NKTR) | 100 | 17.1 | -82.9% |
| Immunovant, Inc. (IMVT) | 100 | 138.1 | +38.1% |
| Arcus Biosciences, … (RCUS) | 100 | 96.2 | -3.8% |
Price return only. Dividends and distributions are not included.
Quick Verdict: KZIA vs NKTR vs IMVT vs RCUS
Each card shows where this stock fits in a portfolio — not just who wins on paper.
KZIA lags the leaders in this set but could rank higher in a more targeted comparison.
NKTR carries the broadest edge in this set and is the clearest fit for income & stability and defensive.
- beta 1.50
- Beta 1.50, current ratio 4.97x
- Beta 1.50 vs KZIA's 2.06
- +5.8% vs KZIA's +45.9%
IMVT is the clearest fit if your priority is long-term compounding and sleep-well-at-night.
- 237.9% 10Y total return vs RCUS's 40.0%
- Lower volatility, beta 1.66, Low D/E 0.0%, current ratio 9.09x
- 2.6% margin vs KZIA's -18.7%
RCUS is the #2 pick in this set and the best alternative if growth exposure is your priority.
- Rev growth -4.3%, EPS growth -4.8%, 3Y rev CAGR 30.2%
- -4.3% revenue growth vs KZIA's -98.2%
- -35.3% ROA vs KZIA's -7.8%
See the full category breakdown
| Category | Winner | Why |
|---|---|---|
| Growth | -4.3% revenue growth vs KZIA's -98.2% | |
| Quality / Margins | 2.6% margin vs KZIA's -18.7% | |
| Stability / Safety | Beta 1.50 vs KZIA's 2.06 | |
| Dividends | Tie | None of these 4 stocks pay a meaningful dividend |
| Momentum (1Y) | +5.8% vs KZIA's +45.9% | |
| Efficiency (ROA) | -35.3% ROA vs KZIA's -7.8% |
KZIA vs NKTR vs IMVT vs RCUS — Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
KZIA vs NKTR vs IMVT vs RCUS — Financial Metrics
Side-by-side numbers across 4 stocks — who leads on profitability, valuation, growth, and risk.
Who Leads Where
RCUS leads in 2 of 6 categories
IMVT leads 1 • NKTR leads 1 • KZIA leads 0 • 1 tied
Explore the data ↓Income & Cash Flow (Last 12 Months)
RCUS leads this category, winning 3 of 6 comparable metrics.
Income & Cash Flow (Last 12 Months)
RCUS and IMVT operate at a comparable scale, with $236M and $0 in trailing revenue. Profitability is closely matched — net margins range from -156.4% (RCUS) to -18.7% (KZIA). On growth, NKTR holds the edge at +3.8% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | ||||
|---|---|---|---|---|
| RevenueTrailing 12 months | $3M | $56M | $0 | $236M |
| EBITDAEarnings before interest/tax | -$40M | -$124M | -$532M | -$391M |
| Net IncomeAfter-tax profit | -$47M | -$158M | -$506M | -$369M |
| Free Cash FlowCash after capex | -$14M | -$204M | -$407M | -$489M |
| Gross MarginGross profit ÷ Revenue | +100.0% | +99.4% | — | +90.7% |
| Operating MarginEBIT ÷ Revenue | -16.9% | -2.2% | — | -168.6% |
| Net MarginNet income ÷ Revenue | -18.7% | -2.8% | — | -156.4% |
| FCF MarginFCF ÷ Revenue | -5.5% | -3.7% | — | -2.1% |
| Rev. Growth (YoY)Latest quarter vs prior year | -99.2% | +3.8% | — | -39.3% |
| EPS Growth (YoY)Latest quarter vs prior year | +79.5% | +49.7% | -14.1% | +10.5% |
Valuation Metrics
RCUS leads this category, winning 2 of 3 comparable metrics.
Valuation Metrics
| Metric | ||||
|---|---|---|---|---|
| Market CapShares × price | $16M | $1.2B | $6.9B | $2.4B |
| Enterprise ValueMkt cap + debt − cash | $13M | $1.3B | $6.0B | $2.3B |
| Trailing P/EPrice ÷ TTM EPS | -1.08x | -6.10x | -12.14x | -7.23x |
| Forward P/EPrice ÷ next-FY EPS est. | — | — | — | — |
| PEG RatioP/E ÷ EPS growth rate | — | — | — | — |
| EV / EBITDAEnterprise value multiple | — | — | — | — |
| Price / SalesMarket cap ÷ Revenue | 530.20x | 21.01x | — | 9.70x |
| Price / BookPrice ÷ Book value/share | — | 11.15x | 7.19x | 4.05x |
| Price / FCFMarket cap ÷ FCF | — | — | — | — |
Profitability & Efficiency
IMVT leads this category, winning 5 of 9 comparable metrics.
Profitability & Efficiency
IMVT delivers a -68.2% return on equity — every $100 of shareholder capital generates $-68 in annual profit, vs $-87 for NKTR. IMVT carries lower financial leverage with a 0.00x debt-to-equity ratio, signaling a more conservative balance sheet compared to NKTR's 1.66x. On the Piotroski fundamental quality scale (0–9), KZIA scores 2/9 vs RCUS's 0/9, reflecting mixed financial health.
| Metric | ||||
|---|---|---|---|---|
| ROE (TTM)Return on equity | — | -87.0% | -68.2% | -69.0% |
| ROA (TTM)Return on assets | -7.8% | -40.7% | -62.2% | -35.3% |
| ROICReturn on invested capital | — | -57.2% | — | -64.1% |
| ROCEReturn on capital employed | — | -55.7% | -68.3% | -42.1% |
| Piotroski ScoreFundamental quality 0–9 | 2 | 2 | 2 | 0 |
| Debt / EquityFinancial leverage | — | 1.66x | 0.00x | 0.16x |
| Net DebtTotal debt minus cash | -$4M | $134M | -$902M | -$123M |
| Cash & Equiv.Liquid assets | $4M | $15M | $902M | $222M |
| Total DebtShort + long-term debt | $396,000 | $149M | $72,000 | $99M |
| Interest CoverageEBIT ÷ Interest expense | — | -4.15x | — | -13.38x |
Total Returns (Dividends Reinvested)
NKTR leads this category, winning 3 of 6 comparable metrics.
Total Returns (Dividends Reinvested)
A $10,000 investment in IMVT five years ago would be worth $31,304 today (with dividends reinvested), compared to $271 for KZIA. Over the past 12 months, NKTR leads with a +577.9% total return vs KZIA's +45.9%. The 3-year compound annual growth rate (CAGR) favors NKTR at 90.8% vs KZIA's -38.9% — a key indicator of consistent wealth creation.
| Metric | ||||
|---|---|---|---|---|
| YTD ReturnYear-to-date | +185.6% | +36.8% | +29.8% | +2.2% |
| 1-Year ReturnPast 12 months | +45.9% | +577.9% | +110.9% | +154.5% |
| 3-Year ReturnCumulative with dividends | -77.2% | +594.5% | +55.0% | +18.3% |
| 5-Year ReturnCumulative with dividends | -97.3% | -77.6% | +213.0% | -3.1% |
| 10-Year ReturnCumulative with dividends | -96.5% | -73.6% | +237.9% | +40.0% |
| CAGR (3Y)Annualised 3-year return | -38.9% | +90.8% | +15.7% | +5.8% |
Risk & Volatility
Evenly matched — NKTR and IMVT each lead in 1 of 2 comparable metrics.
Risk & Volatility
NKTR is the less volatile stock with a 1.50 beta — it tends to amplify market swings less than KZIA's 2.06 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. IMVT currently trades 92.7% from its 52-week high vs NKTR's 54.5% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | ||||
|---|---|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 2.06x | 1.50x | 1.66x | 2.00x |
| 52-Week HighHighest price in past year | $17.40 | $109.00 | $36.27 | $28.72 |
| 52-Week LowLowest price in past year | $4.86 | $7.99 | $14.32 | $7.91 |
| % of 52W HighCurrent price vs 52-week peak | +82.1% | +54.5% | +92.7% | +82.9% |
| RSI (14)Momentum oscillator 0–100 | 53.8 | 32.1 | 57.9 | 46.5 |
| Avg Volume (50D)Average daily shares traded | 237K | 994K | 1.9M | 1.1M |
Analyst Outlook
Insufficient data to determine a leader in this category.
Analyst Outlook
Analyst consensus: NKTR as "Buy", IMVT as "Buy", RCUS as "Buy". Consensus price targets imply 151.9% upside for NKTR (target: $150) vs 29.9% for IMVT (target: $44).
| Metric | ||||
|---|---|---|---|---|
| Analyst RatingConsensus buy/hold/sell | — | Buy | Buy | Buy |
| Price TargetConsensus 12-month target | — | $149.60 | $43.67 | $31.00 |
| # AnalystsCovering analysts | — | 33 | 23 | 18 |
| Dividend YieldAnnual dividend ÷ price | — | — | — | — |
| Dividend StreakConsecutive years of raises | — | — | — | — |
| Dividend / ShareAnnual DPS | — | — | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | 0.0% | 0.0% | 0.0% |
RCUS leads in 2 of 6 categories (Income & Cash Flow, Valuation Metrics). IMVT leads in 1 (Profitability & Efficiency). 1 tied.
KZIA vs NKTR vs IMVT vs RCUS: Key Questions Answered
8 questions · data-driven answers · updated daily
01Is KZIA or NKTR or IMVT or RCUS a better buy right now?
For growth investors, Arcus Biosciences, Inc.
(RCUS) is the stronger pick with -4. 3% revenue growth year-over-year, versus -98. 2% for Kazia Therapeutics Limited (KZIA). Analysts rate Nektar Therapeutics (NKTR) a "Buy" — based on 33 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — KZIA or NKTR or IMVT or RCUS?
Over the past 5 years, Immunovant, Inc.
(IMVT) delivered a total return of +213. 0%, compared to -97. 3% for Kazia Therapeutics Limited (KZIA). Over 10 years, the gap is even starker: IMVT returned +237. 9% versus KZIA's -96. 5%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — KZIA or NKTR or IMVT or RCUS?
By beta (market sensitivity over 5 years), Nektar Therapeutics (NKTR) is the lower-risk stock at 1.
50β versus Kazia Therapeutics Limited's 2. 06β — meaning KZIA is approximately 38% more volatile than NKTR relative to the S&P 500. On balance sheet safety, Immunovant, Inc. (IMVT) carries a lower debt/equity ratio of 0% versus 166% for Nektar Therapeutics — giving it more financial flexibility in a downturn.
04Which is growing faster — KZIA or NKTR or IMVT or RCUS?
By revenue growth (latest reported year), Arcus Biosciences, Inc.
(RCUS) is pulling ahead at -4. 3% versus -98. 2% for Kazia Therapeutics Limited (KZIA). On earnings-per-share growth, the picture is similar: Kazia Therapeutics Limited grew EPS 65. 6% year-over-year, compared to -12. 1% for Nektar Therapeutics. Over a 3-year CAGR, KZIA leads at 61. 3% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.
05Which has better profit margins — KZIA or NKTR or IMVT or RCUS?
Immunovant, Inc.
(IMVT) is the more profitable company, earning 0. 0% net margin versus -492. 9% for Kazia Therapeutics Limited — meaning it keeps 0. 0% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: IMVT leads at 0. 0% versus -338. 5% for KZIA. At the gross margin level — before operating expenses — KZIA leads at 100. 0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
06Which pays a better dividend — KZIA or NKTR or IMVT or RCUS?
None of the stocks in this comparison currently pay a material dividend.
All are effectively zero-yield and should be held for capital appreciation rather than income.
07Is KZIA or NKTR or IMVT or RCUS better for a retirement portfolio?
For long-horizon retirement investors, Immunovant, Inc.
(IMVT) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (+237. 9% 10Y return). Kazia Therapeutics Limited (KZIA) carries a higher beta of 2. 06 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (IMVT: +237. 9%, KZIA: -96. 5%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
08What are the main differences between KZIA and NKTR and IMVT and RCUS?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.
These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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