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Stock Comparison

NERV vs ALTO vs ACAD vs REX vs INVA

Revenue, margins, valuation, and 5-year total return — side by side.

Live fundamentals10-year financials5-year price chart
NERV
Minerva Neurosciences, Inc.

Biotechnology

HealthcareNASDAQ • US
Market Cap$32M
5Y Perf.-84.4%
ALTO
Alto Ingredients, Inc.

Chemicals - Specialty

Basic MaterialsNASDAQ • US
Market Cap$441M
5Y Perf.+702.8%
ACAD
ACADIA Pharmaceuticals Inc.

Biotechnology

HealthcareNASDAQ • US
Market Cap$3.61B
5Y Perf.-56.5%
REX
REX American Resources Corporation

Chemicals - Specialty

Basic MaterialsNYSE • US
Market Cap$1.45B
5Y Perf.+280.1%
INVA
Innoviva, Inc.

Biotechnology

HealthcareNASDAQ • US
Market Cap$1.68B
5Y Perf.+62.7%

NERV vs ALTO vs ACAD vs REX vs INVA — Key Financials

Market cap, revenue, margins, and valuation side-by-side.

Company Snapshot
NERV logoNERV
ALTO logoALTO
ACAD logoACAD
REX logoREX
INVA logoINVA
IndustryBiotechnologyChemicals - SpecialtyBiotechnologyChemicals - SpecialtyBiotechnology
Market Cap$32M$441M$3.61B$1.45B$1.68B
Revenue (TTM)$0.00$916M$1.10B$656M$424M
Net Income (TTM)$-415M$29M$376M$93M$504M
Gross Margin5.0%91.5%16.5%76.2%
Operating Margin2.1%7.4%11.0%14.8%
Forward P/E13.4x54.2x56.7x6.4x
Total Debt$65M$98M$52M$21M$269M
Cash & Equiv.$82M$26M$178M$189M$551M

NERV vs ALTO vs ACAD vs REX vs INVALong-Term Stock Performance

Price return indexed to 100 at period start. Dividends excluded.

NERV
ALTO
ACAD
REX
INVA
StockJun 20Jun 26Return
Minerva Neuroscienc… (NERV)10015.6-84.4%
Alto Ingredients, I… (ALTO)100802.8+702.8%
ACADIA Pharmaceutic… (ACAD)10043.5-56.5%
REX American Resour… (REX)100380.1+280.1%
Innoviva, Inc. (INVA)100162.7+62.7%

Price return only. Dividends and distributions are not included.

Quick Verdict: NERV vs ALTO vs ACAD vs REX vs INVA

Each card shows where this stock fits in a portfolio — not just who wins on paper.

Bottom line: INVA leads in 4 of 7 categories (5-stock set), making it the strongest pick for valuation and capital efficiency and profitability and margin quality. Alto Ingredients, Inc. is the stronger pick specifically for dividend income and shareholder returns and recent price momentum and sentiment. NERV also leads in specific categories worth noting. This set spans 2 sectors — these stocks serve different portfolio roles, not just different price points.
🥇INVA emerged as the overall leader. Track its performance:
NERV
Minerva Neurosciences, Inc.
The Growth Leader

NERV ranks third and is worth considering specifically for growth.

  • 121.0% revenue growth vs ALTO's -4.9%
Best for: growth
ALTO
Alto Ingredients, Inc.
The Income Pick

ALTO is the #2 pick in this set and the best alternative if dividends and momentum is your priority.

  • 0.3% yield; the other 4 pay no meaningful dividend
  • +418.2% vs ACAD's -3.0%
Best for: dividends and momentum
ACAD
ACADIA Pharmaceuticals Inc.
The Healthcare Pick

ACAD lags the leaders in this set but could rank higher in a more targeted comparison.

Best for: healthcare exposure
REX
REX American Resources Corporation
The Long-Run Compounder

REX is the clearest fit if your priority is long-term compounding.

  • 347.0% 10Y total return vs INVA's 108.1%
Best for: long-term compounding
INVA
Innoviva, Inc.
The Income Pick

INVA carries the broadest edge in this set and is the clearest fit for income & stability and growth exposure.

  • Dividend streak 2 yrs, beta 0.06
  • Rev growth 18.5%, EPS growth 8.2%, 3Y rev CAGR 8.7%
  • Lower volatility, beta 0.06, Low D/E 22.9%, current ratio 14.64x
  • PEG 0.62 vs REX's 0.75
Best for: income & stability and growth exposure
See the full category breakdown
CategoryWinnerWhy
GrowthNERV logoNERV121.0% revenue growth vs ALTO's -4.9%
ValueINVA logoINVALower P/E (6.4x vs 56.7x), PEG 0.62 vs 0.75
Quality / MarginsINVA logoINVA118.9% margin vs ALTO's 3.2%
Stability / SafetyINVA logoINVABeta 0.06 vs NERV's 1.28
DividendsALTO logoALTO0.3% yield; the other 4 pay no meaningful dividend
Momentum (1Y)ALTO logoALTO+418.2% vs ACAD's -3.0%
Efficiency (ROA)INVA logoINVA32.4% ROA vs NERV's -6.6%

NERV vs ALTO vs ACAD vs REX vs INVA — Revenue Breakdown by Segment

How each company's revenue is distributed across its business units

NERVMinerva Neurosciences, Inc.

Segment breakdown not available.

ALTOAlto Ingredients, Inc.
FY 2025
Intersegment Eliminations Member
0.0%$-12,612,000
ACADACADIA Pharmaceuticals Inc.
FY 2018
Product
100.0%$224M
REXREX American Resources Corporation
FY 2025
Other Member
100.0%$399,000
INVAInnoviva, Inc.
FY 2025
Royalty
57.5%$236M
Product
41.8%$172M
License And Other Revenue
0.7%$3M

NERV vs ALTO vs ACAD vs REX vs INVA — Financial Metrics

Side-by-side numbers across 5 stocks — who leads on profitability, valuation, growth, and risk.

BEST OVERALLINVALAGGINGACAD

Income & Cash Flow (Last 12 Months)

INVA leads this category, winning 5 of 6 comparable metrics.

ACAD and NERV operate at a comparable scale, with $1.1B and $0 in trailing revenue. INVA is the more profitable business, keeping 118.9% of every revenue dollar as net income compared to ALTO's 3.2%. On growth, INVA holds the edge at +10.6% YoY revenue growth, suggesting stronger near-term business momentum.

MetricNERV logoNERVMinerva Neuroscie…ALTO logoALTOAlto Ingredients,…ACAD logoACADACADIA Pharmaceut…REX logoREXREX American Reso…INVA logoINVAInnoviva, Inc.
RevenueTrailing 12 months$0$916M$1.1B$656M$424M
EBITDAEarnings before interest/tax-$28M$38M$96M$89M$86M
Net IncomeAfter-tax profit-$415M$29M$376M$93M$504M
Free Cash FlowCash after capex-$5.4B$31M$212M$46M$181M
Gross MarginGross profit ÷ Revenue+5.0%+91.5%+16.5%+76.2%
Operating MarginEBIT ÷ Revenue+2.1%+7.4%+11.0%+14.8%
Net MarginNet income ÷ Revenue+3.2%+34.3%+14.1%+118.9%
FCF MarginFCF ÷ Revenue+3.4%+19.4%+7.0%+42.6%
Rev. Growth (YoY)Latest quarter vs prior year-0.8%+9.7%+3.6%+10.6%
EPS Growth (YoY)Latest quarter vs prior year+131.3%-81.8%+119.6%+4.0%
INVA leads this category, winning 5 of 6 comparable metrics.

Valuation Metrics

INVA leads this category, winning 4 of 7 comparable metrics.

At 6.9x trailing earnings, INVA trades at a 81% valuation discount to ALTO's 35.6x P/E. Adjusting for growth (PEG ratio), REX offers better value at 0.23x vs INVA's 0.67x — a lower PEG means you pay less per unit of expected earnings growth.

MetricNERV logoNERVMinerva Neuroscie…ALTO logoALTOAlto Ingredients,…ACAD logoACADACADIA Pharmaceut…REX logoREXREX American Reso…INVA logoINVAInnoviva, Inc.
Market CapShares × price$32M$441M$3.6B$1.4B$1.7B
Enterprise ValueMkt cap + debt − cash$14M$512M$3.5B$1.3B$1.4B
Trailing P/EPrice ÷ TTM EPS-0.13x35.63x9.21x17.58x6.89x
Forward P/EPrice ÷ next-FY EPS est.13.41x54.20x56.70x6.36x
PEG RatioP/E ÷ EPS growth rate0.23x0.67x
EV / EBITDAEnterprise value multiple15.57x25.09x16.44x6.85x
Price / SalesMarket cap ÷ Revenue0.48x3.37x2.22x3.95x
Price / BookPrice ÷ Book value/share1.76x2.94x2.08x1.64x
Price / FCFMarket cap ÷ FCF50.94x34.34x29.30x8.57x
INVA leads this category, winning 4 of 7 comparable metrics.

Profitability & Efficiency

INVA leads this category, winning 6 of 9 comparable metrics.

INVA delivers a 47.6% return on equity — every $100 of shareholder capital generates $48 in annual profit, vs $13 for ALTO. REX carries lower financial leverage with a 0.03x debt-to-equity ratio, signaling a more conservative balance sheet compared to ALTO's 0.40x. On the Piotroski fundamental quality scale (0–9), REX scores 7/9 vs NERV's 2/9, reflecting strong financial health.

MetricNERV logoNERVMinerva Neuroscie…ALTO logoALTOAlto Ingredients,…ACAD logoACADACADIA Pharmaceut…REX logoREXREX American Reso…INVA logoINVAInnoviva, Inc.
ROE (TTM)Return on equity+12.5%+35.6%+13.7%+47.6%
ROA (TTM)Return on assets-6.6%+7.4%+26.2%+12.1%+32.4%
ROICReturn on invested capital+1.9%+10.0%+9.1%+14.2%
ROCEReturn on capital employed-23.2%+2.3%+10.1%+8.8%+12.4%
Piotroski ScoreFundamental quality 0–925675
Debt / EquityFinancial leverage0.40x0.04x0.03x0.23x
Net DebtTotal debt minus cash-$17M$72M-$126M-$167M-$282M
Cash & Equiv.Liquid assets$82M$26M$178M$189M$551M
Total DebtShort + long-term debt$65M$98M$52M$21M$269M
Interest CoverageEBIT ÷ Interest expense0.24x63.45x
INVA leads this category, winning 6 of 9 comparable metrics.

Total Returns (Dividends Reinvested)

REX leads this category, winning 4 of 6 comparable metrics.

A $10,000 investment in REX five years ago would be worth $27,157 today (with dividends reinvested), compared to $1,905 for NERV. Over the past 12 months, ALTO leads with a +418.2% total return vs ACAD's -3.0%. The 3-year compound annual growth rate (CAGR) favors REX at 37.7% vs NERV's -12.1% — a key indicator of consistent wealth creation.

MetricNERV logoNERVMinerva Neuroscie…ALTO logoALTOAlto Ingredients,…ACAD logoACADACADIA Pharmaceut…REX logoREXREX American Reso…INVA logoINVAInnoviva, Inc.
YTD ReturnYear-to-date+15.1%+114.3%-19.3%+35.6%+14.4%
1-Year ReturnPast 12 months+152.0%+418.2%-3.0%+94.9%+6.3%
3-Year ReturnCumulative with dividends-32.2%+128.9%-14.3%+160.9%+69.7%
5-Year ReturnCumulative with dividends-81.0%-9.2%-22.6%+171.6%+77.9%
10-Year ReturnCumulative with dividends-94.4%+2.3%-44.6%+347.0%+108.1%
CAGR (3Y)Annualised 3-year return-12.1%+31.8%-5.0%+37.7%+19.3%
REX leads this category, winning 4 of 6 comparable metrics.

Risk & Volatility

Evenly matched — ALTO and INVA each lead in 1 of 2 comparable metrics.

INVA is the less volatile stock with a 0.06 beta — it tends to amplify market swings less than NERV's 1.28 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. ALTO currently trades 95.2% from its 52-week high vs NERV's 36.2% drawdown — a narrower gap to the peak suggests stronger recent price momentum.

MetricNERV logoNERVMinerva Neuroscie…ALTO logoALTOAlto Ingredients,…ACAD logoACADACADIA Pharmaceut…REX logoREXREX American Reso…INVA logoINVAInnoviva, Inc.
Beta (5Y)Sensitivity to S&P 5001.28x0.23x1.10x0.22x0.06x
52-Week HighHighest price in past year$12.46$5.99$27.81$53.36$25.15
52-Week LowLowest price in past year$1.57$0.92$19.69$22.23$16.52
% of 52W HighCurrent price vs 52-week peak+36.2%+95.2%+75.8%+82.3%+90.4%
RSI (14)Momentum oscillator 0–10037.458.947.932.850.6
Avg Volume (50D)Average daily shares traded154K2.0M1.4M164K660K
Evenly matched — ALTO and INVA each lead in 1 of 2 comparable metrics.

Analyst Outlook

INVA leads this category, winning 1 of 1 comparable metric.

Analyst consensus: NERV as "Buy", ALTO as "Buy", ACAD as "Buy", REX as "Buy", INVA as "Buy". Consensus price targets imply 75.9% upside for INVA (target: $40) vs 10.9% for NERV (target: $5). ALTO is the only dividend payer here at 0.29% yield — a key consideration for income-focused portfolios.

MetricNERV logoNERVMinerva Neuroscie…ALTO logoALTOAlto Ingredients,…ACAD logoACADACADIA Pharmaceut…REX logoREXREX American Reso…INVA logoINVAInnoviva, Inc.
Analyst RatingConsensus buy/hold/sellBuyBuyBuyBuyBuy
Price TargetConsensus 12-month target$5.00$10.00$34.78$60.00$40.00
# AnalystsCovering analysts7237310
Dividend YieldAnnual dividend ÷ price+0.3%
Dividend StreakConsecutive years of raises002
Dividend / ShareAnnual DPS$0.02
Buyback YieldShare repurchases ÷ mkt cap0.0%0.0%0.0%+2.3%+0.3%
INVA leads this category, winning 1 of 1 comparable metric.
Key Takeaway

INVA leads in 4 of 6 categories (Income & Cash Flow, Valuation Metrics). REX leads in 1 (Total Returns). 1 tied.

Best OverallInnoviva, Inc. (INVA)Leads 4 of 6 categories
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NERV vs ALTO vs ACAD vs REX vs INVA: Key Questions Answered

10 questions · data-driven answers · updated daily

01

Is NERV or ALTO or ACAD or REX or INVA a better buy right now?

For growth investors, Innoviva, Inc.

(INVA) is the stronger pick with 18. 5% revenue growth year-over-year, versus -4. 9% for Alto Ingredients, Inc. (ALTO). Innoviva, Inc. (INVA) offers the better valuation at 6. 9x trailing P/E (6. 4x forward), making it the more compelling value choice. Analysts rate Minerva Neurosciences, Inc. (NERV) a "Buy" — based on 7 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.

02

Which has the better valuation — NERV or ALTO or ACAD or REX or INVA?

On trailing P/E, Innoviva, Inc.

(INVA) is the cheapest at 6. 9x versus Alto Ingredients, Inc. at 35. 6x. On forward P/E, Innoviva, Inc. is actually cheaper at 6. 4x. The PEG ratio (P/E divided by earnings growth rate) is the most growth-adjusted single valuation metric: Innoviva, Inc. wins at 0. 62x versus REX American Resources Corporation's 0. 75x — a PEG below 1. 0 traditionally signals the market is underpricing earnings growth.

03

Which is the better long-term investment — NERV or ALTO or ACAD or REX or INVA?

Over the past 5 years, REX American Resources Corporation (REX) delivered a total return of +171.

6%, compared to -81. 0% for Minerva Neurosciences, Inc. (NERV). Over 10 years, the gap is even starker: REX returned +347. 0% versus NERV's -94. 4%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.

04

Which is safer — NERV or ALTO or ACAD or REX or INVA?

By beta (market sensitivity over 5 years), Innoviva, Inc.

(INVA) is the lower-risk stock at 0. 06β versus Minerva Neurosciences, Inc. 's 1. 28β — meaning NERV is approximately 2134% more volatile than INVA relative to the S&P 500. On balance sheet safety, REX American Resources Corporation (REX) carries a lower debt/equity ratio of 3% versus 40% for Alto Ingredients, Inc. — giving it more financial flexibility in a downturn.

05

Which is growing faster — NERV or ALTO or ACAD or REX or INVA?

By revenue growth (latest reported year), Innoviva, Inc.

(INVA) is pulling ahead at 18. 5% versus -4. 9% for Alto Ingredients, Inc. (ALTO). On earnings-per-share growth, the picture is similar: Innoviva, Inc. grew EPS 816. 7% year-over-year, compared to -183. 5% for Minerva Neurosciences, Inc.. Over a 3-year CAGR, ACAD leads at 27. 5% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.

06

Which has better profit margins — NERV or ALTO or ACAD or REX or INVA?

Innoviva, Inc.

(INVA) is the more profitable company, earning 63. 8% net margin versus 0. 0% for Minerva Neurosciences, Inc. — meaning it keeps 63. 8% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: INVA leads at 38. 5% versus 0. 0% for NERV. At the gross margin level — before operating expenses — ACAD leads at 91. 7%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.

07

Is NERV or ALTO or ACAD or REX or INVA more undervalued right now?

The PEG ratio (forward P/E divided by expected earnings growth rate) is the most precise measure of undervaluation relative to growth potential.

By this metric, Innoviva, Inc. (INVA) is the more undervalued stock at a PEG of 0. 62x versus REX American Resources Corporation's 0. 75x. A PEG below 1. 0 is traditionally considered the threshold for growth-adjusted undervaluation. On forward earnings alone, Innoviva, Inc. (INVA) trades at 6. 4x forward P/E versus 56. 7x for REX American Resources Corporation — 50. 3x cheaper on a one-year earnings basis. Analyst consensus price targets imply the most upside for INVA: 75. 9% to $40. 00.

08

Which pays a better dividend — NERV or ALTO or ACAD or REX or INVA?

In this comparison, ALTO (0.

3% yield) pays a dividend. NERV, ACAD, REX, INVA do not pay a meaningful dividend and should not be held primarily for income.

09

Is NERV or ALTO or ACAD or REX or INVA better for a retirement portfolio?

For long-horizon retirement investors, REX American Resources Corporation (REX) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.

22), +347. 0% 10Y return). Both have compounded well over 10 years (REX: +347. 0%, NERV: -94. 4%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.

10

What are the main differences between NERV and ALTO and ACAD and REX and INVA?

These companies operate in different sectors (NERV (Healthcare) and ALTO (Basic Materials) and ACAD (Healthcare) and REX (Basic Materials) and INVA (Healthcare)), which means they face different economic cycles, regulatory environments, and macro sensitivities — making direct comparison nuanced.

In terms of investment character: NERV is a small-cap quality compounder stock; ALTO is a small-cap quality compounder stock; ACAD is a small-cap deep-value stock; REX is a small-cap deep-value stock; INVA is a small-cap high-growth stock. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.

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