Comprehensive Stock Comparison
Compare Synlogic, Inc. (SYBX) vs Regeneron Pharmaceuticals, Inc. (REGN) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Growth |  REGN | 1.0% revenue growth vs SYBX's -99.8% |
| Quality / Margins | REGN | 31.4% net margin vs SYBX's -2.9K% |
| Stability / Safety | REGN | Beta 0.58 vs SYBX's 0.97 |
| Dividends | REGN | 0.4% yield; 1-year raise streak; SYBX pays no meaningful dividend |
| Momentum (1Y) | REGN | +15.1% vs SYBX's -53.1% |
| Efficiency (ROA) | REGN | 11.1% ROA vs SYBX's -19.5%, ROIC 12.4% vs -205.7% |
Who Each Stock Is For
Income & stability
REGNDividend streak 1 yrs, beta 0.58, yield 0.4%
Growth exposure
REGNRev growth 1.0%, EPS growth 8.2%, 3Y rev CAGR 5.6%
Long-term compounding (10Y)
REGN94.0% 10Y total return vs SYBX's -98.0%
Sleep-well-at-night portfolio
REGNLower volatility, beta 0.58, Low D/E 8.7%, current ratio 4.77x
Defensive / Recession hedge
REGNBeta 0.58, yield 0.4%, current ratio 4.77x
Business Model
What each company does and how it makes money
Synlogic is a clinical-stage biopharmaceutical company developing synthetic biotic medicines — engineered probiotics — to treat metabolic and immunological diseases. It generates revenue primarily through research collaborations and milestone payments from partners like Roche, with potential future income from drug sales if its pipeline succeeds. The company's key advantage lies in its proprietary platform for engineering bacterial strains to perform therapeutic functions in the gut — a novel approach distinct from traditional small molecules or biologics.
Regeneron Pharmaceuticals is a biotechnology company that discovers, develops, and commercializes innovative medicines for serious diseases. It generates revenue primarily from sales of its flagship products — EYLEA for eye diseases (~60% of revenue) and Dupixent for inflammatory conditions (~30%) — with additional income from collaborations and royalties. The company's competitive advantage lies in its proprietary VelocImmune technology platform for creating human antibodies and its deep expertise in genetic research, which enables rapid drug discovery and development.
Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
REGN 4
SYBX 1REGN3/4 metricsSYBX2/3 metricsREGN6/7 metricsREGN6/6 metricsREGN2/2 metricsREGN leads in 4 of 6 categories (Financial Metrics, Profitability & Efficiency). SYBX leads in 1 (Valuation Metrics).
Financial Metrics (TTM)
REGN and SYBX operate at a comparable scale, with $14.3B and $0 in trailing revenue. REGN is the more profitable business, keeping 31.4% of every revenue dollar as net income compared to SYBX's -2919.9%.
| Metric | SYBXSynlogic, Inc. | REGNRegeneron Pharmac… |
|---|---|---|
| RevenueTrailing 12 months | $0 | $14.3B |
| EBITDAEarnings before interest/tax | -$3M | $4.2B |
| Net IncomeAfter-tax profit | -$3M | $4.5B |
| Free Cash FlowCash after capex | -$4M | $3.2B |
| Gross MarginGross profit ÷ Revenue | +100.0% | +86.3% |
| Operating MarginEBIT ÷ Revenue | -5118.8% | +25.7% |
| Net MarginNet income ÷ Revenue | -2919.9% | +31.4% |
| FCF MarginFCF ÷ Revenue | -3959.0% | +22.0% |
| Rev. Growth (YoY)Latest quarter vs prior year | — | +2.5% |
| EPS Growth (YoY)Latest quarter vs prior year | — | -2.5% |
Valuation Metrics
| Metric | SYBXSynlogic, Inc. | REGNRegeneron Pharmac… |
|---|---|---|
| Market CapShares × price | $7M | $108.4B |
| Enterprise ValueMkt cap + debt − cash | -$12M | $92.2B |
| Trailing P/EPrice ÷ TTM EPS | -0.31x | 18.99x |
| Forward P/EPrice ÷ next-FY EPS est. | — | 17.38x |
| PEG RatioP/E ÷ EPS growth rate | — | 3.00x |
| EV / EBITDAEnterprise value multiple | — | 21.83x |
| Price / SalesMarket cap ÷ Revenue | 877.42x | 7.55x |
| Price / BookPrice ÷ Book value/share | 0.57x | 2.74x |
| Price / FCFMarket cap ÷ FCF | — | 26.56x |
Profitability & Efficiency
REGN delivers a 14.4% return on equity — every $100 of shareholder capital generates $14 in annual profit, vs $-31 for SYBX. On the Piotroski fundamental quality scale (0–9), REGN scores 7/9 vs SYBX's 2/9, reflecting strong financial health.
| Metric | SYBXSynlogic, Inc. | REGNRegeneron Pharmac… |
|---|---|---|
| ROE (TTM)Return on equity | -31.3% | +14.4% |
| ROA (TTM)Return on assets | -19.5% | +11.1% |
| ROICReturn on invested capital | -2.1% | +12.4% |
| ROCEReturn on capital employed | -120.6% | +10.8% |
| Piotroski ScoreFundamental quality 0–9 | 2 | 7 |
| Debt / EquityFinancial leverage | — | 0.09x |
| Net DebtTotal debt minus cash | -$19M | -$16.2B |
| Cash & Equiv.Liquid assets | $19M | $18.9B |
| Total DebtShort + long-term debt | $0 | $2.7B |
| Interest CoverageEBIT ÷ Interest expense | — | 120.42x |
Total Returns (with DRIP)
A $10,000 investment in REGN five years ago would be worth $17,161 today (with dividends reinvested), compared to $117 for SYBX. Over the past 12 months, REGN leads with a +15.1% total return vs SYBX's -53.1%. The 3-year compound annual growth rate (CAGR) favors REGN at 0.5% vs SYBX's -60.9% — a key indicator of consistent wealth creation.
| Metric | SYBXSynlogic, Inc. | REGNRegeneron Pharmac… |
|---|---|---|
| YTD ReturnYear-to-date | -48.7% | +1.6% |
| 1-Year ReturnPast 12 months | -53.1% | +15.1% |
| 3-Year ReturnCumulative with dividends | -94.0% | +1.5% |
| 5-Year ReturnCumulative with dividends | -98.8% | +71.6% |
| 10-Year ReturnCumulative with dividends | -98.0% | +94.0% |
| CAGR (3Y)Annualised 3-year return | -60.9% | +0.5% |
Risk & Volatility
REGN is the less volatile stock with a 0.58 beta — it tends to amplify market swings less than SYBX's 0.97 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. REGN currently trades 95.9% from its 52-week high vs SYBX's 30.6% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | SYBXSynlogic, Inc. | REGNRegeneron Pharmac… |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 0.97x | 0.58x |
| 52-Week HighHighest price in past year | $1.96 | $821.11 |
| 52-Week LowLowest price in past year | $0.54 | $476.49 |
| % of 52W HighCurrent price vs 52-week peak | +30.6% | +95.9% |
| RSI (14)Momentum oscillator 0–100 | 34.3 | 47.5 |
| Avg Volume (50D)Average daily shares traded | 115K | 762K |
Analyst Outlook
REGN is the only dividend payer here at 0.43% yield — a key consideration for income-focused portfolios.
| Metric | SYBXSynlogic, Inc. | REGNRegeneron Pharmac… |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | — | Buy |
| Price TargetConsensus 12-month target | — | $857.17 |
| # AnalystsCovering analysts | — | 48 |
| Dividend YieldAnnual dividend ÷ price | — | +0.4% |
| Dividend StreakConsecutive years of raises | — | 1 |
| Dividend / ShareAnnual DPS | — | $3.41 |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | +3.2% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Mar 20 | Mar 26 | Change |
|---|---|---|---|
| Synlogic, Inc. (SYBX) | 100 | 2.01 | -98.0% |
| Regeneron Pharmaceu… (REGN) | 100 | 161.99 | +62.0% |
Regeneron Pharmaceu… (REGN) returned +72% over 5 years vs Synlogic, Inc. (SYBX)'s -99%. A $10,000 investment in REGN 5 years ago would be worth $17,161 today (including dividends reinvested).
Chart 2Revenue Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Synlogic, Inc. (SYBX) | $444000.00 | $8000.00 | -98.2% |
| Regeneron Pharmaceu… (REGN) | $4.9B | $14.3B | +195.1% |
Regeneron Pharmaceuticals, Inc.'s revenue grew from $4.9B (2016) to $14.3B (2025) — a 12.8% CAGR.
Chart 3Net Margin Trend — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Synlogic, Inc. (SYBX) | -59.2% | -2919.9% | -4835.4% |
| Regeneron Pharmaceu… (REGN) | 18.4% | 31.4% | +70.5% |
Regeneron Pharmaceuticals, Inc.'s net margin went from 18% (2016) to 31% (2025).
Chart 4P/E Ratio History — 9 Years
| Stock | 2017 | 2025 | Change |
|---|---|---|---|
| Regeneron Pharmaceu… (REGN) | 36.4 | 18.6 | -48.9% |
Regeneron Pharmaceuticals, Inc. has traded in a 9x–36x P/E range over 9 years; current trailing P/E is ~19x.
Chart 5EPS Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Synlogic, Inc. (SYBX) | -8.83 | -1.92 | +78.3% |
| Regeneron Pharmaceu… (REGN) | 7.7 | 41.48 | +438.7% |
Regeneron Pharmaceuticals, Inc.'s EPS grew from $7.70 (2016) to $41.48 (2025) — a 21% CAGR.
Chart 6Free Cash Flow — 5 Years
Synlogic, Inc. generated $-32M FCF in 2024 (+40% vs 2021). Regeneron Pharmaceuticals, Inc. generated $4B FCF in 2025 (-38% vs 2021).
SYBX vs REGN: Frequently Asked Questions
7 questions · data-driven answers · updated daily
01Is SYBX or REGN a better buy right now?
Regeneron Pharmaceuticals, Inc. (REGN) offers the better valuation at 19.0x trailing P/E (17.4x forward), making it the more compelling value choice. Analysts rate Regeneron Pharmaceuticals, Inc. (REGN) a "Buy" — based on 48 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — SYBX or REGN?
Over the past 5 years, Regeneron Pharmaceuticals, Inc. (REGN) delivered a total return of +71.6%, compared to -98.8% for Synlogic, Inc. (SYBX). A $10,000 investment in REGN five years ago would be worth approximately $17K today (assuming dividends reinvested). Over 10 years, the gap is even starker: REGN returned +94.0% versus SYBX's -98.0%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — SYBX or REGN?
By beta (market sensitivity over 5 years), Regeneron Pharmaceuticals, Inc. (REGN) is the lower-risk stock at 0.58β versus Synlogic, Inc.'s 0.97β — meaning SYBX is approximately 69% more volatile than REGN relative to the S&P 500.
04Which has better profit margins — SYBX or REGN?
Regeneron Pharmaceuticals, Inc. (REGN) is the more profitable company, earning 31.4% net margin versus -2919.9% for Synlogic, Inc. — meaning it keeps 31.4% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: REGN leads at 25.7% versus -5118.8% for SYBX. At the gross margin level — before operating expenses — SYBX leads at 100.0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
05Which pays a better dividend — SYBX or REGN?
In this comparison, REGN (0.4% yield) pays a dividend. SYBX does not pay a meaningful dividend and should not be held primarily for income.
06Is SYBX or REGN better for a retirement portfolio?
For long-horizon retirement investors, Regeneron Pharmaceuticals, Inc. (REGN) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.58)). Both have compounded well over 10 years (REGN: +94.0%, SYBX: -98.0%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
07What are the main differences between SYBX and REGN?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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