8-K Announcements
6Jan 20, 2026·SEC
Dec 16, 2025·SEC
Nov 26, 2025·SEC
Synlogic, Inc. (SYBX) fundamental analysis — strengths, weaknesses & financial health based on data analysis
* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.
Synlogic, Inc. (SYBX) stock price & volume — 10-year historical chart
Synlogic, Inc. (SYBX) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR
Synlogic, Inc. (SYBX) competitors in Microbiome and Phage Therapeutics — business model, growth, and fundamentals comparison
Synlogic, Inc. (SYBX) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.
Synlogic, Inc. (SYBX) annual income statement — 10-year revenue, gross profit & net income history
| Line item | Dec'17 | Dec'18 | Dec'19 | Dec'20 | Dec'21 | Dec'22 | Dec'23 | Dec'24 | Dec'25 |
|---|---|---|---|---|---|---|---|---|---|
| Sales/Revenue | 2.44M | 2.52M | 2.22M | 545K | 1.75M | 1.18M | 3.37M | 8K | 0 |
| Revenue Growth % | 450.45% | 3.11% | -11.75% | -75.49% | 221.83% | -32.73% | 185.68% | -99.76% | -100% |
| Cost of Goods Sold | 0 | 14.9M | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| COGS % of Revenue | - | 591.15% | - | - | - | - | - | - | - |
| Gross Profit | 2.44M▲ 0% | -12.38M▼ 606.4% | 2.22M▲ 118.0% | 545K▼ 75.5% | 1.75M▲ 221.8% | 1.18M▼ 32.7% | 3.37M▲ 185.7% | 8K▼ 99.8% | 0▼ 100.0% |
| Gross Margin % | 100% | -491.15% | 100% | 100% | 100% | 100% | 100% | 100% | - |
| Gross Profit Growth % | 757.54% | -606.42% | 117.97% | -75.49% | 221.83% | -32.73% | 185.68% | -99.76% | -100% |
| Operating Expenses | 43.27M | 53.75M | 56.63M | 61.01M | 62.52M | 68.6M | 58.53M | 40.96M | 4.01M |
| OpEx % of Revenue | 1770.38% | 2132.94% | 2546.45% | 11194.68% | 3564.37% | 5813.47% | 1736.34% | 511975% | - |
| Selling, General & Admin | 12.93M | 15.72M | 14.73M | 13.54M | 15.39M | 16.55M | 14.56M | 6.63M | 3.49M |
| SG&A % of Revenue | 528.93% | 623.65% | 662.23% | 2483.85% | 877.54% | 1402.97% | 431.95% | 82887.5% | - |
| Research & Development | 30.34M | 38.03M | 41.91M | 47.47M | 47.13M | 52.04M | 43.97M | 9.15M | 43K |
| R&D % of Revenue | 1241.45% | 1509.29% | 1884.22% | 8710.83% | 2686.83% | 4410.51% | 1304.39% | 114425% | - |
| Other Operating Expenses | 0 | 2.79M | 0 | 0 | 0 | 0 | 0 | 25.17M | 476K |
| Operating Income | -40.82M▲ 0% | -51.23M▼ 25.5% | -54.41M▼ 6.2% | -60.47M▼ 11.1% | -60.77M▼ 0.5% | -67.42M▼ 11.0% | -55.16M▲ 18.2% | -40.95M▲ 25.8% | -4.01M▲ 90.2% |
| Operating Margin % | -1670.38% | -2032.94% | -2446.45% | -11094.68% | -3464.37% | -5713.47% | -1636.34% | -511875% | - |
| Operating Income Growth % | -53.37% | -25.49% | -6.21% | -11.13% | -0.49% | -10.95% | 18.18% | 25.76% | 90.21% |
| EBITDA | -38.51M | -48.81M | -51.71M | -57.83M | -58.32M | -64.9M | -53.2M | -39.66M | -3.53M |
| EBITDA Margin % | -1575.86% | -1936.87% | -2324.95% | -10611.01% | -3325.09% | -5499.92% | -1578.26% | -495687.5% | - |
| EBITDA Growth % | -48.55% | -26.73% | -5.94% | -11.84% | -0.85% | -11.28% | 18.02% | 25.46% | 91.09% |
| D&A (Non-Cash Add-back) | 2.31M | 2.42M | 2.7M | 2.64M | 2.44M | 2.52M | 1.96M | 1.29M | 0 |
| EBIT | -40.32M | -48.39M | -51.35M | -59.17M | -60.56M | -66.14M | -57.27M | -23.35M | -3.53M |
| Net Interest Income | 447K | 2.8M | 3.04M | 1.3M | 208K | 1.26M | 2.47M | 1.43M | 695K |
| Interest Income | 504K | 2.84M | 3.06M | 1.3M | 210K | 1.27M | 2.47M | 1.43M | 695K |
| Interest Expense | 57K | 43K | 21K | 6K | 2K | 2K | 1K | 0 | 0 |
| Other Income/Expense | 447K | 2.79M | 3.04M | 1.29M | 204K | 1.27M | -2.11M | 17.6M | 3M |
| Pretax Income | -40.38M▲ 0% | -48.44M▼ 20.0% | -51.37M▼ 6.1% | -59.17M▼ 15.2% | -60.56M▼ 2.3% | -66.15M▼ 9.2% | -57.27M▲ 13.4% | -23.35M▲ 59.2% | -1M▲ 95.7% |
| Pretax Margin % | -1652.09% | -1922.02% | -2309.94% | -10857.43% | -3452.74% | -5605.68% | -1698.84% | -291925% | - |
| Income Tax | 0 | 0 | 0 | 0 | 0 | 0 | 14K | 5K | 0 |
| Effective Tax Rate % | 0% | 0% | 0% | 0% | 0% | 0% | -0.02% | -0.02% | 0% |
| Net Income | -40.38M▲ 0% | -48.44M▼ 20.0% | -51.37M▼ 6.1% | -59.17M▼ 15.2% | -60.56M▼ 2.3% | -66.15M▼ 9.2% | -57.28M▲ 13.4% | -23.36M▲ 59.2% | -1M▲ 95.7% |
| Net Margin % | -1652.09% | -1922.02% | -2309.94% | -10857.43% | -3452.74% | -5605.68% | -1699.26% | -291987.5% | - |
| Net Income Growth % | -53.71% | -19.96% | -6.07% | -15.18% | -2.35% | -9.22% | 13.4% | 59.22% | 95.7% |
| Net Income (Continuing) | -40.38M | -48.44M | -51.37M | -59.17M | -60.56M | -66.15M | -57.28M | -23.36M | -1M |
| Discontinued Operations | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Minority Interest | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| EPS (Diluted) | -90.07▲ 0% | -30.42▲ 66.2% | -24.11▲ 20.7% | -23.67▲ 1.8% | -15.76▲ 33.4% | -13.57▲ 13.9% | -8.81▲ 35.1% | -1.92▲ 78.2% | -0.08▲ 95.8% |
| EPS Growth % | -920.05% | 66.23% | 20.74% | 1.82% | 33.42% | 13.9% | 35.08% | 78.21% | 95.83% |
| EPS (Basic) | -90.07 | -30.42 | -24.11 | -23.67 | -15.76 | -13.57 | -8.81 | -1.92 | -0.08 |
| Diluted Shares Outstanding | 448.31K | 1.59M | 2.02M | 2.39M | 3.69M | 4.78M | 6.5M | 12.2M | 12.31M |
| Basic Shares Outstanding | 448.31K | 1.59M | 2.02M | 2.39M | 3.69M | 4.78M | 6.5M | 12.2M | 12.31M |
| Dividend Payout Ratio | - | - | - | - | - | - | - | - | - |
Synlogic, Inc. (SYBX) balance sheet — assets, liabilities & shareholders' equity
| Line item | Dec'17 | Dec'18 | Dec'19 | Dec'20 | Dec'21 | Dec'22 | Dec'23 | Dec'24 | Dec'25 |
|---|---|---|---|---|---|---|---|---|---|
| Total Current Assets | 87.03M | 122.73M | 133.25M | 106.85M | 133.31M | 79.78M | 49.91M | 19.78M | 15.4M |
| Cash & Short-Term Investments | 87.03M | 122.73M | 119.57M | 100.44M | 128.59M | 77.63M | 47.75M | 18.86M | 14.67M |
| Cash Only | 87.03M | 11.25M | 26.18M | 32.51M | 16.44M | 15.86M | 23.96M | 18.86M | 14.67M |
| Short-Term Investments | 0 | 111.48M | 93.39M | 67.94M | 112.15M | 61.77M | 23.79M | 0 | 0 |
| Accounts Receivable | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Days Sales Outstanding | - | - | - | - | - | - | - | - | - |
| Inventory | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Days Inventory Outstanding | - | - | - | - | - | - | - | - | - |
| Other Current Assets | 298K | 388K | 648K | 247K | 311K | 175K | 146K | 161K | 729K |
| Total Non-Current Assets | 12.67M | 17.61M | 55.33M | 36.99M | 41.43M | 31.08M | 25.64M | 50K | 50K |
| Property, Plant & Equipment | 9.78M | 14.84M | 30.28M | 26.3M | 22.98M | 21.68M | 17.7M | 0 | 0 |
| Fixed Asset Turnover | 0.25x | 0.17x | 0.07x | 0.02x | 0.08x | 0.05x | 0.19x | - | - |
| Goodwill | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Intangible Assets | 0 | 0 | 16.38M | 9.59M | 0 | 0 | 0 | 0 | 0 |
| Long-Term Investments | 1.1M | 1.1M | 7.5M | 0 | 9.14M | 1.1M | 0 | 50K | 0 |
| Other Non-Current Assets | 1.79M | 1.67M | 1.16M | 1.1M | 9.31M | 8.31M | 7.94M | 0 | 50K |
| Total Assets | 99.7M▲ 0% | 140.34M▲ 40.8% | 188.57M▲ 34.4% | 143.84M▼ 23.7% | 174.74M▲ 21.5% | 110.86M▼ 36.6% | 75.55M▼ 31.9% | 19.83M▼ 73.8% | 15.45M▼ 22.1% |
| Asset Turnover | 0.02x | 0.02x | 0.01x | 0.00x | 0.01x | 0.01x | 0.04x | 0.00x | - |
| Asset Growth % | 55.38% | 40.76% | 34.37% | -23.72% | 21.48% | -36.55% | -31.85% | -73.76% | -22.09% |
| Total Current Liabilities | 9.03M | 8.34M | 8.86M | 8.3M | 10.08M | 12.12M | 20.4M | 7.08M | 3.58M |
| Accounts Payable | 2.68M | 2.38M | 2.17M | 2M | 1.94M | 1.78M | 1.46M | 164K | 103K |
| Days Payables Outstanding | - | 58.31 | - | - | - | - | - | - | - |
| Short-Term Debt | 0 | 0 | 0 | 0 | 3.2M | 4.17M | 0 | 0 | 0 |
| Deferred Revenue (Current) | 444K | 268K | 544K | 0 | 531K | 882K | 0 | 0 | 0 |
| Other Current Liabilities | 3.76M | 393K | 0 | 0 | 907K | 1.89M | 11.61M | 6.91M | 3.48M |
| Current Ratio | 9.64x | 14.71x | 15.03x | 12.87x | 13.23x | 6.58x | 2.45x | 2.80x | 4.30x |
| Quick Ratio | 9.64x | 14.71x | 15.03x | 12.87x | 13.23x | 6.58x | 2.45x | 2.80x | 4.30x |
| Cash Conversion Cycle | - | - | - | - | - | - | - | - | - |
| Total Non-Current Liabilities | 5.63M | 7.9M | 22.81M | 20.4M | 17.39M | 16.13M | 12.49M | 0 | 0 |
| Long-Term Debt | 466K | 210K | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Capital Lease Obligations | 466K | 210K | 22.81M | 20.27M | 17.39M | 16.13M | 12.49M | 0 | 0 |
| Deferred Tax Liabilities | -466K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Non-Current Liabilities | 4.03M | 7.48M | 0 | 131K | 0 | 0 | 0 | 0 | 0 |
| Total Liabilities | 14.66M | 16.24M | 31.67M | 28.7M | 27.47M | 28.25M | 32.9M | 7.08M | 3.58M |
| Total Debt | 891K | 476K | 25.01M | 22.81M | 20.59M | 20.3M | 17.27M | 0 | 0 |
| Net Debt | -86.13M | -10.78M | -1.17M | -9.7M | 4.16M | 4.44M | -6.68M | -18.86M | -14.67M |
| Debt / Equity | 0.01x | 0.00x | 0.16x | 0.20x | 0.14x | 0.25x | 0.40x | - | - |
| Debt / EBITDA | - | - | - | - | - | - | - | - | - |
| Net Debt / EBITDA | - | - | - | - | - | - | - | - | - |
| Interest Coverage | -707.37x | -1125.40x | -2445.33x | -9861.17x | -30279.50x | -33072.50x | -57267.00x | - | - |
| Total Equity | 85.04M▲ 0% | 124.1M▲ 45.9% | 156.91M▲ 26.4% | 115.14M▼ 26.6% | 147.27M▲ 27.9% | 82.61M▼ 43.9% | 42.66M▼ 48.4% | 12.75M▼ 70.1% | 11.86M▼ 7.0% |
| Equity Growth % | 40.9% | 45.93% | 26.44% | -26.62% | 27.91% | -43.9% | -48.37% | -70.11% | -6.96% |
| Book Value per Share | 189.69 | 77.94 | 77.72 | 48.19 | 39.92 | 17.28 | 6.56 | 1.05 | 0.96 |
| Total Shareholders' Equity | 85.04M | 124.1M | 156.91M | 115.14M | 147.27M | 82.61M | 42.66M | 12.75M | 11.86M |
| Common Stock | 16K | 25K | 33K | 38K | 70K | 71K | 10K | 12K | 12K |
| Retained Earnings | -71.65M | -119.77M | -171.14M | -230.31M | -290.87M | -357.02M | -414.3M | -441.65M | -442.66M |
| Treasury Stock | 0 | 0 | 0 | 0 | 0 | -2.52M | -2.52M | -2.52M | -2.52M |
| Accumulated OCI | -9K | -65K | 110K | 14K | -45K | -161K | 6K | 0 | 0 |
| Minority Interest | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Synlogic, Inc. (SYBX) cash flow — operating, investing & free cash flow history
| Line item | Dec'17 | Dec'18 | Dec'19 | Dec'20 | Dec'21 | Dec'22 | Dec'23 | Dec'24 | Dec'25 |
|---|---|---|---|---|---|---|---|---|---|
| Cash from Operations | -31.05M | -42.47M | -75.47M | -39.55M | -52.2M | -56.89M | -51.61M | -31.66M | -4.36M |
| Operating CF Margin % | -1270.66% | -1685.32% | -3393.35% | -7257.43% | -2975.94% | -4821.02% | -1531.12% | -395725% | - |
| Operating CF Growth % | -25.2% | -36.76% | -77.7% | 47.59% | -31.97% | -8.98% | 9.27% | 38.66% | 86.23% |
| Net Income | -40.38M | -48.44M | -51.37M | -59.17M | -60.56M | -66.15M | -61.27M | -23.36M | -1M |
| Depreciation & Amortization | 2.31M | 2.42M | 2.7M | 2.64M | 2.44M | 2.52M | 1.96M | 347K | 0 |
| Stock-Based Compensation | 2.65M | 4.32M | 4.13M | 3.91M | 3.36M | 3.64M | 2.81M | 3.17M | 117K |
| Deferred Taxes | -1K | 0 | 0 | -21K | 261K | 0 | 0 | 0 | 0 |
| Other Non-Cash Items | 1.75M | -1.39M | 88K | 1.74M | 2.1M | 2.38M | 11.06M | -97K | -3.47M |
| Working Capital Changes | 2.61M | 620K | -31.02M | 11.36M | 200K | 723K | -6.17M | -11.72M | 0 |
| Change in Receivables | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Change in Inventory | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Change in Payables | 4.07M | -257K | 0 | -349K | 538K | 0 | 0 | -2.26M | -1.18M |
| Cash from Investing | 9.28M | -87.2M | 10.8M | 32.48M | -53.25M | 58.35M | 38.77M | 25.34M | 167K |
| Capital Expenditures | -2.58M | -5.65M | -1.25M | -395K | -679K | -728K | -214K | -14K | 0 |
| CapEx % of Revenue | 105.48% | 224.37% | 56.25% | 72.48% | 38.71% | 61.69% | 6.35% | 175% | - |
| Acquisitions | 40.43M | 0 | 0 | -28.52M | -1.27M | 0 | 0 | 0 | 0 |
| Investments | - | - | - | - | - | - | - | - | - |
| Other Investing | 11K | -81.55M | 0 | 28.52M | 1.27M | 0 | 16K | 1.33M | 167K |
| Cash from Financing | 66.68M | 82.48M | 79.6M | 13.39M | 89.38M | -2.04M | 20.94M | 172K | 0 |
| Debt Issued (Net) | -408K | -427K | -266K | -208K | -8K | -13K | -13K | -4K | 0 |
| Equity Issued (Net) | 67.08M | 82.67M | 57M | 13.54M | 89.09M | -2.23M | 20.83M | 22K | 0 |
| Dividends Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Share Repurchases | 0 | 0 | 0 | 0 | 0 | -2.52M | 0 | 0 | 0 |
| Other Financing | 5K | 244K | 22.87M | 58K | 301K | 198K | 125K | 154K | 0 |
| Net Change in Cash | 44.9M▲ 0% | -47.19M▼ 205.1% | 14.93M▲ 131.6% | 6.32M▼ 57.7% | -16.07M▼ 354.1% | -577K▲ 96.4% | 8.1M▲ 1503.6% | -6.15M▼ 175.9% | -4.19M▲ 31.8% |
| Free Cash Flow | -33.63M▲ 0% | -48.12M▼ 43.1% | -76.72M▼ 59.4% | -39.95M▲ 47.9% | -52.88M▼ 32.4% | -57.62M▼ 9.0% | -51.83M▲ 10.0% | -31.67M▲ 38.9% | -4.36M▲ 86.2% |
| FCF Margin % | -1376.15% | -1909.68% | -3449.6% | -7329.91% | -3014.65% | -4882.71% | -1537.47% | -395900% | - |
| FCF Growth % | -26.75% | -43.09% | -59.42% | 47.93% | -32.36% | -8.96% | 10.05% | 38.89% | 86.24% |
| FCF per Share | -75.02 | -30.23 | -38.00 | -16.72 | -14.34 | -12.05 | -7.97 | -2.60 | -0.35 |
| FCF Conversion (FCF/Net Income) | 0.77x | 0.88x | 1.47x | 0.67x | 0.86x | 0.86x | 0.90x | 1.36x | 4.34x |
| Interest Paid | 0 | 0 | 21K | 0 | 0 | 2K | 1K | 0 | 0 |
| Taxes Paid | 0 | 0 | 0 | 0 | 0 | 0 | 14K | 5K | 0 |
Synlogic, Inc. (SYBX) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios
| Metric | 2016 | 2017 | 2018 | 2019 | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|---|---|---|---|---|---|
| Return on Equity (ROE) | -36.14% | -55.54% | -46.32% | -36.56% | -43.5% | -46.16% | -57.55% | -91.46% | -84.32% | -8.17% |
| Return on Invested Capital (ROIC) | -99.07% | -139.56% | -68.47% | -30.33% | -34.73% | -35.49% | -42.41% | -67.26% | -205.7% | - |
| Gross Margin | 64.19% | 100% | -491.15% | 100% | 100% | 100% | 100% | 100% | 100% | - |
| Net Margin | -5916.22% | -1652.09% | -1922.02% | -2309.94% | -10857.43% | -3452.74% | -5605.68% | -1699.26% | -291987.5% | - |
| Debt / Equity | 0.02x | 0.01x | 0.00x | 0.16x | 0.20x | 0.14x | 0.25x | 0.40x | - | - |
| Interest Coverage | - | -707.37x | -1125.40x | -2445.33x | -9861.17x | -30279.50x | -33072.50x | -57267.00x | - | - |
| FCF Conversion | 0.94x | 0.77x | 0.88x | 1.47x | 0.67x | 0.86x | 0.86x | 0.90x | 1.36x | 4.34x |
| Revenue Growth | - | 450.45% | 3.11% | -11.75% | -75.49% | 221.83% | -32.73% | 185.68% | -99.76% | -100% |
Synlogic, Inc. (SYBX) SEC filings — annual & quarterly reports (10-K, 10-Q)
Jan 20, 2026·SEC
Dec 16, 2025·SEC
Nov 26, 2025·SEC
Synlogic, Inc. (SYBX) stock FAQ — growth, dividends, profitability & financials explained
Synlogic, Inc. (SYBX) saw revenue decline by 100.0% over the past year.
Synlogic, Inc. (SYBX) reported a net loss of $1.0M for fiscal year 2025.
Synlogic, Inc. (SYBX) has a return on equity (ROE) of -8.2%. Negative ROE indicates the company is unprofitable.
Synlogic, Inc. (SYBX) had negative free cash flow of $4.4M in fiscal year 2025, likely due to heavy capital investments.
Synlogic, Inc. (SYBX) financial analysis — history, returns, DCA and operating performance tools
Historical returns with dividends reinvested
Dollar cost averaging vs lump sum
Yield, growth, payout safety & DRIP
EPS trends, net income & profitability
Long-term charts & historical price data
Sales growth patterns & revenue breakdown
30 years of market, efficiency and balance-sheet ratios
DCF intrinsic value, peer multiples & estimates