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SYBX logoSynlogic, Inc.(SYBX)Earnings, Financials & Key Ratios

SYBX•NASDAQ
Price updated Jun 19, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryMicrobiome and Phage Therapeutics
AboutSynlogic, Inc., a clinical-stage biopharmaceutical company, engages in the discovery and development of synthetic biotic medicines to treat metabolic and immunological diseases in the United States. Its therapeutic programs include SYNB1618 and SYNB1934 that are orally administered, non-systemically absorbed drug candidates, which are in Phase II clinical trials to treat phenylketonuria; SYNB1353, an orally administered, non-systemically absorbed drug candidate to treat homocystinuria; and SYNB8802, an orally administered, non-systemically absorbed drug candidate that is in Phase I clinical trial for the treatment of enteric hyperoxaluria. The company is also developing SYNB1891, an intratumorally administered synthetic biotic medicine that is in Phase I clinical trial to treat solid tumors and lymphoma. It has a collaboration agreement with F. Hoffmann-La Roche Ltd; Hoffmann-La Roche Inc.; and Ginkgo Bioworks, Inc. Synlogic, Inc. is headquartered in Cambridge, Massachusetts.Show more
  • Revenue$0-100.0%
  • EBITDA-$4M+91.1%
  • Net Income-$1M+95.7%
  • EPS (Diluted)-0.08+95.8%
  • ROE-8.17%+90.3%

SYBX Key Insights

Synlogic, Inc. (SYBX) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Strong 5Y profit CAGR of 55.7%
  • ✓High quality earnings: Operating CF exceeds net income
  • ✓Trading at only 0.7x book value

✗Weaknesses

  • ✗Weak Piotroski F-Score: 2/9
  • ✗Trading more than 30% below 52-week high
  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

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SYBX Price & Volume

Synlogic, Inc. (SYBX) stock price & volume — 10-year historical chart

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SYBX Growth Metrics

Synlogic, Inc. (SYBX) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years-
TTM-

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-125%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM-145.6%

Return on Capital

10 Years-52.59%
5 Years-63.31%
3 Years-74.96%
Last Year-32.57%

SYBX Peer Comparison

Synlogic, Inc. (SYBX) competitors in Microbiome and Phage Therapeutics — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
Institutional Holdings
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
IMVT logoIMVTImmunovant, Inc.Direct Competitor7.26B35.34-12.76-68.16%0.00
ACMR logoACMRACM Research, Inc.Direct Competitor7.28B109.8780.2015.24%9.48%5.13%0.16
AGEN logoAGENAgenus Inc.Direct Competitor124.93M3.00-882.3510.37%52.16%
NKTR logoNKTRNektar TherapeuticsProduct Competitor1.19B60.98-6.27-43.89%-284.18%-87%1.66
MIRM logoMIRMMirum Pharmaceuticals, Inc.Product Competitor5.38B107.13-227.9454.74%-194.97%-289.33%1.02
ARWR logoARWRArrowhead Pharmaceuticals, Inc.Product Competitor11.52B81.82-6706.56232.58%-48.38%-55.09%0.73
RCKT logoRCKTRocket Pharmaceuticals, Inc.Product Competitor365.8M3.35-1.67-70.79%0.09
ILMN logoILMNIllumina, Inc.Supply Chain24.6B161.9329.71-0.78%19.43%32.84%0.94

Compare SYBX vs Peers

Synlogic, Inc. (SYBX) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs IMVT

Most directly comparable listed peer for SYBX.

Scale Benchmark

vs TMO

Larger-name benchmark to compare SYBX against a more recognizable public peer.

Peer Set

Compare Top 5

vs IMVT, ACMR, AGEN, NKTR

SYBX Income Statement

Synlogic, Inc. (SYBX) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Sales/Revenue
2.44M2.52M2.22M545K1.75M1.18M3.37M8K00
Revenue Growth %
450.45%3.11%-11.75%-75.49%221.83%-32.73%185.68%-99.76%-100%-
Cost of Goods Sold
014.9M00000000
COGS % of Revenue
-591.15%--------
Gross Profit
2.44M▲ 0%
-12.38M▼ 606.4%
2.22M▲ 118.0%
545K▼ 75.5%
1.75M▲ 221.8%
1.18M▼ 32.7%
3.37M▲ 185.7%
8K▼ 99.8%
0▼ 100.0%
0▲ 0%
Gross Margin %
100%-491.15%100%100%100%100%100%100%--
Gross Profit Growth %
757.54%-606.42%117.97%-75.49%221.83%-32.73%185.68%-99.76%-100%-
Operating Expenses
43.27M53.75M56.63M61.01M62.52M68.6M58.53M40.96M4.01M4.63M
OpEx % of Revenue
1770.38%2132.94%2546.45%11194.68%3564.37%5813.47%1736.34%511975%--
Selling, General & Admin
12.93M15.72M14.73M13.54M15.39M16.55M14.56M6.63M3.49M3.72M
SG&A % of Revenue
528.93%623.65%662.23%2483.85%877.54%1402.97%431.95%82887.5%--
Research & Development
30.34M38.03M41.91M47.47M47.13M52.04M43.97M9.15M43K70K
R&D % of Revenue
1241.45%1509.29%1884.22%8710.83%2686.83%4410.51%1304.39%114425%--
Other Operating Expenses
02.79M0000025.17M476K838K
Operating Income
-40.82M▲ 0%
-51.23M▼ 25.5%
-54.41M▼ 6.2%
-60.47M▼ 11.1%
-60.77M▼ 0.5%
-67.42M▼ 11.0%
-55.16M▲ 18.2%
-40.95M▲ 25.8%
-4.01M▲ 90.2%
-4.63M▲ 0%
Operating Margin %
-1670.38%-2032.94%-2446.45%-11094.68%-3464.37%-5713.47%-1636.34%-511875%--
Operating Income Growth %
-53.37%-25.49%-6.21%-11.13%-0.49%-10.95%18.18%25.76%90.21%-
EBITDA
-38.51M-48.81M-51.71M-57.83M-58.32M-64.9M-53.2M-39.66M-3.53M-3.74M
EBITDA Margin %
-1575.86%-1936.87%-2324.95%-10611.01%-3325.09%-5499.92%-1578.26%-495687.5%--
EBITDA Growth %
-48.55%-26.73%-5.94%-11.84%-0.85%-11.28%18.02%25.46%91.09%-368.58%
D&A (Non-Cash Add-back)
2.31M2.42M2.7M2.64M2.44M2.52M1.96M1.29M00
EBIT
-40.32M-48.39M-51.35M-59.17M-60.56M-66.14M-57.27M-23.35M-3.53M-3.74M
Net Interest Income
447K2.8M3.04M1.3M208K1.26M2.47M1.43M695K635K
Interest Income
504K2.84M3.06M1.3M210K1.27M2.47M1.43M695K635K
Interest Expense
57K43K21K6K2K2K1K000
Other Income/Expense
447K2.79M3.04M1.29M204K1.27M-2.11M17.6M3M3.98M
Pretax Income
-40.38M▲ 0%
-48.44M▼ 20.0%
-51.37M▼ 6.1%
-59.17M▼ 15.2%
-60.56M▼ 2.3%
-66.15M▼ 9.2%
-57.27M▲ 13.4%
-23.35M▲ 59.2%
-1M▲ 95.7%
-641K▲ 0%
Pretax Margin %
-1652.09%-1922.02%-2309.94%-10857.43%-3452.74%-5605.68%-1698.84%-291925%--
Income Tax
00000014K5K00
Effective Tax Rate %
0%0%0%0%0%0%-0.02%-0.02%0%0%
Net Income
-40.38M▲ 0%
-48.44M▼ 20.0%
-51.37M▼ 6.1%
-59.17M▼ 15.2%
-60.56M▼ 2.3%
-66.15M▼ 9.2%
-57.28M▲ 13.4%
-23.36M▲ 59.2%
-1M▲ 95.7%
-641K▲ 0%
Net Margin %
-1652.09%-1922.02%-2309.94%-10857.43%-3452.74%-5605.68%-1699.26%-291987.5%--
Net Income Growth %
-53.71%-19.96%-6.07%-15.18%-2.35%-9.22%13.4%59.22%95.7%-125%
Net Income (Continuing)
-40.38M-48.44M-51.37M-59.17M-60.56M-66.15M-57.28M-23.36M-1M-641K
Discontinued Operations
0000000000
Minority Interest
0000000000
EPS (Diluted)
-90.07▲ 0%
-30.42▲ 66.2%
-24.11▲ 20.7%
-23.67▲ 1.8%
-15.76▲ 33.4%
-13.57▲ 13.9%
-8.81▲ 35.1%
-1.92▲ 78.2%
-0.08▲ 95.8%
-0.05▲ 0%
EPS Growth %
-920.05%66.23%20.74%1.82%33.42%13.9%35.08%78.21%95.83%-145.6%
EPS (Basic)
-90.07-30.42-24.11-23.67-15.76-13.57-8.81-1.92-0.08-
Diluted Shares Outstanding
448.31K1.59M2.02M2.39M3.69M4.78M6.5M12.2M12.31M12.4M
Basic Shares Outstanding
448.31K1.59M2.02M2.39M3.69M4.78M6.5M12.2M12.31M12.39M
Dividend Payout Ratio
----------

SYBX Balance Sheet

Synlogic, Inc. (SYBX) balance sheet — assets, liabilities & shareholders' equity

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Total Current Assets
87.03M122.73M133.25M106.85M133.31M79.78M49.91M19.78M15.4M14.56M
Cash & Short-Term Investments
87.03M122.73M119.57M100.44M128.59M77.63M47.75M18.86M14.67M14.11M
Cash Only
87.03M11.25M26.18M32.51M16.44M15.86M23.96M18.86M14.67M14.11M
Short-Term Investments
0111.48M93.39M67.94M112.15M61.77M23.79M000
Accounts Receivable
0000000000
Days Sales Outstanding
----------
Inventory
0000000000
Days Inventory Outstanding
----------
Other Current Assets
298K388K648K247K311K175K146K161K729K456K
Total Non-Current Assets
12.67M17.61M55.33M36.99M41.43M31.08M25.64M50K50K50K
Property, Plant & Equipment
9.78M14.84M30.28M26.3M22.98M21.68M17.7M000
Fixed Asset Turnover
0.25x0.17x0.07x0.02x0.08x0.05x0.19x---
Goodwill
0000000000
Intangible Assets
0016.38M9.59M000000
Long-Term Investments
1.1M1.1M7.5M09.14M1.1M050K050K
Other Non-Current Assets
1.79M1.67M1.16M1.1M9.31M8.31M7.94M050K50K
Total Assets
99.7M▲ 0%
140.34M▲ 40.8%
188.57M▲ 34.4%
143.84M▼ 23.7%
174.74M▲ 21.5%
110.86M▼ 36.6%
75.55M▼ 31.9%
19.83M▼ 73.8%
15.45M▼ 22.1%
14.61M▲ 0%
Asset Turnover
0.02x0.02x0.01x0.00x0.01x0.01x0.04x0.00x-0.00x
Asset Growth %
55.38%40.76%34.37%-23.72%21.48%-36.55%-31.85%-73.76%-22.09%-80.71%
Total Current Liabilities
9.03M8.34M8.86M8.3M10.08M12.12M20.4M7.08M3.58M2.06M
Accounts Payable
2.68M2.38M2.17M2M1.94M1.78M1.46M164K103K206K
Days Payables Outstanding
-58.31--------
Short-Term Debt
00003.2M4.17M0000
Deferred Revenue (Current)
444K268K544K0531K882K0000
Other Current Liabilities
3.76M393K00907K1.89M11.61M6.91M3.48M1.85M
Current Ratio
9.64x14.71x15.03x12.87x13.23x6.58x2.45x2.80x4.30x7.08x
Quick Ratio
9.64x14.71x15.03x12.87x13.23x6.58x2.45x2.80x4.30x7.08x
Cash Conversion Cycle
----------
Total Non-Current Liabilities
5.63M7.9M22.81M20.4M17.39M16.13M12.49M000
Long-Term Debt
466K210K00000000
Capital Lease Obligations
466K210K22.81M20.27M17.39M16.13M12.49M000
Deferred Tax Liabilities
-466K000000000
Other Non-Current Liabilities
4.03M7.48M0131K000000
Total Liabilities
14.66M16.24M31.67M28.7M27.47M28.25M32.9M7.08M3.58M2.06M
Total Debt
891K476K25.01M22.81M20.59M20.3M17.27M000
Net Debt
-86.13M-10.78M-1.17M-9.7M4.16M4.44M-6.68M-18.86M-14.67M-14.11M
Debt / Equity
0.01x0.00x0.16x0.20x0.14x0.25x0.40x--0.00x
Debt / EBITDA
----------0.00x
Net Debt / EBITDA
---------3.77x
Interest Coverage
-707.37x-1125.40x-2445.33x-9861.17x-30279.50x-33072.50x-57267.00x---
Total Equity
85.04M▲ 0%
124.1M▲ 45.9%
156.91M▲ 26.4%
115.14M▼ 26.6%
147.27M▲ 27.9%
82.61M▼ 43.9%
42.66M▼ 48.4%
12.75M▼ 70.1%
11.86M▼ 7.0%
12.55M▲ 0%
Equity Growth %
40.9%45.93%26.44%-26.62%27.91%-43.9%-48.37%-70.11%-6.96%-53.52%
Book Value per Share
189.6977.9477.7248.1939.9217.286.561.050.961.01
Total Shareholders' Equity
85.04M124.1M156.91M115.14M147.27M82.61M42.66M12.75M11.86M12.55M
Common Stock
16K25K33K38K70K71K10K12K12K12K
Retained Earnings
-71.65M-119.77M-171.14M-230.31M-290.87M-357.02M-414.3M-441.65M-442.66M-441.98M
Treasury Stock
00000-2.52M-2.52M-2.52M-2.52M-2.52M
Accumulated OCI
-9K-65K110K14K-45K-161K6K000
Minority Interest
0000000000

SYBX Cash Flow Statement

Synlogic, Inc. (SYBX) cash flow — operating, investing & free cash flow history

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Cash from Operations
-31.05M-42.47M-75.47M-39.55M-52.2M-56.89M-51.61M-31.66M-4.36M-3.32M
Operating CF Margin %
-1270.66%-1685.32%-3393.35%-7257.43%-2975.94%-4821.02%-1531.12%-395725%--
Operating CF Growth %
-25.2%-36.76%-77.7%47.59%-31.97%-8.98%9.27%38.66%86.23%-21.93%
Net Income
-40.38M-48.44M-51.37M-59.17M-60.56M-66.15M-61.27M-23.36M-1M-641K
Depreciation & Amortization
2.31M2.42M2.7M2.64M2.44M2.52M1.96M347K00
Stock-Based Compensation
2.65M4.32M4.13M3.91M3.36M3.64M2.81M3.17M117K102K
Deferred Taxes
-1K00-21K261K00000
Other Non-Cash Items
1.75M-1.39M88K1.74M2.1M2.38M11.06M-97K-2.39M-2.63M
Working Capital Changes
2.61M620K-31.02M11.36M200K723K-6.17M-11.72M-1.08M-149K
Change in Receivables
0000000000
Change in Inventory
0000000000
Change in Payables
4.07M-257K0-349K538K00-2.26M0313K
Cash from Investing
9.28M-87.2M10.8M32.48M-53.25M58.35M38.77M25.34M167K155K
Capital Expenditures
-2.58M-5.65M-1.25M-395K-679K-728K-214K-14K00
CapEx % of Revenue
105.48%224.37%56.25%72.48%38.71%61.69%6.35%175%--
Acquisitions
40.43M00-28.52M-1.27M00000
Investments
----------
Other Investing
11K-81.55M028.52M1.27M016K1.33M167K155K
Cash from Financing
66.68M82.48M79.6M13.39M89.38M-2.04M20.94M172K00
Debt Issued (Net)
-408K-427K-266K-208K-8K-13K-13K-4K00
Equity Issued (Net)
67.08M82.67M57M13.54M89.09M-2.23M20.83M22K00
Dividends Paid
0000000000
Share Repurchases
00000-2.52M0000
Other Financing
5K244K22.87M58K301K198K125K154K00
Net Change in Cash
44.9M▲ 0%
-47.19M▼ 205.1%
14.93M▲ 131.6%
6.32M▼ 57.7%
-16.07M▼ 354.1%
-577K▲ 96.4%
8.1M▲ 1503.6%
-6.15M▼ 175.9%
-4.19M▲ 31.8%
-3.17M▲ 0%
Free Cash Flow
-33.63M▲ 0%
-48.12M▼ 43.1%
-76.72M▼ 59.4%
-39.95M▲ 47.9%
-52.88M▼ 32.4%
-57.62M▼ 9.0%
-51.83M▲ 10.0%
-31.67M▲ 38.9%
-4.36M▲ 86.2%
-3.32M▲ 0%
FCF Margin %
-1376.15%-1909.68%-3449.6%-7329.91%-3014.65%-4882.71%-1537.47%-395900%--
FCF Growth %
-26.75%-43.09%-59.42%47.93%-32.36%-8.96%10.05%38.89%86.24%80.96%
FCF per Share
-75.02-30.23-38.00-16.72-14.34-12.05-7.97-2.60-0.35-0.27
FCF Conversion (FCF/Net Income)
0.77x0.88x1.47x0.67x0.86x0.86x0.90x1.36x4.34x5.18x
Interest Paid
0021K002K1K000
Taxes Paid
00000014K5K00

SYBX Key Ratios

Synlogic, Inc. (SYBX) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric201720182019202020212022202320242025TTM
Return on Equity (ROE)
-55.54%-46.32%-36.56%-43.5%-46.16%-57.55%-91.46%-84.32%-8.17%-5.42%
Return on Invested Capital (ROIC)
-139.56%-68.47%-30.33%-34.73%-35.49%-42.41%-67.26%-205.7%-98.71%
Gross Margin
100%-491.15%100%100%100%100%100%100%--
Net Margin
-1652.09%-1922.02%-2309.94%-10857.43%-3452.74%-5605.68%-1699.26%-291987.5%--
Debt / Equity
0.01x0.00x0.16x0.20x0.14x0.25x0.40x--0.00x
Interest Coverage
-707.37x-1125.40x-2445.33x-9861.17x-30279.50x-33072.50x-57267.00x---
FCF Conversion
0.77x0.88x1.47x0.67x0.86x0.86x0.90x1.36x4.34x5.18x
Revenue Growth
450.45%3.11%-11.75%-75.49%221.83%-32.73%185.68%-99.76%-100%-
Related:SYBX Dividend History·SYBX Revenue History·SYBX Price History·SYBX P/E History·SYBX Financial Ratios·SYBX Institutional Holders

SYBX SEC Filings & Documents

Synlogic, Inc. (SYBX) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Jan 20, 2026·SEC

Material company update

Dec 16, 2025·SEC

Material company update

Nov 26, 2025·SEC

10-K Annual Reports

4
FY 2026

Mar 12, 2026·SEC

FY 2025

Mar 6, 2025·SEC

FY 2024

Mar 19, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

May 14, 2026·SEC

FY 2025

Nov 13, 2025·SEC

FY 2025

Aug 7, 2025·SEC

SYBX Frequently Asked Questions

Synlogic, Inc. (SYBX) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Synlogic, Inc. (SYBX) saw revenue decline by 100.0% over the past year.

Synlogic, Inc. (SYBX) reported a net loss of $0.6M for fiscal year 2025.

Dividend & Returns

Synlogic, Inc. (SYBX) has a return on equity (ROE) of -8.2%. Negative ROE indicates the company is unprofitable.

Synlogic, Inc. (SYBX) had negative free cash flow of $3.3M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in SYBX back in 2013?

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