Synlogic, Inc. (SYBX) Total Return Calculator with Dividends Reinvested

Synlogic, Inc.

Popular:

The total return for Synlogic, Inc. (SYBX) stock is -53.13% over the past 12 months. So far it's down 48.72% this year. The 5-year total return is -98.83%, meaning $10,000 invested in SYBX stock 5 years ago would be worth $117 today. Total return includes price appreciation plus reinvesting any dividends paid out.

If you invested $10,000 in SYBX 1 year ago, it would be worth $4,688 today — you'd have lost $5,313.

With Dividends Reinvested$4,688-53.13%

Price Only (No DRIP)$4,688-53.13%

Period2025-03-05 → 2026-03-04

Price

Total Return (DRIP)

S&P 500

If You Invested $10,000 in SYBX

1Y$4,688-$5,312 (-53.1%)-53.1% CAGR

3Y$598-$9,402 (-94.0%)-60.9% CAGR

5Y$117-$9,883 (-98.8%)-58.9% CAGR

10Y$199-$9,801 (-98.0%)-32.4% CAGR

15Y$1,835-$8,165 (-81.7%)-10.7% CAGR

20Y$1,835-$8,165 (-81.7%)-8.1% CAGR

30Y$1,835-$8,165 (-81.7%)-5.5% CAGR

Synlogic, Inc. did not pay dividends during this period. Total return = price return.

Loading SYBX total return...

As of 2026-03-05

Returns at a Glance

Period	Total Return	CAGR	Price Only	Div. Contrib.	$10K →
YTD	-48.72%	—	-48.72%	—	$5,128
1Y	-53.13%	-53.13%	-53.13%	—	$4,688
3Y	-94.02%	-60.90%	-94.02%	—	$598
5Y	-98.83%	-58.89%	-98.83%	—	$117
10Y	-98.01%	-32.43%	-98.01%	—	$199
15Y	-81.65%	-10.69%	-81.65%	—	$1,835
20Y	-81.65%	-8.13%	-81.65%	—	$1,835
30Y	-81.65%	-5.50%	-81.65%	—	$1,835

Risk & Highlights

Best Year+1237.31%2015

Worst Year-68.68%2024

Max Drawdown-69.40%2025-10-17 → 2026-01-20

Annual Returns

Year	Total Return	Price Return	Div.	S&P 500	vs S&P
2026YTD	-47.01%	-47.01%	—	+0.41%	-47.4pp
2025	-21.13%	-21.13%	—	+16.64%	-37.8pp
2024	-68.68%	-68.68%	—	+24.00%	-92.7pp
2023	-65.38%	-65.38%	—	+24.81%	-90.2pp
2022	-68.61%	-68.61%	—	-19.95%	-48.7pp

SYBX underperformed the S&P 500 by 69.81pp over the past year (-53.13% vs +16.68%).

Loading summary...

SYBX Peers' Total Return

Biotechnology · Top 11 by market cap

Name	Mkt Cap	30D Rtn	YTD Total Rtn	1Y Total Rtn	Div Contrib	3Y Total Rtn	5Y Total Rtn	10Y Total Rtn
SYBXSynlogic, Inc.	$7M	-4.8%	-48.7%	-53.1%	—	-94.0%	-98.8%	-98.0%
VRTXVertex Pharmaceuticals Incorporated	$121.4B	+4.2%	+5.7%	-2.8%	—	+63.9%	+125.4%	+425.4%
REGNRegeneron Pharmaceuticals, Inc.	$108.4B	+2.7%	+1.6%	+15.1%	+0.5pp	+1.5%	+71.6%	+94.0%
PHGEBiomX Inc.	$82.8B	+38.2%	+194.4%	-48.8%	—	-93.2%	-99.5%	-99.7%
ARGXargenx SE	$46.4B	-8.6%	-10.8%	+17.8%	—	+119.3%	+158.7%	+3159.0%
ALNYAlnylam Pharmaceuticals, Inc.	$43.3B	-1.2%	-18.2%	+31.3%	—	+63.9%	+128.3%	+444.7%
CAICaris Life Sciences, Inc.	$33.2B	-6.5%	-26.4%	-29.1%	—	-29.1%	-29.1%	-29.1%
RPRXRoyalty Pharma plc	$26.8B	+7.6%	+22.7%	+43.1%	+2.7pp	+42.2%	+21.0%	+16.7%
BNTXBioNTech SE	$26.0B	-1.6%	+7.4%	-9.6%	—	-21.1%	+10.1%	+643.8%
MRNAModerna, Inc.	$22.6B	+41.4%	+87.3%	+64.2%	—	-59.9%	-56.3%	+210.8%
ROIVRoivant Sciences Ltd.	$21.4B	+39.6%	+34.6%	+175.9%	—	+275.1%	+197.6%	+183.8%

Compare:SYBX vs VRTX SYBX vs REGN SYBX vs PHGE SYBX vs VRTX vs REGN

About SYBX Dividend Returns

Synlogic, Inc. (SYBX) does not currently pay dividends. Many growth-focused companies reinvest profits back into the business rather than distributing them as dividends.

How We Calculate Total Return

Our total return calculator simulates dividend reinvestment (DRIP) by assuming each dividend payment is used to purchase additional shares at the closing price on the ex-dividend date. This methodology provides an accurate representation of how a dividend reinvestment plan would perform.

Frequently Asked Questions

Q1What is the total return of SYBX over the past year?

Synlogic, Inc. (SYBX) delivered a return of -53.13% over the past year. Since SYBX does not currently pay dividends, the total return equals the price-only return.

Q2How much would $10,000 invested in SYBX be worth today?

A $10,000 investment in Synlogic, Inc. one year ago would be worth $4,688 today, representing a loss of $5,313.

Q3Does SYBX pay dividends?

Synlogic, Inc. (SYBX) does not currently pay dividends. Many growth-focused companies reinvest profits back into the business rather than distributing them as dividends. For SYBX, the total return equals the price-only return.

Q4Did SYBX beat the S&P 500?

No, Synlogic, Inc. (SYBX) underperformed the S&P 500 by 69.81 percentage points over the past year. SYBX delivered a total return of -53.13%, compared to the S&P 500's 16.68%. This means a passive S&P 500 index fund outperformed SYBX by 69.81pp during this period.

Q5What is SYBX's worst drawdown?

Synlogic, Inc. (SYBX) experienced a maximum drawdown of -69.40% over the past year, declining from its peak on 2025-10-17 to its trough on 2026-01-20. The stock has not yet fully recovered to its prior peak. Maximum drawdown measures the worst peak-to-trough decline and is an important risk metric for investors.

Q6What is SYBX's long-term total return over 10, 20, or 30 years?

Synlogic, Inc. (SYBX) has delivered strong long-term returns with dividends reinvested. Over 10 years, the total return is -98.0% (-32.4% CAGR) — $10,000 would have grown to $199. Over 20 years: -81.7% total return (-8.1% CAGR) — $10,000 → $1,835. Over 30 years: -81.7% total return (-5.5% CAGR) — $10,000 → $1,835. Long-term investors benefit from compounding: dividends buy additional shares, which generate their own dividends, creating an exponential growth effect.

Q7What was SYBX's best and worst year?

Synlogic, Inc.'s best calendar year was 2015 with a total return of 1237.3%. Its worst year was 2024 with a total return of -68.7%. This range shows the volatility investors should expect — the difference between the best and worst year is 1306.0 percentage points.