TIL
Instil Bio, Inc.
Biotechnology
Market Cap$54M
5Y Perf.-98.4%
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Side-by-side financial analysisTIL
CRIS
TGTX
FATE
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Stock Comparison
TIL vs CRIS vs TGTX vs FATE
Revenue, margins, valuation, and 5-year total return — side by side.
CRIS
Curis, Inc.
Biotechnology
Market Cap$82M
5Y Perf.-99.8%
TGTX
TG Therapeutics, Inc.
Biotechnology
Market Cap$7.58B
5Y Perf.+2.7%
FATE
Fate Therapeutics, Inc.
Biotechnology
Market Cap$240M
5Y Perf.-97.5%
TIL vs CRIS vs TGTX vs FATE — Key Financials
Market cap, revenue, margins, and valuation side-by-side.
| Company Snapshot |  TIL |  CRIS |  TGTX |  FATE |
|---|---|---|---|---|
| Industry | Biotechnology | Biotechnology | Biotechnology | Biotechnology |
| Market Cap | $54M | $82M | $7.58B | $240M |
| Revenue (TTM) | $0.00 | $7M | $700M | $6M |
| Net Income (TTM) | $-47M | $-21M | $462M | $-130M |
| Gross Margin | — | 99.4% | 83.0% | 53.8% |
| Operating Margin | — | -485.1% | 21.3% | -22.1% |
| Forward P/E | — | — | 35.9x | — |
| Total Debt | $85M | $2M | $261M | $78M |
| Cash & Equiv. | $7M | $5M | $79M | $47M |
TIL vs CRIS vs TGTX vs FATE — Long-Term Stock Performance
Price return indexed to 100 at period start. Dividends excluded.
TIL
CRIS
TGTX
FATE
| Stock | Mar 21 | Jun 26 | Return |
|---|---|---|---|
| Instil Bio, Inc. (TIL) | 100 | 1.6 | -98.4% |
| Curis, Inc. (CRIS) | 100 | 0.2 | -99.8% |
| TG Therapeutics, In… (TGTX) | 100 | 102.7 | +2.7% |
| Fate Therapeutics, … (FATE) | 100 | 2.5 | -97.5% |
Price return only. Dividends and distributions are not included.
Quick Verdict: TIL vs CRIS vs TGTX vs FATE
Each card shows where this stock fits in a portfolio — not just who wins on paper.
Bottom line: TGTX leads in 4 of 6 categories, making it the strongest pick for growth and revenue expansion and profitability and margin quality. Fate Therapeutics, Inc. is the stronger pick specifically for recent price momentum and sentiment. As sector peers, any of these can serve as alternatives in the same allocation.
🥇TGTX emerged as the overall leader. Track its performance:
TIL
Instil Bio, Inc.
The Defensive Pick
TIL is the clearest fit if your priority is defensive.
- Beta 1.55, current ratio 39.53x
Best for: defensive
CRIS
Curis, Inc.
The Secondary Option
CRIS lags the leaders in this set but could rank higher in a more targeted comparison.
Best for: healthcare exposure
TGTX
TG Therapeutics, Inc.
The Income Pick
TGTX carries the broadest edge in this set and is the clearest fit for income & stability and growth exposure.
- Dividend streak 0 yrs, beta 0.65
- Rev growth 87.3%, EPS growth 17.5%, 3Y rev CAGR 5.0%
- 6.1% 10Y total return vs FATE's 15.7%
- Lower volatility, beta 0.65, Low D/E 40.2%, current ratio 4.10x
Best for: income & stability and growth exposure
FATE
Fate Therapeutics, Inc.
The Momentum Pick
FATE is the #2 pick in this set and the best alternative if momentum is your priority.
- +47.1% vs CRIS's -84.8%
Best for: momentum
See the full category breakdown
| Category | Winner | Why |
|---|---|---|
| Growth |  TGTX | 87.3% revenue growth vs FATE's -51.2% |
| Quality / Margins | TGTX | 66.0% margin vs FATE's -20.6% |
| Stability / Safety | TGTX | Beta 0.65 vs CRIS's 1.93 |
| Dividends | Tie | None of these 4 stocks pay a meaningful dividend |
| Momentum (1Y) |  FATE | +47.1% vs CRIS's -84.8% |
| Efficiency (ROA) | TGTX | 42.8% ROA vs CRIS's -79.5% |
TIL vs CRIS vs TGTX vs FATE — Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
FY 2025
FY 2025
FY 2023
TIL vs CRIS vs TGTX vs FATE — Financial Metrics
Side-by-side numbers across 4 stocks — who leads on profitability, valuation, growth, and risk.
BEST OVERALLTGTXLAGGINGFATE
Who Leads Where
TGTX leads in 4 of 6 categories
TIL leads 0 • CRIS leads 0 • FATE leads 0 • 1 tied
Explore the data ↓FATEFate Therapeutics, In…
0leads
CRISCuris, Inc.
0leads
TILInstil Bio, Inc.
0leads
TGTXTG Therapeutics, Inc.
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6 Total Categories
CATEGORYLEADERvs TILvs CRISMETRICS WON
Income & Cash FlowRevenue, margins, and cash flow strength
TGTX5/6
Valuation MetricsMultiples, price ratios, and targets
Tied
—
Profitability & EfficiencyROE, ROIC, leverage, and quality scores
TGTX6/9
Total Returns1Y, 3Y, 5Y total returns with dividends
TGTX4/6
Risk & VolatilityBeta, volatility, and downside exposure
TGTX2/2
Analyst OutlookRatings, price targets, and dividends
—
—
Income & Cash Flow (Last 12 Months)
TGTX leads this category, winning 5 of 6 comparable metrics.
Income & Cash Flow (Last 12 Months)
TGTX and TIL operate at a comparable scale, with $700M and $0 in trailing revenue. TGTX is the more profitable business, keeping 66.0% of every revenue dollar as net income compared to FATE's -20.6%. On growth, TGTX holds the edge at +69.6% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric |  TILInstil Bio, Inc. |  CRISCuris, Inc. | TGTXTG Therapeutics, … | FATEFate Therapeutics… |
|---|---|---|---|---|
| RevenueTrailing 12 months | $0 | $7M | $700M | $6M |
| EBITDAEarnings before interest/tax | -$54M | -$34M | $150M | -$127M |
| Net IncomeAfter-tax profit | -$47M | -$21M | $462M | -$130M |
| Free Cash FlowCash after capex | -$34M | -$29M | -$14M | -$108M |
| Gross MarginGross profit ÷ Revenue | — | +99.4% | +83.0% | +53.8% |
| Operating MarginEBIT ÷ Revenue | — | -4.9% | +21.3% | -22.1% |
| Net MarginNet income ÷ Revenue | — | -3.0% | +66.0% | -20.6% |
| FCF MarginFCF ÷ Revenue | — | -4.1% | -2.0% | -17.1% |
| Rev. Growth (YoY)Latest quarter vs prior year | — | -100.0% | +69.6% | -20.3% |
| EPS Growth (YoY)Latest quarter vs prior year | +85.6% | 0.0% | +2.9% | +18.8% |
TGTX leads this category, winning 5 of 6 comparable metrics.
Valuation Metrics
Evenly matched — TIL and CRIS and FATE each lead in 1 of 3 comparable metrics.
Valuation Metrics
| Metric | TILInstil Bio, Inc. | CRISCuris, Inc. | TGTXTG Therapeutics, … | FATEFate Therapeutics… |
|---|---|---|---|---|
| Market CapShares × price | $54M | $82M | $7.6B | $240M |
| Enterprise ValueMkt cap + debt − cash | $132M | $78M | $7.8B | $271M |
| Trailing P/EPrice ÷ TTM EPS | -0.74x | -0.73x | 17.88x | -1.79x |
| Forward P/EPrice ÷ next-FY EPS est. | — | — | 35.88x | — |
| PEG RatioP/E ÷ EPS growth rate | — | — | — | — |
| EV / EBITDAEnterprise value multiple | — | — | 62.82x | — |
| Price / SalesMarket cap ÷ Revenue | — | 8.63x | 12.30x | 36.13x |
| Price / BookPrice ÷ Book value/share | 0.46x | 10.15x | 12.33x | 1.18x |
| Price / FCFMarket cap ÷ FCF | — | — | — | — |
Evenly matched — TIL and CRIS and FATE each lead in 1 of 3 comparable metrics.
Profitability & Efficiency
TGTX leads this category, winning 6 of 9 comparable metrics.
Profitability & Efficiency
TGTX delivers a 87.4% return on equity — every $100 of shareholder capital generates $87 in annual profit, vs $-139 for CRIS. CRIS carries lower financial leverage with a 0.30x debt-to-equity ratio, signaling a more conservative balance sheet compared to TIL's 0.75x. On the Piotroski fundamental quality scale (0–9), TGTX scores 4/9 vs FATE's 2/9, reflecting mixed financial health.
| Metric | TILInstil Bio, Inc. | CRISCuris, Inc. | TGTXTG Therapeutics, … | FATEFate Therapeutics… |
|---|---|---|---|---|
| ROE (TTM)Return on equity | -39.8% | -138.8% | +87.4% | -58.9% |
| ROA (TTM)Return on assets | -22.4% | -79.5% | +42.8% | -39.4% |
| ROICReturn on invested capital | -18.0% | — | +16.4% | -36.5% |
| ROCEReturn on capital employed | -23.3% | -2.3% | +17.7% | -43.1% |
| Piotroski ScoreFundamental quality 0–9 | 2 | 3 | 4 | 2 |
| Debt / EquityFinancial leverage | 0.75x | 0.30x | 0.40x | 0.38x |
| Net DebtTotal debt minus cash | $79M | -$3M | $182M | $31M |
| Cash & Equiv.Liquid assets | $7M | $5M | $79M | $47M |
| Total DebtShort + long-term debt | $85M | $2M | $261M | $78M |
| Interest CoverageEBIT ÷ Interest expense | -8.24x | -2.47x | 5.67x | — |
TGTX leads this category, winning 6 of 9 comparable metrics.
Total Returns (Dividends Reinvested)
TGTX leads this category, winning 4 of 6 comparable metrics.
Total Returns (Dividends Reinvested)
A $10,000 investment in TGTX five years ago would be worth $12,929 today (with dividends reinvested), compared to $26 for CRIS. Over the past 12 months, FATE leads with a +47.1% total return vs CRIS's -84.8%. The 3-year compound annual growth rate (CAGR) favors TGTX at 23.6% vs CRIS's -70.5% — a key indicator of consistent wealth creation.
| Metric | TILInstil Bio, Inc. | CRISCuris, Inc. | TGTXTG Therapeutics, … | FATEFate Therapeutics… |
|---|---|---|---|---|
| YTD ReturnYear-to-date | -29.7% | -57.0% | +69.1% | +108.1% |
| 1-Year ReturnPast 12 months | -78.9% | -84.8% | +32.5% | +47.1% |
| 3-Year ReturnCumulative with dividends | -29.8% | -97.4% | +89.0% | -61.9% |
| 5-Year ReturnCumulative with dividends | -97.6% | -99.7% | +29.3% | -97.7% |
| 10-Year ReturnCumulative with dividends | -98.5% | -99.7% | +605.4% | +15.7% |
| CAGR (3Y)Annualised 3-year return | -11.1% | -70.5% | +23.6% | -27.5% |
TGTX leads this category, winning 4 of 6 comparable metrics.
Risk & Volatility
TGTX leads this category, winning 2 of 2 comparable metrics.
Risk & Volatility
TGTX is the less volatile stock with a 0.65 beta — it tends to amplify market swings less than CRIS's 1.93 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. TGTX currently trades 98.2% from its 52-week high vs CRIS's 14.3% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | TILInstil Bio, Inc. | CRISCuris, Inc. | TGTXTG Therapeutics, … | FATEFate Therapeutics… |
|---|---|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 1.55x | 1.93x | 0.65x | 1.93x |
| 52-Week HighHighest price in past year | $38.50 | $2.94 | $50.41 | $2.88 |
| 52-Week LowLowest price in past year | $5.67 | $0.41 | $25.28 | $0.91 |
| % of 52W HighCurrent price vs 52-week peak | +20.6% | +14.3% | +98.2% | +71.5% |
| RSI (14)Momentum oscillator 0–100 | 40.9 | 32.3 | 76.1 | 47.8 |
| Avg Volume (50D)Average daily shares traded | 26K | 432K | 2.0M | 3.2M |
TGTX leads this category, winning 2 of 2 comparable metrics.
Analyst Outlook
Insufficient data to determine a leader in this category.
Analyst Outlook
Analyst consensus: CRIS as "Buy", TGTX as "Buy", FATE as "Buy". Consensus price targets imply 167.0% upside for FATE (target: $6) vs 10.1% for TGTX (target: $55).
| Metric | TILInstil Bio, Inc. | CRISCuris, Inc. | TGTXTG Therapeutics, … | FATEFate Therapeutics… |
|---|---|---|---|---|
| Analyst RatingConsensus buy/hold/sell | — | Buy | Buy | Buy |
| Price TargetConsensus 12-month target | — | — | $54.50 | $5.50 |
| # AnalystsCovering analysts | — | 18 | 13 | 31 |
| Dividend YieldAnnual dividend ÷ price | — | — | — | — |
| Dividend StreakConsecutive years of raises | — | — | 0 | — |
| Dividend / ShareAnnual DPS | — | — | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | 0.0% | +1.2% | 0.0% |
Insufficient data to determine a leader in this category.
Key Takeaway
TGTX leads in 4 of 6 categories — strongest in Income & Cash Flow and Profitability & Efficiency. 1 category is tied.
Best OverallTG Therapeutics, Inc. (TGTX)Leads 4 of 6 categories
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TIL vs CRIS vs TGTX vs FATE: Key Questions Answered
9 questions · data-driven answers · updated daily
01Is TIL or CRIS or TGTX or FATE a better buy right now?
For growth investors, TG Therapeutics, Inc.
(TGTX) is the stronger pick with 87. 3% revenue growth year-over-year, versus -51. 2% for Fate Therapeutics, Inc. (FATE). TG Therapeutics, Inc. (TGTX) offers the better valuation at 17. 9x trailing P/E (35. 9x forward), making it the more compelling value choice. Analysts rate Curis, Inc. (CRIS) a "Buy" — based on 18 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — TIL or CRIS or TGTX or FATE?
Over the past 5 years, TG Therapeutics, Inc.
(TGTX) delivered a total return of +29. 3%, compared to -99. 7% for Curis, Inc. (CRIS). Over 10 years, the gap is even starker: TGTX returned +605. 4% versus CRIS's -99. 7%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — TIL or CRIS or TGTX or FATE?
By beta (market sensitivity over 5 years), TG Therapeutics, Inc.
(TGTX) is the lower-risk stock at 0. 65β versus Curis, Inc. 's 1. 93β — meaning CRIS is approximately 197% more volatile than TGTX relative to the S&P 500. On balance sheet safety, Curis, Inc. (CRIS) carries a lower debt/equity ratio of 30% versus 75% for Instil Bio, Inc. — giving it more financial flexibility in a downturn.
04Which is growing faster — TIL or CRIS or TGTX or FATE?
By revenue growth (latest reported year), TG Therapeutics, Inc.
(TGTX) is pulling ahead at 87. 3% versus -51. 2% for Fate Therapeutics, Inc. (FATE). On earnings-per-share growth, the picture is similar: TG Therapeutics, Inc. grew EPS 1747% year-over-year, compared to 6. 1% for Instil Bio, Inc.. Over a 3-year CAGR, TGTX leads at 504. 9% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.
05Which has better profit margins — TIL or CRIS or TGTX or FATE?
TG Therapeutics, Inc.
(TGTX) is the more profitable company, earning 72. 6% net margin versus -20. 5% for Fate Therapeutics, Inc. — meaning it keeps 72. 6% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: TGTX leads at 20. 0% versus -22. 2% for FATE. At the gross margin level — before operating expenses — CRIS leads at 99. 5%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
06Is TIL or CRIS or TGTX or FATE more undervalued right now?
Analyst consensus price targets imply the most upside for FATE: 167.
0% to $5. 50.
07Which pays a better dividend — TIL or CRIS or TGTX or FATE?
None of the stocks in this comparison currently pay a material dividend.
All are effectively zero-yield and should be held for capital appreciation rather than income.
08Is TIL or CRIS or TGTX or FATE better for a retirement portfolio?
For long-horizon retirement investors, TG Therapeutics, Inc.
(TGTX) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0. 65), +605. 4% 10Y return). Curis, Inc. (CRIS) carries a higher beta of 1. 93 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (TGTX: +605. 4%, CRIS: -99. 7%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
09What are the main differences between TIL and CRIS and TGTX and FATE?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.
In terms of investment character: TIL is a small-cap quality compounder stock; CRIS is a small-cap quality compounder stock; TGTX is a small-cap high-growth stock; FATE is a small-cap quality compounder stock. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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