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ACIU logoAC Immune S.A.(ACIU)Earnings, Financials & Key Ratios

ACIU•NASDAQ
Price updated Jun 19, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryNeuroscience and Psychiatry Therapies
AboutAC Immune SA, a clinical stage biopharmaceutical company, discovers, designs, and develops medicines and diagnostic products for the prevention and treatment of neurodegenerative diseases associated with protein misfolding. Its SupraAntigen and Morphomer platforms are designed to generate vaccines, antibodies, and small molecules, which selectively interact with misfolded proteins that are common in a range of neurodegenerative diseases. The company is developing Crenezumab, a humanized, conformation-specific monoclonal antibody, which is in Phase II clinical prevention trial for the treatment of Alzheimer's disease (AD). It is also developing ACI-24, an anti-Abeta vaccine candidate that is in Phase II clinical study for AD, as well as completed Phase Ib clinical study for Down syndrome; ACI-35, an anti-Tau vaccine candidate that has completed Phase Ib clinical study; and Tau- positron emission tomography (PET) imaging tracer, which is in Phase II clinical study. In addition, the company is researching and developing small molecule Tau aggregation inhibitors for AD and NeuroOrphan indications. Further, it has discovery and preclinical stage molecules targeting range of neurodegenerative diseases, which include diagnostics targeting TDP-43, alpha-synuclein, and NLRP3. AC Immune SA has license agreements and collaborations with Genentech, Inc.; Biogen International GmbH; Janssen Pharmaceuticals, Inc.; Life Molecular Imaging SA; Eli Lilly and Company; and WuXi Biologics. The company was incorporated in 2003 and is headquartered in Lausanne, Switzerland.Show more
  • Revenue$4M-86.9%
  • EBITDA-$66M-32.1%
  • Net Income-$70M-38.4%
  • EPS (Diluted)-0.70-37.3%
  • Gross Margin100%+177.4%
  • EBITDA Margin-1857.26%-910.0%
  • Operating Margin-1927.32%-904.9%
  • Net Margin-1971.65%-957.5%
  • ROE-89.62%-140.2%

ACIU Key Insights

AC Immune S.A. (ACIU) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

No significant strengths identified

✗Weaknesses

  • ✗Weak Piotroski F-Score: 2/9
  • ✗Negative free cash flow
  • ✗Weak momentum: RS Rating 19 (bottom 19%)
  • ✗Sales declining 25.4% over 5 years
  • ✗Trading more than 30% below 52-week high
  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

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ACIU Price & Volume

AC Immune S.A. (ACIU) stock price & volume — 10-year historical chart

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ACIU Growth Metrics

AC Immune S.A. (ACIU) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-21.28%
5 Years-25.37%
3 Years-3.17%
TTM-86.92%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-38.15%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM-37.25%

Return on Capital

10 Years-27.05%
5 Years-41.36%
3 Years-46.27%
Last Year-72.6%

ACIU Recent Earnings

AC Immune S.A. (ACIU) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 8/12 qtrs (67%)●Beat Revenue 8/12 qtrs (80%)
Q2 2026Latest
Apr 30, 2026
Metric
Actual
Est
EPS
$0.19+5.0%
$0.20
Rev
$1M+325.0%
$329,435
Q2 2026
Apr 29, 2026
Metric
Actual
Est
EPS
$0.19+5.0%
$0.20
Rev
$1M+325.0%
$329,435
Q2 2026
Mar 13, 2026
Metric
Actual
Est
EPS
$0.18+5.3%
$0.19
Rev
$428,876-70.3%
$1M
Q4 2025
Nov 4, 2025
Metric
Actual
Est
EPS
$0.20+9.1%
$0.22
Rev
$1M+3.2%
$1M
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestApr 30, 2026
$0.19vs $0.20+5.0%
$1Mvs $329,435+325.0%
Q2 2026Apr 29, 2026
$0.19vs $0.20+5.0%
$1Mvs $329,435+325.0%
Q2 2026Mar 13, 2026
$0.18vs $0.19+5.3%
$428,876vs $1M-70.3%
Q4 2025Nov 4, 2025
$0.20vs $0.22+9.1%
$1Mvs $1M+3.2%
Based on last 12 quarters of dataView full earnings history →

ACIU Peer Comparison

AC Immune S.A. (ACIU) competitors in Neuroscience and Psychiatry Therapies — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
Institutional Holdings
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
PRAX logoPRAXPraxis Precision Medicines, Inc.Direct Competitor8.15B282.31-20.94-100%-43.02%0.00
SAVA logoSAVACassava Sciences, Inc.Direct Competitor63.77M1.32-2.54-95.77%
ANVS logoANVSAnnovis Bio, Inc.Direct Competitor34.43M1.75-1.25-318.08%
NRXP logoNRXPNRx Pharmaceuticals, Inc.Direct Competitor68.62M3.97-2.96-10.7%
BIIB logoBIIBBiogen Inc.Product Competitor29.02B196.5822.261.39%13.92%7.55%0.38
LLY logoLLYEli Lilly and CompanyProduct Competitor1.04T1098.1347.8544.7%34.98%101.17%1.60
IONS logoIONSIonis Pharmaceuticals, Inc.Product Competitor12.25B74.12-31.1433.87%-30.87%-58.57%5.35
PRTA logoPRTAProthena Corporation plcProduct Competitor467.51M8.93-1.97-92.84%-260.92%-49.88%0.05

Compare ACIU vs Peers

AC Immune S.A. (ACIU) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs PRAX

Most directly comparable listed peer for ACIU.

Scale Benchmark

vs LLY

Larger-name benchmark to compare ACIU against a more recognizable public peer.

Peer Set

Compare Top 5

vs PRAX, SAVA, ANVS, NRXP

ACIU Income Statement

AC Immune S.A. (ACIU) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Sales/Revenue
20.25M7.19M110.46M15.43M03.94M14.8M27.31M3.57M
Revenue Growth %
-12.75%-64.48%1435.39%-86.03%-100%-276.14%84.51%-86.92%
Cost of Goods Sold
32.66M44.28M50.43M59.49M0054.61M62.57M0
COGS % of Revenue
161.26%615.47%45.66%385.5%--368.93%229.12%-
Gross Profit
-12.41M▲ 0%
-37.08M▼ 198.9%
60.02M▲ 261.9%
-44.06M▼ 173.4%
0▲ 100.0%
3.94M▲ 0%
-39.8M▼ 1111.6%
-35.26M▲ 11.4%
3.57M▲ 110.1%
Gross Margin %
-61.26%-515.47%54.34%-285.5%-100%-268.93%-129.12%100%
Gross Profit Growth %
-384.69%-198.86%261.86%-173.4%100%--1111.56%11.42%110.13%
Operating Expenses
42.79M56.74M15.49M17.2M79.01M74.78M13.82M17.12M72.44M
OpEx % of Revenue
211.28%788.77%14.02%111.49%-1900.43%93.37%62.68%2027.32%
Selling, General & Admin
6.27M7.56M16.06M18.56M10.88M9.58M10.58M11.43M11.65M
SG&A % of Revenue
30.98%105.14%14.54%120.26%-243.51%71.45%41.87%326.11%
Research & Development
32.66M44.28M50.43M59.49M62.28M60.34M54.61M62.57M56.44M
R&D % of Revenue
161.26%615.47%45.66%385.5%-1533.32%368.93%229.12%1579.51%
Other Operating Expenses
3.86M4.9M-51M-60.84M5.85M4.86M-51.36M-56.89M4.35M
Operating Income
-22.54M▲ 0%
-49.55M▼ 119.8%
44.54M▲ 189.9%
-61.26M▼ 237.6%
-79.01M▼ 29.0%
-70.85M▲ 10.3%
-53.62M▲ 24.3%
-52.38M▲ 2.3%
-68.86M▼ 31.5%
Operating Margin %
-111.28%-688.77%40.32%-396.99%--1800.43%-362.3%-191.8%-1927.32%
Operating Income Growth %
-115.56%-119.84%189.88%-237.55%-28.97%10.33%24.31%2.32%-31.47%
EBITDA
-21.96M-48.59M45.81M-59.73M-76.6M-68.49M-51.41M-50.22M-66.36M
EBITDA Margin %
-108.41%-675.41%41.47%-387.05%--1740.48%-347.33%-183.88%-1857.26%
EBITDA Growth %
-115.75%-121.27%194.28%-230.38%-28.26%10.59%24.94%2.32%-32.15%
D&A (Non-Cash Add-back)
580K961K1.27M1.53M2.41M2.36M2.21M2.16M2.5M
EBIT
-26.26M-50.62M44.54M-61.26M-72.41M-70.39M-54.05M-50.78M-70.26M
Net Interest Income
176K-207K-1.62M-106K5.9M-286K868K3.06M1.67M
Interest Income
330K127K303K78K6.49M69K1.04M3.2M1.86M
Interest Expense
147K334K1.93M184K581K355K176K133K191K
Other Income/Expense
-3.87M-1.4M906K-661K6.02M107K-599K1.47M-1.58M
Pretax Income
-26.41M▲ 0%
-50.95M▼ 92.9%
45.44M▲ 189.2%
-61.92M▼ 236.3%
-72.99M▼ 17.9%
-70.74M▲ 3.1%
-54.22M▲ 23.3%
-50.91M▲ 6.1%
-70.45M▼ 38.4%
Pretax Margin %
-130.39%-708.24%41.14%-401.28%--1797.71%-366.35%-186.43%-1971.65%
Income Tax
147K0003K13K10K3K0
Effective Tax Rate %
-0.56%0%0%0%-0%-0.02%-0.02%-0.01%0%
Net Income
-26.41M▲ 0%
-50.95M▼ 92.9%
45.44M▲ 189.2%
-61.92M▼ 236.3%
-73M▼ 17.9%
-70.75M▲ 3.1%
-54.23M▲ 23.3%
-50.92M▲ 6.1%
-70.45M▼ 38.4%
Net Margin %
-130.39%-708.24%41.14%-401.28%--1798.04%-366.41%-186.44%-1971.65%
Net Income Growth %
-272.2%-92.92%189.19%-236.26%-17.89%3.07%23.35%6.12%-38.36%
Net Income (Continuing)
-26.41M-50.95M45.44M-61.92M-73M-70.75M-54.23M-50.92M-70.45M
Discontinued Operations
000000000
Minority Interest
000000000
EPS (Diluted)
-0.46▲ 0%
-0.82▼ 78.3%
0.64▲ 178.0%
-0.86▼ 234.4%
-0.97▼ 12.8%
-0.85▲ 12.4%
-0.64▲ 24.7%
-0.51▲ 20.3%
-0.70▼ 37.3%
EPS Growth %
-228.57%-78.26%178.05%-234.38%-12.79%12.37%24.71%20.31%-37.25%
EPS (Basic)
-0.46-0.820.64-0.86-0.97-0.85-0.64-0.51-0.70
Diluted Shares Outstanding
57.36M61.84M71.1M71.9M74.95M83.55M84.69M99.69M100.75M
Basic Shares Outstanding
57.08M61.84M70.6M71.9M74.95M83.55M84.69M99.69M100.75M
Dividend Payout Ratio
---------

ACIU Balance Sheet

AC Immune S.A. (ACIU) balance sheet — assets, liabilities & shareholders' equity

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Total Current Assets
129.53M192.93M292.77M231.77M202.63M128.09M125.15M171.99M96.83M
Cash & Short-Term Investments
124.38M186.46M288.59M225.89M198.22M122.59M103.05M165.49M91.52M
Cash Only
124.38M156.46M193.59M160.89M82.22M31.59M78.49M36.27M26.83M
Short-Term Investments
030M95M65M116M91M24.55M129.21M64.69M
Accounts Receivable
3.72M4.1M1.4M1.59M975K408K15.05M1.1M681.77K
Days Sales Outstanding
66.98208.124.6237.63-37.84371.0414.6969.65
Inventory
-1.36M00000000
Days Inventory Outstanding
---------
Other Current Assets
000329K428K392K622K1.1M0
Total Non-Current Assets
2.48M3.63M6.48M6.97M58.81M57.84M57.66M58.92M57.59M
Property, Plant & Equipment
2.35M3.32M6.17M6.64M8.03M7.07M6.88M8.09M6.54M
Fixed Asset Turnover
8.61x2.16x17.90x2.32x-0.56x2.15x3.38x0.55x
Goodwill
000000000
Intangible Assets
000050.42M50.42M50.42M50.42M50.47M
Long-Term Investments
126K304K304K000361K0584.66K
Other Non-Current Assets
000334K363K361K0415K0
Total Assets
132.01M▲ 0%
196.56M▲ 48.9%
299.25M▲ 52.2%
238.74M▼ 20.2%
261.44M▲ 9.5%
185.94M▼ 28.9%
182.81M▼ 1.7%
230.91M▲ 26.3%
154.43M▼ 33.1%
Asset Turnover
0.15x0.04x0.37x0.06x-0.02x0.08x0.12x0.02x
Asset Growth %
-15.43%48.89%52.25%-20.22%9.51%-28.88%-1.68%26.31%-33.12%
Total Current Liabilities
9.75M13.08M17.51M14.02M20.03M11.48M13.58M100.84M94.8M
Accounts Payable
1.09M1.98M142K2.18M2M929K1.68M2.66M2.07M
Days Payables Outstanding
12.216.311.0313.4--11.2215.51-
Short-Term Debt
0332K652K00000852.97K
Deferred Revenue (Current)
355K351K4.48M000138K083.8M
Other Current Liabilities
000306K717K587K085.06M3.83M
Current Ratio
13.28x14.75x16.72x16.53x10.12x11.16x9.22x1.71x1.02x
Quick Ratio
13.42x14.75x16.72x16.53x10.12x11.16x9.22x1.71x1.02x
Cash Conversion Cycle
---------
Total Non-Current Liabilities
5.42M5.85M9.3M9.24M9.44M5.47M8.6M17.8M14.69M
Long-Term Debt
494K186K0000000
Capital Lease Obligations
395K01.81M1.78M2.34M2.25M2.83M4.4M3.69M
Deferred Tax Liabilities
000000000
Other Non-Current Liabilities
4.53M5.67M7.49M7.46M7.1M3.21M5.77M13.4M8.66M
Total Liabilities
15.17M18.93M26.81M23.26M29.46M16.95M22.17M118.64M109.49M
Total Debt
395K518K2.91M2.22M2.91M2.8M3.5M5.43M4.55M
Net Debt
-123.98M-155.94M-190.68M-158.67M-79.31M-28.79M-75M-30.85M-22.28M
Debt / Equity
0.00x0.00x0.01x0.01x0.01x0.02x0.02x0.05x0.10x
Debt / EBITDA
--0.06x------
Net Debt / EBITDA
---4.16x------
Interest Coverage
-178.67x-151.55x23.12x-332.93x-124.63x-198.27x-307.09x-381.80x-367.83x
Total Equity
116.84M▲ 0%
177.62M▲ 52.0%
272.44M▲ 53.4%
215.48M▼ 20.9%
231.98M▲ 7.7%
168.99M▼ 27.2%
160.64M▼ 4.9%
112.27M▼ 30.1%
44.93M▼ 60.0%
Equity Growth %
-17.94%52.02%53.38%-20.91%7.66%-27.15%-4.94%-30.11%-59.98%
Book Value per Share
2.042.873.833.003.102.021.901.130.45
Total Shareholders' Equity
116.84M177.62M272.44M215.48M231.98M168.99M160.64M112.27M44.93M
Common Stock
1.15M1.35M1.44M1.54M1.79M1.8M2.09M2.23M2.26M
Retained Earnings
-72.61M-121.88M-75.52M-132.85M-200.94M-264.01M-316.2M-368.24M-439.52M
Treasury Stock
000-100K-124K-124K-105K-218K-218.25K
Accumulated OCI
179.35M-3.54M00010K-51K-5K7.01K
Minority Interest
000000000

ACIU Cash Flow Statement

AC Immune S.A. (ACIU) cash flow — operating, investing & free cash flow history

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Cash from Operations
-22.09M-44.08M55.22M-59.52M-65.69M-73.57M-60.41M65.84M-66.15M
Operating CF Margin %
-109.08%-612.7%49.99%-385.7%--1869.58%-408.13%241.1%-1851.33%
Operating CF Growth %
-291.32%-99.5%225.28%-207.78%-10.37%-11.99%17.89%209%-200.46%
Net Income
-26.41M-50.95M45.44M-61.92M-73M-70.75M-54.23M-50.92M-67.28M
Depreciation & Amortization
580K961K1.69M1.97M2.41M2.36M2.21M2.16M2.39M
Stock-Based Compensation
1.58M2.52M2.83M4.09M4.13M3.33M4.37M5.47M0
Deferred Taxes
177K131K00130K0000
Other Non-Cash Items
3.97M1.45M-400K922K-6.2M-72K2.4M1.61M5.21M
Working Capital Changes
-1.99M1.81M5.65M-4.57M6.84M-8.43M-15.16M107.51M-6.47M
Change in Receivables
-401K698K2.5M-532K-99K603K-14.8M13.55M877.68K
Change in Inventory
000000000
Change in Payables
-2.85M0000000-565.38K
Cash from Investing
-1.84M-32.04M-66.89M28.33M-53.66M23.76M65.64M-105.29M60.69M
Capital Expenditures
-1.8M-1.86M-1.89M-1.71M-2.63M-1.24M-801K-576K-859.54K
CapEx % of Revenue
8.9%25.83%1.71%11.06%-31.49%5.41%2.11%24.06%
Acquisitions
0000000014.32K
Investments
---------
Other Investing
-40K-178K030.04M-51.03M25M66.45M-104.71M-162.36K
Cash from Financing
271K109.38M49.62M-803K40.75M-1.35M43.25M-1.12M-974.14K
Debt Issued (Net)
200K198K50.06M-946K22.95M-569K-548K-683K-1.03M
Equity Issued (Net)
0111.53M0017.8M-1K43.8M111K5.73K
Dividends Paid
000000000
Share Repurchases
000-100K0-8K000
Other Financing
71K-2.35M-441K143K-6K-776K0-548K46.13K
Net Change in Cash
-27.83M▲ 0%
32.09M▲ 215.3%
37.13M▲ 15.7%
-32.69M▼ 188.1%
-78.68M▼ 140.6%
-50.63M▲ 35.6%
46.91M▲ 192.6%
-42.22M▼ 190.0%
-4.92M▲ 88.3%
Free Cash Flow
-23.9M▲ 0%
-45.94M▼ 92.2%
53.34M▲ 216.1%
-61.22M▼ 214.8%
-68.32M▼ 11.6%
-74.81M▼ 9.5%
-61.21M▲ 18.2%
65.27M▲ 206.6%
-67.01M▼ 202.7%
FCF Margin %
-117.98%-638.53%48.29%-396.75%--1901.07%-413.55%238.99%-1875.39%
FCF Growth %
-265.1%-92.23%216.11%-214.79%-11.6%-9.49%18.18%206.63%-202.67%
FCF per Share
-0.42-0.740.75-0.85-0.91-0.90-0.720.65-0.67
FCF Conversion (FCF/Net Income)
0.84x0.87x1.22x0.96x0.90x1.04x1.11x-1.29x0.94x
Interest Paid
000000000
Taxes Paid
000000000

ACIU Key Ratios

AC Immune S.A. (ACIU) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric2016201720182019202020212022202320242025
Return on Equity (ROE)
-6.65%-20.38%-34.61%20.19%-25.38%-32.63%-35.29%-32.91%-37.31%-89.62%
Return on Invested Capital (ROIC)
---511.32%64.58%-66.31%-56.58%-36.28%-35.61%-47.03%-99.25%
Gross Margin
-11.03%-61.26%-515.47%54.34%-285.5%-100%-268.93%-129.12%100%
Net Margin
-30.57%-130.39%-708.24%41.14%-401.28%--1798.04%-366.41%-186.44%-1971.65%
Debt / Equity
-0.00x0.00x0.01x0.01x0.01x0.02x0.02x0.05x0.10x
Interest Coverage
-27.69x-178.67x-151.55x23.12x-332.93x-124.63x-198.27x-307.09x-381.80x-367.83x
FCF Conversion
0.80x0.84x0.87x1.22x0.96x0.90x1.04x1.11x-1.29x0.94x
Revenue Growth
-40.61%-12.75%-64.48%1435.39%-86.03%-100%-276.14%84.51%-86.92%
Related:ACIU Dividend History·ACIU Revenue History·ACIU Price History·ACIU P/E History·ACIU Financial Ratios·ACIU Institutional Holders

ACIU Frequently Asked Questions

AC Immune S.A. (ACIU) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

AC Immune S.A. (ACIU) reported $3.6M in revenue for fiscal year 2025. This represents a 59% decrease from $8.6M in 2013.

AC Immune S.A. (ACIU) saw revenue decline by 86.9% over the past year.

AC Immune S.A. (ACIU) reported a net loss of $70.3M for fiscal year 2025.

Dividend & Returns

AC Immune S.A. (ACIU) has a return on equity (ROE) of -89.6%. Negative ROE indicates the company is unprofitable.

AC Immune S.A. (ACIU) had negative free cash flow of $70.1M in fiscal year 2025, likely due to heavy capital investments.

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