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ANVSAnnovis Bio, Inc.
$1.75$34M
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ANVS logoAnnovis Bio, Inc.(ANVS)Earnings, Financials & Key Ratios

ANVS•NYSE
Price updated Jun 19, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryNeuroscience and Psychiatry Therapies
AboutAnnovis Bio, Inc., a clinical stage drug platform company, develops drugs to treat neurodegeneration. The company's lead compound is Buntanetap, an orally administered drug, which has completed Phase 2a clinical trials for the treatment of Alzheimer's disease (AD) and Parkinson's disease, as well as is in clinical trials for Alzheimer's disease in Down Syndrome and other chronic neurodegenerative disorders. It is also developing ANVS405 for protecting the traumatic brain injury and stroke; and ANVS301, which is in Phase I clinical trials to increase cognitive capability in later stages of AD and dementia. The company was incorporated in 2008 and is based in Berwyn, Pennsylvania.Show more
  • Revenue$0
  • EBITDA-$30M-11.2%
  • Net Income-$29M-17.3%
  • EPS (Diluted)-1.40+99.9%
  • ROE-220.61%+93.0%

ANVS Key Insights

Annovis Bio, Inc. (ANVS) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓High quality earnings: Operating CF exceeds net income

✗Weaknesses

  • ✗Profits declining 39.5% over 5 years
  • ✗Weak Piotroski F-Score: 2/9
  • ✗Shares diluted 68.0% in last year
  • ✗Trading more than 30% below 52-week high
  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

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ANVS Price & Volume

Annovis Bio, Inc. (ANVS) stock price & volume — 10-year historical chart

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ANVS Growth Metrics

Annovis Bio, Inc. (ANVS) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years-
TTM-

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-40.82%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM26.5%

Return on Capital

10 Years-189.83%
5 Years-187.83%
3 Years-271.08%
Last Year-216.04%

ANVS Recent Earnings

Annovis Bio, Inc. (ANVS) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 6/12 qtrs (50%)
Q2 2026Latest
May 15, 2026
Metric
Actual
Est
EPS
$0.63-59.5%
$0.40
Rev
—
—
Q2 2026
Mar 16, 2026
Metric
Actual
Est
EPS
$0.39-26.5%
$0.31
Rev
—
—
Q4 2025
Nov 12, 2025
Metric
Actual
Est
EPS
$0.37-2.8%
$0.36
Rev
—
—
Q3 2025
Aug 12, 2025
Metric
Actual
Est
EPS
$0.32+11.1%
$0.36
Rev
—
—
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 15, 2026
$0.63vs $0.40-59.5%
—
Q2 2026Mar 16, 2026
$0.39vs $0.31-26.5%
—
Q4 2025Nov 12, 2025
$0.37vs $0.36-2.8%
—
Q3 2025Aug 12, 2025
$0.32vs $0.36+11.1%
—
Based on last 12 quarters of dataView full earnings history →

ANVS Peer Comparison

Annovis Bio, Inc. (ANVS) competitors in Neuroscience and Psychiatry Therapies — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
Institutional Holdings
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
SAVA logoSAVACassava Sciences, Inc.Direct Competitor63.77M1.32-2.54-95.77%
PRTA logoPRTAProthena Corporation plcDirect Competitor467.51M8.93-1.97-92.84%-260.92%-49.88%0.05
ACAD logoACADACADIA Pharmaceuticals Inc.Direct Competitor3.7B21.629.4411.87%34.3%35.65%0.04
AVXL logoAVXLAnavex Life Sciences Corp.Direct Competitor252.99M2.73-5.06-38.76%
ATHA logoATHAAthira Pharma, Inc.Direct Competitor17.12M4.34-0.17-381.01%0.03
BIIB logoBIIBBiogen Inc.Product Competitor29.02B196.5822.261.39%13.92%7.55%0.38
LLY logoLLYEli Lilly and CompanyProduct Competitor1.04T1098.1347.8544.7%34.98%101.17%1.60
ALNY logoALNYAlnylam Pharmaceuticals, Inc.Product Competitor37.1B278.09119.3565.19%13.46%98.29%1.62

Compare ANVS vs Peers

Annovis Bio, Inc. (ANVS) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs SAVA

Most directly comparable listed peer for ANVS.

Scale Benchmark

vs LLY

Larger-name benchmark to compare ANVS against a more recognizable public peer.

Peer Set

Compare Top 5

vs SAVA, PRTA, ACAD, AVXL

ANVS Income Statement

Annovis Bio, Inc. (ANVS) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Sales/Revenue
0000000000
Revenue Growth %
----------
Cost of Goods Sold
0000000000
COGS % of Revenue
----------
Gross Profit
0▲ 0%
0▲ 0%
0▲ 0%
0▲ 0%
0▲ 0%
0▲ 0%
0▲ 0%
0▲ 0%
0▲ 0%
0▲ 0%
Gross Margin %
----------
Gross Profit Growth %
----------
Operating Expenses
682.43K713.94K1.61M6.64M14.54M25.51M45.03M26.69M29.7M41.42M
OpEx % of Revenue
----------
Selling, General & Admin
409.06K602.33K829.37K3.59M6.06M9M6.24M6.7M4.48M1.3B
SG&A % of Revenue
----------
Research & Development
273.37K111.61K776.26K3.05M8.48M16.52M38.79M20M25.22M16.74B
R&D % of Revenue
----------
Other Operating Expenses
00378000000-1000K
Operating Income
-682K▲ 0%
-714K▼ 4.7%
-1.61M▼ 124.9%
-6.64M▼ 313.5%
-14.54M▼ 118.9%
-25.51M▼ 75.5%
-45.03M▼ 76.5%
-26.69M▲ 40.7%
-29.7M▼ 11.2%
-41.42M▲ 0%
Operating Margin %
----------
Operating Income Growth %
--4.69%-124.93%-313.46%-118.93%-75.49%-76.53%40.72%-11.24%-
EBITDA
433-6300-14.5M-25.51M-45.03M-26.69M-29.7M-41.42M
EBITDA Margin %
----------
EBITDA Growth %
--114.55%100%---75.93%-76.53%40.72%-11.24%-64.59%
D&A (Non-Cash Add-back)
682.43K713.94K1.61M6.64M000003
EBIT
-682K-714K-1.61M-6.64M-14.5M-25.51M-45.03M-26.69M-29.7M-41.42M
Net Interest Income
000-47.18M13.34K182.71K667.9K-1.52M699.06K649.25K
Interest Income
00047.23K13.34K182.71K667.9K331.85K699.06K649.25K
Interest Expense
8466047.23M0001.85M00
Other Income/Expense
8466614.64K1.18M50.09K182.71K-11.17M2.1M841.06K501.25K
Pretax Income
-682K▲ 0%
-714K▼ 4.7%
-991K▼ 38.8%
-5.46M▼ 451.2%
-14.49M▼ 165.2%
-25.33M▼ 74.8%
-56.2M▼ 121.9%
-24.59M▲ 56.2%
-28.85M▼ 17.3%
-40.92M▲ 0%
Pretax Margin %
----------
Income Tax
0-13200000000
Effective Tax Rate %
0%0.02%0%0%0%0%0%0%0%0%
Net Income
-682K▲ 0%
-714K▼ 4.7%
-991K▼ 38.8%
-5.46M▼ 451.2%
-14.49M▼ 165.2%
-25.33M▼ 74.8%
-56.2M▼ 121.9%
-24.59M▲ 56.2%
-28.85M▼ 17.3%
-40.92M▲ 0%
Net Margin %
----------
Net Income Growth %
--4.69%-38.8%-451.17%-165.23%-74.83%-121.9%56.25%-17.34%-40.82%
Net Income (Continuing)
-682K-714K-991K-5.46M-14.49M-25.33M-56.2M-24.59M-28.85M-40.92M
Discontinued Operations
0000000000
Minority Interest
0000000000
EPS (Diluted)
-0.16▲ 0%
-0.16▲ 0.0%
-0.17▼ 6.3%
-0.87▼ 411.8%
-1.90▼ 118.4%
-3.10▼ 63.2%
-6.23▼ 101.0%
-2009.77▼ 32159.6%
-1.40▲ 99.9%
-1.47▲ 0%
EPS Growth %
-0%-6.25%-411.76%-118.39%-63.16%-100.97%-32159.55%99.93%26.5%
EPS (Basic)
-0.16-0.16-0.17-0.87-1.90-3.10-6.23-2018.50-1.40-
Diluted Shares Outstanding
4.39M4.4M6.84M6.31M7.63M8.16M9.02M12.23M20.55M27.85M
Basic Shares Outstanding
4.39M4.4M6.84M6.31M7.63M8.16M9.02M12.18M20.55M27.85M
Dividend Payout Ratio
----------

ANVS Balance Sheet

Annovis Bio, Inc. (ANVS) balance sheet — assets, liabilities & shareholders' equity

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Total Current Assets
357.96K50.99K747.51K8.12M46M36.02M10.21M13.93M21.08M16.24M
Cash & Short-Term Investments
347.47K35.31K1.86K8.07M45.69M28.38M5.75M10.55M19.53M14.22M
Cash Only
347.47K35.31K1.86K8.07M45.69M28.38M5.75M10.55M19.53M14.22M
Short-Term Investments
0000000000
Accounts Receivable
00735.08K0000000
Days Sales Outstanding
----------
Inventory
00-745.64M0000000
Days Inventory Outstanding
----------
Other Current Assets
00745.65M6.44K9.87K7.54M20.8K7.5K07.5K
Total Non-Current Assets
00369.6K0000000
Property, Plant & Equipment
0000000000
Fixed Asset Turnover
----------
Goodwill
0000000000
Intangible Assets
0000000000
Long-Term Investments
0000000000
Other Non-Current Assets
00369.6K0000000
Total Assets
357.96K▲ 0%
50.99K▼ 85.8%
1.12M▲ 2090.7%
8.12M▲ 626.8%
46M▲ 466.6%
36.02M▼ 21.7%
10.21M▼ 71.7%
13.93M▲ 36.4%
21.08M▲ 51.4%
16.24M▲ 0%
Asset Turnover
---------0.00x
Asset Growth %
--85.76%2090.75%626.82%466.57%-21.69%-71.66%36.42%51.39%356.97%
Total Current Liabilities
490.22K567.94K2.01M578.38K1.51M7.7M4.28M3.88M3.64M12.79M
Accounts Payable
71.11K68.42K1.23M341.86K688.07K3.96M1.29M2.31M2.59M5.28M
Days Payables Outstanding
----------
Short-Term Debt
0000000000
Deferred Revenue (Current)
0000000000
Other Current Liabilities
415.35K477.88K645.34K220.03K105.67K02731.21M1.04M6.78M
Current Ratio
0.73x0.09x0.37x14.04x30.54x4.68x2.39x3.59x5.80x1.27x
Quick Ratio
0.73x0.09x371.20x14.04x30.54x4.68x2.39x3.59x5.80x1.27x
Cash Conversion Cycle
----------
Total Non-Current Liabilities
6.83M7.08M7.68M00013.68M737K595K327K
Long-Term Debt
00499.81K0000000
Capital Lease Obligations
0000000000
Deferred Tax Liabilities
0000000000
Other Non-Current Liabilities
6.83M7.08M7.18M00013.68M737K595K327K
Total Liabilities
7.32M7.64M9.69M578.38K1.51M7.7M17.96M4.62M4.23M13.12M
Total Debt
00499.81K0000000
Net Debt
-347.47K-35.31K497.95K-8.07M-45.69M-28.38M-5.75M-10.55M-19.53M-14.22M
Debt / Equity
---------0.00x
Debt / EBITDA
----------0.00x
Net Debt / EBITDA
-802.48x--------0.34x
Interest Coverage
-8119.05x-10818.18x--0.14x----14.40x--
Total Equity
-6.97M▲ 0%
-7.59M▼ 9.0%
-8.58M▼ 12.9%
7.54M▲ 187.9%
44.49M▲ 490.0%
28.32M▼ 36.3%
-7.75M▼ 127.4%
9.31M▲ 220.1%
16.85M▲ 81.0%
3.13M▲ 0%
Equity Growth %
--9.02%-12.94%187.93%490.04%-36.34%-127.37%220.09%81.05%1227.22%
Book Value per Share
-1.58-1.73-1.251.205.833.47-0.860.760.820.11
Total Shareholders' Equity
-6.97M-7.59M-8.58M7.54M44.49M28.32M-7.75M9.31M16.85M3.13M
Common Stock
0006898108161.05K1.41K2.72K2.85K
Retained Earnings
-7.07M-7.79M-8.78M-14.24M-28.73M-54.05M-110.26M-134.85M-163.7M-181.31M
Treasury Stock
0000000000
Accumulated OCI
-6.83M-7.08M-7.08M0000000
Minority Interest
0000000000

ANVS Cash Flow Statement

Annovis Bio, Inc. (ANVS) cash flow — operating, investing & free cash flow history

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Cash from Operations
-537.48K-558.61K-476.54K-3.97M-9.13M-17.31M-39.97M-21.89B-25.62B-9.03B
Operating CF Margin %
----------
Operating CF Growth %
--3.93%14.69%-733.26%-129.98%-89.58%-130.85%-54681.29%-17.01%-111234.07%
Net Income
-682.35K-713.87K-990.98K-5.46M-14.49M-25.33M-56.2M-24.59B-28.85B-40.92M
Depreciation & Amortization
001.19M0000000
Stock-Based Compensation
48.49K82.73K8.48K1.86M4.7M9.15M4.63M3.84B1.8B184.12M
Deferred Taxes
00-1.19M0000000
Other Non-Cash Items
11.58K85.41K84.43K27.02K0011.84M-1.14B1.44B8.4B
Working Capital Changes
96.37K72.53K421.53K-400.71K657.35K-1.14M-228.6K681.71K1.58M12.76M
Change in Receivables
00-735.08K735.08K000000
Change in Inventory
00735.08K0000000
Change in Payables
61.83K-2.68K969.09K-695.66K346.22K3.27M-2.67M1.01M284.54K3.91M
Cash from Investing
0000000000
Capital Expenditures
0000000000
CapEx % of Revenue
----------
Acquisitions
0000000000
Investments
----------
Other Investing
0000000000
Cash from Financing
332.5K246.45K443.09K12.04M46.74M4.61K17.34M26.69B34.6B3.71B
Debt Issued (Net)
00530K12.03M000000
Equity Issued (Net)
0009.22K46.65M4.61K16.89M18.67M34.6M18.52M
Dividends Paid
0000000000
Share Repurchases
0000000000
Other Financing
332.5K246.45K-86.91K095.1K0458.38K26.67B34.57B3.69B
Net Change in Cash
-204.99K▲ 0%
-312.16K▼ 52.3%
-33.45K▲ 89.3%
8.07M▲ 24231.0%
37.61M▲ 365.9%
-17.31M▼ 146.0%
-22.62M▼ 30.7%
4.8B▲ 21305.0%
8.98B▲ 87.2%
-5.32B▲ 0%
Free Cash Flow
-537.48K▲ 0%
-558.61K▼ 3.9%
-476.54K▲ 14.7%
-3.97M▼ 733.3%
-9.13M▼ 130.0%
-17.31M▼ 89.6%
-39.97M▼ 130.9%
-21.89B▼ 54681.3%
-25.62B▼ 17.0%
-9.03B▲ 0%
FCF Margin %
----------
FCF Growth %
--3.93%14.69%-733.26%-129.98%-89.58%-130.85%-54681.29%-17.01%-39223.8%
FCF per Share
-0.12-0.13-0.07-0.63-1.20-2.12-4.43-1789.51-1246.58-324.23
FCF Conversion (FCF/Net Income)
0.79x0.78x0.48x0.73x0.63x0.68x0.71x890.37x887.90x220.63x
Interest Paid
0000000000
Taxes Paid
0000000000

ANVS Key Ratios

Annovis Bio, Inc. (ANVS) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric20182019202020212022202320242025TTM
Return on Equity (ROE)
---72.43%-55.68%-69.57%-546.39%-3159.09%-220.61%-318.08%
Return on Invested Capital (ROIC)
--------845.16%
Debt / Equity
--------0.00x
Interest Coverage
-10818.18x--0.14x----14.40x--
FCF Conversion
0.78x0.48x0.73x0.63x0.68x0.71x890.37x887.90x220.63x
Related:ANVS Dividend History·ANVS Revenue History·ANVS Price History·ANVS P/E History·ANVS Financial Ratios·ANVS Institutional Holders

ANVS SEC Filings & Documents

Annovis Bio, Inc. (ANVS) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 20, 2026·SEC

Material company update

May 15, 2026·SEC

Material company update

Apr 10, 2026·SEC

10-K Annual Reports

2
FY 2026

Mar 13, 2026·SEC

FY 2025

Mar 21, 2025·SEC

10-Q Quarterly Reports

6
FY 2026

May 15, 2026·SEC

FY 2025

Nov 12, 2025·SEC

FY 2025

Aug 12, 2025·SEC

ANVS Frequently Asked Questions

Annovis Bio, Inc. (ANVS) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Annovis Bio, Inc. (ANVS) grew revenue by 0.0% over the past year. Growth has been modest.

Annovis Bio, Inc. (ANVS) reported a net loss of $40.9M for fiscal year 2025.

Dividend & Returns

Annovis Bio, Inc. (ANVS) has a return on equity (ROE) of -220.6%. Negative ROE indicates the company is unprofitable.

Annovis Bio, Inc. (ANVS) had negative free cash flow of $9.03B in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in ANVS back in 2017?

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