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Centessa Pharmaceuticals plc (CNTA) 10-Year Financial Performance & Capital Metrics

CNTA • • Industrial / General
HealthcareBiotechnologyRare Genetic DiseasesGene Therapy & Rare Diseases
AboutCentessa Pharmaceuticals plc, a clinical-stage pharmaceutical company, discovers, develops, and delivers medicines to patients. Its registrational pipeline products include Lixivaptan, a vasopressin V2 receptor small molecule inhibitor that is in Phase III clinical development for the treatment of autosomal dominant polycystic kidney disease; and SerpinPC, an activated protein C inhibitor, which is in Phase IIa clinical development for the treatment of hemophilia A and B. The company also has emerging pipeline products under clinical proof of concept stage comprising LB101, a PD-L1xCD47 LockBody, as well as LB201, a PD-L1xCD3 LockBody, which are designed to selectively drive potent CD47 and CD3 effector function activity while avoiding systemic toxicity; ZF874, a small molecule pharmacological chaperone folding corrector of the Z variant of alpha-1-antitrypsin in Phase I clinical development for the treatment of alpha-1-antitrypsin deficiency; MGX292, a recombinant modified BMP9 replacement protein designed to overcome the deficiency in BMP9 signaling in Pulmonary Arterial Hypertension; and OX2R Agonists that are oral and intranasal selective orexin receptor 2 agonists designed to leverage structural insights and to directly target the underlying pathophysiology of orexin neuron loss in Narcolepsy Type 1. In addition, the company has exploratory pipeline products under clinical proof of concept stage containing CBS001, an anti-LIGHT antibody, which preferentially binds the inflammatory membrane form of LIGHT in inflammatory/fibrotic diseases; and CBS004, a humanized mAb specific to BDCA2, expressed exclusively on plasmacytoid dendritic cells in systemic sclerosis, systemic lupus erythematosus, and other autoimmune diseases. Centessa Pharmaceuticals plc was incorporated in 2020 and is based in Altrincham, the United Kingdom.Show more
  • Revenue $0 -100.0%
  • EBITDA -$200M -17.4%
  • Net Income -$236M -56.0%
  • EPS (Diluted) -2.06 -31.2%
  • Gross Margin -
  • EBITDA Margin -
  • Operating Margin -
  • Net Margin -
  • ROE -73.93% -40.0%
  • ROIC -91.85% +26.7%
  • Debt/Equity 0.29 -18.5%
  • Interest Coverage -19.93 -15.2%
Technical Analysis

Key Insights

Based on financial data analysis

✓Strengths

  • ✓Momentum leader: RS Rating 80 (top 20%)

✗Weaknesses

  • ✗Weak Piotroski F-Score: 3/9
  • ✗Shares diluted 19.0% in last year
  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

Price & Volume

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Growth Metrics

Revenue CAGR

10Y-
5Y-
3Y-
TTM118.88%

Profit (Net Income) CAGR

10Y-
5Y-
3Y-
TTM-50.5%

EPS CAGR

10Y-
5Y-
3Y-
TTM-19.61%

ROCE

10Y Avg-119.46%
5Y Avg-119.46%
3Y Avg-45.67%
Latest-47.89%

Peer Comparison

Gene Therapy & Rare Diseases
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Per Share
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Sector-Specific
NameMarket CapCurrent PriceP/E RatioRevenue Growth 1YNet MarginROEFCF YieldDebt/Equity
KRYSKrystal Biotech, Inc.8.18B282.0194.00473.02%53.3%17.48%1.46%0.01
BMRNBioMarin Pharmaceutical Inc.10.58B55.0724.9217.97%16.82%8.59%4.49%0.11
SRPTSarepta Therapeutics, Inc.2.23B21.319.1152.97%-11.25%-20.57%0.88
RAREUltragenyx Pharmaceutical Inc.2.27B23.50-3.7429.01%-91.95%-35.88%0.15
DYNDyne Therapeutics, Inc.2.7B16.42-4.87-61.26%0.04
TVTXTravere Therapeutics, Inc.2.54B28.40-6.9660.55%-20.32%-120.36%6.80
BEAMBeam Therapeutics Inc.3.25B32.05-7.00-83.18%-7.44%-42.92%0.22
SLNOSoleno Therapeutics, Inc.2.25B41.95-9.58-79.5%-15.85%0.22

Profit & Loss

Dec 2020Dec 2021Dec 2022Dec 2023Dec 2024
Sales/Revenue+0006.85M0
Revenue Growth %-----1%
Cost of Goods Sold+00000
COGS % of Revenue-----
Gross Profit+0006.85M0
Gross Margin %---1%-
Gross Profit Growth %-----1%
Operating Expenses+10.44M374.87M212.26M178.14M201.06M
OpEx % of Revenue---25.99%-
Selling, General & Admin1.14M43.01M55.2M53.73M50.81M
SG&A % of Revenue---7.84%-
Research & Development9.3M96.32M155.08M124.41M150.24M
R&D % of Revenue---18.15%-
Other Operating Expenses0235.54M1.98M00
Operating Income+-10.44M-374.87M-212.26M-171.28M-201.06M
Operating Margin %----24.99%-
Operating Income Growth %--34.91%0.43%0.19%-0.17%
EBITDA+-10.29M-374.83M-212.13M-170.47M-200.11M
EBITDA Margin %----24.88%-
EBITDA Growth %--35.44%0.43%0.2%-0.17%
D&A (Non-Cash Add-back)034K131K810K942K
EBIT-10.29M-139.33M-209.68M-166.24M-222.82M
Net Interest Income+-378K-2.55M-7.03M570K3.93M
Interest Income00244K10.48M14.02M
Interest Expense378K2.55M7.28M9.91M10.09M
Other Income/Expense-223K-6.92M-4.69M-4.86M-31.86M
Pretax Income+-10.66M-381.79M-216.95M-176.14M-232.91M
Pretax Margin %----25.7%-
Income Tax+0114K-747K-25.06M2.84M
Effective Tax Rate %1%1%1%0.86%1.01%
Net Income+-10.66M-381.9M-216.21M-151.09M-235.76M
Net Margin %----22.05%-
Net Income Growth %--34.82%0.43%0.3%-0.56%
Net Income (Continuing)-10.66M-381.9M-216.21M-151.09M-235.76M
Discontinued Operations00000
Minority Interest00000
EPS (Diluted)+-0.08-4.24-2.31-1.57-2.06
EPS Growth %--53.57%0.46%0.32%-0.31%
EPS (Basic)-0.08-4.24-2.31-1.57-2.06
Diluted Shares Outstanding70.89M89.99M93.4M96.18M114.47M
Basic Shares Outstanding70.89M89.99M93.4M96.18M114.47M
Dividend Payout Ratio-----

Balance Sheet

Dec 2020Dec 2021Dec 2022Dec 2023Dec 2024
Total Current Assets+11.16M628.77M437.75M315.09M536.41M
Cash & Short-Term Investments7.23M595.08M393.64M256.55M482.18M
Cash Only7.23M595.08M393.64M128.03M383.22M
Short-Term Investments000128.52M98.96M
Accounts Receivable016.81M26.72M39.15M45.3M
Days Sales Outstanding---2.09K-
Inventory00000
Days Inventory Outstanding-----
Other Current Assets3.93M993K3.27M1.62M1.78M
Total Non-Current Assets+552K861K6.56M45.15M40.39M
Property, Plant & Equipment0162K1.17M12.95M11.76M
Fixed Asset Turnover---0.53x-
Goodwill00000
Intangible Assets00000
Long-Term Investments00000
Other Non-Current Assets552K699K1.88M2.55M2.05M
Total Assets+11.72M629.63M444.31M360.25M576.8M
Asset Turnover---0.02x-
Asset Growth %-52.74%-0.29%-0.19%0.6%
Total Current Liabilities+8.62M24.64M38.34M39.38M58M
Accounts Payable1.03M8.06M13.84M11.81M7.14M
Days Payables Outstanding-----
Short-Term Debt5.63M0000
Deferred Revenue (Current)00000
Other Current Liabilities922K4.97M7.95M839K10.18M
Current Ratio1.30x25.52x11.42x8.00x9.25x
Quick Ratio1.30x25.52x11.42x8.00x9.25x
Cash Conversion Cycle-----
Total Non-Current Liabilities+0113.44M69.8M84.62M117.25M
Long-Term Debt075.7M69.8M75.7M108.94M
Capital Lease Obligations0008.89M8.29M
Deferred Tax Liabilities00000
Other Non-Current Liabilities037.74M029K29K
Total Liabilities8.62M138.08M108.14M124M175.25M
Total Debt+5.63M75.7M69.8M84.59M117.23M
Net Debt-1.6M-519.38M-323.84M-43.44M-266M
Debt / Equity1.82x0.15x0.21x0.36x0.29x
Debt / EBITDA-----
Net Debt / EBITDA-----
Interest Coverage-27.62x-147.08x-29.17x-17.29x-19.93x
Total Equity+3.1M491.55M336.17M236.24M401.55M
Equity Growth %-157.67%-0.32%-0.3%0.7%
Book Value per Share0.045.463.602.463.51
Total Shareholders' Equity3.1M491.55M336.17M236.24M401.55M
Common Stock25.55M252K265K273K359K
Retained Earnings-23.84M-385.65M-601.86M-752.95M-988.7M
Treasury Stock00000
Accumulated OCI572K688K-1.5M1.49M4.21M
Minority Interest00000

Cash Flow

Dec 2020Dec 2021Dec 2022Dec 2023Dec 2024
Cash from Operations+-10.63M-136.14M-200.55M-160.34M-142.06M
Operating CF Margin %----23.4%-
Operating CF Growth %--11.81%-0.47%0.2%0.11%
Net Income-10.66M-381.85M-216.21M-151.09M-235.76M
Depreciation & Amortization033.99K131K810K942K
Stock-Based Compensation336K024.96M29.39M33.55M
Deferred Taxes00-2.86M-26.63M2.65M
Other Non-Cash Items186K251.06M-3.75M6.03M34.46M
Working Capital Changes-489K-5.38M-2.83M-18.86M22.1M
Change in Receivables-1.46M-6.72M-11.71M0-6.6M
Change in Inventory00000
Change in Payables-49K06.35M-2.73M-4.58M
Cash from Investing+063.25M-931K-127M31.27M
Capital Expenditures0-185.98K-1.14M-169K-34K
CapEx % of Revenue---0.02%-
Acquisitions-----
Investments-----
Other Investing00206K00
Cash from Financing+1.36M660.07M457K21.12M364.75M
Debt Issued (Net)-----
Equity Issued (Net)-----
Dividends Paid00000
Share Repurchases-----
Other Financing1K0457K310K5.91M
Net Change in Cash-----
Free Cash Flow+-10.63M-136.33M-201.68M-160.51M-142.09M
FCF Margin %----23.42%-
FCF Growth %--11.82%-0.48%0.2%0.11%
FCF per Share-0.15-1.51-2.16-1.67-1.24
FCF Conversion (FCF/Net Income)1.00x0.36x0.93x1.06x0.60x
Interest Paid007.28M9.91M10.09M
Taxes Paid001.3M2.94M82K

Key Ratios

Metric20202021202220232024
Return on Equity (ROE)-344.19%-154.41%-52.24%-52.79%-73.93%
Return on Invested Capital (ROIC)---1291.66%-125.25%-91.85%
Gross Margin---100%-
Net Margin----2204.65%-
Debt / Equity1.82x0.15x0.21x0.36x0.29x
Interest Coverage-27.62x-147.08x-29.17x-17.29x-19.93x
FCF Conversion1.00x0.36x0.93x1.06x0.60x
Revenue Growth-----100%

Revenue by Segment

2021
Lixivaptan200M
Lixivaptan Growth-

Frequently Asked Questions

Growth & Financials

Centessa Pharmaceuticals plc (CNTA) reported $15.0M in revenue for fiscal year 2024.

Centessa Pharmaceuticals plc (CNTA) saw revenue decline by 100.0% over the past year.

Centessa Pharmaceuticals plc (CNTA) reported a net loss of $242.7M for fiscal year 2024.

Dividend & Returns

Centessa Pharmaceuticals plc (CNTA) has a return on equity (ROE) of -73.9%. Negative ROE indicates the company is unprofitable.

Centessa Pharmaceuticals plc (CNTA) had negative free cash flow of $181.2M in fiscal year 2024, likely due to heavy capital investments.

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