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ENSC logoEnsysce Biosciences, Inc.(ENSC)Earnings, Financials & Key Ratios

ENSC•NASDAQ
$0.37
$1M mkt cap·Price updated May 7, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryDrug Delivery Technology Platforms
AboutEnsysce Biosciences, Inc., a clinical-stage pharmaceutical company, engages in developing various prescription drugs for severe pain relief in opioid addiction, misuse, abuse, and overdose in the United States. It develops products using Trypsin Activated Abuse Protection platform, an abuse-resistant opioid prodrug technology; and Multi-Pill Abuse Resistance platform, an over-dose protection opioid prodrug technology. The company is developing PF614, a TAAP prodrug candidate of oxycodone, which is in Phase II clinical trial for the treatment of acute or chronic pain; and PF614-MPAR, a combination product of PF614 and nafamostat that is in Phase I clinical trial for overdose protection against excessive oral ingestion, as well as an oral and inhalation drug product of nafamostat for use against coronaviral infections and other pulmonary diseases, such as cystic fibrosis. It is also developing PF329, an extended-release prodrug of hydromorphone that is similar to PF614; PF8001 and PF8026 are extended and immediate-release prodrugs of amphetamine for ADHD medication abuse; and PF26810, an extended-release prodrug of methadone for opioid use disorder. The company is based in La Jolla, California.Show more
  • Revenue$5M+133.5%
  • EBITDA-$7M+37.2%
  • Net Income-$8M+24.7%
  • EPS (Diluted)-4.57+2.6%
  • Gross Margin-38.57%+83.9%
  • EBITDA Margin-129.17%+73.1%
  • Operating Margin-129.17%+73.1%
  • Net Margin-153.3%+67.8%
  • ROE-585.41%
  • Debt/Equity0.09
  • Interest Coverage-5.22+82.8%
Technical→

ENSC Key Insights

Ensysce Biosciences, Inc. (ENSC) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Company is almost debt free
  • ✓High quality earnings: Operating CF exceeds net income
  • ✓Strong 5Y sales CAGR of 24.2%
  • ✓Share count reduced 22.8% through buybacks
  • ✓Trading at only 0.2x book value

✗Weaknesses

  • ✗Negative free cash flow
  • ✗Weak momentum: RS Rating 3 (bottom 3%)
  • ✗Trading more than 30% below 52-week high

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

ENSC Price & Volume

Ensysce Biosciences, Inc. (ENSC) stock price & volume — 10-year historical chart

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ENSC Growth Metrics

Ensysce Biosciences, Inc. (ENSC) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years24.19%
3 Years13.84%
TTM1.51%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-38.45%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM34.6%

Return on Capital

10 Years-124%
5 Years-486.77%
3 Years-486.77%
Last Year-486.77%

ENSC Peer Comparison

Ensysce Biosciences, Inc. (ENSC) competitors in Drug Delivery Technology Platforms — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
COLL logoCOLLCollegium Pharmaceutical, Inc.Direct Competitor1.27B39.3222.7323.62%9.41%26.74%3.12
PCRX logoPCRXPacira BioSciences, Inc.Direct Competitor929.88M23.64147.753.63%1.27%1.31%0.66
AVDL logoAVDLAvadel Pharmaceuticals plcProduct Competitor2.1B21.64-42.435.05%-0.11%-0.33%0.02
NKTR logoNKTRNektar TherapeuticsProduct Competitor1.69B83.37-8.57-43.89%-297.07%-399.1%1.66
PRGO logoPRGOPerrigo Company plcSupply Chain1.61B11.72-1.14-2.75%-43.5%-50.65%1.35
PAHC logoPAHCPhibro Animal Health CorporationSupply Chain1.75B43.1636.2727.37%6.29%30.81%2.67
ATAI logoATAIAtai Beckley N.VOften Compared964.15M4.01-4.31-1.91%-51.09%-96.43%0.21
MNMD logoMNMDMind Medicine (MindMed) Inc.Often Compared2.04B20.69-10.04-102.48%

Compare ENSC vs Peers

Ensysce Biosciences, Inc. (ENSC) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs COLL

Most directly comparable listed peer for ENSC.

Scale Benchmark

vs AVDL

Larger-name benchmark to compare ENSC against a more recognizable public peer.

Peer Set

Compare Top 5

vs COLL, PCRX, AVDL, NKTR

ENSC Income Statement

Ensysce Biosciences, Inc. (ENSC) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24TTM
Sales/Revenue001.76M3.93M3.53M2.52M2.23M5.21M4.49M
Revenue Growth %---122.86%-10.18%-28.54%-11.59%133.53%1.51%
Cost of Goods Sold01.56M3.4M20115119.84M7.59M7.22M8.68M
COGS % of Revenue--192.88%0.01%0%786.08%340.07%138.56%-
Gross Profit
0▲ 0%
-1.56M▲ 0%
-1.64M▼ 5.1%
3.93M▲ 339.9%
3.53M▼ 10.2%
-17.31M▼ 590.3%
-5.36M▲ 69.1%
-2.01M▲ 62.5%
-4.19M▲ 0%
Gross Margin %---92.88%99.99%100%-686.08%-240.12%-38.57%-93.42%
Gross Profit Growth %---5.09%339.94%-10.17%-590.29%69.06%62.49%-
Operating Expenses146.69K-600K6.93M5.54M23.4M6.91M5.36M4.72M6.84M
OpEx % of Revenue--392.86%141.03%662.71%273.82%240.3%90.61%-
Selling, General & Admin146.69K06.93M1.15M18.71M6.91M5.36M4.72M4.96M
SG&A % of Revenue--392.86%29.37%529.89%273.82%240.3%90.61%-
Research & Development003.4M4.39M4.69M19.84M7.59M7.22M10.57M
R&D % of Revenue--192.88%111.66%132.82%786.08%340.07%138.56%-
Other Operating Expenses00-3.4M00-19.84M-7.59M-7.22M-3M
Operating Income
-147K▲ 0%
-959K▼ 552.4%
-8.57M▼ 793.5%
-1.61M▲ 81.2%
-19.87M▼ 1131.7%
-24.22M▼ 21.9%
-10.72M▲ 55.8%
-6.73M▲ 37.2%
-11.04M▲ 0%
Operating Margin %---485.74%-41.04%-562.71%-959.91%-480.41%-129.17%-245.89%
Operating Income Growth %--552.38%-793.46%81.17%-1131.67%-21.9%55.75%37.21%-
EBITDA-27.55K2.68M-8.57M-1.61M-19.87M-24.22M-10.72M-6.73M-1.94M
EBITDA Margin %---485.73%-41.03%-562.71%-959.9%-480.41%-129.17%-43.27%
EBITDA Growth %-9811.49%-420.18%81.17%-1131.82%-21.9%55.75%37.21%-61.54%
D&A (Non-Cash Add-back)00201201151151-349.07M
EBIT-27.55K2.68M-8.57M834.62K-25.93M-24.22M-10.72M-6.73M-10.99M
Net Interest Income004.25M-276K1.92M1.14M-354K-1.29M-24.14K
Interest Income03.63M4.25M719.65K3.21M1.25M000
Interest Expense000995.5K1.29M109.53K353.94K1.29M24.14K
Other Income/Expense119.14K3.63M-1.53M1.45M-9.28M14.41K91.91K-1.26M62.96K
Pretax Income
-27.56K▲ 0%
2.68M▲ 9810.4%
-10.1M▼ 477.5%
-160.88K▲ 98.4%
-29.15M▼ 18017.1%
-24.21M▲ 16.9%
-10.63M▲ 56.1%
-7.99M▲ 24.8%
-10.97M▲ 0%
Pretax Margin %---572.7%-4.09%-825.38%-959.33%-476.29%-153.3%-244.49%
Income Tax3.63K553.92K0000000
Effective Tax Rate %-13.19%20.7%0%0%0%0%0%0%0%
Net Income
-31.19K▲ 0%
-1.34M▼ 4205.5%
-10.1M▼ 652.2%
56.77K▲ 100.6%
-29.08M▼ 51330.8%
-24.17M▲ 16.9%
-10.61M▲ 56.1%
-7.99M▲ 24.7%
-10.97M▲ 0%
Net Margin %---572.7%1.44%-823.62%-957.93%-475.71%-153.3%-244.48%
Net Income Growth %--4205.45%-652.22%100.56%-51330.78%16.89%56.09%24.74%-38.45%
Net Income (Continuing)-31.19K2.12M-10.1M-160.88K-29.15M-24.21M-10.63M-7.99M-10.97M
Discontinued Operations000000000
Minority Interest000-217.63K-279.81K-315.21K-328.41K-328.48K-328.65K
EPS (Diluted)
-0.01▲ 0%
-0.22▼ 4130.8%
0.24▲ 209.1%
0.56▲ 133.3%
-355.68▼ 63614.3%
-139.44▲ 60.8%
-4.69▲ 96.6%
-4.57▲ 2.6%
-3.80▲ 0%
EPS Growth %--209.09%133.33%-63614.29%60.8%96.64%2.56%34.6%
EPS (Basic)-0.01-0.220.240.56-355.68-139.44-4.69-4.57-
Diluted Shares Outstanding5.98M6.01M6.09M6.37M84.02K179.93K2.26M1.75M2.89M
Basic Shares Outstanding5.98M6.01M6.09M4.46M84.02K179.93K2.26M1.75M2.89M
Dividend Payout Ratio---------

ENSC Balance Sheet

Ensysce Biosciences, Inc. (ENSC) balance sheet — assets, liabilities & shareholders' equity

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24TTM
Total Current Assets2.31M1.92M618.59K347.88K15.66M5.3M2.29M5.34M2.93M
Cash & Short-Term Investments2.09M1.66M341.54K194.21K12.26M3.15M1.12M3.5M1.67M
Cash Only2.09M1.66M341.54K194.21K12.26M3.15M1.12M3.5M1.67M
Short-Term Investments000000000
Accounts Receivable0170.53K173.55K0441.72K276.82K97.56K124.11K4.41K
Days Sales Outstanding--35.91-45.6640.0415.968.727.56
Inventory0000-441.72K0000
Days Inventory Outstanding---------
Other Current Assets0068.81K23.54K2.59M1.33M18K18K68.13K
Total Non-Current Assets200.12M202.92M5.35K3.93K754.76K585.88K419.22K252.55K251.19K
Property, Plant & Equipment0035115124.72B000123.64K
Fixed Asset Turnover--5025.53x26034.50x0.00x---145.20x
Goodwill000000000
Intangible Assets000000000
Long-Term Investments200.12M202.92M0000000
Other Non-Current Assets005K3.78K-24.72B585.88K419.22K252.55K883.84K
Total Assets
202.43M▲ 0%
204.83M▲ 1.2%
623.94K▼ 99.7%
351.81K▼ 43.6%
16.42M▲ 4566.6%
5.89M▼ 64.2%
2.71M▼ 54.0%
5.6M▲ 106.7%
3.18M▲ 0%
Asset Turnover--2.83x11.17x0.22x0.43x0.82x0.93x0.95x
Asset Growth %-1.19%-99.7%-43.62%4566.58%-64.15%-53.98%106.69%130.85%
Total Current Liabilities156.24K437.89K7.3M7.01M16.48M9.46M3.33M2.21M2.3M
Accounts Payable00540.78K1.72M301.1K2.94M1.94M1.36M463.46K
Days Payables Outstanding--58.011000K727.83K54.1793.1468.6236.57
Short-Term Debt002.62M4.25M12.75M4.27M854.7K301.66K364.07K
Deferred Revenue (Current)000159.05K00000
Other Current Liabilities152.6K437.89K2.93M670.26K00001.48M
Current Ratio14.77x4.38x0.08x0.05x0.95x0.56x0.69x2.42x2.42x
Quick Ratio14.77x4.38x0.08x0.05x0.98x0.56x0.69x2.42x2.42x
Cash Conversion Cycle---------9.01
Total Non-Current Liabilities7M7M06.75M8.09M450.49K26.39K10.1K35
Long-Term Debt00004.44M140.15K000
Capital Lease Obligations000000000
Deferred Tax Liabilities01.76K0000000
Other Non-Current Liabilities00003.65M310.35K26.39K10.1K141.34K
Total Liabilities7.16M7.44M7.3M7.01M24.58M9.91M3.36M2.22M2.3M
Total Debt002.62M4.27M17.21M4.43M854.7K301.66K364.07K
Net Debt-2.09M-1.66M2.28M4.08M4.95M1.29M-268.91K-3.2M-1.31M
Debt / Equity-------0.09x0.09x
Debt / EBITDA---------0.19x
Net Debt / EBITDA--0.62x------0.67x
Interest Coverage----1.62x-15.34x-221.16x-30.28x-5.22x-455.37x
Total Equity
195.27M▲ 0%
197.39M▲ 1.1%
-6.68M▼ 103.4%
-6.66M▲ 0.3%
-8.16M▼ 22.5%
-4.03M▲ 50.6%
-651.27K▲ 83.8%
3.38M▲ 619.0%
874.71K▲ 0%
Equity Growth %-1.09%-103.38%0.27%-22.52%50.61%83.84%618.98%618.68%
Book Value per Share32.6332.87-1.10-1.05-97.10-22.40-0.291.930.30
Total Shareholders' Equity195.27M197.39M-6.68M-6.44M-7.88M-3.71M-322.86K3.71M1.2M
Common Stock6736045.99K1.58K12453315136320
Retained Earnings-31.19K2.09M-56.02M-55.96M-85.85M-110.93M-121.56M-129.54M-136.95M
Treasury Stock000000000
Accumulated OCI-673-6040000000
Minority Interest000-217.63K-279.81K-315.21K-328.41K-328.48K-328.65K

ENSC Cash Flow Statement

Ensysce Biosciences, Inc. (ENSC) cash flow — operating, investing & free cash flow history

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24TTM
Cash from Operations-251.83K-1.24M10.99M-1.25M-8.24M-17.89M-10.78M-7.5T-7.5T
Operating CF Margin %--623.31%-31.73%-233.41%-708.87%-483.19%-99999900%-
Operating CF Growth %--391.7%987.93%-111.34%-560.78%-117.02%39.73%-69598346.45%7.41%
Net Income-31.19K-1.34M365.95K-160.88K-29.15M-24.21M-10.63M-7.99M-10.97M
Depreciation & Amortization0002011510000
Stock-Based Compensation000178.68K121.76K1.07M879.16K110.72B329.74K
Deferred Taxes01.76K-1.76K-2.45M00000
Other Non-Cash Items-231.1K-317.21K8.17M997.46K22.09M-233.42K-85.79K-7.61T-455.64K
Working Capital Changes-101.5K273.13K2.46M185.1K-1.3M5.48M-947.08K-851.25K4.05M
Change in Receivables0-170.53K0173.55K-441.72K164.9K179.26K-26.55K1.78M
Change in Inventory000-173.55K00000
Change in Payables111.96K317.28K01.18M-1.42M2.64M-1.23M-578.93K-835.51K
Cash from Investing-200M838.59K-566.29K183.4M04.5K00-123.64K
Capital Expenditures00000000-123.64K
CapEx % of Revenue--0%------
Acquisitions000000000
Investments---------
Other Investing0838.59K0183.4M04.5K000
Cash from Financing202.34M-32K-11.03M1.1M20.31M8.77M8.76M9.88T4.69M
Debt Issued (Net)00566.27K1.1M13.91M6.13M605.43K-485.19K-111.27K
Equity Issued (Net)202.34M-32K-11.59M06.63M3.78M9.05M1.67M4.05M
Dividends Paid0000000-290M0
Share Repurchases00-11.58M000000
Other Financing0000-225.68K-1.14M-899.55K9.88T750.36K
Net Change in Cash
2.09M▲ 0%
-431.68K▼ 120.7%
-597.25K▼ 38.4%
-147.32K▲ 75.3%
12.07M▲ 8293.3%
-9.12M▼ 175.5%
-2.02M▲ 77.8%
2.38T▲ 117507898.5%
-2.48M▲ 0%
Free Cash Flow
-251.83K▲ 0%
-1.24M▼ 391.7%
10.99M▲ 987.9%
-1.25M▼ 111.3%
-8.24M▼ 560.8%
-17.89M▼ 117.0%
-10.78M▲ 39.7%
-7.5T▼ 69598346.5%
-7.17M▲ 0%
FCF Margin %--623.31%-31.73%-233.41%-708.87%-483.19%-99999900%-159.71%
FCF Growth %--391.7%987.93%-111.34%-560.78%-117.02%39.73%-69598346.45%16.07%
FCF per Share-0.04-0.211.81-0.20-98.10-99.41-4.76-999999.00-999999.00
FCF Conversion (FCF/Net Income)8.07x0.92x-1.09x-21.97x0.28x0.74x1.02x939363.97x0.65x
Interest Paid000000000
Taxes Paid0001.6K1.6K1.6K3.2K3.2K0

ENSC Key Ratios

Ensysce Biosciences, Inc. (ENSC) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric2018201920202021202220232024TTM
Return on Equity (ROE)-0.68%-10.59%-----585.41%-437.36%
Return on Invested Capital (ROIC)-0.37%-6.72%------3507.78%
Gross Margin--92.88%99.99%100%-686.08%-240.12%-38.57%-93.42%
Net Margin--572.7%1.44%-823.62%-957.93%-475.71%-153.3%-244.48%
Debt / Equity------0.09x0.09x
Interest Coverage---1.62x-15.34x-221.16x-30.28x-5.22x-455.37x
FCF Conversion0.92x-1.09x-21.97x0.28x0.74x1.02x939363.97x0.65x
Revenue Growth--122.86%-10.18%-28.54%-11.59%133.53%1.51%

ENSC Frequently Asked Questions

Ensysce Biosciences, Inc. (ENSC) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Ensysce Biosciences, Inc. (ENSC) reported $4.5M in revenue for fiscal year 2024.

Ensysce Biosciences, Inc. (ENSC) grew revenue by 133.5% over the past year. This is strong growth.

Ensysce Biosciences, Inc. (ENSC) reported a net loss of $11.0M for fiscal year 2024.

Dividend & Returns

Yes, Ensysce Biosciences, Inc. (ENSC) pays a dividend with a yield of 100.00%. This makes it attractive for income-focused investors.

Ensysce Biosciences, Inc. (ENSC) has a return on equity (ROE) of -585.4%. Negative ROE indicates the company is unprofitable.

Ensysce Biosciences, Inc. (ENSC) had negative free cash flow of $7.2M in fiscal year 2024, likely due to heavy capital investments.

Explore More ENSC

Ensysce Biosciences, Inc. (ENSC) financial analysis — history, returns, DCA and operating performance tools

Total Return Calculator

Historical returns with dividends reinvested

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DCA Calculator

Dollar cost averaging vs lump sum

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Dividend History

Yield, growth, payout safety & DRIP

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Earnings History

EPS trends, net income & profitability

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Price History

Long-term charts & historical price data

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Revenue History

Sales growth patterns & revenue breakdown

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Financial Ratios

30 years of market, efficiency and balance-sheet ratios

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Valuation

DCF intrinsic value, peer multiples & estimates

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