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MNPR logoMonopar Therapeutics Inc.(MNPR)Earnings, Financials & Key Ratios

MNPR•NASDAQ
$63.86
$425M mkt cap·Price updated May 6, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryOncology Therapeutics Developers
AboutMonopar Therapeutics Inc., a clinical-stage biopharmaceutical company, engages in developing therapeutics for the treatment of cancer in the United States. Its lead product candidate in development is Validive, a clonidine hydrochloride mucobuccal tablet that is in Phase 2b/3 clinical trial for the prevention of chemoradiotherapy induced severe oral mucositis in patients with oropharyngeal cancer. The company also engages in developing Camsirubicin, an analog of doxorubicin, which is in Phase 1b clinical trial for the treatment of advanced soft tissue sarcoma; MNPR-101, a urokinase plasminogen activator receptor targeted antibody for the treatment of various cancers; MNPR-101 RIT, a radioimmunotherapeutic based on MNPR-101 for the potential treatment of cancer and severe COVID-19; and MNPR-202, an analog of camsirubicin to potentially treat doxorubicin-and camsirubicin-resistant cancers. Monopar Therapeutics Inc. has collaborations with the Grupo Español de Investigación en Sarcomas for the development of camsirubicin in patients with advanced soft tissue sarcoma; NorthStar Medical Radioisotopes, LLC to develop radio-immuno-therapeutics targeting severe COVID-19; and the Cancer Science Institute of Singapore to evaluate the activity of MNPR-202 and related analogs in various types of cancer. The company was incorporated in 2014 and is headquartered in Wilmette, Illinois.Show more
  • Revenue$0
  • EBITDA-$16M-83.0%
  • Net Income-$16M-85.5%
  • EPS (Diluted)-1.36-134.5%
  • ROE-51.42%+52.0%
  • ROIC-321.43%+94.3%
Technical→

MNPR Key Insights

Monopar Therapeutics Inc. (MNPR) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Share count reduced 20.9% through buybacks

✗Weaknesses

  • ✗Low quality earnings: Net income not backed by cash flow
  • ✗Trading more than 30% below 52-week high
  • ✗Expensive at 13.3x book value
  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

MNPR Price & Volume

Monopar Therapeutics Inc. (MNPR) stock price & volume — 10-year historical chart

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MNPR Growth Metrics

Monopar Therapeutics Inc. (MNPR) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years-
TTM-

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-200.27%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM-350%

Return on Capital

10 Years-75.7%
5 Years-67.43%
3 Years-79.5%
Last Year-53.32%

MNPR Recent Earnings

Monopar Therapeutics Inc. (MNPR) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 8/12 qtrs (67%)
Q2 2026Latest
Mar 27, 2026
EPS
$0.61
Est $0.51
-19.1%
Revenue
—
Q4 2025
Nov 13, 2025
EPS
$0.48
Est $0.46
-4.3%
Revenue
—
Q3 2025
Aug 12, 2025
EPS
$0.35
Est $0.47
+25.5%
Revenue
—
Q2 2025
May 13, 2025
EPS
$0.38
Est $0.65
+41.5%
Revenue
—
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMar 27, 2026
$0.61vs $0.51-19.1%
—
Q4 2025Nov 13, 2025
$0.48vs $0.46-4.3%
—
Q3 2025Aug 12, 2025
$0.35vs $0.47+25.5%
—
Q2 2025May 13, 2025
$0.38vs $0.65+41.5%
—
Based on last 12 quarters of dataView full earnings history →

MNPR Peer Comparison

Monopar Therapeutics Inc. (MNPR) competitors in Oncology Therapeutics Developers — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
CLDX logoCLDXCelldex Therapeutics, Inc.Direct Competitor2.29B34.39-8.82-78.63%-172.53%-49.09%0.00
IMVT logoIMVTImmunovant, Inc.Direct Competitor5.83B28.67-10.50-47.07%0.00
TPVG logoTPVGTriplePoint Venture Growth BDC Corp.Direct Competitor225.54M5.574.5736.55%13.09%1.33
NKTR logoNKTRNektar TherapeuticsDirect Competitor1.67B85.09-8.75-43.89%-192.87%-356.81%0.95
ADXN logoADXNAddex Therapeutics LtdDirect Competitor4.52M6.850.64-74.95%-90.18%-78.31%0.00
CASI logoCASICASI Pharmaceuticals, Inc.Product Competitor2.33M0.15-0.06-15.77%-183.93%-301.8%11.96
AGEN logoAGENAgenus Inc.Product Competitor137.4M3.89-1144.1210.37%0.1%
SNDX logoSNDXSyndax Pharmaceuticals, Inc.Product Competitor1.82B20.65-6.286.28%-112.01%-256.66%5.36

Compare MNPR vs Peers

Monopar Therapeutics Inc. (MNPR) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs CLDX

Most directly comparable listed peer for MNPR.

Scale Benchmark

vs RVMD

Larger-name benchmark to compare MNPR against a more recognizable public peer.

Peer Set

Compare Top 5

vs CLDX, IMVT, TPVG, NKTR

MNPR Income Statement

Monopar Therapeutics Inc. (MNPR) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
Line itemDec'16Dec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24TTM
Sales/Revenue0000000000
Revenue Growth %----------
Cost of Goods Sold0000000000
COGS % of Revenue----------
Gross Profit
0▲ 0%
0▲ 0%
0▲ 0%
0▲ 0%
0▲ 0%
0▲ 0%
0▲ 0%
0▲ 0%
0▲ 0%
0▲ 0%
Gross Margin %----------
Gross Profit Growth %----------
Operating Expenses1.19M16.6M3.4M4.32M6.51M9.13M10.54M8.83M16.16M21.62M
OpEx % of Revenue----------
Selling, General & Admin912.47K1.17M1.63M2.36M2.44M2.63M2.95M3.23M3.16M5.74M
SG&A % of Revenue----------
Research & Development280.36K935.32K1.77M1.97M4.07M6.49M7.59M5.6M13.01M15.89M
R&D % of Revenue----------
Other Operating Expenses014.5M00000000
Operating Income
-1.19M▲ 0%
-16.6M▼ 1291.9%
-3.4M▲ 79.5%
-4.32M▼ 27.1%
-6.51M▼ 50.5%
-9.13M▼ 40.2%
-10.54M▼ 15.4%
-8.83M▲ 16.2%
-16.16M▼ 83.0%
-21.62M▲ 0%
Operating Margin %----------
Operating Income Growth %-73.12%-1291.9%79.5%-27.06%-50.54%-40.23%-15.44%16.19%-83.01%-
EBITDA0-14.5M-72K-4.22M0-9.13M-10.54M-8.83M-16.16M-20.04M
EBITDA Margin %----------
EBITDA Growth %100%-99.5%-5767.88%100%--15.44%16.19%-83.01%-316.04%
D&A (Non-Cash Add-back)1.19M2.1M3.33M06.51M00000
EBIT-1.18M-16.55M-3.33M-4.22M-6.51M-9.13M-10.54M-8.83M-16.16M-20.04M
Net Interest Income00098.89K81.9K24.02K21.24K429.04K404.02K657M
Interest Income7.23K48.26K103.22K98.89K81.9K24.02K21.24K429.04K404.02K657M
Interest Expense7.23K48.26K103.22K0000000
Other Income/Expense7.23K48.26K31.15K98.89K204.3K24.02K21.24K429.04K575.3K2.18M
Pretax Income
-1.18M▲ 0%
-16.55M▼ 1297.3%
-3.3M▲ 80.1%
-4.22M▼ 28.0%
-6.3M▼ 49.2%
-9.1M▼ 44.4%
-10.52M▼ 15.5%
-8.4M▲ 20.1%
-15.59M▼ 85.5%
-19.44M▲ 0%
Pretax Margin %----------
Income Tax8000-71.61K0000000
Effective Tax Rate %-0.07%0%2.17%0%0%0%0%0%0%0%
Net Income
-1.19M▲ 0%
-16.55M▼ 1296.3%
-3.23M▲ 80.5%
-4.22M▼ 30.9%
-6.3M▼ 49.2%
-9.1M▼ 44.4%
-10.52M▼ 15.5%
-8.4M▲ 20.1%
-15.59M▼ 85.5%
-19.44M▲ 0%
Net Margin %----------
Net Income Growth %-72.58%-1296.34%80.5%-30.88%-49.23%-44.39%-15.52%20.1%-85.5%-200.27%
Net Income (Continuing)-1.19M-16.55M-3.23M-4.22M-6.3M-9.1M-10.52M-8.4M-15.59M-19.44M
Discontinued Operations0000000000
Minority Interest0000000000
EPS (Diluted)
-0.12▲ 0%
-1.59▼ 1225.0%
-0.31▲ 80.5%
-0.40▼ 29.0%
-0.58▼ 45.0%
-0.73▼ 25.9%
-0.83▼ 13.7%
-0.58▲ 30.1%
-1.36▼ 134.5%
-2.73▲ 0%
EPS Growth %-42.52%-1225%80.5%-29.03%-45%-25.86%-13.7%30.12%-134.48%-350%
EPS (Basic)-0.12-1.59-0.31-0.40-0.58-0.73-0.83-0.58-1.36-
Diluted Shares Outstanding9.86M10.42M10.42M10.59M10.96M12.47M12.72M14.51M11.48M7.12M
Basic Shares Outstanding9.85M10.42M10.42M10.59M10.96M12.47M12.72M14.51M11.44M7.12M
Dividend Payout Ratio----------

MNPR Balance Sheet

Monopar Therapeutics Inc. (MNPR) balance sheet — assets, liabilities & shareholders' equity

Line itemDec'16Dec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24TTM
Total Current Assets2.1M9.13M7.32M13.23M16.8M20.52M13.17M7.33M60.29M144.09M
Cash & Short-Term Investments2.07M8.98M6.89M13.21M16.74M20.3M13.12M7.27M60.21M143.68M
Cash Only2.07M8.98M6.89M13.21M16.74M20.3M8.19M7.27M45.82M127.68M
Short-Term Investments0000004.93M014.4M16M
Accounts Receivable0000000000
Days Sales Outstanding----------
Inventory0000000000
Days Inventory Outstanding----------
Other Current Assets00015.71K62.69K217.75K45.98K66.43K78.87K415K
Total Non-Current Assets800.39K800.03K410.67K122.38K68.86K061.23K12.65K0107K
Property, Plant & Equipment00000061.23K12.65K0106.67K
Fixed Asset Turnover---------0.00x
Goodwill0000000000
Intangible Assets0730.65M00000000
Long-Term Investments800.39K000000000
Other Non-Current Assets0-729.85M410.67K122.38K68.86K0000334
Total Assets
2.9M▲ 0%
9.93M▲ 243.0%
7.32M▼ 26.3%
13.35M▲ 82.5%
16.87M▲ 26.3%
20.52M▲ 21.7%
13.23M▼ 35.5%
7.35M▼ 44.5%
60.29M▲ 720.8%
144.2M▲ 0%
Asset Turnover---------0.00x
Asset Growth %2.39%242.98%-26.31%82.46%26.34%21.66%-35.55%-44.47%720.83%4164.86%
Total Current Liabilities64.51K311.87K399.55K724.16K1.18M1.58M3.13M1.76M5.25M2.57M
Accounts Payable64.51K311.87K399.55K724.16K1.18M1.58M3.13M1.76M2.25M2.54M
Days Payables Outstanding----------
Short-Term Debt0000000000
Deferred Revenue (Current)0000000000
Other Current Liabilities0000000000
Current Ratio32.48x29.28x18.32x18.27x14.28x12.98x4.21x4.17x11.47x11.47x
Quick Ratio32.48x29.28x18.32x18.27x14.28x12.98x4.21x4.17x11.47x11.47x
Cash Conversion Cycle----------
Total Non-Current Liabilities0000008.41K0071.45K
Long-Term Debt0000000000
Capital Lease Obligations0000008.41K00151.25K
Deferred Tax Liabilities0000000000
Other Non-Current Liabilities000000000570
Total Liabilities64.51K311.87K399.55K724.16K1.18M1.58M3.14M1.76M5.25M2.64M
Total Debt0000008.41K00102.24K
Net Debt-2.07M-8.98M-6.89M-13.21M-16.74M-20.3M-8.18M-7.27M-45.82M-127.57M
Debt / Equity------0.00x--0.00x
Debt / EBITDA----------0.01x
Net Debt / EBITDA---------6.37x
Interest Coverage-164.94x-344.07x-32.97x-------
Total Equity
2.83M▲ 0%
9.62M▲ 239.8%
6.92M▼ 28.1%
12.63M▲ 82.5%
15.69M▲ 24.3%
18.94M▲ 20.7%
10.09M▼ 46.7%
5.59M▼ 44.6%
55.04M▲ 885.0%
141.56M▲ 0%
Equity Growth %2.79%239.78%-28.08%82.53%24.26%20.71%-46.73%-44.62%884.95%5020.44%
Book Value per Share0.290.920.661.191.431.520.790.394.7919.87
Total Shareholders' Equity2.83M9.62M6.92M12.63M15.69M18.94M10.09M5.59M55.04M141.56M
Common Stock09.29K9.29K10.59K11.45K12.6K12.95K14.9K6.1K6.66K
Retained Earnings-1.87M-18.43M-21.66M-25.88M-32.19M-41.29M-51.8M-60.21M-75.79M-84.31M
Treasury Stock0000000000
Accumulated OCI00-2.4K-10.97K-7.87K-3.16K8.94K-14.13K35.99K11.7K
Minority Interest0000000000

MNPR Cash Flow Statement

Monopar Therapeutics Inc. (MNPR) cash flow — operating, investing & free cash flow history

Line itemDec'16Dec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24TTM
Cash from Operations-1.19M-2.63M-2.89M-3.02M-4.66M-7.32M-7.23M-7.86M-6.4M-6.4M
Operating CF Margin %----------
Operating CF Growth %-87.74%-119.94%-9.87%-4.54%-54.5%-56.95%1.21%-8.71%18.5%-330.37%
Net Income-1.19M-16.55M-3.23M-4.22M-6.3M-9.1M-10.52M-8.4M-15.59M-19.44M
Depreciation & Amortization0000000000
Stock-Based Compensation0305.2K529.33K1.01M1.32M1.47M1.64M1.9M1.14M4.01M
Deferred Taxes0000000000
Other Non-Cash Items9.33K13.5M441.65K0-122.4K0004.55M4.55M
Working Capital Changes-9.04K120.58K-188.16K196.02K443.81K317.77K1.65M-1.35M3.49M47.43K
Change in Receivables0000000000
Change in Inventory0000000000
Change in Payables-9.33K247.36K87.68K243.53K447.6K403.97K1.48M-1.33M506.79K784.62K
Cash from Investing000000-4.92M4.93M-14.34M-15.6M
Capital Expenditures0000000000
CapEx % of Revenue----------
Acquisitions0000000000
Investments----------
Other Investing0000000000
Cash from Financing1.26M9.54M-206.27K9.35M8.18M10.88M32.87K2.03M59.29M148.1M
Debt Issued (Net)0000122.4K00000
Equity Issued (Net)1000K1000K01000K1000K1000K109.34K1000K1000K2.02M
Dividends Paid0000000000
Share Repurchases000000000-35M
Other Financing04.83M-206.27K-874.81K-115.57K-45.77K-76.46K-46.97K-104.14K-901.19K
Net Change in Cash
67.87K▲ 0%
6.91M▲ 10079.9%
-2.89M▼ 141.8%
6.32M▲ 318.8%
3.52M▼ 44.3%
3.57M▲ 1.2%
-12.12M▼ 439.7%
-920.11K▲ 92.4%
38.55M▲ 4289.7%
121.66M▲ 0%
Free Cash Flow
-1.19M▲ 0%
-2.63M▼ 119.9%
-2.89M▼ 9.9%
-3.02M▼ 4.5%
-4.66M▼ 54.5%
-7.32M▼ 56.9%
-7.23M▲ 1.2%
-7.86M▼ 8.7%
-6.4M▲ 18.5%
-10.83M▲ 0%
FCF Margin %----------
FCF Growth %-87.74%-119.94%-9.87%-4.54%-54.5%-56.95%1.21%-8.71%18.5%-81.96%
FCF per Share-0.12-0.25-0.28-0.29-0.43-0.59-0.57-0.54-0.56-0.56
FCF Conversion (FCF/Net Income)1.01x0.16x0.89x0.71x0.74x0.80x0.69x0.94x0.41x0.56x
Interest Paid0000000000
Taxes Paid0000000000

MNPR Key Ratios

Monopar Therapeutics Inc. (MNPR) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric201620172018201920202021202220232024TTM
Return on Equity (ROE)-42.45%-265.93%-39.04%-43.23%-44.52%-52.57%-72.44%-107.19%-51.42%-25.72%
Return on Invested Capital (ROIC)-118.69%-1784.05%-769.75%----2878.57%-5671.91%-321.43%-321.43%
Debt / Equity------0.00x--0.00x
Interest Coverage-164.94x-344.07x-32.97x-------
FCF Conversion1.01x0.16x0.89x0.71x0.74x0.80x0.69x0.94x0.41x0.56x

MNPR SEC Filings & Documents

Monopar Therapeutics Inc. (MNPR) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Mar 27, 2026·SEC

Material company update

Mar 2, 2026·SEC

Material company update

Nov 13, 2025·SEC

10-K Annual Reports

3
FY 2026

Mar 27, 2026·SEC

FY 2025

Mar 31, 2025·SEC

FY 2024

Mar 28, 2024·SEC

10-Q Quarterly Reports

6
FY 2025

Nov 13, 2025·SEC

FY 2025

Aug 12, 2025·SEC

FY 2025

May 13, 2025·SEC

MNPR Frequently Asked Questions

Monopar Therapeutics Inc. (MNPR) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Monopar Therapeutics Inc. (MNPR) grew revenue by 0.0% over the past year. Growth has been modest.

Monopar Therapeutics Inc. (MNPR) reported a net loss of $19.4M for fiscal year 2024.

Dividend & Returns

Monopar Therapeutics Inc. (MNPR) has a return on equity (ROE) of -51.4%. Negative ROE indicates the company is unprofitable.

Monopar Therapeutics Inc. (MNPR) had negative free cash flow of $10.8M in fiscal year 2024, likely due to heavy capital investments.

Explore More MNPR

Monopar Therapeutics Inc. (MNPR) financial analysis — history, returns, DCA and operating performance tools

Total Return Calculator

Historical returns with dividends reinvested

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DCA Calculator

Dollar cost averaging vs lump sum

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Dividend History

Yield, growth, payout safety & DRIP

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Earnings History

EPS trends, net income & profitability

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Price History

Long-term charts & historical price data

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Revenue History

Sales growth patterns & revenue breakdown

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Financial Ratios

30 years of market, efficiency and balance-sheet ratios

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Valuation

DCF intrinsic value, peer multiples & estimates

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