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PRTA logoProthena Corporation plc(PRTA)Earnings, Financials & Key Ratios

PRTA•NASDAQ
$11.18
$602M mkt cap·Price updated May 6, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryNeuroscience and Psychiatry Therapies
AboutProthena Corporation plc, a late-stage clinical company, focuses on discovery and development of novel therapies for life-threatening diseases in the United States. The company is involved in developing Birtamimab, an investigational humanized antibody that is in Phase III clinical trial for the treatment of AL amyloidosis; Prasinezumab, a humanized monoclonal antibody, which is in Phase IIb clinical trial for the treatment of Parkinson's disease; PRX004 that completed Phase I clinical trial for the treatment of Transthyretin amyloidosis; and PRX005, which is in Phase I clinical trial for the treatment of Alzheimer's disease. Its discovery and preclinical programs include PRX012 for the treatment of Alzheimer's disease; and dual Aß-Tau vaccine for the treatment and prevention of Alzheimer's disease. Prothena Corporation plc has a license, development, and commercialization agreement with F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. to develop and commercialize antibodies that target alpha-synuclein; and a collaboration agreement with Bristol-Myers Squibb to develop antibodies. The company was founded in 2012 and is based in Dublin, Ireland.Show more
  • Revenue$10M-92.8%
  • EBITDA-$181M-17.7%
  • Net Income-$244M-99.6%
  • EPS (Diluted)-4.53-99.6%
  • Gross Margin61.77%-38.2%
  • EBITDA Margin-1867.6%-1542.6%
  • Operating Margin-1905.82%-1566.6%
  • Net Margin-2520.57%-2685.3%
  • ROE-63.62%-172.6%
  • ROIC-2099.82%-377.9%
  • Debt/Equity0.05+121.9%
Technical→

PRTA Key Insights

Prothena Corporation plc (PRTA) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Company is almost debt free
  • ✓Strong 5Y sales CAGR of 62.6%
  • ✓Trading near 52-week high

✗Weaknesses

  • ✗Profits declining 17.0% over 5 years
  • ✗Weak Piotroski F-Score: 1/9
  • ✗Negative free cash flow
  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

PRTA Price & Volume

Prothena Corporation plc (PRTA) stock price & volume — 10-year historical chart

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PRTA Growth Metrics

Prothena Corporation plc (PRTA) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years19.68%
5 Years62.56%
3 Years-43.57%
TTM-92.84%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-99.57%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM-97.39%

Return on Capital

10 Years-26.78%
5 Years-21.35%
3 Years-34.19%
Last Year-47.05%

PRTA Recent Earnings

Prothena Corporation plc (PRTA) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 4/12 qtrs (33%)●Beat Revenue 3/12 qtrs (25%)
Q1 2026Latest
Feb 19, 2026
EPS
$0.44
Est $0.45
+2.2%
Revenue
$21,000
Est $1M
-98.4%
Q4 2025
Nov 6, 2025
EPS
$0.67
Est $0.60
-11.7%
Revenue
$2M
Est $666,670
+262.2%
Q3 2025
Aug 4, 2025
EPS
$1.86
Est $1.11
-67.6%
Revenue
$4M
Est $7M
-33.4%
Q2 2025
May 8, 2025
EPS
$1.12
Est $0.92
-21.7%
Revenue
$3M
Est $15M
-81.6%
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q1 2026LatestFeb 19, 2026
$0.44vs $0.45+2.2%
$21,000vs $1M-98.4%
Q4 2025Nov 6, 2025
$0.67vs $0.60-11.7%
$2Mvs $666,670+262.2%
Q3 2025Aug 4, 2025
$1.86vs $1.11-67.6%
$4Mvs $7M-33.4%
Q2 2025May 8, 2025
$1.12vs $0.92-21.7%
$3Mvs $15M-81.6%
Based on last 12 quarters of dataView full earnings history →

PRTA Peer Comparison

Prothena Corporation plc (PRTA) competitors in Neuroscience and Psychiatry Therapies — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
FOLD logoFOLDAmicus Therapeutics, Inc.Direct Competitor4.47B14.49-80.5032.29%-2.35%-6.1%2.29
RARE logoRAREUltragenyx Pharmaceutical Inc.Direct Competitor2.55B25.93-4.4520.13%-91.03%-6.08%
IONS logoIONSIonis Pharmaceuticals, Inc.Direct Competitor12.7B76.85-32.2933.87%-30.87%-58.57%5.35
ALNY logoALNYAlnylam Pharmaceuticals, Inc.Direct Competitor40.43B303.00130.0465.19%13.46%98.29%1.62
RCUS logoRCUSArcus Biosciences, Inc.Direct Competitor2.62B26.00-7.90-4.26%-156.36%-68.97%0.16
BIIB logoBIIBBiogen Inc.Product Competitor28.15B190.6821.591.39%13.92%7.55%0.38
REGN logoREGNRegeneron Pharmaceuticals, Inc.Product Competitor74.89B720.7817.380.99%29.65%14.32%0.09
ARVN logoARVNArvinas, Inc.Product Competitor656.24M10.26-8.02-0.3%-30.77%-14.25%0.02

Compare PRTA vs Peers

Prothena Corporation plc (PRTA) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs FOLD

Most directly comparable listed peer for PRTA.

Scale Benchmark

vs JNJ

Larger-name benchmark to compare PRTA against a more recognizable public peer.

Peer Set

Compare Top 5

vs FOLD, RARE, IONS, ALNY

PRTA Income Statement

Prothena Corporation plc (PRTA) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Sales/Revenue27.52M955K814K853K200.58M53.91M91.37M135.16M9.68M
Revenue Growth %2508.44%-96.53%-14.76%4.79%23414.3%-73.13%69.5%47.92%-92.84%
Cost of Goods Sold134.55M101.18M50.84M74.88M00003.7M
COGS % of Revenue488.92%10595.08%6245.21%8778.9%----38.23%
Gross Profit
-107.03M▲ 0%
-100.23M▲ 6.4%
-50.02M▲ 50.1%
-74.03M▼ 48.0%
200.58M▲ 370.9%
53.91M▼ 73.1%
91.37M▲ 69.5%
135.16M▲ 47.9%
5.98M▼ 95.6%
Gross Margin %-388.92%-10495.08%-6145.21%-8678.9%100%100%100%100%61.77%
Gross Profit Growth %9.66%6.35%50.09%-48%370.94%-73.13%69.5%47.92%-95.57%
Operating Expenses182.77M143.66M35.67M38.7M128.6M185.46M282.41M289.72M190.54M
OpEx % of Revenue664.17%15043.46%4382.68%4537.28%64.12%344.05%309.08%214.36%1967.6%
Selling, General & Admin48.23M42.48M35.74M38.7M46.32M49.9M61.84M67.2M59.39M
SG&A % of Revenue175.25%4448.38%4390.17%4537.28%23.09%92.57%67.68%49.72%613.3%
Research & Development134.55M101.18M50.84M75.09M82.28M135.56M220.57M222.52M134.85M
R&D % of Revenue488.92%10595.08%6245.21%8803.4%41.02%251.48%241.4%164.64%1392.52%
Other Operating Expenses-2.35M2.74M-50.9M-75.09M0000-3.7M
Operating Income
-155.25M▲ 0%
-158.85M▼ 2.3%
-85.7M▲ 46.1%
-112.73M▼ 31.5%
71.97M▲ 163.8%
-131.56M▼ 282.8%
-191.04M▼ 45.2%
-154.56M▲ 19.1%
-184.56M▼ 19.4%
Operating Margin %-564.17%-16634.03%-10527.89%-13216.18%35.88%-244.05%-209.08%-114.36%-1905.82%
Operating Income Growth %2.68%-2.32%46.05%-31.55%163.84%-282.78%-45.21%19.09%-19.41%
EBITDA-152.19M-155.64M-84.13M-111.22M73.09M-130.81M-190.11M-153.67M-180.86M
EBITDA Margin %-553.03%-16297.28%-10335.75%-13038.69%36.44%-242.67%-208.06%-113.7%-1867.6%
EBITDA Growth %3.13%-2.27%45.94%-32.2%165.72%-278.98%-45.33%19.17%-17.69%
D&A (Non-Cash Add-back)3.07M3.22M1.56M1.51M1.11M744K928K893K3.7M
EBIT-153.91M-152.42M-85.76M-112.73M71.97M-131.56M-191.04M-154.56M-200.83M
Net Interest Income-142K2.69M8.2M1.37M42K6.35M31.01M25.82M14.14M
Interest Income3.55M6.39M8.2M1.37M42K6.35M31.01M25.82M14.14M
Interest Expense3.69M3.7M0000000
Other Income/Expense-2.35M2.74M8.4M1.87M-54K5.95M30.56M25.63M-16.27M
Pretax Income
-157.6M▲ 0%
-156.12M▲ 0.9%
-77.3M▲ 50.5%
-110.86M▼ 43.4%
71.92M▲ 164.9%
-125.61M▼ 274.6%
-160.48M▼ 27.8%
-128.93M▲ 19.7%
-200.83M▼ 55.8%
Pretax Margin %-572.71%-16347.12%-9496.07%-12996.6%35.86%-233.01%-175.64%-95.39%-2073.82%
Income Tax-4.37M-470K379K283K4.95M-8.66M-13.45M-6.62M43.26M
Effective Tax Rate %2.77%0.3%-0.49%-0.26%6.88%6.89%8.38%5.13%-21.54%
Net Income
-153.24M▲ 0%
-155.65M▼ 1.6%
-77.68M▲ 50.1%
-111.14M▼ 43.1%
66.97M▲ 160.3%
-116.95M▼ 274.6%
-147.03M▼ 25.7%
-122.31M▲ 16.8%
-244.09M▼ 99.6%
Net Margin %-556.84%-16297.91%-9542.63%-13029.78%33.39%-216.95%-160.92%-90.49%-2520.57%
Net Income Growth %4.29%-1.57%50.09%-43.08%160.26%-274.62%-25.72%16.81%-99.57%
Net Income (Continuing)-153.24M-155.65M-77.68M-111.14M66.97M-116.95M-147.03M-122.31M-244.09M
Discontinued Operations000000000
Minority Interest000000000
EPS (Diluted)
-4.07▲ 0%
-3.93▲ 3.4%
-1.95▲ 50.4%
-2.78▼ 42.6%
1.38▲ 149.6%
-2.47▼ 279.0%
-2.76▼ 11.7%
-2.27▲ 17.8%
-4.53▼ 99.6%
EPS Growth %12.66%3.44%50.38%-42.56%149.64%-278.99%-11.74%17.75%-99.56%
EPS (Basic)-4.07-3.93-1.95-2.781.51-2.47-2.76-2.27-4.53
Diluted Shares Outstanding37.65M39.56M39.88M39.91M48.46M47.37M53.22M53.77M53.83M
Basic Shares Outstanding37.65M39.56M39.88M39.91M44.23M47.37M53.22M53.77M53.83M
Dividend Payout Ratio---------

PRTA Balance Sheet

Prothena Corporation plc (PRTA) balance sheet — assets, liabilities & shareholders' equity

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Total Current Assets426.33M431.39M378.38M299.28M584.81M719.1M639.28M485.41M315.19M
Cash & Short-Term Investments417.62M427.66M375.72M295.38M579.09M710.41M618.83M471.39M307.53M
Cash Only417.62M427.66M375.72M295.38M579.09M710.41M618.83M471.39M307.53M
Short-Term Investments000000000
Accounts Receivable240K2K68K15K13K62K5.16M00
Days Sales Outstanding3.180.7630.496.420.020.4220.61--
Inventory-240K00000000
Days Inventory Outstanding---------
Other Current Assets0001.35M766K1.71M3.49M1.17M7.66M
Total Non-Current Assets70M67.41M40.89M33.69M24.56M38.94M57.1M61.7M11.61M
Property, Plant & Equipment54.99M52.84M27.15M20.36M14.13M8.01M16M13.79M10.27M
Fixed Asset Turnover0.50x0.02x0.03x0.04x14.19x6.73x5.71x9.80x0.94x
Goodwill000000000
Intangible Assets000000000
Long-Term Investments4.06M4.06M00000860K860K
Other Non-Current Assets6.9M4.87M3.79M1.69M3.35M12.72M7.21M3.81M482K
Total Assets
496.33M▲ 0%
498.8M▲ 0.5%
419.27M▼ 15.9%
332.98M▼ 20.6%
609.37M▲ 83.0%
758.03M▲ 24.4%
696.38M▼ 8.1%
547.11M▼ 21.4%
326.8M▼ 40.3%
Asset Turnover0.06x0.00x0.00x0.00x0.33x0.07x0.13x0.25x0.03x
Asset Growth %7.9%0.5%-15.94%-20.58%83.01%24.4%-8.13%-21.44%-40.27%
Total Current Liabilities37.37M14.93M17.71M25.85M33.45M50.15M56.89M48.5M40.84M
Accounts Payable13.63M1.47M1.24M4.12M3.69M9.27M25.39M7.77M5.88M
Days Payables Outstanding36.985.38.9220.07----579.25
Short-Term Debt000000002.89M
Deferred Revenue (Current)-857K110.24M007.66M11.44M08.85M2.66M
Other Current Liabilities1.72M837K322K516K405K503K2.13M29.27M29.42M
Current Ratio11.41x28.90x21.36x11.58x17.48x14.34x11.24x10.01x7.72x
Quick Ratio11.41x28.90x21.36x11.58x17.48x14.34x11.24x10.01x7.72x
Cash Conversion Cycle---------
Total Non-Current Liabilities51.77M160.87M128.63M123.12M109.87M85.85M78.13M11.68M5.49M
Long-Term Debt000000005.49M
Capital Lease Obligations51.52M49.9M17.84M12.33M6.39M010.72M8.23M5.49M
Deferred Tax Liabilities-254K-49.9M0000000
Other Non-Current Liabilities254K110.97M553K553K553K553K00-5.49M
Total Liabilities89.14M175.8M146.35M148.97M143.32M135.99M135.02M60.18M46.33M
Total Debt52.25M51.55M22.94M17.84M12.33M6.47M11.84M10.84M13.86M
Net Debt-365.37M-376.11M-352.78M-277.54M-566.77M-703.93M-607M-460.55M-293.67M
Debt / Equity0.13x0.16x0.08x0.10x0.03x0.01x0.02x0.02x0.05x
Debt / EBITDA----0.17x----
Net Debt / EBITDA-----7.75x----
Interest Coverage-41.73x-41.23x-------
Total Equity
407.19M▲ 0%
323M▼ 20.7%
272.92M▼ 15.5%
184.01M▼ 32.6%
466.04M▲ 153.3%
622.04M▲ 33.5%
561.37M▼ 9.8%
486.93M▼ 13.3%
280.47M▼ 42.4%
Equity Growth %11.44%-20.68%-15.5%-32.58%153.28%33.47%-9.75%-13.26%-42.4%
Book Value per Share10.818.166.844.619.6213.1310.559.065.21
Total Shareholders' Equity407.19M323M272.92M184.01M466.04M622.04M561.37M486.93M280.47M
Common Stock385K399K399K399K466K521K537K538K538K
Retained Earnings-442.35M-598M-671.88M-783.03M-716.05M-833M-980.03M-1.1B-1.35B
Treasury Stock000000000
Accumulated OCI-7.74M-10.5M0000000
Minority Interest000000000

PRTA Cash Flow Statement

Prothena Corporation plc (PRTA) cash flow — operating, investing & free cash flow history

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Cash from Operations-131.18M-28.28M-52.97M-80.36M92.61M-108.82M-133.91M-150.05M-163.58M
Operating CF Margin %-476.7%-2960.84%-6507.25%-9421.1%46.17%-201.88%-146.55%-111.02%-1689.18%
Operating CF Growth %-11.87%78.45%-87.33%-51.72%215.23%-217.51%-23.05%-12.06%-9.02%
Net Income-153.24M-155.65M-77.68M-111.14M66.97M-116.95M-147.03M-122.31M-244.09M
Depreciation & Amortization3.07M3.22M6.82M1.51M1.11M744K928K893K895K
Stock-Based Compensation26.76M27.01M23.59M22.01M24.66M31.32M40.91M45.96M37.64M
Deferred Taxes-2.2M-1.59M-1.25M-1.69M4.57M-11.13M-15.69M-9.35M43.24M
Other Non-Cash Items1.59M4.28M05.46M5.69M6M7.5M2.69M2.91M
Working Capital Changes-7.16M94.45M-4.45M3.48M-10.4M-18.8M-20.53M-67.94M-4.17M
Change in Receivables-62K238K053K15K0-5.16M5.16M0
Change in Inventory-396.2M9.6M0000-8.9M00
Change in Payables147K-25.63M-78K7.73M-492K11.87M22.86M-18.3M-15.78M
Cash from Investing-3.52M-1.73M-547K-196K-575K-464K-2.77M-298K-138K
Capital Expenditures-3.63M-1.77M-555K-196K-575K-464K-2.81M-298K-138K
CapEx % of Revenue13.18%185.13%68.18%22.98%0.29%0.86%3.08%0.22%1.43%
Acquisitions105K39K0000000
Investments---------
Other Investing105K39K8K00037K00
Cash from Financing165.4M40.04M228K215K190.33M241.46M45.1M1.55M-139K
Debt Issued (Net)-2.76M-4.4M0000000
Equity Issued (Net)150.32M39.76M00174.79M223.62M23.58M-353K-139K
Dividends Paid000000000
Share Repurchases0000000-353K0
Other Financing17.84M4.69M228K215K15.54M17.84M21.52M1.91M0
Net Change in Cash
30.7M▲ 0%
10.04M▼ 67.3%
-53.29M▼ 630.8%
-80.34M▼ 50.8%
282.36M▲ 451.4%
132.17M▼ 53.2%
-91.58M▼ 169.3%
-148.79M▼ 62.5%
-163.86M▼ 10.1%
Free Cash Flow
-134.81M▲ 0%
-30.04M▲ 77.7%
-53.52M▼ 78.2%
-80.56M▼ 50.5%
92.03M▲ 214.2%
-109.28M▼ 218.7%
-136.72M▼ 25.1%
-150.35M▼ 10.0%
-163.72M▼ 8.9%
FCF Margin %-489.88%-3145.97%-6575.43%-9444.08%45.88%-202.74%-149.63%-111.24%-1690.6%
FCF Growth %-0.67%77.71%-78.15%-50.51%214.24%-218.75%-25.1%-9.97%-8.89%
FCF per Share-3.58-0.76-1.34-2.021.90-2.31-2.57-2.80-3.04
FCF Conversion (FCF/Net Income)0.86x0.18x0.68x0.72x1.38x0.93x0.91x1.23x0.67x
Interest Paid000000000
Taxes Paid294K01.58M1.37M580K2.66M1.55M3.17M0

PRTA Key Ratios

Prothena Corporation plc (PRTA) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric2016201720182019202020212022202320242025
Return on Equity (ROE)-44.1%-39.67%-42.63%-26.07%-48.65%20.61%-21.5%-24.85%-23.34%-63.62%
Return on Invested Capital (ROIC)-1203.55%-325.18%-------439.41%-2099.82%
Gross Margin-11230.24%-388.92%-10495.08%-6145.21%-8678.9%100%100%100%100%61.77%
Net Margin-15176.11%-556.84%-16297.91%-9542.63%-13029.78%33.39%-216.95%-160.92%-90.49%-2520.57%
Debt / Equity0.14x0.13x0.16x0.08x0.10x0.03x0.01x0.02x0.02x0.05x
Interest Coverage-184.20x-41.73x-41.23x-------
FCF Conversion0.73x0.86x0.18x0.68x0.72x1.38x0.93x0.91x1.23x0.67x
Revenue Growth-34.35%2508.44%-96.53%-14.76%4.79%23414.3%-73.13%69.5%47.92%-92.84%

PRTA SEC Filings & Documents

Prothena Corporation plc (PRTA) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Feb 27, 2026·SEC

Material company update

Feb 19, 2026·SEC

Material company update

Dec 12, 2025·SEC

10-K Annual Reports

3
FY 2026

Feb 27, 2026·SEC

FY 2025

Feb 27, 2025·SEC

FY 2024

Feb 22, 2024·SEC

10-Q Quarterly Reports

6
FY 2025

Nov 6, 2025·SEC

FY 2025

Aug 4, 2025·SEC

FY 2025

May 8, 2025·SEC

PRTA Frequently Asked Questions

Prothena Corporation plc (PRTA) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Prothena Corporation plc (PRTA) reported $9.7M in revenue for fiscal year 2025. This represents a 679% increase from $1.2M in 2010.

Prothena Corporation plc (PRTA) saw revenue decline by 92.8% over the past year.

Prothena Corporation plc (PRTA) reported a net loss of $244.1M for fiscal year 2025.

Dividend & Returns

Prothena Corporation plc (PRTA) has a return on equity (ROE) of -63.6%. Negative ROE indicates the company is unprofitable.

Prothena Corporation plc (PRTA) had negative free cash flow of $167.6M in fiscal year 2025, likely due to heavy capital investments.

Explore More PRTA

Prothena Corporation plc (PRTA) financial analysis — history, returns, DCA and operating performance tools

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Dividend History

Yield, growth, payout safety & DRIP

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Earnings History

EPS trends, net income & profitability

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Price History

Long-term charts & historical price data

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Revenue History

Sales growth patterns & revenue breakdown

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Financial Ratios

30 years of market, efficiency and balance-sheet ratios

→

Valuation

DCF intrinsic value, peer multiples & estimates

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