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CYCNCyclerion Therapeutics, Inc.
$3.20$14M
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CYCN logoCyclerion Therapeutics, Inc.(CYCN)Earnings, Financials & Key Ratios

CYCN•NASDAQ
Price updated Jun 19, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryNeuroscience and Psychiatry Therapies
AboutCyclerion Therapeutics, Inc., a clinical-stage biopharmaceutical company, engages in the discovering, development, and commercialization of medicines for serious central nervous system (CNS) diseases. Its lead product candidate is CY6463, a CNS-penetrant, soluble guanylate cyclase (sGC) stimulator that is in Phase IIa trials for the treatment of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes, as well as Alzheimer's disease with vascular pathology; and Phase 1 trials diagnosed with schizophrenia in adults. It is also developing Praliciguat, an orally administered systemic sGC stimulator, which is in Phase II studies to treat resistant hypertension and diabetic nephropathy; Olinciguat, an orally administered vascular sGC stimulator that is in Phase II studies for the sickle cell disease; and CY3018 for the treatment of disorders of the CNS. It has license agreement with Akebia Therapeutics, Inc. for the development, manufacture, medical affairs, and commercialization of pharmaceutical products, including pharmaceutical compound, and other related products and forms. The company was incorporated in 2018 and is headquartered in Cambridge, Massachusetts.Show more
  • Revenue$2M+3.7%
  • EBITDA-$5M-37.1%
  • Net Income-$4M-15.4%
  • EPS (Diluted)-1.09+9.9%
  • Gross Margin100%
  • EBITDA Margin-239.78%-32.2%
  • Operating Margin-239.78%-32.2%
  • Net Margin-170.11%-11.3%
  • ROE-39.34%-29.6%

CYCN Key Insights

Cyclerion Therapeutics, Inc. (CYCN) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Strong 5Y profit CAGR of 46.1%
  • ✓Momentum leader: RS Rating 93 (top 7%)
  • ✓Trading at only 1.1x book value

✗Weaknesses

  • ✗Weak Piotroski F-Score: 1/9
  • ✗Negative free cash flow
  • ✗Shares diluted 28.1% in last year
  • ✗Trading more than 30% below 52-week high
  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

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CYCN Price & Volume

Cyclerion Therapeutics, Inc. (CYCN) stock price & volume — 10-year historical chart

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CYCN Growth Metrics

Cyclerion Therapeutics, Inc. (CYCN) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-2.01%
3 Years91.14%
TTM-4.23%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-79.21%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM-21.37%

Return on Capital

10 Years-81.22%
5 Years-69.81%
3 Years-70.21%
Last Year-55.46%

CYCN Recent Earnings

Cyclerion Therapeutics, Inc. (CYCN) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 6/12 qtrs (86%)●Beat Revenue 0/12 qtrs (0%)
Q2 2026Latest
May 12, 2026
Metric
Actual
Est
EPS
$0.76+95.6%
$17.20
Rev
—
—
Q2 2026
Mar 30, 2026
Metric
Actual
Est
EPS
$0.19+50.0%
$0.38
Rev
$100,000+0.0%
$100,000
Q2 2026
Mar 25, 2026
Metric
Actual
Est
EPS
$0.38+0.0%
$0.38
Rev
$100,000+0.0%
$100,000
Q4 2025
Nov 12, 2025
Metric
Actual
Est
EPS
$0.30
—
Rev
$875,000
—
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 12, 2026
$0.76vs $17.20+95.6%
—
Q2 2026Mar 30, 2026
$0.19vs $0.38+50.0%
$100,000vs $100,000+0.0%
Q2 2026Mar 25, 2026
$0.38vs $0.38+0.0%
$100,000vs $100,000+0.0%
Q4 2025Nov 12, 2025
$0.30
$875,000
Based on last 12 quarters of dataView full earnings history →

CYCN Peer Comparison

Cyclerion Therapeutics, Inc. (CYCN) competitors in Neuroscience and Psychiatry Therapies — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
Institutional Holdings
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
ADMA logoADMAADMA Biologics, Inc.Direct Competitor1.93B8.3113.8519.63%32.43%38.97%0.17
IMVT logoIMVTImmunovant, Inc.Direct Competitor7.26B35.34-12.76-68.16%0.00
KALA logoKALAKALA BIO, Inc.Direct Competitor79.17M3.61-1.09-13.36%
PRTA logoPRTAProthena Corporation plcDirect Competitor467.51M8.93-1.97-92.84%-260.92%-49.88%0.05
MNKD logoMNKDMannKind CorporationProduct Competitor1.22B3.9419722.23%-6.63%
AGIO logoAGIOAgios Pharmaceuticals, Inc.Product Competitor2.03B34.16-4.8048.03%-6.4%-34.11%0.05
RARE logoRAREUltragenyx Pharmaceutical Inc.Product Competitor2.7B27.44-4.7120.13%-91.03%-6.08%
FOLD logoFOLDAmicus Therapeutics, Inc.Product Competitor4.55B14.49-164.8520.05%-4.27%-12.02%1.76

Compare CYCN vs Peers

Cyclerion Therapeutics, Inc. (CYCN) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs ADMA

Most directly comparable listed peer for CYCN.

Scale Benchmark

vs ABBV

Larger-name benchmark to compare CYCN against a more recognizable public peer.

Peer Set

Compare Top 5

vs ADMA, IMVT, KALA, PRTA

CYCN Income Statement

Cyclerion Therapeutics, Inc. (CYCN) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Sales/Revenue
004.51M2.3M3.32M297K02M2.07M1.99M
Revenue Growth %
----49.06%44.6%-91.05%-100%-3.7%-4.23%
Cost of Goods Sold
1.75M1.53M95.14M56.41M05.58M0000
COGS % of Revenue
--2110.94%2457.06%-1878.45%----
Gross Profit
-1.75M▲ 0%
-1.53M▲ 12.4%
-90.63M▼ 5831.5%
-54.12M▲ 40.3%
3.32M▲ 106.1%
-5.28M▼ 259.1%
0▲ 100.0%
2M▲ 0%
2.07M▲ 3.7%
1.99M▲ 0%
Gross Margin %
---2010.94%-2357.06%100%-1778.45%-100%100%100%
Gross Profit Growth %
-12.44%-5831.48%40.29%106.13%-259.1%100%-3.7%-
Operating Expenses
93.92M115.25M34.4M27.15M58.52M13.26M12.95M5.63M7.05M8.72M
OpEx % of Revenue
--763.35%1182.36%1762.5%4463.97%-281.4%339.78%-
Selling, General & Admin
15.12M27.54M34.4M28.82M20.62M13.26M8.33M5.34M6.09M7.07M
SG&A % of Revenue
--763.35%1255.05%621.08%4463.97%-267.1%293.54%-
Research & Development
78.8M87.72M95.14M56.41M37.64M5.98M1.51M286K959K1.65M
R&D % of Revenue
--2110.94%2457.06%1133.61%2013.13%-14.3%46.24%-
Other Operating Expenses
00-95.14M-58.08M259K-5.98M3.1M000
Operating Income
-93.92M▲ 0%
-115.25M▼ 22.7%
-125.04M▼ 8.5%
-81.27M▲ 35.0%
-55.2M▲ 32.1%
-18.54M▲ 66.4%
-12.95M▲ 30.1%
-3.63M▲ 72.0%
-4.97M▼ 37.1%
-6.72M▲ 0%
Operating Margin %
---2774.28%-3539.42%-1662.5%-6242.42%--181.4%-239.78%-337.43%
Operating Income Growth %
--22.71%-8.49%35.01%32.08%66.41%30.15%71.99%-37.07%-
EBITDA
-92.18M-113.72M-122.34M-78.97M-54.72M-18.48M-12.89M-3.63M-4.97M-6.7M
EBITDA Margin %
---2714.38%-3439.37%-1648.28%-6220.54%--181.4%-239.78%-335.93%
EBITDA Growth %
--23.38%-7.57%35.45%30.7%66.24%30.25%71.85%-37.07%-93.11%
D&A (Non-Cash Add-back)
1.75M1.53M2.7M2.3M472K65K65K000
EBIT
-93.92M-115.25M-125.04M-82.93M-54.31M-18.54M-9.65M-3.63M-4.97M-6.7M
Net Interest Income
002.03M588K-16K294K358K208K128K132K
Interest Income
002.03M588K0294K358K208K128K132K
Interest Expense
000016K00000
Other Income/Expense
002.03M3.46M3.55M294K358K571K1.45M1.45M
Pretax Income
-93.92M▲ 0%
-115.25M▼ 22.7%
-123.01M▼ 6.7%
-77.8M▲ 36.8%
-51.65M▲ 33.6%
-18.25M▲ 64.7%
-12.59M▲ 31.0%
-3.06M▲ 75.7%
-3.53M▼ 15.4%
-5.28M▲ 0%
Pretax Margin %
---2729.27%-3388.59%-1555.63%-6143.43%--152.85%-170.11%-264.73%
Income Tax
0000000000
Effective Tax Rate %
0%0%0%0%0%0%0%0%0%0%
Net Income
-93.92M▲ 0%
-115.25M▼ 22.7%
-123.01M▼ 6.7%
-77.8M▲ 36.8%
-51.65M▲ 33.6%
-44.08M▲ 14.7%
-5.26M▲ 88.1%
-3.06M▲ 41.9%
-3.53M▼ 15.4%
-5.28M▲ 0%
Net Margin %
---2729.27%-3388.59%-1555.63%-14841.08%--152.85%-170.11%-264.73%
Net Income Growth %
--22.71%-6.73%36.75%33.62%14.66%88.06%41.92%-15.41%-79.21%
Net Income (Continuing)
-93.92M-115.25M-123.01M-77.8M-51.65M-18.25M-12.59M-3.06M-3.53M-5.28M
Discontinued Operations
00000-25.83M7.33M000
Minority Interest
0000000000
EPS (Diluted)
-68.80▲ 0%
-84.42▼ 22.7%
-88.37▼ 4.7%
-47.80▲ 45.9%
-26.40▲ 44.8%
-20.15▲ 23.7%
-8.99▲ 55.4%
-1.21▲ 86.5%
-1.09▲ 9.9%
-1.25▲ 0%
EPS Growth %
--22.7%-4.68%45.91%44.77%23.67%55.38%86.54%9.92%-21.37%
EPS (Basic)
-68.80-84.42-88.37-47.80-26.40-20.15-8.99-1.21-1.09-
Diluted Shares Outstanding
1.37M1.37M1.37M1.52M1.96M2.17M2.34M2.52M3.23M4.21M
Basic Shares Outstanding
1.37M1.37M1.37M1.52M1.96M2.17M2.34M2.52M3.23M4.21M
Dividend Payout Ratio
----------

CYCN Balance Sheet

Cyclerion Therapeutics, Inc. (CYCN) balance sheet — assets, liabilities & shareholders' equity

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Total Current Assets
1.26M879K101.2M58.5M55.46M14.82M8.02M4.22M4.63M3.09M
Cash & Short-Term Investments
0097.59M54.4M53.96M13.38M7.57M3.23M3.24M2.82M
Cash Only
0097.59M54.4M53.96M13.38M7.57M3.23M3.24M2.82M
Short-Term Investments
0000000000
Accounts Receivable
001.47M127K100K96K0556K1M0
Days Sales Outstanding
--119.3720.1910.99117.98-101.47175.9974.4
Inventory
0000928K00000
Days Inventory Outstanding
----------
Other Current Assets
8K12K162K1.56M468K537K11K16K11K266K
Total Non-Current Assets
4.21M6.52M85.28M56.88M3.87M3.26M5.35M5.35M5.35M5.42M
Property, Plant & Equipment
4.13M6.5M79.75M50.27M1.47M1.22M00066K
Fixed Asset Turnover
--0.06x0.05x2.26x0.24x---120.79x
Goodwill
0000000000
Intangible Assets
0000000000
Long-Term Investments
004.99M0005.35M5.35M5.35M10.7M
Other Non-Current Assets
80K25K540K6.61M2.41M2.04M0005.35M
Total Assets
5.47M▲ 0%
7.4M▲ 35.3%
186.48M▲ 2419.6%
115.38M▼ 38.1%
59.33M▼ 48.6%
18.08M▼ 69.5%
13.37M▼ 26.0%
9.57M▼ 28.4%
9.98M▲ 4.3%
8.51M▲ 0%
Asset Turnover
--0.02x0.02x0.06x0.02x-0.21x0.21x0.21x
Asset Growth %
-35.3%2419.63%-38.13%-48.58%-69.53%-26.02%-28.41%4.28%0.8%
Total Current Liabilities
14.04M17.85M18.25M16.95M11.09M7.63M2.09M725K900K1.71M
Accounts Payable
1.8M2.78M3.31M1.15M1.83M2.97M1.2M390K508K457K
Days Payables Outstanding
376.92664.3112.77.43-194.31----
Short-Term Debt
003.42M3.51M000000
Deferred Revenue (Current)
0000000000
Other Current Liabilities
5.62M7.27M5.05M176K7.28M68K102K63K51K1.26M
Current Ratio
0.09x0.05x5.55x3.45x5.00x1.94x3.85x5.83x5.15x1.80x
Quick Ratio
0.09x0.05x5.55x3.45x4.92x1.94x3.85x5.83x5.15x1.80x
Cash Conversion Cycle
---------74.4
Total Non-Current Liabilities
0070.5M38.93M000000
Long-Term Debt
0000000000
Capital Lease Obligations
0070.5M38.93M000000
Deferred Tax Liabilities
0000000000
Other Non-Current Liabilities
0000000000
Total Liabilities
14.04M17.85M88.75M55.88M11.09M7.63M2.09M725K900K1.71M
Total Debt
0073.92M45.73M000000
Net Debt
00-23.68M-8.66M-53.96M-13.38M-7.57M-3.23M-3.24M-2.82M
Debt / Equity
--0.76x0.77x-----0.00x
Debt / EBITDA
----------0.00x
Net Debt / EBITDA
---------0.42x
Interest Coverage
-----3394.63x-----
Total Equity
-8.57M▲ 0%
-10.45M▼ 21.9%
97.73M▲ 1035.7%
59.49M▼ 39.1%
48.25M▼ 18.9%
10.45M▼ 78.3%
11.29M▲ 8.0%
8.85M▼ 21.6%
9.09M▲ 2.7%
6.79M▲ 0%
Equity Growth %
--21.92%1035.65%-39.12%-18.9%-78.34%8%-21.6%2.66%-6.08%
Book Value per Share
-6.28-7.6571.3939.1424.654.814.833.512.821.61
Total Shareholders' Equity
-8.57M-10.45M97.73M59.49M48.25M10.45M11.29M8.85M9.09M6.79M
Common Stock
0000000000
Retained Earnings
00-85.63M-163.43M-215.08M-259.15M-264.42M-267.49M-271.02M-274.2M
Treasury Stock
0000000000
Accumulated OCI
-15.87M-15.49M-20K-27K-23K-20K-12K000
Minority Interest
0000000000

CYCN Cash Flow Statement

Cyclerion Therapeutics, Inc. (CYCN) cash flow — operating, investing & free cash flow history

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Cash from Operations
-81.22M-97.5M-102.22M-72.49M-36.52M-40.61M-21.25M-4.33M-3.31M-3.52M
Operating CF Margin %
---2267.92%-3157.23%-1099.91%-13673.74%--216.65%-159.79%-
Operating CF Growth %
--20.05%-4.83%29.08%49.62%-11.21%47.69%79.6%23.52%-420.96%
Net Income
-93.92M-115.25M-123.01M-77.8M-51.65M-18.25M-12.59M-3.06M-3.53M-5.28M
Depreciation & Amortization
1.75M1.53M2.7M2.3M472K65K0000
Stock-Based Compensation
9.49M12.43M19.63M14.99M9.61M00625K441K232K
Deferred Taxes
0000000000
Other Non-Cash Items
12.59M14.51M751K-4.38M3.64M-19.58M-4.05M-363K0153K
Working Capital Changes
1.47M3.79M-2.29M-7.59M1.41M-2.85M-4.6M-1.54M-227K1.37M
Change in Receivables
00-1.47M1.35M27K4K96K-556K-444K581K
Change in Inventory
00-3.18M0000000
Change in Payables
392K979K-250K-1.1M393K1.14M-1.77M-445K118K-26K
Cash from Investing
-1.4M-3.44M-6.71M18K1.46M010.4M00-66K
Capital Expenditures
-1.4M-3.44M-6.89M-1.52M-7K0000-66K
CapEx % of Revenue
--152.83%66.38%0.21%----3.31%
Acquisitions
00173K00010.4M000
Investments
----------
Other Investing
00173K1.54M1.46M00000
Cash from Financing
82.62M100.94M211.57M28.09M30.79M29K5.02M03.32M2.77M
Debt Issued (Net)
0003.51M000000
Equity Issued (Net)
00175M24.25M30.5M29K5.02M01.25M2.77M
Dividends Paid
0000000000
Share Repurchases
00000000-130K0
Other Financing
82.62M100.94M36.57M331K282K0002.08M0
Net Change in Cash
0▲ 0%
0▲ 0%
102.62M▲ 0%
-44.39M▼ 143.3%
-4.27M▲ 90.4%
-40.58M▼ 850.1%
-5.81M▲ 85.7%
-4.34M▲ 25.3%
8K▲ 100.2%
-816K▲ 0%
Free Cash Flow
-82.62M▲ 0%
-100.94M▼ 22.2%
-109.1M▼ 8.1%
-74.01M▲ 32.2%
-36.52M▲ 50.7%
-40.61M▼ 11.2%
-21.25M▲ 47.7%
-4.33M▲ 79.6%
-3.31M▲ 23.5%
-3.59M▲ 0%
FCF Margin %
---2420.75%-3223.61%-1100.12%-13673.74%--216.65%-159.79%-180.03%
FCF Growth %
--22.17%-8.09%32.16%50.65%-11.19%47.69%79.6%23.52%-4.61%
FCF per Share
-60.52-73.94-79.70-48.69-18.66-18.69-9.09-1.72-1.03-0.85
FCF Conversion (FCF/Net Income)
0.86x0.85x0.83x0.93x0.71x0.92x4.04x1.42x0.94x0.68x
Interest Paid
0000000000
Taxes Paid
0000000000

CYCN Key Ratios

Cyclerion Therapeutics, Inc. (CYCN) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric20182019202020212022202320242025TTM
Return on Equity (ROE)
--281.86%-98.97%-95.87%-150.19%-48.42%-30.36%-39.34%-62.1%
Return on Invested Capital (ROIC)
--294.86%-97.61%-183.5%--2468.42%-58.3%-65.07%-99.15%
Gross Margin
--2010.94%-2357.06%100%-1778.45%-100%100%100%
Net Margin
--2729.27%-3388.59%-1555.63%-14841.08%--152.85%-170.11%-264.73%
Debt / Equity
-0.76x0.77x-----0.00x
Interest Coverage
----3394.63x-----
FCF Conversion
0.85x0.83x0.93x0.71x0.92x4.04x1.42x0.94x0.68x
Revenue Growth
---49.06%44.6%-91.05%-100%-3.7%-4.23%
Related:CYCN Dividend History·CYCN Revenue History·CYCN Price History·CYCN P/E History·CYCN Financial Ratios·CYCN Institutional Holders

CYCN SEC Filings & Documents

Cyclerion Therapeutics, Inc. (CYCN) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Apr 1, 2026·SEC

Material company update

Feb 17, 2026·SEC

Material company update

Jan 6, 2026·SEC

10-K Annual Reports

3
FY 2025

Mar 4, 2025·SEC

FY 2024

Mar 5, 2024·SEC

FY 2023

Mar 22, 2023·SEC

10-Q Quarterly Reports

6
FY 2026

May 12, 2026·SEC

FY 2025

Nov 12, 2025·SEC

FY 2025

Aug 5, 2025·SEC

CYCN Frequently Asked Questions

Cyclerion Therapeutics, Inc. (CYCN) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Cyclerion Therapeutics, Inc. (CYCN) reported $2.0M in revenue for fiscal year 2025.

Cyclerion Therapeutics, Inc. (CYCN) grew revenue by 3.7% over the past year. Growth has been modest.

Cyclerion Therapeutics, Inc. (CYCN) reported a net loss of $5.3M for fiscal year 2025.

Dividend & Returns

Cyclerion Therapeutics, Inc. (CYCN) has a return on equity (ROE) of -39.3%. Negative ROE indicates the company is unprofitable.

Cyclerion Therapeutics, Inc. (CYCN) had negative free cash flow of $3.6M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in CYCN back in 2017?

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