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CYCNCyclerion Therapeutics, Inc.
$23.52$16M
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CYCN logo

Cyclerion Therapeutics, Inc.

CYCN
NASDAQ · Biotechnology
$23.52
At close - Sep 22, 4:00 PM EDT - USD
Market Cap$16M
P/E-3.1x
52W High$36.33
Volume435.85K
OverviewTerminalAnalysisFinancialsValuationEarningsBreakoutsOwnership
VCP Research Verdict2026Q1

Persistent Operational Burn Threatens Clinical Pipeline Viability

Cyclerion Therapeutics faces a precarious financial outlook characterized by a lack of sustainable revenue, as evidenced by the 100% revenue contraction in 2026Q1. The company's reliance on sporadic milestone payments to fund its sGC stimulator pipeline is ins...

GrowthContracting
ProfitabilityNegative
ValuationReview
TechnicalsMixed
Explore valuation models
MARKET ACTION

CYCN price & volume

Price trend, volume and key moving averages

Launch Terminal
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Decision Checklist4 Core Signals

What matters now

The signals most likely to change the investment case.

01

Earnings momentum

6/12 Beats

EPS beat 6 of last 12 quarters

02

Valuation risk

-115% Peers

P/E is 115% below peer median

03

Market leadership

RS 99 · Leader

High momentum (Outperforming 99% of market)

04

Mixed Trend

Mixed

Price < 50DMA but > 200DMA

Next CatalystConfirmed earnings · Nov 11

Market performance

Price History →

Trailing total returns as of 9/24/2026, which may include dividends or other distributions. Benchmark is S&P 500 (^GSPC).

YTD Return
CYCN+1655.22%
S&P 500 (^GSPC)+12.39%
1-Year Return
CYCN+678.81%
S&P 500 (^GSPC)+15.77%
3-Year Return
CYCN+535.68%
S&P 500 (^GSPC)+77.64%
5-Year Return
CYCN-66.30%
S&P 500 (^GSPC)+64.47%

Growth & profitability

Annual revenue & EPS trend
Revenue
$2M+3.7% YoY
Net income
-$4M-15.4% YoY
Free cash flow
-$3M+23.5% YoY
Operating margin
-239.8%-58.4 pts YoY
ROIC (TTM)-65.1%
Avg ROIC 5Y-
ROE (TTM)-39.3%
Piotroski Score1 / 9
Financial Statements →
03

Monitor what changed

Recent results and news deserve attention only when they alter the forward view.

OPERATING RESULTS

Recent Earnings

Earnings History
EPS Beat Rate6/12 (86%)
Revenue Beat Rate2/12 (50%)
QuarterEPS (Act vs Est)Revenue (Act vs Est)
Q3 2026Latest
Aug 4, 2026
-$0.41+94.2%
vs -$7.10
—
vs $2M
Q2 2026
May 12, 2026
-$0.76+95.6%
vs -$17.20
—
vs —
Q2 2026
Mar 30, 2026
-$0.19+50.0%
vs -$0.38
$100,000+0.0%
vs $100,000
Q2 2026
Mar 25, 2026
-$0.38+0.0%
vs -$0.38
$100,000+0.0%
vs $100,000
Historical baseline: 12 quarters analyzedGAAP / Adjusted
MARKET COVERAGE

Latest News

1 Stories
GlobeNewsWire·Sep 8, 2026
Korsana Biosciences Completes Closing of Merger with Cyclerion Therapeutics and Previously Announced Private Placement of $380 Million

Advancing lead program KRSA-028 toward the clinic, with Phase 1 healthy volunteer data expected mid-2027 and interim proof-of-concept data in Alzheimer's patients anticipated by year-end 2027 or first quarter of 2028

Filtered for Cyclerion Therapeutics, Inc.More Headlines
04

Compare before deciding

Benchmark CYCN against direct peers instead of judging its metrics in isolation.

Peers Comparison

Key metrics vs top competitors for Cyclerion Therapeutics, Inc. (CYCN)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
CYCN logoCYCNCyclerion Therapeutics, Inc.Current
$23.52$15.73M-3.083.7%-170.11%-39.34%—
ADMA logoADMAADMA Biologics, Inc.
$9.70$2.25B16.1719.63%32.98%39.59%—
IMVT logoIMVTImmunovant, Inc.
$34.54$7.13B-12.47—-7585.86%-69.59%—
KALA logoKALAKALA BIO, Inc.
$0.56$10.83M-0.17——-187.45%—
PRTA logoPRTAProthena Corporation plc
$8.68$454.43M-1.92-92.84%-80.67%-14.98%—
MNKD logoMNKDMannKind Corporation
$3.34$1.07B167.0022.23%-11.08%——

Compare CYCN vs Peers

Cyclerion Therapeutics, Inc. (CYCN) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs ADMA

Most directly comparable listed peer for CYCN.

Scale Benchmark

vs ABBV

Larger-name benchmark to compare CYCN against a more recognizable public peer.

Peer Set

Compare Top 5

vs ADMA, IMVT, KALA, PRTA

05

Keep researching

Verify the primary filings, follow material updates, and answer the remaining questions.

CYCN SEC Filings & Documents

Cyclerion Therapeutics, Inc. (CYCN) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Apr 1, 2026·SEC

Material company update

Feb 17, 2026·SEC

Material company update

Jan 6, 2026·SEC

10-K Annual Reports

3
FY 2025

Mar 4, 2025·SEC

FY 2024

Mar 5, 2024·SEC

FY 2023

Mar 22, 2023·SEC

10-Q Quarterly Reports

6
FY 2026

Aug 4, 2026·SEC

FY 2026

May 12, 2026·SEC

FY 2025

Nov 12, 2025·SEC

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CYCN Frequently Asked Questions

Cyclerion Therapeutics, Inc. (CYCN) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
What is Cyclerion Therapeutics, Inc.'s revenue?

Cyclerion Therapeutics, Inc. (CYCN) reported $1.9M in revenue for fiscal year 2025.

How fast is Cyclerion Therapeutics, Inc. growing?

Cyclerion Therapeutics, Inc. (CYCN) grew revenue by 3.7% over the past year. Growth has been modest.

Is CYCN profitable?

Cyclerion Therapeutics, Inc. (CYCN) reported a net loss of $6.7M for fiscal year 2025.

Dividend & Returns
What is CYCN's return on equity?

Cyclerion Therapeutics, Inc. (CYCN) has a return on equity (ROE) of -39.3%. Negative ROE indicates the company is unprofitable.

What is Cyclerion Therapeutics, Inc.'s free cash flow?

Cyclerion Therapeutics, Inc. (CYCN) had negative free cash flow of $4.5M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in CYCN back in 2017?

Total return calculator · dividends reinvested · 9+ years of data

See returns →