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PRMEPrime Medicine, Inc.
$3.54$639M
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PRME logo

Prime Medicine, Inc.

PRME
NASDAQ · Biotechnology
$3.54
At close - Sep 22, 4:00 PM EDT - USD
Market Cap$639M
P/E-2.6x
52W High$6.94
Volume2.71M
OverviewTerminalAnalysisFinancialsValuationEarningsBreakoutsOwnership
VCP Research Verdict2026Q2

Pre-Revenue Gene Editing Platform Faces Severe Liquidity Crisis

Prime Medicine is a pre-commercial gene editing company whose investment thesis is entirely dependent on the clinical and commercial success of its pipeline, as its financials show no sustainable revenue generation. The company's quarterly cash burn consistent...

GrowthMixed
ProfitabilityWeak
ValuationReview
TechnicalsNeutral
Explore valuation models
MARKET ACTION

PRME price & volume

Price trend, volume and key moving averages

Launch Terminal
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Decision Checklist4 Core Signals

What matters now

The signals most likely to change the investment case.

01

Earnings momentum

4/12 Beats

EPS beat 4 of last 12 quarters

02

Valuation risk

-103% Peers

P/E is 103% below peer median

03

Market leadership

RS 40 · Lag

Laggard (Underperforming 60% of market)

04

Trend Check

N/A

Trend data unavailable

Next CatalystConfirmed earnings · Nov 6

Market performance

Price History →

Trailing total returns as of 9/23/2026, which may include dividends or other distributions. Benchmark is S&P 500 (^GSPC).

YTD Return
PRME+0.28%
S&P 500 (^GSPC)+13.20%
1-Year Return
PRME-29.06%
S&P 500 (^GSPC)+15.98%
3-Year Return
PRME-68.05%
S&P 500 (^GSPC)+91.49%
5-Year Return
PRME-76.97%
S&P 500 (^GSPC)+89.07%

Growth & profitability

Annual revenue & EPS trend
Revenue
$5M+55.3% YoY
Net income
-$201M-2.7% YoY
Free cash flow
-$167M-28.4% YoY
Operating margin
-4498.1%+2289.3 pts YoY
ROIC (TTM)-168.3%
Avg ROIC 5Y-
ROE (TTM)-146.8%
Piotroski Score3 / 9
Financial Statements →
03

Monitor what changed

Recent results and news deserve attention only when they alter the forward view.

OPERATING RESULTS

Recent Earnings

Earnings History
EPS Beat Rate4/12 (33%)
Revenue Beat Rate1/12 (10%)
QuarterEPS (Act vs Est)Revenue (Act vs Est)
Q3 2026Latest
Aug 6, 2026
-$0.24+6.7%
vs -$0.26
$1M-48.7%
vs $2M
Q2 2026
May 7, 2026
-$0.28-16.7%
vs -$0.24
$856,000-63.2%
vs $2M
Q2 2026
Mar 3, 2026
-$0.22+12.0%
vs -$0.25
$842,000-34.6%
vs $1M
Q4 2025
Nov 7, 2025
-$0.32-14.3%
vs -$0.28
$1M-40.3%
vs $2M
Historical baseline: 12 quarters analyzedGAAP / Adjusted
MARKET COVERAGE

Latest News

5 Stories
GlobeNewsWire·Sep 10, 2026
Prime Drink Group Provides Bi-Weekly MCTO Status Report

MONTREAL, Sept. 10, 2026 (GLOBE NEWSWIRE) -- Prime Drink Group Corp. (CSE: PRME) (“Prime” or the “Company”) announces that further to its news releases dated July 30, August 14 and August 27, 2026, the Company voluntarily applied for and the Company's principal regulator, the British Columbia Securities Commission (the “BCSC”) granted a management cease trade order (the “MCTO”) dated July 30, 2026, under National Policy 12-203 Management Cease Trade Orders (“NP 12-203”) and provided the Company with an extension to file its annual financial statements for the year ended March 31, 2026, including the related management's discussion and analysis, and Chief Executive Officer and Chief Financial certifications on or before July 29, 2026 (collectively the “Annual Financial Filings”). The deadline has been extended to on or before September 28, 2026.

GlobeNewsWire·Sep 3, 2026
Prime Medicine to Participate in Upcoming Investor Conferences

CAMBRIDGE, Mass., Sept. 03, 2026 (GLOBE NEWSWIRE) -- Prime Medicine, Inc. (Nasdaq: PRME), a biotechnology company committed to delivering a new class of differentiated one-time curative genetic therapies, today announced that company management will participate in three upcoming conferences: Wells Fargo 21st Annual Healthcare Conference: Company management will host 1x1 meetings on Thursday, September 10, 2026, in Boston, MA.

Defense World·Sep 2, 2026
BlackRock Inc. Acquires Shares of 9,602,041 Prime Medicine, Inc. $PRME

BlackRock Inc. acquired a new stake in shares of Prime Medicine, Inc. (NASDAQ: PRME) in the undefined quarter, according to its most recent disclosure with the Securities and Exchange Commission (SEC). The institutional investor acquired 9,602,041 shares of the company's stock, valued at approximately $35,432,000. BlackRock Inc. owned about 5.32% of Prime Medicine

Seeking Alpha·Aug 15, 2026
Prime Medicine: Soon In The Clinic

Prime Medicine trades at a $548M valuation, significantly undervaluing its broad, potentially best-in-class gene-editing pipeline. PRME's therapies target five indications across liver, lung, and immunology/oncology, with leading preclinical efficacy and multi-billion-dollar addressable markets. Recent IND/CTA clearances, RMAT designation, and patent wins highlight PRME's clinical and strategic momentum despite a 54% stock decline from 52-week highs.

Filtered for Prime Medicine, Inc.More Headlines
04

Compare before deciding

Benchmark PRME against direct peers instead of judging its metrics in isolation.

Peers Comparison

Key metrics vs top competitors for Prime Medicine, Inc. (PRME)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
PRME logoPRMEPrime Medicine, Inc.Current
$3.54$639.39M-2.6255.28%-4342.44%-146.81%—
BEAM logoBEAMBeam Therapeutics Inc.
$25.93$2.67B-32.01120.01%-54.75%-7.7%—
CRSP logoCRSPCRISPR Therapeutics AG
$59.03$5.69B-9.12-89.97%-3368.72%-24.39%—
EDIT logoEDITEditas Medicine, Inc.
$2.92$448.11M-1.6225.39%-157.32%-196.63%—
NTLA logoNTLAIntellia Therapeutics, Inc.
$12.69$1.42B-3.3316.92%-672.16%-57.79%—
KRRO logoKRROKorro Bio, Inc.
$10.34$102.92M-0.83181.46%-4477.08%-114.26%—

Compare PRME vs Peers

Prime Medicine, Inc. (PRME) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs BEAM

Most directly comparable listed peer for PRME.

Scale Benchmark

vs MRNA

Larger-name benchmark to compare PRME against a more recognizable public peer.

Peer Set

Compare Top 5

vs BEAM, CRSP, EDIT, NTLA

05

Keep researching

Verify the primary filings, follow material updates, and answer the remaining questions.

PRME SEC Filings & Documents

Prime Medicine, Inc. (PRME) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Aug 6, 2026·SEC

Material company update

Jul 8, 2026·SEC

Material company update

Jun 8, 2026·SEC

10-K Annual Reports

1
FY 2026

Mar 3, 2026·SEC

10-Q Quarterly Reports

2
FY 2026

Aug 6, 2026·SEC

FY 2026

May 7, 2026·SEC

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PRME Frequently Asked Questions

Prime Medicine, Inc. (PRME) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
What is Prime Medicine, Inc.'s revenue?

Prime Medicine, Inc. (PRME) reported $4.1M in revenue for fiscal year 2025.

How fast is Prime Medicine, Inc. growing?

Prime Medicine, Inc. (PRME) grew revenue by 55.3% over the past year. This is strong growth.

Is PRME profitable?

Prime Medicine, Inc. (PRME) reported a net loss of $187.9M for fiscal year 2025.

Dividend & Returns
What is PRME's return on equity?

Prime Medicine, Inc. (PRME) has a return on equity (ROE) of -146.8%. Negative ROE indicates the company is unprofitable.

What is Prime Medicine, Inc.'s free cash flow?

Prime Medicine, Inc. (PRME) had negative free cash flow of $156.8M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in PRME back in 2019?

Total return calculator · dividends reinvested · 7+ years of data

See returns →