Prime Medicine, Inc. (PRME) Stock Price History
Historical prices from 2022 to 2026
- 1M
- +14.9%
- 3M
- -8.5%
- YTD
- -8.5%
- 1Y
- +79.4%
- 3Y
- -40.3%
- 5Y
- -26.8%
Loading 10-year price history...
PRME Historical Performance
PRME Annual Returns
Year-by-year price performance · 2022–2026
- 2022 annual price return
- +20.9%
- 2023 annual price return
- -49.5%
- 2024 annual price return
- -66.7%
- 2025 annual price return
- +16.1%
- 2026 annual price return
- +30.9%
PRME Stock Price Trajectory (2022–2026)
As of June 22, 2026, Prime Medicine, Inc. (PRME) trades at $3.23, representing a +79.4% return over the past year. The stock has delivered a -79.0% total return over five years (-26.8% CAGR), reflecting challenging market conditions.
The stock reached its all-time high of $21.73 on November 14, 2022. From this peak, PRME has corrected -85.1%, currently trading 18% below its 200-day moving average, suggesting potential weakness.
When compared to Healthcare sector peers BEAM (+100.9% 1Y), CRSP (+21.7% 1Y), and EDIT (+14.5% 1Y), PRME has underperformed the peer group average. Compare PRME vs BEAM →
PRME Historical Price Data · from 2022
Rows 1–50 of 919| Date | Open | High | Low | Close | Volume | Change % |
|---|---|---|---|---|---|---|
| 2026-06-18 | 3.27 | 3.37 | 3.10 | 3.23 | 3.19M | +2.22% |
| 2026-06-17 | 2.91 | 3.27 | 2.87 | 3.16 | 4.18M | +10.10% |
| 2026-06-16 | 2.90 | 2.98 | 2.81 | 2.87 | 2.14M | -1.03% |
| 2026-06-15 | 2.90 | 3.06 | 2.84 | 2.90 | 2.70M | +4.50% |
| 2026-06-12 | 2.82 | 2.86 | 2.76 | 2.77 | 1.70M | -1.60% |
| 2026-06-11 | 2.71 | 2.87 | 2.67 | 2.82 | 2.48M | +4.06% |
| 2026-06-10 | 2.86 | 2.96 | 2.71 | 2.71 | 2.50M | -5.90% |
| 2026-06-09 | 2.99 | 3.05 | 2.79 | 2.88 | 2.32M | -2.70% |
| 2026-06-08 | 3.13 | 3.15 | 2.92 | 2.96 | 2.46M | -3.27% |
| 2026-06-05 | 3.42 | 3.44 | 2.94 | 3.06 | 4.46M | -11.82% |
| 2026-06-04 | 3.17 | 3.61 | 3.17 | 3.47 | 3.83M | +10.51% |
| 2026-06-03 | 3.27 | 3.27 | 3.08 | 3.14 | 3.36M | -2.18% |
| 2026-06-02 | 3.37 | 3.37 | 3.06 | 3.21 | 3.30M | -5.59% |
| 2026-06-01 | 3.54 | 3.54 | 3.28 | 3.40 | 2.47M | -4.23% |
| 2026-05-29 | 3.38 | 3.56 | 3.26 | 3.55 | 3.26M | +4.41% |
| 2026-05-28 | 3.23 | 3.43 | 3.12 | 3.40 | 2.22M | +3.03% |
| 2026-05-27 | 2.98 | 3.45 | 2.98 | 3.30 | 4.61M | +11.11% |
| 2026-05-26 | 3.01 | 3.05 | 2.89 | 2.97 | 2.32M | 0.00% |
| 2026-05-22 | 2.95 | 3.10 | 2.95 | 2.97 | 2.21M | +0.68% |
| 2026-05-21 | 2.81 | 2.97 | 2.75 | 2.95 | 1.98M | +4.24% |
| 2026-05-20 | 2.70 | 2.87 | 2.70 | 2.83 | 2.15M | +4.81% |
| 2026-05-19 | 2.78 | 2.81 | 2.68 | 2.70 | 2.17M | -3.91% |
| 2026-05-18 | 2.94 | 2.98 | 2.75 | 2.81 | 3.62M | -4.10% |
| 2026-05-15 | 3.08 | 3.09 | 2.93 | 2.93 | 3.09M | -6.39% |
| 2026-05-14 | 3.30 | 3.34 | 3.11 | 3.13 | 2.21M | -4.28% |
| 2026-05-13 | 3.26 | 3.35 | 3.23 | 3.27 | 2.31M | -1.06% |
| 2026-05-12 | 3.25 | 3.35 | 3.19 | 3.31 | 3.05M | +2.01% |
| 2026-05-11 | 3.28 | 3.60 | 3.19 | 3.24 | 3.19M | +0.93% |
| 2026-05-08 | 3.21 | 3.40 | 3.08 | 3.21 | 2.44M | +3.05% |
| 2026-05-07 | 3.41 | 3.55 | 3.06 | 3.12 | 3.94M | -8.65% |
| 2026-05-06 | 3.46 | 3.48 | 3.28 | 3.41 | 2.69M | +0.59% |
| 2026-05-05 | 3.49 | 3.55 | 3.28 | 3.39 | 2.65M | -2.02% |
| 2026-05-04 | 3.40 | 3.58 | 3.37 | 3.46 | 1.10M | +1.47% |
| 2026-05-01 | 3.52 | 3.53 | 3.35 | 3.41 | 1.78M | -3.81% |
| 2026-04-30 | 3.54 | 3.69 | 3.50 | 3.54 | 1.55M | +0.42% |
| 2026-04-29 | 3.63 | 3.69 | 3.51 | 3.53 | 1.41M | -4.34% |
| 2026-04-28 | 3.64 | 3.79 | 3.62 | 3.69 | 1.57M | +0.54% |
| 2026-04-27 | 3.73 | 3.98 | 3.64 | 3.67 | 1.48M | -0.81% |
| 2026-04-24 | 3.82 | 3.85 | 3.66 | 3.70 | 1.45M | -3.65% |
| 2026-04-23 | 3.97 | 4.03 | 3.78 | 3.84 | 1.84M | -3.03% |
| 2026-04-22 | 3.82 | 3.97 | 3.81 | 3.96 | 1.76M | +3.94% |
| 2026-04-21 | 3.89 | 3.96 | 3.75 | 3.81 | 2.11M | -2.06% |
| 2026-04-20 | 3.77 | 3.92 | 3.69 | 3.89 | 1.04M | +2.10% |
| 2026-04-17 | 3.78 | 3.91 | 3.76 | 3.81 | 1.88M | +3.81% |
| 2026-04-16 | 3.79 | 3.79 | 3.61 | 3.67 | 1.51M | -3.17% |
| 2026-04-15 | 3.76 | 3.84 | 3.65 | 3.79 | 2.17M | +2.43% |
| 2026-04-14 | 3.76 | 3.87 | 3.65 | 3.70 | 2.44M | +1.09% |
| 2026-04-13 | 3.38 | 3.73 | 3.36 | 3.66 | 1.80M | +6.71% |
| 2026-04-10 | 3.50 | 3.54 | 3.27 | 3.43 | 1.68M | -2.28% |
| 2026-04-09 | 3.50 | 3.55 | 3.45 | 3.51 | 1.27M | -0.85% |
Intrinsic Valuation
DCF models, multiple analysis, and analyst estimates.
Historical Returns
10-year return with dividends reinvested.
DCA Calculator
See how regular investing compounds over time.
Peer Comparison
Compare growth, multiples, and margins vs sector.
PRME — Frequently Asked Questions
Quick answers to the most common questions about buying PRME stock.
How has PRME stock performed recently?
PRME returned +79.4% over the past year, beating its 5-year annualized CAGR of -26.8%. The stock trades below its 200-day moving average, confirming the uptrend.
What is PRME's all-time high price?
Prime Medicine, Inc. reached $21.73 on 2022-11-14. The 52-week high is $6.94. Current 1-year return of +79.4% places the stock closer to historical peaks.
Where can I download PRME historical price data?
This page provides PRME daily OHLCV data with 50-day MA, 200-day MA, and RSI indicators. Data spans 2022-2026, downloadable in CSV format.