Prime Medicine, Inc. (PRME) Stock Price History
Historical prices from 2022 to 2026
- 1M
- +32.9%
- 3M
- +57.6%
- YTD
- +31.7%
- 1Y
- +11.2%
- 3Y
- -15.7%
- 5Y
- -21.3%
Loading 10-year price history...
PRME Historical Performance
PRME Annual Returns
Year-by-year price performance · 2022–2026
- 2022 annual price return
- +20.9%
- 2023 annual price return
- -49.5%
- 2024 annual price return
- -66.7%
- 2025 annual price return
- +16.1%
- 2026 annual price return
- +13.0%
PRME Stock Price Trajectory (2022–2026)
As of November 8, 2026, Prime Medicine, Inc. (PRME) trades at $4.65, representing a +11.2% return over the past year. The stock has delivered a -69.7% total return over five years (-21.3% CAGR), reflecting challenging market conditions.
The stock reached its all-time high of $21.73 on November 14, 2022. From this peak, PRME has corrected -78.6%, currently trading 33% above its 200-day moving average, indicating continued institutional support.
When compared to Healthcare sector peers BEAM (+14.1% 1Y), CRSP (-11.6% 1Y), and EDIT (-4.5% 1Y), PRME has underperformed the peer group average. Compare PRME vs BEAM →
PRME Historical Price Data · from 2022
Rows 1–50 of 1,016| Date | Open | High | Low | Close | Volume | Change % |
|---|---|---|---|---|---|---|
| 2026-11-06 | 4.53 | 4.70 | 4.46 | 4.65 | 3.06M | +4.49% |
| 2026-11-05 | 4.86 | 4.91 | 4.30 | 4.45 | 4.75M | -10.46% |
| 2026-11-04 | 4.75 | 5.12 | 4.59 | 4.97 | 4.40M | +9.23% |
| 2026-11-03 | 4.50 | 4.89 | 4.43 | 4.55 | 4.12M | +2.48% |
| 2026-11-02 | 4.86 | 4.86 | 4.36 | 4.44 | 4.12M | -5.93% |
| 2026-10-30 | 5.02 | 5.20 | 4.68 | 4.72 | 6.57M | -9.92% |
| 2026-10-29 | 5.29 | 5.91 | 5.19 | 5.24 | 10.35M | -2.24% |
| 2026-10-28 | 4.24 | 5.43 | 4.11 | 5.36 | 15.20M | +23.22% |
| 2026-10-27 | 3.62 | 4.41 | 3.57 | 4.35 | 8.82M | +20.50% |
| 2026-10-26 | 3.68 | 3.70 | 3.57 | 3.61 | 2.51M | -1.63% |
| 2026-10-23 | 3.70 | 3.70 | 3.38 | 3.67 | 4.56M | -1.61% |
| 2026-10-22 | 3.68 | 3.92 | 3.62 | 3.73 | 4.66M | -2.10% |
| 2026-10-21 | 3.92 | 4.01 | 3.80 | 3.81 | 2.44M | -2.81% |
| 2026-10-20 | 3.75 | 4.05 | 3.73 | 3.92 | 3.69M | +2.35% |
| 2026-10-19 | 3.56 | 3.87 | 3.49 | 3.83 | 4.25M | +10.37% |
| 2026-10-16 | 3.55 | 3.61 | 3.41 | 3.47 | 4.39M | -3.88% |
| 2026-10-15 | 3.12 | 3.65 | 3.06 | 3.61 | 6.30M | +15.34% |
| 2026-10-14 | 3.21 | 3.22 | 3.05 | 3.13 | 4.24M | -5.72% |
| 2026-10-13 | 3.61 | 3.61 | 3.27 | 3.32 | 4.06M | -8.03% |
| 2026-10-12 | 3.95 | 3.97 | 3.58 | 3.61 | 3.14M | -9.52% |
| 2026-10-09 | 3.57 | 4.14 | 3.54 | 3.99 | 8.07M | +11.45% |
| 2026-10-08 | 3.83 | 3.90 | 3.52 | 3.58 | 7.73M | -8.21% |
| 2026-10-07 | 3.36 | 4.02 | 3.30 | 3.90 | 11.20M | +11.43% |
| 2026-10-06 | 3.56 | 3.72 | 3.26 | 3.50 | 12.02M | +9.03% |
| 2026-10-05 | 3.00 | 3.26 | 2.88 | 3.21 | 4.72M | +7.72% |
| 2026-10-02 | 3.05 | 3.08 | 2.92 | 2.98 | 2.11M | -0.33% |
| 2026-10-01 | 3.05 | 3.11 | 2.98 | 2.99 | 2.83M | -2.29% |
| 2026-09-30 | 3.11 | 3.19 | 3.02 | 3.06 | 3.13M | -0.97% |
| 2026-09-29 | 2.93 | 3.14 | 2.88 | 3.09 | 3.61M | +7.29% |
| 2026-09-28 | 2.85 | 2.92 | 2.77 | 2.88 | 3.68M | -0.69% |
| 2026-09-25 | 3.42 | 3.44 | 2.88 | 2.90 | 7.12M | -5.54% |
| 2026-09-24 | 3.11 | 3.13 | 2.99 | 3.07 | 4.49M | -1.92% |
| 2026-09-23 | 3.53 | 3.53 | 3.12 | 3.13 | 3.33M | -11.58% |
| 2026-09-22 | 3.22 | 3.57 | 3.20 | 3.54 | 2.73M | +10.97% |
| 2026-09-21 | 3.19 | 3.27 | 3.10 | 3.19 | 2.95M | +2.24% |
| 2026-09-18 | 3.13 | 3.17 | 3.05 | 3.12 | 4.67M | -0.64% |
| 2026-09-17 | 3.11 | 3.39 | 3.10 | 3.14 | 3.25M | +4.67% |
| 2026-09-16 | 3.18 | 3.22 | 2.93 | 3.00 | 3.29M | -4.46% |
| 2026-09-15 | 3.18 | 3.22 | 3.00 | 3.14 | 2.57M | -1.26% |
| 2026-09-14 | 3.10 | 3.28 | 3.10 | 3.18 | 1.62M | +1.60% |
| 2026-09-11 | 3.38 | 3.44 | 3.10 | 3.13 | 3.08M | -6.57% |
| 2026-09-10 | 3.37 | 3.42 | 3.31 | 3.35 | 2.39M | -3.46% |
| 2026-09-09 | 3.47 | 3.54 | 3.29 | 3.47 | 4.23M | -2.53% |
| 2026-09-08 | 3.65 | 3.65 | 3.41 | 3.56 | 3.60M | -3.78% |
| 2026-09-04 | 3.83 | 3.86 | 3.65 | 3.70 | 1.62M | -0.27% |
| 2026-09-03 | 3.70 | 3.72 | 3.49 | 3.71 | 2.31M | +1.09% |
| 2026-09-02 | 3.50 | 3.71 | 3.47 | 3.67 | 2.47M | +2.80% |
| 2026-09-01 | 3.54 | 3.71 | 3.48 | 3.57 | 2.46M | -0.56% |
| 2026-08-31 | 3.54 | 3.64 | 3.46 | 3.59 | 2.09M | -0.55% |
| 2026-08-28 | 3.57 | 3.70 | 3.48 | 3.61 | 2.69M | -0.82% |
PRME Chart Terminal
Live VCP patterns, Cup & Handle overlays, support/resistance, and AI trade plans.
Live Breakouts Feed
High-probability breakout stocks crossing their pivot across 5 pattern engines.
Intrinsic Valuation
DCF models, multiple analysis, and analyst estimates.
Historical Returns
10-year return with dividends reinvested.
Peer Comparison
Compare growth, multiples, and margins vs sector.
PRME — Frequently Asked Questions
Quick answers to the most common questions about buying PRME stock.
How has PRME stock performed recently?
PRME returned +11.2% over the past year, beating its 5-year annualized CAGR of -21.3%. The stock trades above its 200-day moving average, confirming the uptrend.
What is PRME's all-time high price?
Prime Medicine, Inc. reached $21.73 on 2022-11-14. The 52-week high is $5.91. Current 1-year return of +11.2% places the stock closer to historical peaks.
Where can I download PRME historical price data?
This page provides PRME daily OHLCV data with 50-day MA, 200-day MA, and RSI indicators. Data spans 2022-2026, downloadable in CSV format.