Prime Medicine, Inc. (PRME) Stock Price History
Historical prices from 2022 to 2026
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Historical Performance
Short-Term Returns
PRME Stock Price Trajectory (2022–2026)
As of February 28, 2026, Prime Medicine, Inc. (PRME) trades at $4.62, representing a +83.3% return over the past year. The stock has delivered a -21.4% return over five years, reflecting challenging market conditions.
The stock reached its all-time high of $21.73 on November 14, 2022. From this peak, PRME has corrected -78.7%, currently trading 23% above its 200-day moving average, indicating continued institutional support.
When compared to Healthcare sector peers ALNY (+34.9% 1Y), IONS (+144.5% 1Y), and ARWR (+234.6% 1Y), PRME has underperformed the peer group average. Compare PRME vs ALNY →
Historical Price Data
Showing 30 of 842 records| Date | Open | High | Low | Close | Volume | Change % |
|---|---|---|---|---|---|---|
| 2026-02-27 | 4.22 | 4.63 | 4.22 | 4.62 | 4 | +5.48% |
| 2026-02-26 | 4.12 | 4.47 | 4.10 | 4.38 | 4 | +6.05% |
| 2026-02-25 | 3.88 | 4.15 | 3.85 | 4.13 | 4 | +7.83% |
| 2026-02-24 | 3.35 | 3.86 | 3.35 | 3.83 | 3 | +14.67% |
| 2026-02-23 | 3.29 | 3.39 | 3.17 | 3.34 | 3 | +2.14% |
| 2026-02-20 | 3.28 | 3.37 | 3.20 | 3.27 | 3 | -1.80% |
| 2026-02-19 | 3.25 | 3.35 | 3.18 | 3.33 | 1.40M | +1.22% |
| 2026-02-18 | 3.28 | 3.39 | 3.22 | 3.29 | 1.09M | +1.55% |
| 2026-02-17 | 3.27 | 3.29 | 3.20 | 3.24 | 159K | -1.82% |
| 2026-02-13 | 3.35 | 3.47 | 3.28 | 3.30 | 1.44M | -0.60% |
| 2026-02-12 | 3.45 | 3.50 | 3.20 | 3.32 | 2.49M | -3.77% |
| 2026-02-11 | 3.42 | 3.46 | 3.28 | 3.45 | 1.48M | +0.88% |
| 2026-02-10 | 3.57 | 3.65 | 3.40 | 3.42 | 1.49M | -4.74% |
| 2026-02-09 | 3.58 | 3.62 | 3.40 | 3.59 | 1.89M | +0.56% |
| 2026-02-06 | 3.36 | 3.59 | 3.30 | 3.57 | 3.63M | +10.19% |
| 2026-02-05 | 3.42 | 3.45 | 3.21 | 3.24 | 4.52M | -6.76% |
| 2026-02-04 | 3.81 | 3.84 | 3.42 | 3.48 | 3.29M | -8.79% |
| 2026-02-03 | 3.86 | 4.03 | 3.55 | 3.81 | 2.78M | +0.26% |
| 2026-02-02 | 3.75 | 4.04 | 3.75 | 3.80 | 2.79M | -0.26% |
| 2026-01-30 | 4.04 | 4.21 | 3.75 | 3.81 | 3.74M | -8.19% |
| 2026-01-29 | 4.00 | 4.18 | 3.99 | 4.15 | 2.84M | +2.98% |
| 2026-01-28 | 4.35 | 4.40 | 4.01 | 4.03 | 2.13M | -5.84% |
| 2026-01-27 | 4.31 | 4.56 | 4.22 | 4.28 | 2.18M | +2.39% |
| 2026-01-26 | 4.40 | 4.41 | 4.08 | 4.18 | 2.15M | -5.64% |
| 2026-01-24 | 4.66 | 4.66 | 4.34 | 4.43 | 2.25M | 0.00% |
| 2026-01-23 | 4.66 | 4.66 | 4.34 | 4.43 | 2.25M | -5.24% |
| 2026-01-22 | 4.01 | 4.70 | 3.99 | 4.67 | 5.01M | +16.58% |
| 2026-01-21 | 4.00 | 4.07 | 3.82 | 4.01 | 2.94M | +3.08% |
| 2026-01-20 | 3.77 | 4.00 | 3.73 | 3.89 | 2.57M | -2.26% |
| 2026-01-16 | 3.98 | 4.16 | 3.79 | 3.98 | 3.69M | -0.25% |
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How has PRME stock performed recently?
PRME returned +83.3% over the past year, beating its 5-year annualized CAGR of -21.4%. The stock trades above its 200-day moving average, confirming the uptrend.
What is PRME's all-time high price?
Prime Medicine, Inc. reached $21.73 on 2022-11-14. The 52-week high is $6.94. Current 1-year return of +83.3% places the stock closer to historical peaks.
Where can I download PRME historical price data?
This page provides PRME daily OHLCV data with 50-day MA, 200-day MA, and RSI indicators. Data spans 2022-2026, downloadable in CSV format.