Prime Medicine, Inc. (PRME) Earnings History
Net Loss7 years of earnings data (2019–2025) · Currently unprofitable on a TTM basis
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Prime Medicine, Inc. (PRME) Earnings Overview
As of June 22, 2026, Prime Medicine, Inc. (PRME) reported trailing twelve-month net income of -$198M, reflecting +18.3% year-over-year growth. The company earned $-1.12 per diluted share over the past four quarters, with a net profit margin of -4342.4%.
Looking at the long-term picture, PRME's historical earnings data spans multiple years. The company achieved its highest annual net income of -$3M in fiscal 2019.
Prime Medicine, Inc. is currently reporting a net loss, though operating performance should be evaluated in the context of growth investments and industry dynamics View revenue history →
Compared to peers including BEAM (-$65M net income, -57.2% margin), CRSP (-$569M net income, -16569.8% margin), EDIT (-$109M net income, -395.0% margin), PRME has room to improve margins relative to the peer group. Compare PRME vs BEAM →
PRME Earnings vs Peers
Earnings metrics vs comparable public companies
PRME Historical Earnings Data (2019–2025)
7 years| Fiscal Year | Net Income | YoY % | Operating Income | EPS (Diluted) | Net Margin | Op. Margin |
|---|---|---|---|---|---|---|
| 2025 | -$201M | -2.7% | -$208M | $-1.35 | -4342.4% | -4498.1% |
| 2024 | -$196M | +1.1% | -$202M | $-1.65 | -6566.6% | -6787.4% |
| 2023 | -$198M | -62.6% | -$205M | $-2.18 | - | - |
| 2022 | -$122M | +26.3% | -$117M | $-1.46 | - | - |
| 2021 | -$165M | -4749.5% | -$84M | $-1.92 | - | - |
| 2020 | -$3M | -34.8% | $-932,000 | $-0.05 | -65.5% | -17.9% |
| 2019 | -$3M | - | -$2M | $-0.03 | - | - |
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Intrinsic Valuation
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PRME — Frequently Asked Questions
Quick answers to the most common questions about buying PRME stock.
What is PRME earnings per share (EPS)?
PRME trailing twelve-month (TTM) diluted EPS is $-1.12, reflecting +18.3% year-over-year growth. The 5-year EPS CAGR is N/A. Complete EPS history from 2019 to 2025 is available in the table on this page.
What is Prime Medicine, Inc.'s net income?
Prime Medicine, Inc. (PRME) trailing twelve-month net income is $-198M as of 2025. Earnings grew +18.3% year-over-year.
Is PRME profitable?
PRME is not currently profitable on a TTM basis, reporting a net loss of $-198M. Net margin is -4342.4%. Investors should monitor for a return to profitability.
What is PRME's earnings growth rate?
PRME compound annual EPS growth rates (CAGR): 1-Year: N/A, 3-Year: N/A, 5-Year: N/A, 10-Year: N/A. These figures measure the annualised rate of diluted EPS growth over each period, based on data from 2019 to 2025.
What are PRME's profit margins?
Prime Medicine, Inc. net profit margin is -4342.4%, operating margin is -4498.1%, and gross margin is -58.1%. Below-average margins reflect competitive or cost pressures. Return on Equity is -146.8%.
Is PRME growing earnings?
Yes, PRME earnings are accelerating — EPS growth of +18.3% exceeds the 5-year CAGR of N/A. TTM net income reached $-198M. Earnings momentum is strengthening.
What was PRME's best earnings year?
Prime Medicine, Inc.'s highest annual net income on record is $-3M, achieved in fiscal year 2019. Earnings history on this page spans 2019 to 2025 and includes all annual and quarterly figures.
What were PRME's earnings last quarter?
PRME's most recent reported quarter was Q1 2026. Net income was $-49M with diluted EPS of $-0.28. For a full breakdown of all quarters, see the quarterly earnings table on this page.