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XENEXenon Pharmaceuticals Inc.
$52.91$4.2B
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XENE logoXenon Pharmaceuticals Inc.(XENE)Earnings, Financials & Key Ratios

XENE•NASDAQ
Price updated Jun 19, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryNeuroscience and Psychiatry Therapies
AboutXenon Pharmaceuticals Inc., a clinical-stage biopharmaceutical company, engages in developing therapeutics to treat patients with neurological disorders in Canada. Its clinical development pipeline includes XEN496, A Kv7 potassium channel opener that is Phase III clinical trials for the treatment of KCNQ2 developmental and epilepsy encephalopathy; and XEN1101, A Kv7 potassium channel opener, which is in Phase II clinical trial for the treatment of epilepsy and other neurological disorders. The company's product candidates also comprise NBI-921352, a selective Nav1.6 sodium channel inhibitor that is in Phase II clinical trials for the treatment of SCN8A developmental and epileptic encephalopathy, and other potential indications, including adult focal epilepsy; and XEN007, A central nervous system-acting calcium channel modulator, which is in Phase II clinical trials. It has a license and collaboration agreement with the Neurocrine Biosciences, Inc. to develop treatments for epilepsy; and with Flexion Therapeutics, Inc. to develop PCRX301 (XEN402, a Nav1.7 inhibitor) for the treatment of post-operative pain. Xenon Pharmaceuticals Inc. was incorporated in 1996 and is headquartered in Burnaby, Canada.Show more
  • Revenue$8M
  • EBITDA-$371M-33.9%
  • Net Income-$346M-47.6%
  • EPS (Diluted)-4.36-44.9%
  • Gross Margin66.09%
  • EBITDA Margin-4940.36%
  • Operating Margin-4974.27%
  • Net Margin-4612.13%
  • ROE-51.76%-85.8%

XENE Key Insights

Xenon Pharmaceuticals Inc. (XENE) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Company is almost debt free

✗Weaknesses

  • ✗Profits declining 64.4% over 5 years
  • ✗Negative free cash flow
  • ✗Sales declining 25.3% over 5 years
  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

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XENE Price & Volume

Xenon Pharmaceuticals Inc. (XENE) stock price & volume — 10-year historical chart

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XENE Growth Metrics

Xenon Pharmaceuticals Inc. (XENE) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-7.05%
5 Years-25.26%
3 Years-7.36%
TTM-100%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-52.38%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM-45.51%

Return on Capital

10 Years-35.34%
5 Years-28.79%
3 Years-34.11%
Last Year-43.83%

XENE Recent Earnings

Xenon Pharmaceuticals Inc. (XENE) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 7/12 qtrs (58%)●Beat Revenue 2/12 qtrs (100%)
Q2 2026Latest
May 7, 2026
Metric
Actual
Est
EPS
$1.17+0.0%
$1.17
Rev
—
$1M
Q1 2026
Feb 26, 2026
Metric
Actual
Est
EPS
$1.31-9.2%
$1.20
Rev
—
$178,571
Q4 2025
Nov 3, 2025
Metric
Actual
Est
EPS
$1.15+0.9%
$1.16
Rev
—
—
Q3 2025
Aug 11, 2025
Metric
Actual
Est
EPS
$1.07-3.9%
$1.03
Rev
—
—
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 7, 2026
$1.17vs $1.17+0.0%
—vs $1M
Q1 2026Feb 26, 2026
$1.31vs $1.20-9.2%
—vs $178,571
Q4 2025Nov 3, 2025
$1.15vs $1.16+0.9%
—
Q3 2025Aug 11, 2025
$1.07vs $1.03-3.9%
—
Based on last 12 quarters of dataView full earnings history →

XENE Peer Comparison

Xenon Pharmaceuticals Inc. (XENE) competitors in Neuroscience and Psychiatry Therapies — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
Institutional Holdings
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
PRAX logoPRAXPraxis Precision Medicines, Inc.Direct Competitor8.15B282.31-20.94-100%-43.02%0.00
ACAD logoACADACADIA Pharmaceuticals Inc.Direct Competitor3.7B21.629.4411.87%34.3%35.65%0.04
PTCT logoPTCTPTC Therapeutics, Inc.Direct Competitor6.55B78.9810.15114.51%-22.58%
ARVN logoARVNArvinas, Inc.Direct Competitor494.88M7.67-5.99-0.3%-247.54%-44.39%0.02
OVID logoOVIDOvid Therapeutics Inc.Product Competitor299.38M2.27-9.4611.81%-339.33%-22.51%0.10
LGND logoLGNDLigand Pharmaceuticals IncorporatedProduct Competitor5.51B274.8844.8460.4%55.95%16.19%0.44
NKTR logoNKTRNektar TherapeuticsProduct Competitor1.19B60.98-6.27-43.89%-284.18%-87%1.66
ABBV logoABBVAbbVie Inc.Supply Chain383.17B216.6391.418.57%6.91%62.15%

Compare XENE vs Peers

Xenon Pharmaceuticals Inc. (XENE) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs PRAX

Most directly comparable listed peer for XENE.

Scale Benchmark

vs JNJ

Larger-name benchmark to compare XENE against a more recognizable public peer.

Peer Set

Compare Top 5

vs PRAX, ACAD, PTCT, ARVN

XENE Income Statement

Xenon Pharmaceuticals Inc. (XENE) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Sales/Revenue
311K06.83M32.17M18.44M9.43M007.5M0
Revenue Growth %
-82.75%-100%-371.02%-42.68%-48.83%-100%---100%
Cost of Goods Sold
25.57M6M0000167.51M2.56M2.54M78.3M
COGS % of Revenue
8222.83%-------33.91%-
Gross Profit
-25.26M▲ 0%
-6M▲ 76.2%
6.83M▲ 213.8%
32.17M▲ 371.0%
18.44M▼ 42.7%
9.43M▼ 48.8%
-167.51M▼ 1875.6%
-2.56M▲ 98.5%
4.96M▲ 293.6%
-78.3M▲ 0%
Gross Margin %
-8122.83%-100%100%100%100%--66.09%-
Gross Profit Growth %
-3766.47%76.25%213.82%371.02%-42.68%-48.83%-1875.62%98.47%293.63%-
Operating Expenses
32.89M32.02M49.65M63.47M97.43M138.58M46.54M276.74M378.03M334.36M
OpEx % of Revenue
10574.28%-727.02%197.31%528.45%1468.91%--5040.36%-
Selling, General & Admin
7.31M8.38M10.8M12.94M21.97M32.81M46.54M68.9M79.63M84.41M
SG&A % of Revenue
2351.45%-158.19%40.24%119.15%347.78%--1061.76%-
Research & Development
25.57M23.63M38.84M50.52M75.46M105.77M167.51M210.39M300.94M328.25M
R&D % of Revenue
8222.83%-568.82%157.07%409.3%1121.13%--4012.51%-
Other Operating Expenses
000000-167.51M-2.56M-2.54M-2.24M
Operating Income
-32.58M▲ 0%
-38.02M▼ 16.7%
-42.82M▼ 12.6%
-31.3M▲ 26.9%
-78.99M▼ 152.4%
-129.14M▼ 63.5%
-214.05M▼ 65.7%
-279.3M▼ 30.5%
-373.07M▼ 33.6%
-412.66M▲ 0%
Operating Margin %
-10474.28%--627.02%-97.31%-428.45%-1368.91%---4974.27%-
Operating Income Growth %
-31.26%-16.7%-12.63%26.9%-152.37%-63.49%-65.75%-30.48%-33.57%-
EBITDA
-31.93M-37.43M-42.39M-30.66M-78.09M-127.74M-210.51M-276.74M-370.53M-410.19M
EBITDA Margin %
-10265.59%--620.74%-95.31%-423.53%-1354.02%---4940.36%-
EBITDA Growth %
-33.29%-17.24%-13.25%27.68%-154.71%-63.58%-64.8%-31.46%-33.89%-41.27%
D&A (Non-Cash Add-back)
649K586K429K644K906K1.41M3.54M2.56M2.54M2.47M
EBIT
-30.7M-33.13M-40.18M-28.61M-78.99M-129.14M-214.05M-238.42M-344.89M-401.5M
Net Interest Income
477K-178K919K1.79M466K8.71M27.62M41.94M26.83M26.52M
Interest Income
477K1.22M2.35M2.28M466K8.71M27.62M41.94M26.83M26.52M
Interest Expense
01.39M1.43M484K000000
Other Income/Expense
1.87M6.4M1.2M2.21M105K3.89M31.37M40.88M28.18M27.51M
Pretax Income
-30.7M▲ 0%
-34.5M▼ 12.4%
-41.62M▼ 20.6%
-29.09M▲ 30.1%
-78.89M▼ 171.1%
-125.25M▼ 58.8%
-182.69M▼ 45.9%
-238.42M▼ 30.5%
-344.89M▼ 44.7%
-385.15M▲ 0%
Pretax Margin %
-9872.67%--609.43%-90.45%-427.88%-1327.7%---4598.59%-
Income Tax
04.91M-23K-257K-6K118K-292K-4.09M1.02M-1.98M
Effective Tax Rate %
0%-14.24%0.06%0.88%0.01%-0.09%0.16%1.72%-0.29%0.51%
Net Income
-30.7M▲ 0%
-34.5M▼ 12.4%
-41.59M▼ 20.6%
-28.84M▲ 30.7%
-78.88M▼ 173.5%
-125.37M▼ 58.9%
-182.39M▼ 45.5%
-234.33M▼ 28.5%
-345.91M▼ 47.6%
-383.17M▲ 0%
Net Margin %
-9872.67%--609.09%-89.65%-427.85%-1328.95%---4612.13%-
Net Income Growth %
-33.51%-12.35%-20.58%30.67%-173.54%-58.94%-45.48%-28.48%-47.62%-52.38%
Net Income (Continuing)
-30.7M-34.5M-41.59M-28.84M-78.88M-125.37M-182.39M-234.33M-345.91M-383.17M
Discontinued Operations
0000000000
Minority Interest
0000000000
EPS (Diluted)
-1.71▲ 0%
-1.78▼ 4.1%
-1.54▲ 13.5%
-0.83▲ 46.1%
-1.77▼ 113.3%
-2.06▼ 16.4%
-2.73▼ 32.5%
-3.01▼ 10.3%
-4.36▼ 44.9%
-4.39▲ 0%
EPS Growth %
-15.54%-4.09%13.48%46.1%-113.25%-16.38%-32.52%-10.26%-44.85%-45.51%
EPS (Basic)
-1.71-1.78-1.54-0.83-1.77-2.06-2.73-3.01-4.36-
Diluted Shares Outstanding
18M19.43M25.94M34.54M43.63M60.54M66.89M77.89M79.25M87.35M
Basic Shares Outstanding
17.99M19.43M25.94M34.54M43.63M60.54M66.89M77.89M79.25M87.35M
Dividend Payout Ratio
----------

XENE Balance Sheet

Xenon Pharmaceuticals Inc. (XENE) balance sheet — assets, liabilities & shareholders' equity

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Total Current Assets
44.82M121.44M144.87M181.78M559.02M600.3M644.96M635.26M560.65M1.11B
Cash & Short-Term Investments
43.67M119.31M141.36M177M551.77M592.09M638.08M626.9M548.89M1.09B
Cash Only
20.49M67.75M24.75M45.01M175.69M57.24M148.64M142.71M199.16M545.87M
Short-Term Investments
23.18M51.55M116.6M131.99M376.09M534.85M489.44M484.19M349.72M548.88M
Accounts Receivable
438K151K813K1.82M2.77M986K874K1.47M1.37M1.17M
Days Sales Outstanding
514.05-43.4520.6754.7438.15--66.72-
Inventory
0000000000
Days Inventory Outstanding
----------
Other Current Assets
000007.22M6.01M6.89M10.39M10.72M
Total Non-Current Assets
1.3M991K2.83M7.4M12.99M153.85M319.84M162.88M421.02M280.18M
Property, Plant & Equipment
1.07M991K2.59M6.88M12.52M16.91M18.85M18.22M15.35M0
Fixed Asset Turnover
0.29x-2.63x4.68x1.47x0.56x--0.49x0.00x
Goodwill
0000000000
Intangible Assets
0000000000
Long-Term Investments
00000128.68M292.79M127.5M37.15M512.31M
Other Non-Current Assets
230K-105K0007.75M7.4M7.5M7.15M35.3M
Total Assets
46.12M▲ 0%
122.43M▲ 165.4%
147.7M▲ 20.6%
189.19M▲ 28.1%
572.01M▲ 202.4%
754.15M▲ 31.8%
964.8M▲ 27.9%
798.14M▼ 17.3%
981.67M▲ 23.0%
1.39B▲ 0%
Asset Turnover
0.01x-0.05x0.17x0.03x0.01x--0.01x0.00x
Asset Growth %
-31.66%165.45%20.64%28.09%202.35%31.84%27.93%-17.27%22.99%58.57%
Total Current Liabilities
4.08M4.12M43.38M14.78M14.32M22.7M27.27M35.59M41.79M39.81M
Accounts Payable
1.25M665K2.47M3.04M3.82M8.49M8.6M5.07M3.88M5.75M
Days Payables Outstanding
17.8840.45----18.73722.87557.6222.11
Short-Term Debt
700K04.65M000001.53M0
Deferred Revenue (Current)
0-15.01M29.74M3.64M000000
Other Current Liabilities
44K1.73M3.45M2.86M5.94M5.82M347K9.93M21.6M32.24M
Current Ratio
10.98x29.48x3.34x12.30x39.03x26.44x23.65x17.85x13.42x27.79x
Quick Ratio
10.98x29.48x3.34x12.30x39.03x26.44x23.65x17.85x13.42x27.79x
Cash Conversion Cycle
----------
Total Non-Current Liabilities
6.1M15.01M12.34M3.05M7.65M9.95M9.6M7.65M358.12M9.18M
Long-Term Debt
6.1M15.01M10.89M0000000
Capital Lease Obligations
00743K3.05M7.65M9.95M9.6M7.65M6.41M26.43M
Deferred Tax Liabilities
00000000348.51M348.51M
Other Non-Current Liabilities
000000003.2M3.25M
Total Liabilities
10.19M19.13M55.72M17.83M21.97M32.65M36.88M43.24M399.91M48.99M
Total Debt
6.8M15.01M16.45M3.31M8.26M10.44M10.9M9.02M7.94M7.49M
Net Debt
-13.68M-52.74M-8.3M-41.69M-167.43M-46.81M-137.74M-133.7M-191.22M-538.38M
Debt / Equity
0.19x0.15x0.18x0.02x0.02x0.01x0.01x0.01x0.01x0.01x
Debt / EBITDA
----------0.02x
Net Debt / EBITDA
---------1.31x
Interest Coverage
--23.76x-28.02x-59.11x------
Total Equity
35.93M▲ 0%
103.3M▲ 187.5%
91.98M▼ 11.0%
171.35M▲ 86.3%
550.03M▲ 221.0%
721.5M▲ 31.2%
927.92M▲ 28.6%
754.9M▼ 18.6%
581.76M▼ 22.9%
1.34B▲ 0%
Equity Growth %
-43.77%187.46%-10.96%86.3%220.99%31.17%28.61%-18.65%-22.94%12.35%
Book Value per Share
2.005.323.554.9612.6111.9213.879.697.3415.32
Total Shareholders' Equity
35.93M103.3M91.98M171.35M550.03M721.5M927.92M754.9M581.76M1.34B
Common Stock
173.84M265.92M294.24M397.75M783.17M1.07B1.44B1.46B1.6B2.42B
Retained Earnings
-173.39M-207.88M-249.66M-278.49M-357.37M-482.75M-665.14M-899.47M-1.25B-1.35B
Treasury Stock
0000000000
Accumulated OCI
-990K-990K-990K-990K-990K-3M-77K-1.61M335K-1.21M
Minority Interest
0000000000

XENE Cash Flow Statement

Xenon Pharmaceuticals Inc. (XENE) cash flow — operating, investing & free cash flow history

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Cash from Operations
-28.73M-34.72M-4.63M-48.12M-69.5M-98.43M-145.33M-181.39M-279.12M-306.36M
Operating CF Margin %
-9236.66%--67.83%-149.61%-376.97%-1043.35%---3721.57%-
Operating CF Growth %
-46.81%-20.88%86.66%-938.95%-44.42%-41.62%-47.64%-24.81%-53.88%-235.04%
Net Income
-30.7M-34.5M-41.59M-28.84M-78.88M-125.37M-182.39M-234.33M-345.91M-383.17M
Depreciation & Amortization
649K586K429K644K906K1.62M3.54M2.56M2.54M2.47M
Stock-Based Compensation
2.24M2.63M2.92M5.68M10.02M20.38M32.37M50.72M53.71M58.43M
Deferred Taxes
-1.47M646K-133K-285K58K-44K-292K-8.86M-3.2M-837K
Other Non-Cash Items
11K-4.11M223K766K1.05M5.66M-4.19M2.81M9.38M8.72M
Working Capital Changes
556K30K33.52M-26.09M-2.65M-676K5.63M5.71M4.36M8.02M
Change in Receivables
-232K175K-653K-1.03M-459K1.76M130K-614K104K7.48M
Change in Inventory
613K-783K-4.54M-2.02M-2.97M00000
Change in Payables
-3K783K4.54M2.02M2.97M8.06M3.93M8.53M5.51M2.24M
Cash from Investing
24.29M-28.99M-66.29M-16.82M-246.77M-296M-117.17M165M218M-223.79M
Capital Expenditures
-315K-507K-1.24M-2.64M-2.05M-2.89M-5.62M-3.08M-799K-889K
CapEx % of Revenue
101.29%-18.16%8.2%11.12%30.68%--10.65%-
Acquisitions
-52.62M-48.52M-75.44M-214.71M-144.75M296M0000
Investments
----------
Other Investing
52.62M48.52M75.44M214.71M144.75M-296M000-213.11M
Cash from Financing
7.07M111.59M27.52M85.8M447.54M278.47M353.52M12.13M117.11M958.98M
Debt Issued (Net)
6.89M8.45M0-16.74M000000
Equity Issued (Net)
0102.85M27.4M102.46M447.28M277.77M353.49M12.08M117.11M959.22M
Dividends Paid
0000000000
Share Repurchases
0000000000
Other Financing
177K288K122K82K260K705K35K47K0-247.43K
Net Change in Cash
3.39M▲ 0%
47.27M▲ 1293.9%
-43M▼ 191.0%
20.25M▲ 147.1%
130.68M▲ 545.2%
-118.45M▼ 190.6%
91.4M▲ 177.2%
-5.93M▼ 106.5%
56.45M▲ 1051.8%
429.21M▲ 0%
Free Cash Flow
-29.04M▲ 0%
-35.23M▼ 21.3%
-5.87M▲ 83.3%
-50.76M▼ 764.5%
-71.55M▼ 41.0%
-101.32M▼ 41.6%
-150.94M▼ 49.0%
-184.46M▼ 22.2%
-279.92M▼ 51.7%
-307.25M▲ 0%
FCF Margin %
-9337.94%--85.99%-157.81%-388.09%-1074.03%---3732.23%-
FCF Growth %
-46.33%-21.31%83.33%-764.46%-40.96%-41.61%-48.97%-22.21%-51.75%-52.63%
FCF per Share
-1.61-1.81-0.23-1.47-1.64-1.67-2.26-2.37-3.53-3.52
FCF Conversion (FCF/Net Income)
0.94x1.01x0.11x1.67x0.88x0.79x0.80x0.77x0.81x0.80x
Interest Paid
0000000000
Taxes Paid
0000000001.65M

XENE Key Ratios

Xenon Pharmaceuticals Inc. (XENE) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric201720182019202020212022202320242025TTM
Return on Equity (ROE)
-61.51%-49.55%-42.6%-21.9%-21.87%-19.72%-22.12%-27.85%-51.76%-49.23%
Return on Invested Capital (ROIC)
-70.76%-78.32%-47.85%-22.01%-23.13%-18.32%-21.92%-29.68%-55.31%-57.3%
Gross Margin
-8122.83%-100%100%100%100%--66.09%-
Net Margin
-9872.67%--609.09%-89.65%-427.85%-1328.95%---4612.13%-
Debt / Equity
0.19x0.15x0.18x0.02x0.02x0.01x0.01x0.01x0.01x0.01x
Interest Coverage
--23.76x-28.02x-59.11x------
FCF Conversion
0.94x1.01x0.11x1.67x0.88x0.79x0.80x0.77x0.81x0.80x
Revenue Growth
-82.75%-100%-371.02%-42.68%-48.83%-100%---100%
Related:XENE Dividend History·XENE Revenue History·XENE Price History·XENE P/E History·XENE Financial Ratios·XENE Institutional Holders

XENE SEC Filings & Documents

Xenon Pharmaceuticals Inc. (XENE) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 7, 2026·SEC

Material company update

Apr 13, 2026·SEC

Material company update

Mar 13, 2026·SEC

10-K Annual Reports

3
FY 2026

Feb 26, 2026·SEC

FY 2025

Feb 27, 2025·SEC

FY 2024

Feb 29, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

May 7, 2026·SEC

FY 2025

Nov 3, 2025·SEC

FY 2025

Aug 11, 2025·SEC

XENE Frequently Asked Questions

Xenon Pharmaceuticals Inc. (XENE) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Xenon Pharmaceuticals Inc. (XENE) reported $7.5M in revenue for fiscal year 2025. This represents a 48% decrease from $14.3M in 2012.

Xenon Pharmaceuticals Inc. (XENE) grew revenue by 0.0% over the past year. Growth has been modest.

Xenon Pharmaceuticals Inc. (XENE) reported a net loss of $383.2M for fiscal year 2025.

Dividend & Returns

Xenon Pharmaceuticals Inc. (XENE) has a return on equity (ROE) of -51.8%. Negative ROE indicates the company is unprofitable.

Xenon Pharmaceuticals Inc. (XENE) had negative free cash flow of $307.3M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in XENE back in 2012?

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How much would $100/month in XENE be worth today?

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