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ZYMEZymeworks Inc.
$27.57$2.0B
Overview & Tools
OverviewChart Terminal ↗Visualize
Valuation & Forecasts
Valuation ModelsEstimatesDCF Model
Price & Analyst Data
Analyst TargetsPrice History
Financial Statements
Income StatementBalance SheetCash FlowRatios & Margins
Performance
P/E HistoryRevenue HistoryEarnings HistoryDividend HistoryTotal Return
Discovery & Screens
Live BreakoutsStock ScreenerOwnership
ZYME logo

Zymeworks Inc.

ZYME
NASDAQ · Biotechnology
$27.57
At close - Sep 22, 4:00 PM EDT - USD
Market Cap$2.03B
P/E-25.5x
52W High$31.21
Volume445.93K
OverviewTerminalAnalysisFinancialsValuationEarningsBreakoutsOwnership
VCP Research Verdict2026Q2

Revenue Collapse and Cash Burn Threaten Liquidity

Zymeworks' licensing-driven revenue spike in 2025Q2 ($48.7M) has reversed sharply, with revenue falling to zero in 2026Q2 and gross margin swinging to -18.2% in 2026Q1, indicating the end of its asset-light revenue model. The company's cash burn has intensifie...

GrowthDecelerating
ProfitabilityNegative
ValuationReview
TechnicalsHealthy
Explore valuation models
MARKET ACTION

ZYME price & volume

Price trend, volume and key moving averages

Launch Terminal
Loading chart...
Decision Checklist4 Core Signals

What matters now

The signals most likely to change the investment case.

01

Earnings momentum

6/12 Beats

EPS beat 6 of last 12 quarters

02

Valuation risk

-150% Peers

P/E is 150% below peer median

03

Market leadership

RS 73 · Avg

Average momentum (RS Rating: 73)

04

Healthy Uptrend

Uptrend

Price > 50DMA > 200DMA

Next CatalystEstimated earnings · Nov 6

Market performance

Price History →

Trailing total returns as of 9/23/2026, which may include dividends or other distributions. Benchmark is S&P 500 (^GSPC).

YTD Return
ZYME+3.55%
S&P 500 (^GSPC)+13.20%
1-Year Return
ZYME+66.76%
S&P 500 (^GSPC)+15.98%
3-Year Return
ZYME+330.70%
S&P 500 (^GSPC)+88.69%
5-Year Return
ZYME-11.37%
S&P 500 (^GSPC)+79.67%
02

Test the fundamentals

Check whether operating performance supports the current valuation.

VALUATION & INTRINSIC VALUE

Valuation Scenarios

Valuation Analysis
Trailing P/E5Y Low
-25.5x
Forward P/E
18.9x
EV/EBITDA
N/A
FCF YieldCash Flow
N/A

Valuation vs 5-Year History

Multiple Range
Metric
Current
5Y Median
Historical Range
Percentile
P/E
-25.5x
4.1x
0th· Low
EV/EBITDA
N/A
1.0x
N/A
Price/FCF
N/A
3.9x
N/A
Current Multiple
5Y Median (50th %ile)

Intrinsic Value Scenarios

DCF Projection
Bear$3.41-87.6%
Base (Fair)$29.37+10.5%
Bull$5.84-78.8%
$3.41 Bear$29.37 Base$5.84 Bull
Current Market Price: $27.57
Trades at a 6.1% discount to Base DCF ($29.37)
Open DCF & Valuation Models →Chart Terminal ↗

Growth & profitability

Annual revenue & EPS trend
Revenue
$106M+38.9% YoY
Net income
-$81M+33.9% YoY
Free cash flow
-$35M+69.5% YoY
Operating margin
-87.3%+92.4 pts YoY
ROIC (TTM)-25.9%
Avg ROIC 5Y-
ROE (TTM)-26.7%
Piotroski Score5 / 9
Financial Statements →
03

Monitor what changed

Recent results and news deserve attention only when they alter the forward view.

OPERATING RESULTS

Recent Earnings

Earnings History
EPS Beat Rate6/12 (50%)
Revenue Beat Rate7/12 (58%)
QuarterEPS (Act vs Est)Revenue (Act vs Est)
Q3 2026Latest
Aug 6, 2026
-$0.62-7.9%
vs -$0.57
$5M+1.2%
vs $5M
Q2 2026
May 7, 2026
-$0.59-490.0%
vs -$0.10
$2M-90.1%
vs $24M
Q2 2026
Mar 2, 2026
-$0.55-57.1%
vs -$0.35
$3M-86.9%
vs $19M
Q4 2025
Nov 6, 2025
-$0.26+13.3%
vs -$0.30
$28M+41.7%
vs $19M
Historical baseline: 12 quarters analyzedGAAP / Adjusted
MARKET COVERAGE

Latest News

5 Stories
Seeking Alpha·Sep 14, 2026
Zymeworks Inc. (ZYME) Presents at Morgan Stanley 24th Annual Global Healthcare Conference Transcript

Zymeworks Inc. (ZYME) Presents at Morgan Stanley 24th Annual Global Healthcare Conference Transcript

Defense World·Sep 8, 2026
Jupiter Topco LLC Buys New Position in Zymeworks Inc. $ZYME

Jupiter Topco LLC bought a new position in shares of Zymeworks Inc. (NASDAQ: ZYME) in the undefined quarter, according to the company in its most recent disclosure with the Securities and Exchange Commission. The firm bought 18,200 shares of the company's stock, valued at approximately $476,000. A number of other hedge funds have

Seeking Alpha·Aug 27, 2026
Zymeworks: Transitioning Into A Royalty-Driven Biopharma Platform Post Ziihera Approval

Zymeworks Inc. is transitioning from a development-stage biotech to a royalty-driven, revenue-generating platform following zanidatamab's FDA approval. Zanidatamab's first-line HER2+ gastroesophageal cancer approval expands the eligible patient population and unlocks a $250M milestone plus 10–20% tiered royalties. ZYME's near-term upside hinges on commercial execution, label expansions, and integrating durable cash-flow assets like YUPELRI from the pending Theravance acquisition.

Defense World·Aug 27, 2026
Bank of America Corp DE Raises Position in Zymeworks Inc. $ZYME

Bank of America Corp DE lifted its stake in Zymeworks Inc. (NASDAQ: ZYME) by 164.5% during the undefined quarter, according to the company in its most recent disclosure with the Securities and Exchange Commission. The firm owned 236,754 shares of the company's stock after buying an additional 147,230 shares during the period. Bank

Filtered for Zymeworks Inc.More Headlines
04

Compare before deciding

Benchmark ZYME against direct peers instead of judging its metrics in isolation.

Peers Comparison

Key metrics vs top competitors for Zymeworks Inc. (ZYME)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
ZYME logoZYMEZymeworks Inc.Current
$27.57$2.03B-25.5238.87%-76.56%-26.72%—
IMVT logoIMVTImmunovant, Inc.
$37.29$7.7B-13.46—-7585.86%-69.59%—
RCUS logoRCUSArcus Biosciences, Inc.
$26.87$3.38B-8.17-4.26%-386.32%-87.98%—
MRUS logoMRUSMerus N.V.
$90.00$6.83B-26.87-12.38%-654.43%-50.62%—
AGIO logoAGIOAgios Pharmaceuticals, Inc.
$34.97$2.08B-4.9148.03%-418.24%-35.67%—
TPST logoTPSTTempest Therapeutics, Inc.
$1.04$15.8M-0.16——-1270.11%—

Compare ZYME vs Peers

Zymeworks Inc. (ZYME) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs IMVT

Most directly comparable listed peer for ZYME.

Scale Benchmark

vs LLY

Larger-name benchmark to compare ZYME against a more recognizable public peer.

Peer Set

Compare Top 5

vs IMVT, RCUS, MRUS, AGIO

05

Keep researching

Verify the primary filings, follow material updates, and answer the remaining questions.

ZYME SEC Filings & Documents

Zymeworks Inc. (ZYME) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Aug 6, 2026·SEC

Material company update

Jun 29, 2026·SEC

Material company update

May 14, 2026·SEC

10-K Annual Reports

3
FY 2026

Mar 2, 2026·SEC

FY 2025

Mar 5, 2025·SEC

FY 2024

Mar 6, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

Aug 6, 2026·SEC

FY 2026

May 7, 2026·SEC

FY 2025

Nov 6, 2025·SEC

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ZYME Frequently Asked Questions

Zymeworks Inc. (ZYME) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
What is Zymeworks Inc.'s revenue?

Zymeworks Inc. (ZYME) reported $32.5M in revenue for fiscal year 2025. This represents a 1848% increase from $1.7M in 2014.

How fast is Zymeworks Inc. growing?

Zymeworks Inc. (ZYME) grew revenue by 38.9% over the past year. This is strong growth.

Is ZYME profitable?

Zymeworks Inc. (ZYME) reported a net loss of $45.12B for fiscal year 2025.

Dividend & Returns
What is ZYME's return on equity?

Zymeworks Inc. (ZYME) has a return on equity (ROE) of -26.7%. Negative ROE indicates the company is unprofitable.

What is Zymeworks Inc.'s free cash flow?

Zymeworks Inc. (ZYME) had negative free cash flow of $166.0M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in ZYME back in 2014?

Total return calculator · dividends reinvested · 12+ years of data

See returns →