ORGO vs MDXG

For growth investors, MiMedx Group, Inc.

(MDXG) is the stronger pick with 20. 0% revenue growth year-over-year, versus 17. 0% for Organogenesis Holdings Inc. (ORGO). MiMedx Group, Inc. (MDXG) offers the better valuation at 11. 5x trailing P/E (295. 2x forward), making it the more compelling value choice. Analysts rate Organogenesis Holdings Inc. (ORGO) a "Buy" — based on 5 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.

On trailing P/E, MiMedx Group, Inc.

(MDXG) is the cheapest at 11. 5x versus Organogenesis Holdings Inc. at 16. 7x.

Over the past 5 years, MiMedx Group, Inc.

(MDXG) delivered a total return of -62. 9%, compared to -88. 1% for Organogenesis Holdings Inc. (ORGO). Over 10 years, the gap is even starker: MDXG returned -48. 5% versus ORGO's -74. 2%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.

By beta (market sensitivity over 5 years), MiMedx Group, Inc.

(MDXG) is the lower-risk stock at 1. 22β versus Organogenesis Holdings Inc. 's 1. 92β — meaning ORGO is approximately 58% more volatile than MDXG relative to the S&P 500. On balance sheet safety, MiMedx Group, Inc. (MDXG) carries a lower debt/equity ratio of 9% versus 31% for Organogenesis Holdings Inc. — giving it more financial flexibility in a downturn.

By revenue growth (latest reported year), MiMedx Group, Inc.

(MDXG) is pulling ahead at 20. 0% versus 17. 0% for Organogenesis Holdings Inc. (ORGO). On earnings-per-share growth, the picture is similar: Organogenesis Holdings Inc. grew EPS 1600% year-over-year, compared to 14. 3% for MiMedx Group, Inc.. Over a 3-year CAGR, MDXG leads at 16. 1% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.

MiMedx Group, Inc.

(MDXG) is the more profitable company, earning 11. 6% net margin versus 6. 6% for Organogenesis Holdings Inc. — meaning it keeps 11. 6% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: MDXG leads at 15. 3% versus 10. 0% for ORGO. At the gross margin level — before operating expenses — MDXG leads at 82. 6%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.

Analyst consensus price targets imply the most upside for ORGO: 258.

4% to $9. 00.

In this comparison, ORGO (3.

5% yield) pays a dividend. MDXG does not pay a meaningful dividend and should not be held primarily for income.

For long-horizon retirement investors, MiMedx Group, Inc.

(MDXG) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 1. 22)). Organogenesis Holdings Inc. (ORGO) carries a higher beta of 1. 92 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (MDXG: -48. 5%, ORGO: -74. 2%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.

Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.

ORGO pays a dividend while MDXG does not, making them suitable for different income and tax situations. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.