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ACON vs XTNT vs GKOS vs MDXG vs ATEC

Revenue, margins, valuation, and 5-year total return — side by side.

Live fundamentals10-year financials5-year price chart
ACON
Aclarion, Inc.

Medical - Healthcare Information Services

HealthcareNASDAQ • US
Market Cap$3M
5Y Perf.-100.0%
XTNT
Xtant Medical Holdings, Inc.

Medical - Devices

HealthcareAMEX • US
Market Cap$80M
5Y Perf.-12.2%
GKOS
Glaukos Corporation

Medical - Devices

HealthcareNYSE • US
Market Cap$7.85B
5Y Perf.+183.7%
MDXG
MiMedx Group, Inc.

Biotechnology

HealthcareNASDAQ • US
Market Cap$548M
5Y Perf.-6.6%
ATEC
Alphatec Holdings, Inc.

Medical - Devices

HealthcareNASDAQ • US
Market Cap$1.17B
5Y Perf.-28.6%

ACON vs XTNT vs GKOS vs MDXG vs ATEC — Key Financials

Market cap, revenue, margins, and valuation side-by-side.

Company Snapshot
ACON logoACON
XTNT logoXTNT
GKOS logoGKOS
MDXG logoMDXG
ATEC logoATEC
IndustryMedical - Healthcare Information ServicesMedical - DevicesMedical - DevicesBiotechnologyMedical - Devices
Market Cap$3M$80M$7.85B$548M$1.17B
Revenue (TTM)$75.73B$133M$551M$389M$595M
Net Income (TTM)$-7.23T$2M$-189M$31M$-125M
Gross Margin9.0%62.0%78.1%81.0%89.6%
Operating Margin-93.1%4.8%-15.6%10.2%-9.6%
Forward P/E295.2x27.1x
Total Debt$0.00$35M$140M$23M$620M
Cash & Equiv.$12.02T$6M$91M$166M$161M

ACON vs XTNT vs GKOS vs MDXG vs ATECLong-Term Stock Performance

Price return indexed to 100 at period start. Dividends excluded.

ACON
XTNT
GKOS
MDXG
ATEC
StockApr 22May 26Return
Aclarion, Inc. (ACON)1000.0-100.0%
Xtant Medical Holdi… (XTNT)10087.8-12.2%
Glaukos Corporation (GKOS)100283.7+183.7%
MiMedx Group, Inc. (MDXG)10093.4-6.6%
Alphatec Holdings, … (ATEC)10071.4-28.6%

Price return only. Dividends and distributions are not included.

Quick Verdict: ACON vs XTNT vs GKOS vs MDXG vs ATEC

Each card shows where this stock fits in a portfolio — not just who wins on paper.

Bottom line: ACON and MDXG are tied at the top with 2 categories each (5-stock set) — the right choice depends on your priorities. MiMedx Group, Inc. is the stronger pick specifically for profitability and margin quality and operational efficiency and capital deployment. XTNT, GKOS, and ATEC also each lead in at least one category. As sector peers, any of these can serve as alternatives in the same allocation.
ACON
Aclarion, Inc.
The Growth Play

ACON has the current edge in this matchup, primarily because of its strength in growth exposure and defensive.

  • Rev growth 1000K%, EPS growth 99.8%, 3Y rev CAGR 106.8%
  • Beta 0.98, yield 100.0%, current ratio 14.81x
  • 1000K% revenue growth vs MDXG's 20.0%
  • 100.0% yield; 1-year raise streak; the other 4 pay no meaningful dividend
Best for: growth exposure and defensive
XTNT
Xtant Medical Holdings, Inc.
The Income Pick

XTNT ranks third and is worth considering specifically for income & stability and sleep-well-at-night.

  • beta 0.69
  • Lower volatility, beta 0.69, Low D/E 81.8%, current ratio 2.35x
  • Beta 0.69 vs MDXG's 1.22
Best for: income & stability and sleep-well-at-night
GKOS
Glaukos Corporation
The Long-Run Compounder

GKOS is the clearest fit if your priority is long-term compounding.

  • 457.1% 10Y total return vs ATEC's 225.4%
  • +52.0% vs ACON's -56.2%
Best for: long-term compounding
MDXG
MiMedx Group, Inc.
The Quality Compounder

MDXG is the #2 pick in this set and the best alternative if quality and efficiency is your priority.

  • 7.9% margin vs ACON's -95.5%
  • 9.7% ROA vs ACON's -211.6%, ROIC 42.3% vs -12.9%
Best for: quality and efficiency
ATEC
Alphatec Holdings, Inc.
The Value Play

ATEC is the clearest fit if your priority is value.

  • Better valuation composite
Best for: value
See the full category breakdown
CategoryWinnerWhy
GrowthACON logoACON1000K% revenue growth vs MDXG's 20.0%
ValueATEC logoATECBetter valuation composite
Quality / MarginsMDXG logoMDXG7.9% margin vs ACON's -95.5%
Stability / SafetyXTNT logoXTNTBeta 0.69 vs MDXG's 1.22
DividendsACON logoACON100.0% yield; 1-year raise streak; the other 4 pay no meaningful dividend
Momentum (1Y)GKOS logoGKOS+52.0% vs ACON's -56.2%
Efficiency (ROA)MDXG logoMDXG9.7% ROA vs ACON's -211.6%, ROIC 42.3% vs -12.9%

ACON vs XTNT vs GKOS vs MDXG vs ATEC — Revenue Breakdown by Segment

How each company's revenue is distributed across its business units

ACONAclarion, Inc.

Segment breakdown not available.

XTNTXtant Medical Holdings, Inc.
FY 2024
Orthobiologics
56.6%$66M
Spinal Implant
42.1%$49M
License Revenue
1.3%$2M
GKOSGlaukos Corporation
FY 2019
Glaucoma
97.5%$231M
Corneal Health
2.5%$6M
MDXGMiMedx Group, Inc.
FY 2025
Surgical
100.0%$142M
ATECAlphatec Holdings, Inc.
FY 2025
Products And Services
100.0%$764M

ACON vs XTNT vs GKOS vs MDXG vs ATEC — Financial Metrics

Side-by-side numbers across 5 stocks — who leads on profitability, valuation, growth, and risk.

BEST OVERALLMDXGLAGGINGATEC

Income & Cash Flow (Last 12 Months)

MDXG leads this category, winning 3 of 6 comparable metrics.

ACON is the larger business by revenue, generating $75.7B annually — 569.0x XTNT's $133M. MDXG is the more profitable business, keeping 7.9% of every revenue dollar as net income compared to ACON's -95.5%. On growth, ACON holds the edge at +999999.0% YoY revenue growth, suggesting stronger near-term business momentum.

MetricACON logoACONAclarion, Inc.XTNT logoXTNTXtant Medical Hol…GKOS logoGKOSGlaukos Corporati…MDXG logoMDXGMiMedx Group, Inc.ATEC logoATECAlphatec Holdings…
RevenueTrailing 12 months$75.7B$133M$551M$389M$595M
EBITDAEarnings before interest/tax-$7.05T$11M-$40M$53M$4M
Net IncomeAfter-tax profit-$7.23T$2M-$189M$31M-$125M
Free Cash FlowCash after capex-$7.16T$5M-$18M$66M$7M
Gross MarginGross profit ÷ Revenue+9.0%+62.0%+78.1%+81.0%+89.6%
Operating MarginEBIT ÷ Revenue-93.1%+4.8%-15.6%+10.2%-9.6%
Net MarginNet income ÷ Revenue-95.5%+1.3%-34.3%+7.9%-21.1%
FCF MarginFCF ÷ Revenue-94.6%+3.9%-3.4%+17.0%+1.2%
Rev. Growth (YoY)Latest quarter vs prior year+999999.0%+19.0%+41.2%-33.1%-100.0%
EPS Growth (YoY)Latest quarter vs prior year+99.9%+123.7%-6.3%-2.4%+37.1%
MDXG leads this category, winning 3 of 6 comparable metrics.

Valuation Metrics

Evenly matched — ACON and MDXG each lead in 2 of 6 comparable metrics.

On an enterprise value basis, MDXG's 5.1x EV/EBITDA is more attractive than ATEC's 3752.1x.

MetricACON logoACONAclarion, Inc.XTNT logoXTNTXtant Medical Hol…GKOS logoGKOSGlaukos Corporati…MDXG logoMDXGMiMedx Group, Inc.ATEC logoATECAlphatec Holdings…
Market CapShares × price$3M$80M$7.9B$548M$1.2B
Enterprise ValueMkt cap + debt − cash-$12.02T$109M$7.9B$405M$1.6B
Trailing P/EPrice ÷ TTM EPS-0.23x-4.75x-40.90x11.53x-8.07x
Forward P/EPrice ÷ next-FY EPS est.295.20x27.09x
PEG RatioP/E ÷ EPS growth rate
EV / EBITDAEnterprise value multiple5.14x3752.09x
Price / SalesMarket cap ÷ Revenue0.00x0.68x15.47x1.31x1.54x
Price / BookPrice ÷ Book value/share0.00x1.77x11.69x2.15x32.28x
Price / FCFMarket cap ÷ FCF7.51x422.56x
Evenly matched — ACON and MDXG each lead in 2 of 6 comparable metrics.

Profitability & Efficiency

MDXG leads this category, winning 6 of 9 comparable metrics.

MDXG delivers a 12.9% return on equity — every $100 of shareholder capital generates $13 in annual profit, vs $-4 for ATEC. MDXG carries lower financial leverage with a 0.09x debt-to-equity ratio, signaling a more conservative balance sheet compared to ATEC's 17.21x. On the Piotroski fundamental quality scale (0–9), ATEC scores 6/9 vs XTNT's 2/9, reflecting solid financial health.

MetricACON logoACONAclarion, Inc.XTNT logoXTNTXtant Medical Hol…GKOS logoGKOSGlaukos Corporati…MDXG logoMDXGMiMedx Group, Inc.ATEC logoATECAlphatec Holdings…
ROE (TTM)Return on equity-2.3%+3.8%-26.5%+12.9%-4.4%
ROA (TTM)Return on assets-2.1%+1.8%-20.1%+9.7%-15.8%
ROICReturn on invested capital-12.9%-12.8%-9.2%+42.3%-12.6%
ROCEReturn on capital employed-109.9%-17.9%-10.3%+25.7%-13.7%
Piotroski ScoreFundamental quality 0–942356
Debt / EquityFinancial leverage0.82x0.21x0.09x17.21x
Net DebtTotal debt minus cash-$12.02T$29M$49M-$144M$459M
Cash & Equiv.Liquid assets$12.02T$6M$91M$166M$161M
Total DebtShort + long-term debt$0$35M$140M$23M$620M
Interest CoverageEBIT ÷ Interest expense1.55x-18.69x25.32x-3.29x
MDXG leads this category, winning 6 of 9 comparable metrics.

Total Returns (Dividends Reinvested)

GKOS leads this category, winning 6 of 6 comparable metrics.

A $10,000 investment in GKOS five years ago would be worth $16,155 today (with dividends reinvested), compared to $0 for ACON. Over the past 12 months, GKOS leads with a +52.0% total return vs ACON's -56.2%. The 3-year compound annual growth rate (CAGR) favors GKOS at 31.7% vs ACON's -96.9% — a key indicator of consistent wealth creation.

MetricACON logoACONAclarion, Inc.XTNT logoXTNTXtant Medical Hol…GKOS logoGKOSGlaukos Corporati…MDXG logoMDXGMiMedx Group, Inc.ATEC logoATECAlphatec Holdings…
YTD ReturnYear-to-date-36.5%-24.0%+21.2%-43.1%-62.7%
1-Year ReturnPast 12 months-56.2%+10.0%+52.0%-47.1%-37.8%
3-Year ReturnCumulative with dividends-100.0%-12.3%+128.7%-36.6%-47.8%
5-Year ReturnCumulative with dividends-100.0%-66.1%+61.5%-62.9%-48.7%
10-Year ReturnCumulative with dividends-100.0%-97.8%+457.1%-48.5%+225.4%
CAGR (3Y)Annualised 3-year return-96.9%-4.3%+31.7%-14.1%-19.5%
GKOS leads this category, winning 6 of 6 comparable metrics.

Risk & Volatility

Evenly matched — XTNT and GKOS each lead in 1 of 2 comparable metrics.

XTNT is the less volatile stock with a 0.69 beta — it tends to amplify market swings less than MDXG's 1.22 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. GKOS currently trades 91.4% from its 52-week high vs ACON's 26.3% drawdown — a narrower gap to the peak suggests stronger recent price momentum.

MetricACON logoACONAclarion, Inc.XTNT logoXTNTXtant Medical Hol…GKOS logoGKOSGlaukos Corporati…MDXG logoMDXGMiMedx Group, Inc.ATEC logoATECAlphatec Holdings…
Beta (5Y)Sensitivity to S&P 5000.98x0.69x1.20x1.22x1.13x
52-Week HighHighest price in past year$12.03$0.95$146.75$7.99$23.29
52-Week LowLowest price in past year$2.34$0.44$73.16$3.02$6.85
% of 52W HighCurrent price vs 52-week peak+26.3%+60.0%+91.4%+46.2%+33.3%
RSI (14)Momentum oscillator 0–10048.360.963.049.326.8
Avg Volume (50D)Average daily shares traded103K142K678K1.4M3.0M
Evenly matched — XTNT and GKOS each lead in 1 of 2 comparable metrics.

Analyst Outlook

Insufficient data to determine a leader in this category.

Analyst consensus: GKOS as "Buy", MDXG as "Buy", ATEC as "Buy". Consensus price targets imply 222.6% upside for ATEC (target: $25) vs 9.3% for GKOS (target: $147). ACON is the only dividend payer here at 100.00% yield — a key consideration for income-focused portfolios.

MetricACON logoACONAclarion, Inc.XTNT logoXTNTXtant Medical Hol…GKOS logoGKOSGlaukos Corporati…MDXG logoMDXGMiMedx Group, Inc.ATEC logoATECAlphatec Holdings…
Analyst RatingConsensus buy/hold/sellBuyBuyBuy
Price TargetConsensus 12-month target$146.67$10.00$25.00
# AnalystsCovering analysts241516
Dividend YieldAnnual dividend ÷ price+100.0%
Dividend StreakConsecutive years of raises1
Dividend / ShareAnnual DPS$10196.68
Buyback YieldShare repurchases ÷ mkt cap+45.0%0.0%0.0%+0.6%0.0%
Insufficient data to determine a leader in this category.
Key Takeaway

MDXG leads in 2 of 6 categories (Income & Cash Flow, Profitability & Efficiency). GKOS leads in 1 (Total Returns). 2 tied.

Best OverallMiMedx Group, Inc. (MDXG)Leads 2 of 6 categories
Loading custom metrics...

ACON vs XTNT vs GKOS vs MDXG vs ATEC: Key Questions Answered

10 questions · data-driven answers · updated daily

01

Is ACON or XTNT or GKOS or MDXG or ATEC a better buy right now?

For growth investors, Aclarion, Inc.

(ACON) is the stronger pick with 999999% revenue growth year-over-year, versus 20. 0% for MiMedx Group, Inc. (MDXG). MiMedx Group, Inc. (MDXG) offers the better valuation at 11. 5x trailing P/E (295. 2x forward), making it the more compelling value choice. Analysts rate Glaukos Corporation (GKOS) a "Buy" — based on 24 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.

02

Which has the better valuation — ACON or XTNT or GKOS or MDXG or ATEC?

On forward P/E, Alphatec Holdings, Inc.

is actually cheaper at 27. 1x — notably different from the trailing picture, reflecting expected earnings growth.

03

Which is the better long-term investment — ACON or XTNT or GKOS or MDXG or ATEC?

Over the past 5 years, Glaukos Corporation (GKOS) delivered a total return of +61.

5%, compared to -100. 0% for Aclarion, Inc. (ACON). Over 10 years, the gap is even starker: GKOS returned +457. 1% versus ACON's -100. 0%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.

04

Which is safer — ACON or XTNT or GKOS or MDXG or ATEC?

By beta (market sensitivity over 5 years), Xtant Medical Holdings, Inc.

(XTNT) is the lower-risk stock at 0. 69β versus MiMedx Group, Inc. 's 1. 22β — meaning MDXG is approximately 77% more volatile than XTNT relative to the S&P 500. On balance sheet safety, MiMedx Group, Inc. (MDXG) carries a lower debt/equity ratio of 9% versus 17% for Alphatec Holdings, Inc. — giving it more financial flexibility in a downturn.

05

Which is growing faster — ACON or XTNT or GKOS or MDXG or ATEC?

By revenue growth (latest reported year), Aclarion, Inc.

(ACON) is pulling ahead at 999999% versus 20. 0% for MiMedx Group, Inc. (MDXG). On earnings-per-share growth, the picture is similar: Aclarion, Inc. grew EPS 99. 8% year-over-year, compared to -18. 4% for Glaukos Corporation. Over a 3-year CAGR, ACON leads at 106. 8% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.

06

Which has better profit margins — ACON or XTNT or GKOS or MDXG or ATEC?

MiMedx Group, Inc.

(MDXG) is the more profitable company, earning 11. 6% net margin versus -95. 5% for Aclarion, Inc. — meaning it keeps 11. 6% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: MDXG leads at 15. 3% versus -93. 1% for ACON. At the gross margin level — before operating expenses — MDXG leads at 82. 6%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.

07

Is ACON or XTNT or GKOS or MDXG or ATEC more undervalued right now?

On forward earnings alone, Alphatec Holdings, Inc.

(ATEC) trades at 27. 1x forward P/E versus 295. 2x for MiMedx Group, Inc. — 268. 1x cheaper on a one-year earnings basis. Analyst consensus price targets imply the most upside for ATEC: 222. 6% to $25. 00.

08

Which pays a better dividend — ACON or XTNT or GKOS or MDXG or ATEC?

In this comparison, ACON (100.

0% yield) pays a dividend. XTNT, GKOS, MDXG, ATEC do not pay a meaningful dividend and should not be held primarily for income.

09

Is ACON or XTNT or GKOS or MDXG or ATEC better for a retirement portfolio?

For long-horizon retirement investors, Aclarion, Inc.

(ACON) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0. 98), 100. 0% yield). Both have compounded well over 10 years (ACON: -100. 0%, MDXG: -48. 5%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.

10

What are the main differences between ACON and XTNT and GKOS and MDXG and ATEC?

Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.

ACON pays a dividend while XTNT, GKOS, MDXG, ATEC do not, making them suitable for different income and tax situations. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.

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