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HBIO vs MLAB vs RGEN vs WAT vs A

Revenue, margins, valuation, and 5-year total return — side by side.

Live fundamentals10-year financials5-year price chart
HBIO
Harvard Bioscience, Inc.

Medical - Instruments & Supplies

HealthcareNASDAQ • US
Market Cap$304M
5Y Perf.-74.3%
MLAB
Mesa Laboratories, Inc.

Hardware, Equipment & Parts

TechnologyNASDAQ • US
Market Cap$586M
5Y Perf.-59.8%
RGEN
Repligen Corporation

Medical - Instruments & Supplies

HealthcareNASDAQ • US
Market Cap$7.13B
5Y Perf.-3.5%
WAT
Waters Corporation

Medical - Diagnostics & Research

HealthcareNYSE • US
Market Cap$22.83B
5Y Perf.+75.3%
A
Agilent Technologies, Inc.

Medical - Diagnostics & Research

HealthcareNYSE • US
Market Cap$33.58B
5Y Perf.+34.6%

HBIO vs MLAB vs RGEN vs WAT vs A — Key Financials

Market cap, revenue, margins, and valuation side-by-side.

Company Snapshot
HBIO logoHBIO
MLAB logoMLAB
RGEN logoRGEN
WAT logoWAT
A logoA
IndustryMedical - Instruments & SuppliesHardware, Equipment & PartsMedical - Instruments & SuppliesMedical - Diagnostics & ResearchMedical - Diagnostics & Research
Market Cap$304M$586M$7.13B$22.83B$33.58B
Revenue (TTM)$87M$248M$763M$3.77B$7.07B
Net Income (TTM)$-57M$4M$51M$449M$1.29B
Gross Margin53.0%60.6%51.5%55.0%38.8%
Operating Margin-0.7%7.0%8.7%17.1%20.6%
Forward P/E11.7x64.3x24.4x19.9x
Total Debt$36M$181M$690M$1.41B$3.35B
Cash & Equiv.$9M$27M$566M$588M$1.79B

HBIO vs MLAB vs RGEN vs WAT vs ALong-Term Stock Performance

Price return indexed to 100 at period start. Dividends excluded.

HBIO
MLAB
RGEN
WAT
A
StockMay 20May 26Return
Harvard Bioscience,… (HBIO)10025.7-74.3%
Mesa Laboratories, … (MLAB)10040.2-59.8%
Repligen Corporation (RGEN)10096.5-3.5%
Waters Corporation (WAT)100175.3+75.3%
Agilent Technologie… (A)100134.6+34.6%

Price return only. Dividends and distributions are not included.

Quick Verdict: HBIO vs MLAB vs RGEN vs WAT vs A

Each card shows where this stock fits in a portfolio — not just who wins on paper.

Bottom line: A leads in 3 of 7 categories (5-stock set), making it the strongest pick for profitability and margin quality and dividend income and shareholder returns. Harvard Bioscience, Inc. is the stronger pick specifically for recent price momentum and sentiment. MLAB, RGEN, and WAT also each lead in at least one category. This set spans 2 sectors — these stocks serve different portfolio roles, not just different price points.
HBIO
Harvard Bioscience, Inc.
The Momentum Pick

HBIO is the #2 pick in this set and the best alternative if momentum is your priority.

  • +126.3% vs MLAB's -11.2%
Best for: momentum
MLAB
Mesa Laboratories, Inc.
The Value Play

MLAB ranks third and is worth considering specifically for value.

  • Lower P/E (11.7x vs 24.4x)
Best for: value
RGEN
Repligen Corporation
The Growth Play

RGEN is the clearest fit if your priority is growth exposure and long-term compounding.

  • Rev growth 16.4%, EPS growth 287.0%, 3Y rev CAGR -2.7%
  • 369.1% 10Y total return vs A's 205.7%
  • Lower volatility, beta 1.76, Low D/E 32.8%, current ratio 8.37x
  • 16.4% revenue growth vs HBIO's -8.1%
Best for: growth exposure and long-term compounding
WAT
Waters Corporation
The Defensive Choice

WAT is the clearest fit if your priority is stability.

  • Beta 1.07 vs HBIO's 2.03, lower leverage
Best for: stability
A
Agilent Technologies, Inc.
The Income Pick

A carries the broadest edge in this set and is the clearest fit for income & stability and valuation efficiency.

  • Dividend streak 10 yrs, beta 1.23, yield 0.8%
  • PEG 1.35 vs WAT's 4.70
  • Beta 1.23, yield 0.8%, current ratio 1.96x
  • 18.3% margin vs HBIO's -65.5%
Best for: income & stability and valuation efficiency
See the full category breakdown
CategoryWinnerWhy
GrowthRGEN logoRGEN16.4% revenue growth vs HBIO's -8.1%
ValueMLAB logoMLABLower P/E (11.7x vs 24.4x)
Quality / MarginsA logoA18.3% margin vs HBIO's -65.5%
Stability / SafetyWAT logoWATBeta 1.07 vs HBIO's 2.03, lower leverage
DividendsA logoA0.8% yield, 10-year raise streak, vs MLAB's 0.6%, (3 stocks pay no dividend)
Momentum (1Y)HBIO logoHBIO+126.3% vs MLAB's -11.2%
Efficiency (ROA)A logoA10.1% ROA vs HBIO's -71.3%, ROIC 13.5% vs -0.7%

HBIO vs MLAB vs RGEN vs WAT vs A — Revenue Breakdown by Segment

How each company's revenue is distributed across its business units

HBIOHarvard Bioscience, Inc.
FY 2025
Instruments, Equipment, Software, and Accessories
90.4%$78M
Service, Maintenance, and Warranty Contracts
9.6%$8M
MLABMesa Laboratories, Inc.
FY 2025
Product
82.3%$198M
Service
17.7%$43M
RGENRepligen Corporation
FY 2025
Product
50.0%$738M
Filtration Products
27.3%$403M
Chromatography Products
10.4%$153M
Proteins Products
6.6%$97M
Process Analytics Products
5.5%$81M
Other products
0.2%$3M
WATWaters Corporation
FY 2025
Waters Instrument Systems
34.8%$1.1B
Waters Service
34.1%$1.1B
Chemistry Consumables
19.9%$631M
Ta Instrument Systems
7.7%$244M
Ta Service
3.4%$108M
AAgilent Technologies, Inc.
FY 2025
Agilent CrossLab
41.9%$2.9B
Life Sciences and Applied Markets
39.2%$2.7B
Applied Markets
18.9%$1.3B

HBIO vs MLAB vs RGEN vs WAT vs A — Financial Metrics

Side-by-side numbers across 5 stocks — who leads on profitability, valuation, growth, and risk.

BEST OVERALLMLABLAGGINGRGEN

Income & Cash Flow (Last 12 Months)

MLAB leads this category, winning 3 of 6 comparable metrics.

A is the larger business by revenue, generating $7.1B annually — 81.6x HBIO's $87M. A is the more profitable business, keeping 18.3% of every revenue dollar as net income compared to HBIO's -65.5%. On growth, WAT holds the edge at +91.5% YoY revenue growth, suggesting stronger near-term business momentum.

MetricHBIO logoHBIOHarvard Bioscienc…MLAB logoMLABMesa Laboratories…RGEN logoRGENRepligen Corporat…WAT logoWATWaters CorporationA logoAAgilent Technolog…
RevenueTrailing 12 months$87M$248M$763M$3.8B$7.1B
EBITDAEarnings before interest/tax$5M$37M$155M$953M$1.7B
Net IncomeAfter-tax profit-$57M$4M$51M$449M$1.3B
Free Cash FlowCash after capex$5M$38M$104M$264M$993M
Gross MarginGross profit ÷ Revenue+53.0%+60.6%+51.5%+55.0%+38.8%
Operating MarginEBIT ÷ Revenue-0.7%+7.0%+8.7%+17.1%+20.6%
Net MarginNet income ÷ Revenue-65.5%+1.5%+6.7%+11.9%+18.3%
FCF MarginFCF ÷ Revenue+5.9%+15.2%+13.7%+7.0%+14.1%
Rev. Growth (YoY)Latest quarter vs prior year-3.3%+3.6%+14.8%+91.5%+7.0%
EPS Growth (YoY)Latest quarter vs prior year+3.1%+50.0%-142.9%-3.6%
MLAB leads this category, winning 3 of 6 comparable metrics.

Valuation Metrics

MLAB leads this category, winning 5 of 7 comparable metrics.

At 26.0x trailing earnings, A trades at a 82% valuation discount to RGEN's 147.0x P/E. Adjusting for growth (PEG ratio), A offers better value at 1.76x vs WAT's 6.29x — a lower PEG means you pay less per unit of expected earnings growth.

MetricHBIO logoHBIOHarvard Bioscienc…MLAB logoMLABMesa Laboratories…RGEN logoRGENRepligen Corporat…WAT logoWATWaters CorporationA logoAAgilent Technolog…
Market CapShares × price$304M$586M$7.1B$22.8B$33.6B
Enterprise ValueMkt cap + debt − cash$331M$740M$7.3B$23.7B$35.1B
Trailing P/EPrice ÷ TTM EPS-5.30x-294.78x147.01x32.55x25.96x
Forward P/EPrice ÷ next-FY EPS est.11.71x64.26x24.36x19.87x
PEG RatioP/E ÷ EPS growth rate6.29x1.76x
EV / EBITDAEnterprise value multiple62.25x18.12x52.45x21.51x19.89x
Price / SalesMarket cap ÷ Revenue3.51x2.43x9.66x7.21x4.83x
Price / BookPrice ÷ Book value/share21.95x3.60x3.40x8.17x5.00x
Price / FCFMarket cap ÷ FCF54.08x13.86x75.94x42.30x29.15x
MLAB leads this category, winning 5 of 7 comparable metrics.

Profitability & Efficiency

A leads this category, winning 3 of 9 comparable metrics.

A delivers a 18.7% return on equity — every $100 of shareholder capital generates $19 in annual profit, vs $-4 for HBIO. RGEN carries lower financial leverage with a 0.33x debt-to-equity ratio, signaling a more conservative balance sheet compared to HBIO's 2.61x. On the Piotroski fundamental quality scale (0–9), RGEN scores 7/9 vs WAT's 4/9, reflecting strong financial health.

MetricHBIO logoHBIOHarvard Bioscienc…MLAB logoMLABMesa Laboratories…RGEN logoRGENRepligen Corporat…WAT logoWATWaters CorporationA logoAAgilent Technolog…
ROE (TTM)Return on equity-3.9%+2.0%+2.5%+8.0%+18.7%
ROA (TTM)Return on assets-71.3%+0.9%+1.8%+4.6%+10.1%
ROICReturn on invested capital-0.7%+3.7%+2.2%+20.3%+13.5%
ROCEReturn on capital employed-1.0%+4.9%+2.2%+18.5%+14.5%
Piotroski ScoreFundamental quality 0–946745
Debt / EquityFinancial leverage2.61x1.14x0.33x0.55x0.50x
Net DebtTotal debt minus cash$27M$154M$124M$820M$1.6B
Cash & Equiv.Liquid assets$9M$27M$566M$588M$1.8B
Total DebtShort + long-term debt$36M$181M$690M$1.4B$3.4B
Interest CoverageEBIT ÷ Interest expense-0.13x2.36x2.64x6.72x19.53x
A leads this category, winning 3 of 9 comparable metrics.

Total Returns (Dividends Reinvested)

WAT leads this category, winning 3 of 6 comparable metrics.

A $10,000 investment in WAT five years ago would be worth $11,133 today (with dividends reinvested), compared to $925 for HBIO. Over the past 12 months, HBIO leads with a +126.3% total return vs MLAB's -11.2%. The 3-year compound annual growth rate (CAGR) favors WAT at 5.7% vs HBIO's -51.4% — a key indicator of consistent wealth creation.

MetricHBIO logoHBIOHarvard Bioscienc…MLAB logoMLABMesa Laboratories…RGEN logoRGENRepligen Corporat…WAT logoWATWaters CorporationA logoAAgilent Technolog…
YTD ReturnYear-to-date+4.1%+33.8%-23.1%-8.3%-13.6%
1-Year ReturnPast 12 months+126.3%-11.2%-0.4%+1.4%+11.3%
3-Year ReturnCumulative with dividends-88.5%-33.0%-19.3%+18.1%-8.2%
5-Year ReturnCumulative with dividends-90.7%-56.5%-32.7%+11.3%-8.0%
10-Year ReturnCumulative with dividends-76.2%+4.5%+369.1%+162.0%+205.7%
CAGR (3Y)Annualised 3-year return-51.4%-12.5%-6.9%+5.7%-2.8%
WAT leads this category, winning 3 of 6 comparable metrics.

Risk & Volatility

WAT leads this category, winning 2 of 2 comparable metrics.

WAT is the less volatile stock with a 1.07 beta — it tends to amplify market swings less than HBIO's 2.03 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. WAT currently trades 84.6% from its 52-week high vs HBIO's 71.8% drawdown — a narrower gap to the peak suggests stronger recent price momentum.

MetricHBIO logoHBIOHarvard Bioscienc…MLAB logoMLABMesa Laboratories…RGEN logoRGENRepligen Corporat…WAT logoWATWaters CorporationA logoAAgilent Technolog…
Beta (5Y)Sensitivity to S&P 5002.03x1.78x1.76x1.07x1.23x
52-Week HighHighest price in past year$9.46$131.20$175.77$414.15$160.27
52-Week LowLowest price in past year$0.59$55.45$109.52$275.05$104.79
% of 52W HighCurrent price vs 52-week peak+71.8%+80.9%+71.9%+84.6%+74.0%
RSI (14)Momentum oscillator 0–10065.866.155.164.952.5
Avg Volume (50D)Average daily shares traded59K123K905K999K2.0M
WAT leads this category, winning 2 of 2 comparable metrics.

Analyst Outlook

A leads this category, winning 2 of 2 comparable metrics.

Analyst consensus: HBIO as "Buy", MLAB as "Hold", RGEN as "Buy", WAT as "Hold", A as "Buy". Consensus price targets imply 39.9% upside for A (target: $166) vs -11.6% for HBIO (target: $6). For income investors, A offers the higher dividend yield at 0.84% vs MLAB's 0.60%.

MetricHBIO logoHBIOHarvard Bioscienc…MLAB logoMLABMesa Laboratories…RGEN logoRGENRepligen Corporat…WAT logoWATWaters CorporationA logoAAgilent Technolog…
Analyst RatingConsensus buy/hold/sellBuyHoldBuyHoldBuy
Price TargetConsensus 12-month target$6.00$94.00$168.00$402.57$166.00
# AnalystsCovering analysts58233438
Dividend YieldAnnual dividend ÷ price+0.6%+0.8%
Dividend StreakConsecutive years of raises00110
Dividend / ShareAnnual DPS$0.64$0.99
Buyback YieldShare repurchases ÷ mkt cap0.0%0.0%0.0%+0.1%+1.3%
A leads this category, winning 2 of 2 comparable metrics.
Key Takeaway

MLAB leads in 2 of 6 categories (Income & Cash Flow, Valuation Metrics). A leads in 2 (Profitability & Efficiency, Analyst Outlook).

Best OverallMesa Laboratories, Inc. (MLAB)Leads 2 of 6 categories
Loading custom metrics...

HBIO vs MLAB vs RGEN vs WAT vs A: Key Questions Answered

10 questions · data-driven answers · updated daily

01

Is HBIO or MLAB or RGEN or WAT or A a better buy right now?

For growth investors, Repligen Corporation (RGEN) is the stronger pick with 16.

4% revenue growth year-over-year, versus -8. 1% for Harvard Bioscience, Inc. (HBIO). Agilent Technologies, Inc. (A) offers the better valuation at 26. 0x trailing P/E (19. 9x forward), making it the more compelling value choice. Analysts rate Harvard Bioscience, Inc. (HBIO) a "Buy" — based on 5 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.

02

Which has the better valuation — HBIO or MLAB or RGEN or WAT or A?

On trailing P/E, Agilent Technologies, Inc.

(A) is the cheapest at 26. 0x versus Repligen Corporation at 147. 0x. On forward P/E, Mesa Laboratories, Inc. is actually cheaper at 11. 7x — notably different from the trailing picture, reflecting expected earnings growth. The PEG ratio (P/E divided by earnings growth rate) is the most growth-adjusted single valuation metric: Agilent Technologies, Inc. wins at 1. 35x versus Waters Corporation's 4. 70x — a reasonable growth-adjusted valuation.

03

Which is the better long-term investment — HBIO or MLAB or RGEN or WAT or A?

Over the past 5 years, Waters Corporation (WAT) delivered a total return of +11.

3%, compared to -90. 7% for Harvard Bioscience, Inc. (HBIO). Over 10 years, the gap is even starker: RGEN returned +369. 1% versus HBIO's -76. 2%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.

04

Which is safer — HBIO or MLAB or RGEN or WAT or A?

By beta (market sensitivity over 5 years), Waters Corporation (WAT) is the lower-risk stock at 1.

07β versus Harvard Bioscience, Inc. 's 2. 03β — meaning HBIO is approximately 90% more volatile than WAT relative to the S&P 500. On balance sheet safety, Repligen Corporation (RGEN) carries a lower debt/equity ratio of 33% versus 3% for Harvard Bioscience, Inc. — giving it more financial flexibility in a downturn.

05

Which is growing faster — HBIO or MLAB or RGEN or WAT or A?

By revenue growth (latest reported year), Repligen Corporation (RGEN) is pulling ahead at 16.

4% versus -8. 1% for Harvard Bioscience, Inc. (HBIO). On earnings-per-share growth, the picture is similar: Repligen Corporation grew EPS 287. 0% year-over-year, compared to -357. 1% for Harvard Bioscience, Inc.. Over a 3-year CAGR, MLAB leads at 9. 3% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.

06

Which has better profit margins — HBIO or MLAB or RGEN or WAT or A?

Waters Corporation (WAT) is the more profitable company, earning 20.

3% net margin versus -65. 5% for Harvard Bioscience, Inc. — meaning it keeps 20. 3% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: WAT leads at 28. 2% versus -0. 7% for HBIO. At the gross margin level — before operating expenses — MLAB leads at 62. 6%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.

07

Is HBIO or MLAB or RGEN or WAT or A more undervalued right now?

The PEG ratio (forward P/E divided by expected earnings growth rate) is the most precise measure of undervaluation relative to growth potential.

By this metric, Agilent Technologies, Inc. (A) is the more undervalued stock at a PEG of 1. 35x versus Waters Corporation's 4. 70x. A PEG below 1. 5 suggests fair-to-attractive pricing relative to expected growth. On forward earnings alone, Mesa Laboratories, Inc. (MLAB) trades at 11. 7x forward P/E versus 64. 3x for Repligen Corporation — 52. 5x cheaper on a one-year earnings basis. Analyst consensus price targets imply the most upside for A: 39. 9% to $166. 00.

08

Which pays a better dividend — HBIO or MLAB or RGEN or WAT or A?

In this comparison, A (0.

8% yield), MLAB (0. 6% yield) pay a dividend. HBIO, RGEN, WAT do not pay a meaningful dividend and should not be held primarily for income.

09

Is HBIO or MLAB or RGEN or WAT or A better for a retirement portfolio?

For long-horizon retirement investors, Agilent Technologies, Inc.

(A) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 1. 23), 0. 8% yield, +205. 7% 10Y return). Harvard Bioscience, Inc. (HBIO) carries a higher beta of 2. 03 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (A: +205. 7%, HBIO: -76. 2%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.

10

What are the main differences between HBIO and MLAB and RGEN and WAT and A?

These companies operate in different sectors (HBIO (Healthcare) and MLAB (Technology) and RGEN (Healthcare) and WAT (Healthcare) and A (Healthcare)), which means they face different economic cycles, regulatory environments, and macro sensitivities — making direct comparison nuanced.

In terms of investment character: HBIO is a small-cap quality compounder stock; MLAB is a small-cap quality compounder stock; RGEN is a small-cap high-growth stock; WAT is a mid-cap quality compounder stock; A is a mid-cap quality compounder stock. MLAB, A pay a dividend while HBIO, RGEN, WAT do not, making them suitable for different income and tax situations. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.

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