Biotechnology
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4 / 10Stock Comparison
LPCN vs ANIP vs PRGO vs AMRX
Revenue, margins, valuation, and 5-year total return — side by side.
Drug Manufacturers - Specialty & Generic
Drug Manufacturers - Specialty & Generic
Drug Manufacturers - Specialty & Generic
LPCN vs ANIP vs PRGO vs AMRX — Key Financials
Market cap, revenue, margins, and valuation side-by-side.
| Company Snapshot | ||||
|---|---|---|---|---|
| Industry | Biotechnology | Drug Manufacturers - Specialty & Generic | Drug Manufacturers - Specialty & Generic | Drug Manufacturers - Specialty & Generic |
| Market Cap | $13M | $1.78B | $1.61B | $4.31B |
| Revenue (TTM) | $2M | $883M | $4.18B | $3.02B |
| Net Income (TTM) | $-11M | $78M | $-1.82B | $72M |
| Gross Margin | -13.4% | 69.1% | 34.2% | 36.9% |
| Operating Margin | -413.6% | 12.6% | -4.1% | -0.2% |
| Forward P/E | — | 9.2x | 5.6x | 13.8x |
| Total Debt | $0.00 | $325M | $3.97B | $124M |
| Cash & Equiv. | $5M | $286M | $532M | $282M |
LPCN vs ANIP vs PRGO vs AMRX — Long-Term Stock Performance
Price return indexed to 100 at period start. Dividends excluded.
| Stock | May 20 | May 26 | Return |
|---|---|---|---|
| Lipocine Inc. (LPCN) | 100 | 15.4 | -84.6% |
| ANI Pharmaceuticals… (ANIP) | 100 | 270.2 | +170.2% |
| Perrigo Company plc (PRGO) | 100 | 21.4 | -78.6% |
| Amneal Pharmaceutic… (AMRX) | 100 | 281.7 | +181.7% |
Price return only. Dividends and distributions are not included.
Quick Verdict: LPCN vs ANIP vs PRGO vs AMRX
Each card shows where this stock fits in a portfolio — not just who wins on paper.
LPCN lags the leaders in this set but could rank higher in a more targeted comparison.
ANIP carries the broadest edge in this set and is the clearest fit for growth exposure and long-term compounding.
- Rev growth 43.8%, EPS growth 419.2%, 3Y rev CAGR 40.8%
- 84.7% 10Y total return vs AMRX's -54.9%
- Lower volatility, beta 0.63, Low D/E 60.1%, current ratio 2.71x
- Beta 0.63, yield 0.1%, current ratio 2.71x
PRGO is the #2 pick in this set and the best alternative if income & stability is your priority.
- Dividend streak 10 yrs, beta 1.18, yield 9.8%
- Lower P/E (5.6x vs 13.8x)
- 9.8% yield, 10-year raise streak, vs ANIP's 0.1%, (2 stocks pay no dividend)
AMRX is the clearest fit if your priority is momentum.
- +90.0% vs PRGO's -51.2%
See the full category breakdown
| Category | Winner | Why |
|---|---|---|
| Growth | 43.8% revenue growth vs LPCN's -82.3% | |
| Value | Lower P/E (5.6x vs 13.8x) | |
| Quality / Margins | 8.9% margin vs LPCN's -5.7% | |
| Stability / Safety | Beta 0.63 vs PRGO's 1.18, lower leverage | |
| Dividends | 9.8% yield, 10-year raise streak, vs ANIP's 0.1%, (2 stocks pay no dividend) | |
| Momentum (1Y) | +90.0% vs PRGO's -51.2% | |
| Efficiency (ROA) | 5.4% ROA vs LPCN's -59.4%, ROIC 11.2% vs -64.7% |
LPCN vs ANIP vs PRGO vs AMRX — Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
LPCN vs ANIP vs PRGO vs AMRX — Financial Metrics
Side-by-side numbers across 4 stocks — who leads on profitability, valuation, growth, and risk.
Who Leads Where
PRGO leads in 2 of 6 categories
ANIP leads 1 • AMRX leads 1 • LPCN leads 0 • 2 tied
Explore the data ↓Income & Cash Flow (Last 12 Months)
ANIP leads this category, winning 6 of 6 comparable metrics.
Income & Cash Flow (Last 12 Months)
PRGO is the larger business by revenue, generating $4.2B annually — 2086.9x LPCN's $2M. ANIP is the more profitable business, keeping 8.9% of every revenue dollar as net income compared to LPCN's -5.7%. On growth, ANIP holds the edge at +29.6% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | ||||
|---|---|---|---|---|
| RevenueTrailing 12 months | $2M | $883M | $4.2B | $3.0B |
| EBITDAEarnings before interest/tax | -$8M | $203M | $58M | $169M |
| Net IncomeAfter-tax profit | -$11M | $78M | -$1.8B | $72M |
| Free Cash FlowCash after capex | -$8M | $128M | $108M | $150M |
| Gross MarginGross profit ÷ Revenue | -13.4% | +69.1% | +34.2% | +36.9% |
| Operating MarginEBIT ÷ Revenue | -4.1% | +12.6% | -4.1% | -0.2% |
| Net MarginNet income ÷ Revenue | -5.7% | +8.9% | -43.5% | +2.4% |
| FCF MarginFCF ÷ Revenue | -3.9% | +14.5% | +2.6% | +5.0% |
| Rev. Growth (YoY)Latest quarter vs prior year | +27.2% | +29.6% | -7.2% | +11.5% |
| EPS Growth (YoY)Latest quarter vs prior year | -54.3% | +3.1% | -56.4% | +2.1% |
Valuation Metrics
PRGO leads this category, winning 4 of 6 comparable metrics.
Valuation Metrics
At 25.3x trailing earnings, ANIP trades at a 59% valuation discount to AMRX's 62.4x P/E. On an enterprise value basis, PRGO's 7.4x EV/EBITDA is more attractive than ANIP's 9.0x.
| Metric | ||||
|---|---|---|---|---|
| Market CapShares × price | $13M | $1.8B | $1.6B | $4.3B |
| Enterprise ValueMkt cap + debt − cash | $8M | $1.8B | $5.1B | $4.2B |
| Trailing P/EPrice ÷ TTM EPS | -1.41x | 25.27x | -1.14x | 62.36x |
| Forward P/EPrice ÷ next-FY EPS est. | — | 9.25x | 5.56x | 13.81x |
| PEG RatioP/E ÷ EPS growth rate | — | — | — | — |
| EV / EBITDAEnterprise value multiple | — | 8.99x | 7.42x | — |
| Price / SalesMarket cap ÷ Revenue | 6.58x | 2.02x | 0.38x | 1.43x |
| Price / BookPrice ÷ Book value/share | 0.94x | 3.29x | 0.55x | 4.62x |
| Price / FCFMarket cap ÷ FCF | — | 9.62x | 11.12x | 15.98x |
Profitability & Efficiency
Evenly matched — ANIP and AMRX each lead in 4 of 9 comparable metrics.
Profitability & Efficiency
ANIP delivers a 14.5% return on equity — every $100 of shareholder capital generates $14 in annual profit, vs $-67 for LPCN. AMRX carries lower financial leverage with a 0.13x debt-to-equity ratio, signaling a more conservative balance sheet compared to PRGO's 1.35x. On the Piotroski fundamental quality scale (0–9), AMRX scores 8/9 vs LPCN's 0/9, reflecting strong financial health.
| Metric | ||||
|---|---|---|---|---|
| ROE (TTM)Return on equity | -66.7% | +14.5% | -50.7% | +7.5% |
| ROA (TTM)Return on assets | -59.4% | +5.4% | -19.8% | +2.0% |
| ROICReturn on invested capital | -64.7% | +11.2% | +3.7% | -0.2% |
| ROCEReturn on capital employed | -58.5% | +9.9% | +4.3% | -0.2% |
| Piotroski ScoreFundamental quality 0–9 | 0 | 6 | 4 | 8 |
| Debt / EquityFinancial leverage | — | 0.60x | 1.35x | 0.13x |
| Net DebtTotal debt minus cash | -$5M | $40M | $3.4B | -$158M |
| Cash & Equiv.Liquid assets | $5M | $286M | $532M | $282M |
| Total DebtShort + long-term debt | $0 | $325M | $4.0B | $124M |
| Interest CoverageEBIT ÷ Interest expense | — | 1.82x | -7.20x | 2.09x |
Total Returns (Dividends Reinvested)
AMRX leads this category, winning 5 of 6 comparable metrics.
Total Returns (Dividends Reinvested)
A $10,000 investment in AMRX five years ago would be worth $26,385 today (with dividends reinvested), compared to $1,011 for LPCN. Over the past 12 months, AMRX leads with a +90.0% total return vs PRGO's -51.2%. The 3-year compound annual growth rate (CAGR) favors AMRX at 89.4% vs PRGO's -25.2% — a key indicator of consistent wealth creation.
| Metric | ||||
|---|---|---|---|---|
| YTD ReturnYear-to-date | -70.1% | +7.0% | -13.5% | +8.4% |
| 1-Year ReturnPast 12 months | -27.6% | +18.5% | -51.2% | +90.0% |
| 3-Year ReturnCumulative with dividends | -42.1% | +97.1% | -58.1% | +579.2% |
| 5-Year ReturnCumulative with dividends | -89.9% | +117.4% | -60.1% | +163.8% |
| 10-Year ReturnCumulative with dividends | -98.4% | +84.7% | -77.7% | -54.9% |
| CAGR (3Y)Annualised 3-year return | -16.7% | +25.4% | -25.2% | +89.4% |
Risk & Volatility
Evenly matched — ANIP and AMRX each lead in 1 of 2 comparable metrics.
Risk & Volatility
ANIP is the less volatile stock with a 0.63 beta — it tends to amplify market swings less than PRGO's 1.18 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. AMRX currently trades 90.3% from its 52-week high vs LPCN's 19.3% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | ||||
|---|---|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 0.86x | 0.63x | 1.18x | 1.17x |
| 52-Week HighHighest price in past year | $12.37 | $99.50 | $28.44 | $15.20 |
| 52-Week LowLowest price in past year | $1.81 | $56.71 | $9.23 | $7.02 |
| % of 52W HighCurrent price vs 52-week peak | +19.3% | +84.3% | +41.2% | +90.3% |
| RSI (14)Momentum oscillator 0–100 | 34.1 | 64.4 | 60.9 | 62.7 |
| Avg Volume (50D)Average daily shares traded | 463K | 328K | 3.4M | 1.7M |
Analyst Outlook
PRGO leads this category, winning 2 of 2 comparable metrics.
Analyst Outlook
Analyst consensus: ANIP as "Buy", PRGO as "Hold", AMRX as "Buy". Consensus price targets imply 70.6% upside for PRGO (target: $20) vs 23.9% for AMRX (target: $17). PRGO is the only dividend payer here at 9.81% yield — a key consideration for income-focused portfolios.
| Metric | ||||
|---|---|---|---|---|
| Analyst RatingConsensus buy/hold/sell | — | Buy | Hold | Buy |
| Price TargetConsensus 12-month target | — | $124.00 | $20.00 | $17.00 |
| # AnalystsCovering analysts | — | 10 | 36 | 16 |
| Dividend YieldAnnual dividend ÷ price | — | +0.1% | +9.8% | — |
| Dividend StreakConsecutive years of raises | — | 0 | 10 | 0 |
| Dividend / ShareAnnual DPS | — | $0.05 | $1.15 | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | +0.7% | 0.0% | 0.0% |
PRGO leads in 2 of 6 categories (Valuation Metrics, Analyst Outlook). ANIP leads in 1 (Income & Cash Flow). 2 tied.
LPCN vs ANIP vs PRGO vs AMRX: Key Questions Answered
10 questions · data-driven answers · updated daily
01Is LPCN or ANIP or PRGO or AMRX a better buy right now?
For growth investors, ANI Pharmaceuticals, Inc.
(ANIP) is the stronger pick with 43. 8% revenue growth year-over-year, versus -82. 3% for Lipocine Inc. (LPCN). ANI Pharmaceuticals, Inc. (ANIP) offers the better valuation at 25. 3x trailing P/E (9. 2x forward), making it the more compelling value choice. Analysts rate ANI Pharmaceuticals, Inc. (ANIP) a "Buy" — based on 10 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which has the better valuation — LPCN or ANIP or PRGO or AMRX?
On trailing P/E, ANI Pharmaceuticals, Inc.
(ANIP) is the cheapest at 25. 3x versus Amneal Pharmaceuticals, Inc. at 62. 4x. On forward P/E, Perrigo Company plc is actually cheaper at 5. 6x — notably different from the trailing picture, reflecting expected earnings growth.
03Which is the better long-term investment — LPCN or ANIP or PRGO or AMRX?
Over the past 5 years, Amneal Pharmaceuticals, Inc.
(AMRX) delivered a total return of +163. 8%, compared to -89. 9% for Lipocine Inc. (LPCN). Over 10 years, the gap is even starker: ANIP returned +84. 7% versus LPCN's -98. 4%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
04Which is safer — LPCN or ANIP or PRGO or AMRX?
By beta (market sensitivity over 5 years), ANI Pharmaceuticals, Inc.
(ANIP) is the lower-risk stock at 0. 63β versus Perrigo Company plc's 1. 18β — meaning PRGO is approximately 88% more volatile than ANIP relative to the S&P 500. On balance sheet safety, Amneal Pharmaceuticals, Inc. (AMRX) carries a lower debt/equity ratio of 13% versus 135% for Perrigo Company plc — giving it more financial flexibility in a downturn.
05Which is growing faster — LPCN or ANIP or PRGO or AMRX?
By revenue growth (latest reported year), ANI Pharmaceuticals, Inc.
(ANIP) is pulling ahead at 43. 8% versus -82. 3% for Lipocine Inc. (LPCN). On earnings-per-share growth, the picture is similar: ANI Pharmaceuticals, Inc. grew EPS 419. 2% year-over-year, compared to -723. 2% for Perrigo Company plc. Over a 3-year CAGR, LPCN leads at 58. 1% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.
06Which has better profit margins — LPCN or ANIP or PRGO or AMRX?
ANI Pharmaceuticals, Inc.
(ANIP) is the more profitable company, earning 8. 9% net margin versus -487. 1% for Lipocine Inc. — meaning it keeps 8. 9% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: ANIP leads at 12. 6% versus -524. 7% for LPCN. At the gross margin level — before operating expenses — ANIP leads at 69. 1%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
07Is LPCN or ANIP or PRGO or AMRX more undervalued right now?
On forward earnings alone, Perrigo Company plc (PRGO) trades at 5.
6x forward P/E versus 13. 8x for Amneal Pharmaceuticals, Inc. — 8. 2x cheaper on a one-year earnings basis. Analyst consensus price targets imply the most upside for PRGO: 70. 6% to $20. 00.
08Which pays a better dividend — LPCN or ANIP or PRGO or AMRX?
In this comparison, PRGO (9.
8% yield) pays a dividend. LPCN, ANIP, AMRX do not pay a meaningful dividend and should not be held primarily for income.
09Is LPCN or ANIP or PRGO or AMRX better for a retirement portfolio?
For long-horizon retirement investors, ANI Pharmaceuticals, Inc.
(ANIP) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0. 63)). Both have compounded well over 10 years (ANIP: +84. 7%, AMRX: -54. 9%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
10What are the main differences between LPCN and ANIP and PRGO and AMRX?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.
In terms of investment character: LPCN is a small-cap quality compounder stock; ANIP is a small-cap high-growth stock; PRGO is a small-cap income-oriented stock; AMRX is a small-cap quality compounder stock. PRGO pays a dividend while LPCN, ANIP, AMRX do not, making them suitable for different income and tax situations. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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