POAI vs SDGR

For growth investors, Schrödinger, Inc.

(SDGR) is the stronger pick with 23. 3% revenue growth year-over-year, versus -0. 2% for Predictive Oncology Inc. (POAI). Analysts rate Schrödinger, Inc. (SDGR) a "Buy" — based on 12 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.

Over the past 5 years, Schrödinger, Inc.

(SDGR) delivered a total return of -80. 6%, compared to -98. 4% for Predictive Oncology Inc. (POAI). Over 10 years, the gap is even starker: SDGR returned -53. 6% versus POAI's -100. 0%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.

By beta (market sensitivity over 5 years), Predictive Oncology Inc.

(POAI) is the lower-risk stock at 1. 55β versus Schrödinger, Inc. 's 1. 72β — meaning SDGR is approximately 11% more volatile than POAI relative to the S&P 500.

By revenue growth (latest reported year), Schrödinger, Inc.

(SDGR) is pulling ahead at 23. 3% versus -0. 2% for Predictive Oncology Inc. (POAI). On earnings-per-share growth, the picture is similar: Schrödinger, Inc. grew EPS 45. 1% year-over-year, compared to 35. 6% for Predictive Oncology Inc.. Over a 3-year CAGR, SDGR leads at 12. 2% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.

Schrödinger, Inc.

(SDGR) is the more profitable company, earning -40. 4% net margin versus -751. 4% for Predictive Oncology Inc. — meaning it keeps -40. 4% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: SDGR leads at -65. 2% versus -673. 7% for POAI. At the gross margin level — before operating expenses — SDGR leads at 55. 7%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.

None of the stocks in this comparison currently pay a material dividend.

All are effectively zero-yield and should be held for capital appreciation rather than income.

For long-horizon retirement investors, Predictive Oncology Inc.

(POAI) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding. Schrödinger, Inc. (SDGR) carries a higher beta of 1. 72 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (POAI: -100. 0%, SDGR: -53. 6%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.

Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.

In terms of investment character: POAI is a small-cap quality compounder stock; SDGR is a small-cap high-growth stock. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.