Comprehensive Stock Comparison
Compare Relay Therapeutics, Inc. (RLAY) vs Exelixis, Inc. (EXEL) Stock
Analyze side-by-side fundamentals, valuation, growth, and profitability to decide which stock is the better buy.
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Quick Verdict
| Category | Winner | Why |
|---|---|---|
| Growth | RLAY | 53.4% revenue growth vs EXEL's 7.0% |
| Quality / Margins | EXEL | 29.6% net margin vs RLAY's -18.0% |
| Stability / Safety | EXEL | Beta 0.63 vs RLAY's 1.70 |
| Dividends | Tie | Neither pays a meaningful dividend |
| Momentum (1Y) | RLAY | +200.9% vs EXEL's +13.9% |
| Efficiency (ROA) | EXEL | 24.0% ROA vs RLAY's -44.5%, ROIC 32.1% vs -37.3% |
Who Each Stock Is For
Income & stability
Growth exposure
Long-term compounding (10Y)
Sleep-well-at-night portfolio
Defensive / Recession hedge
Business Model
What each company does and how it makes money
Relay Therapeutics is a clinical-stage biotech company developing precision medicines for cancer and genetic diseases using computational drug discovery. It generates revenue primarily through research collaborations and licensing deals — with no commercial products yet — while advancing its own pipeline of targeted oncology therapies. Its key competitive advantage is proprietary technology that analyzes protein motion to design more effective small molecule drugs, potentially accelerating and improving the drug discovery process.
Exelixis is an oncology-focused biotechnology company that discovers, develops, and commercializes targeted cancer therapies. It generates revenue primarily from sales of its flagship drug Cabometyx — which accounts for the vast majority of its revenue — along with royalties from partnered products like Cotellic. The company's competitive advantage lies in its deep expertise in tyrosine kinase inhibitors and its focused pipeline targeting difficult-to-treat cancers.
Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
Financial Metrics Comparison
Side-by-side fundamentals across 2 stocks. BestLagging
Financial Scorecard
EXEL leads in 3 of 6 categories (Financial Metrics, Profitability & Efficiency). RLAY leads in 1 (Valuation Metrics). 1 tied.
Financial Metrics (TTM)
EXEL is the larger business by revenue, generating $2.3B annually — 149.0x RLAY's $15M. EXEL is the more profitable business, keeping 29.6% of every revenue dollar as net income compared to RLAY's -18.0%.
| Metric | RLAYRelay Therapeutic… | EXELExelixis, Inc. |
|---|---|---|
| RevenueTrailing 12 months | $15M | $2.3B |
| EBITDAEarnings before interest/tax | -$303M | $830M |
| Net IncomeAfter-tax profit | -$276M | $678M |
| Free Cash FlowCash after capex | -$236M | $753M |
| Gross MarginGross profit ÷ Revenue | — | +96.6% |
| Operating MarginEBIT ÷ Revenue | -19.7% | +35.0% |
| Net MarginNet income ÷ Revenue | -18.0% | +29.6% |
| FCF MarginFCF ÷ Revenue | -15.4% | +32.9% |
| Rev. Growth (YoY)Latest quarter vs prior year | — | +10.8% |
| EPS Growth (YoY)Latest quarter vs prior year | +31.1% | +75.0% |
Valuation Metrics
| Metric | RLAYRelay Therapeutic… | EXELExelixis, Inc. |
|---|---|---|
| Market CapShares × price | $1.8B | $11.8B |
| Enterprise ValueMkt cap + debt − cash | $1.7B | $11.5B |
| Trailing P/EPrice ÷ TTM EPS | -6.37x | 15.85x |
| Forward P/EPrice ÷ next-FY EPS est. | — | 13.29x |
| PEG RatioP/E ÷ EPS growth rate | — | 0.31x |
| EV / EBITDAEnterprise value multiple | — | 13.19x |
| Price / SalesMarket cap ÷ Revenue | 116.18x | 5.09x |
| Price / BookPrice ÷ Book value/share | 3.10x | 5.75x |
| Price / FCFMarket cap ÷ FCF | — | 13.36x |
Profitability & Efficiency
EXEL delivers a 31.4% return on equity — every $100 of shareholder capital generates $31 in annual profit, vs $-49 for RLAY. RLAY carries lower financial leverage with a 0.06x debt-to-equity ratio, signaling a more conservative balance sheet compared to EXEL's 0.08x. On the Piotroski fundamental quality scale (0–9), EXEL scores 7/9 vs RLAY's 5/9, reflecting strong financial health.
| Metric | RLAYRelay Therapeutic… | EXELExelixis, Inc. |
|---|---|---|
| ROE (TTM)Return on equity | -48.8% | +31.4% |
| ROA (TTM)Return on assets | -44.5% | +24.0% |
| ROICReturn on invested capital | -37.3% | +32.1% |
| ROCEReturn on capital employed | -42.7% | +35.0% |
| Piotroski ScoreFundamental quality 0–9 | 5 | 7 |
| Debt / EquityFinancial leverage | 0.06x | 0.08x |
| Net DebtTotal debt minus cash | -$52M | -$309M |
| Cash & Equiv.Liquid assets | $84M | $482M |
| Total DebtShort + long-term debt | $32M | $173M |
| Interest CoverageEBIT ÷ Interest expense | — | — |
Total Returns (with DRIP)
A $10,000 investment in EXEL five years ago would be worth $19,758 today (with dividends reinvested), compared to $2,553 for RLAY. Over the past 12 months, RLAY leads with a +200.9% total return vs EXEL's +13.9%. The 3-year compound annual growth rate (CAGR) favors EXEL at 37.1% vs RLAY's -14.0% — a key indicator of consistent wealth creation.
| Metric | RLAYRelay Therapeutic… | EXELExelixis, Inc. |
|---|---|---|
| YTD ReturnYear-to-date | +25.4% | +1.1% |
| 1-Year ReturnPast 12 months | +200.9% | +13.9% |
| 3-Year ReturnCumulative with dividends | -36.5% | +158.0% |
| 5-Year ReturnCumulative with dividends | -74.5% | +97.6% |
| 10-Year ReturnCumulative with dividends | -70.7% | +1110.4% |
| CAGR (3Y)Annualised 3-year return | -14.0% | +37.1% |
Risk & Volatility
EXEL is the less volatile stock with a 0.63 beta — it tends to amplify market swings less than RLAY's 1.70 beta. A beta below 1.0 means the stock typically moves less than the S&P 500.
| Metric | RLAYRelay Therapeutic… | EXELExelixis, Inc. |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 1.70x | 0.63x |
| 52-Week HighHighest price in past year | $11.43 | $49.62 |
| 52-Week LowLowest price in past year | $1.78 | $32.38 |
| % of 52W HighCurrent price vs 52-week peak | +89.8% | +88.8% |
| RSI (14)Momentum oscillator 0–100 | 59.3 | 53.1 |
| Avg Volume (50D)Average daily shares traded | 1.9M | 2.1M |
Analyst Outlook
Wall Street rates RLAY as "Buy" and EXEL as "Buy". Consensus price targets imply 31.6% upside for RLAY (target: $14) vs 0.8% for EXEL (target: $44).
| Metric | RLAYRelay Therapeutic… | EXELExelixis, Inc. |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | Buy |
| Price TargetConsensus 12-month target | $13.50 | $44.40 |
| # AnalystsCovering analysts | 14 | 32 |
| Dividend YieldAnnual dividend ÷ price | — | — |
| Dividend StreakConsecutive years of raises | — | — |
| Dividend / ShareAnnual DPS | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | +0.1% | +8.0% |
Historical Charts
Charts are rendered on first load. Hover for details.
Chart 1Total Return — 5 Years (Rebased to 100)
| Stock | Jul 20 | Feb 26 | Change |
|---|---|---|---|
| Relay Therapeutics,… (RLAY) | 100 | 23.25 | -76.7% |
| Exelixis, Inc. (EXEL) | 100 | 180.71 | +80.7% |
Exelixis, Inc. (EXEL) returned +98% over 5 years vs Relay Therapeutics,… (RLAY)'s -74%. A $10,000 investment in EXEL 5 years ago would be worth $19,758 today (including dividends reinvested).
Chart 2Revenue Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Relay Therapeutics,… (RLAY) | $0.00 | $15M | — |
| Exelixis, Inc. (EXEL) | $191M | $2.3B | +1111.8% |
Exelixis, Inc.'s revenue grew from $191M (2016) to $2.3B (2025) — a 31.9% CAGR.
Chart 3Net Margin Trend — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Relay Therapeutics,… (RLAY) | -63.4% | -18.0% | +71.6% |
| Exelixis, Inc. (EXEL) | -36.7% | 33.7% | +192.0% |
Exelixis, Inc.'s net margin went from -37% (2016) to 34% (2025).
Chart 4P/E Ratio History — 9 Years
| Stock | 2017 | 2025 | Change |
|---|---|---|---|
| Exelixis, Inc. (EXEL) | 62 | 15.8 | -74.5% |
Exelixis, Inc. has traded in a 9x–62x P/E range over 9 years; current trailing P/E is ~16x.
Chart 5EPS Growth — 10 Years
| Stock | 2016 | 2025 | Change |
|---|---|---|---|
| Relay Therapeutics,… (RLAY) | -19.63 | -1.61 | +91.8% |
| Exelixis, Inc. (EXEL) | -0.28 | 2.78 | +1092.9% |
Exelixis, Inc.'s EPS grew from $-0.28 (2016) to $2.78 (2025).
Chart 6Free Cash Flow — 5 Years
Relay Therapeutics, Inc. generated $-236M FCF in 2025 (-203% vs 2021). Exelixis, Inc. generated $884M FCF in 2025 (+163% vs 2021).
RLAY vs EXEL: Frequently Asked Questions
8 questions · data-driven answers · updated daily
01Is RLAY or EXEL a better buy right now?
Exelixis, Inc. (EXEL) offers the better valuation at 15.8x trailing P/E (13.3x forward), making it the more compelling value choice. Analysts rate Relay Therapeutics, Inc. (RLAY) a "Buy" — based on 14 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — RLAY or EXEL?
Over the past 5 years, Exelixis, Inc. (EXEL) delivered a total return of +97.6%, compared to -74.5% for Relay Therapeutics, Inc. (RLAY). A $10,000 investment in EXEL five years ago would be worth approximately $20K today (assuming dividends reinvested). Over 10 years, the gap is even starker: EXEL returned +1110% versus RLAY's -70.7%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — RLAY or EXEL?
By beta (market sensitivity over 5 years), Exelixis, Inc. (EXEL) is the lower-risk stock at 0.63β versus Relay Therapeutics, Inc.'s 1.70β — meaning RLAY is approximately 172% more volatile than EXEL relative to the S&P 500. On balance sheet safety, Relay Therapeutics, Inc. (RLAY) carries a lower debt/equity ratio of 6% versus 8% for Exelixis, Inc. — giving it more financial flexibility in a downturn.
04Which has better profit margins — RLAY or EXEL?
Exelixis, Inc. (EXEL) is the more profitable company, earning 33.7% net margin versus -1800.6% for Relay Therapeutics, Inc. — meaning it keeps 33.7% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: EXEL leads at 37.6% versus -1971.6% for RLAY. At the gross margin level — before operating expenses — EXEL leads at 96.6%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
05Is RLAY or EXEL more undervalued right now?
Analyst consensus price targets imply the most upside for RLAY: 31.6% to $13.50.
06Which pays a better dividend — RLAY or EXEL?
None of the stocks in this comparison currently pay a material dividend. All are effectively zero-yield and should be held for capital appreciation rather than income.
07Is RLAY or EXEL better for a retirement portfolio?
For long-horizon retirement investors, Exelixis, Inc. (EXEL) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.63), +1110% 10Y return). Relay Therapeutics, Inc. (RLAY) carries a higher beta of 1.70 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (EXEL: +1110%, RLAY: -70.7%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
08What are the main differences between RLAY and EXEL?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both. In terms of investment character: RLAY is a small-cap quality compounder stock; EXEL is a mid-cap deep-value stock. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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