Drug Manufacturers - Specialty & Generic
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SISI vs DBVT vs ALKS vs AGRI
Revenue, margins, valuation, and 5-year total return — side by side.
Biotechnology
Biotechnology
Agricultural Farm Products
SISI vs DBVT vs ALKS vs AGRI — Key Financials
Market cap, revenue, margins, and valuation side-by-side.
| Company Snapshot | ||||
|---|---|---|---|---|
| Industry | Drug Manufacturers - Specialty & Generic | Biotechnology | Biotechnology | Agricultural Farm Products |
| Market Cap | $1K | $1690.08T | $5.83B | $312K |
| Revenue (TTM) | $10M | $0.00 | $1.56B | $1M |
| Net Income (TTM) | $-39M | $-168M | $153M | $-19M |
| Gross Margin | 6.9% | — | 65.4% | 38.8% |
| Operating Margin | -143.5% | — | 12.3% | -10.6% |
| Forward P/E | — | — | 24.5x | — |
| Total Debt | $30M | $22M | $70M | $1M |
| Cash & Equiv. | $366K | $194M | $1.12B | $490K |
SISI vs DBVT vs ALKS vs AGRI — Long-Term Stock Performance
Price return indexed to 100 at period start. Dividends excluded.
| Stock | Jul 21 | Mar 26 | Return |
|---|---|---|---|
| Shineco, Inc. (SISI) | 100 | 0.0 | -100.0% |
| DBV Technologies S.… (DBVT) | 100 | 40.4 | -59.6% |
| Alkermes plc (ALKS) | 100 | 116.4 | +16.4% |
| AgriFORCE Growing S… (AGRI) | 100 | 0.0 | -100.0% |
Price return only. Dividends and distributions are not included.
Quick Verdict: SISI vs DBVT vs ALKS vs AGRI
Each card shows where this stock fits in a portfolio — not just who wins on paper.
SISI is the #2 pick in this set and the best alternative if growth exposure is your priority.
- Rev growth 16.8%, EPS growth 41.1%, 3Y rev CAGR 48.0%
- 16.8% revenue growth vs DBVT's -100.0%
DBVT is the clearest fit if your priority is income & stability.
- Dividend streak 0 yrs, beta 1.26
- +100.5% vs SISI's -99.2%
ALKS carries the broadest edge in this set and is the clearest fit for long-term compounding and sleep-well-at-night.
- -12.0% 10Y total return vs DBVT's -87.1%
- Lower volatility, beta 1.00, Low D/E 3.8%, current ratio 3.55x
- Beta 1.00, current ratio 3.55x
- 9.8% margin vs AGRI's -14.4%
AGRI lags the leaders in this set but could rank higher in a more targeted comparison.
See the full category breakdown
| Category | Winner | Why |
|---|---|---|
| Growth | 16.8% revenue growth vs DBVT's -100.0% | |
| Quality / Margins | 9.8% margin vs AGRI's -14.4% | |
| Stability / Safety | Beta 1.00 vs AGRI's 2.22, lower leverage | |
| Dividends | Tie | None of these 4 stocks pay a meaningful dividend |
| Momentum (1Y) | +100.5% vs SISI's -99.2% | |
| Efficiency (ROA) | 5.4% ROA vs AGRI's -117.7%, ROIC 18.9% vs -98.0% |
SISI vs DBVT vs ALKS vs AGRI — Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
Segment breakdown not available.
SISI vs DBVT vs ALKS vs AGRI — Financial Metrics
Side-by-side numbers across 4 stocks — who leads on profitability, valuation, growth, and risk.
Who Leads Where
ALKS leads in 2 of 6 categories
SISI leads 1 • DBVT leads 0 • AGRI leads 0 • 2 tied
Explore the data ↓Income & Cash Flow (Last 12 Months)
ALKS leads this category, winning 5 of 6 comparable metrics.
Income & Cash Flow (Last 12 Months)
ALKS and DBVT operate at a comparable scale, with $1.6B and $0 in trailing revenue. ALKS is the more profitable business, keeping 9.8% of every revenue dollar as net income compared to AGRI's -14.4%. On growth, ALKS holds the edge at +28.2% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | ||||
|---|---|---|---|---|
| RevenueTrailing 12 months | $10M | $0 | $1.6B | $1M |
| EBITDAEarnings before interest/tax | -$9M | -$112M | $212M | -$13M |
| Net IncomeAfter-tax profit | -$39M | -$168M | $153M | -$19M |
| Free Cash FlowCash after capex | $2M | -$151M | $392M | -$9M |
| Gross MarginGross profit ÷ Revenue | +6.9% | — | +65.4% | +38.8% |
| Operating MarginEBIT ÷ Revenue | -143.5% | — | +12.3% | -10.6% |
| Net MarginNet income ÷ Revenue | -4.0% | — | +9.8% | -14.4% |
| FCF MarginFCF ÷ Revenue | +19.4% | — | +25.1% | -6.8% |
| Rev. Growth (YoY)Latest quarter vs prior year | -97.0% | — | +28.2% | — |
| EPS Growth (YoY)Latest quarter vs prior year | +92.0% | +91.5% | -4.1% | +12.6% |
Valuation Metrics
SISI leads this category, winning 2 of 3 comparable metrics.
Valuation Metrics
| Metric | ||||
|---|---|---|---|---|
| Market CapShares × price | $1,352 | $1690.08T | $5.8B | $311,837 |
| Enterprise ValueMkt cap + debt − cash | $29M | $1690.08T | $4.8B | $1M |
| Trailing P/EPrice ÷ TTM EPS | -0.00x | -0.75x | 24.47x | -0.02x |
| Forward P/EPrice ÷ next-FY EPS est. | — | — | — | — |
| PEG RatioP/E ÷ EPS growth rate | — | — | — | — |
| EV / EBITDAEnterprise value multiple | — | — | 17.01x | — |
| Price / SalesMarket cap ÷ Revenue | 0.00x | — | 3.95x | 4.59x |
| Price / BookPrice ÷ Book value/share | 0.00x | 0.65x | 3.25x | 0.05x |
| Price / FCFMarket cap ÷ FCF | — | — | 12.14x | — |
Profitability & Efficiency
ALKS leads this category, winning 8 of 9 comparable metrics.
Profitability & Efficiency
ALKS delivers a 8.8% return on equity — every $100 of shareholder capital generates $9 in annual profit, vs $-160 for AGRI. ALKS carries lower financial leverage with a 0.04x debt-to-equity ratio, signaling a more conservative balance sheet compared to SISI's 0.81x. On the Piotroski fundamental quality scale (0–9), ALKS scores 7/9 vs SISI's 2/9, reflecting strong financial health.
| Metric | ||||
|---|---|---|---|---|
| ROE (TTM)Return on equity | -149.3% | -130.2% | +8.8% | -159.9% |
| ROA (TTM)Return on assets | -45.5% | -89.0% | +5.4% | -117.7% |
| ROICReturn on invested capital | -21.6% | — | +18.9% | -98.0% |
| ROCEReturn on capital employed | -31.6% | -145.7% | +14.2% | -117.1% |
| Piotroski ScoreFundamental quality 0–9 | 2 | 4 | 7 | 3 |
| Debt / EquityFinancial leverage | 0.81x | 0.13x | 0.04x | 0.24x |
| Net DebtTotal debt minus cash | $29M | -$172M | -$1.0B | $995,040 |
| Cash & Equiv.Liquid assets | $366,140 | $194M | $1.1B | $489,868 |
| Total DebtShort + long-term debt | $30M | $22M | $70M | $1M |
| Interest CoverageEBIT ÷ Interest expense | -18.13x | -189.82x | 32.30x | -7.20x |
Total Returns (Dividends Reinvested)
Evenly matched — DBVT and ALKS each lead in 3 of 6 comparable metrics.
Total Returns (Dividends Reinvested)
A $10,000 investment in ALKS five years ago would be worth $16,165 today (with dividends reinvested), compared to $0 for SISI. Over the past 12 months, DBVT leads with a +100.5% total return vs SISI's -99.2%. The 3-year compound annual growth rate (CAGR) favors DBVT at 5.7% vs AGRI's -96.9% — a key indicator of consistent wealth creation.
| Metric | ||||
|---|---|---|---|---|
| YTD ReturnYear-to-date | +1.7% | +3.6% | +23.8% | -52.4% |
| 1-Year ReturnPast 12 months | -99.2% | +100.5% | +15.2% | -95.6% |
| 3-Year ReturnCumulative with dividends | -100.0% | +18.1% | +13.2% | -100.0% |
| 5-Year ReturnCumulative with dividends | -100.0% | -68.3% | +61.7% | -100.0% |
| 10-Year ReturnCumulative with dividends | -100.0% | -87.1% | -12.0% | -100.0% |
| CAGR (3Y)Annualised 3-year return | -96.4% | +5.7% | +4.2% | -96.9% |
Risk & Volatility
Evenly matched — SISI and ALKS each lead in 1 of 2 comparable metrics.
Risk & Volatility
SISI is the less volatile stock with a -0.50 beta — it tends to amplify market swings less than AGRI's 2.22 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. ALKS currently trades 95.6% from its 52-week high vs SISI's 0.7% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | ||||
|---|---|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | -0.50x | 1.26x | 1.00x | 2.22x |
| 52-Week HighHighest price in past year | $45.50 | $26.18 | $36.60 | $19.26 |
| 52-Week LowLowest price in past year | $0.00 | $7.53 | $25.17 | $0.55 |
| % of 52W HighCurrent price vs 52-week peak | +0.7% | +75.3% | +95.6% | +4.0% |
| RSI (14)Momentum oscillator 0–100 | 59.3 | 47.4 | 60.5 | 30.6 |
| Avg Volume (50D)Average daily shares traded | 200 | 252K | 2.2M | 443K |
Analyst Outlook
Insufficient data to determine a leader in this category.
Analyst Outlook
Analyst consensus: DBVT as "Buy", ALKS as "Buy", AGRI as "Buy". Consensus price targets imply 134.8% upside for DBVT (target: $46) vs 31.5% for ALKS (target: $46).
| Metric | ||||
|---|---|---|---|---|
| Analyst RatingConsensus buy/hold/sell | — | Buy | Buy | Buy |
| Price TargetConsensus 12-month target | — | $46.33 | $46.00 | — |
| # AnalystsCovering analysts | — | 15 | 28 | 2 |
| Dividend YieldAnnual dividend ÷ price | — | — | — | — |
| Dividend StreakConsecutive years of raises | — | 0 | 0 | — |
| Dividend / ShareAnnual DPS | — | — | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | 0.0% | +0.5% | 0.0% |
ALKS leads in 2 of 6 categories (Income & Cash Flow, Profitability & Efficiency). SISI leads in 1 (Valuation Metrics). 2 tied.
SISI vs DBVT vs ALKS vs AGRI: Key Questions Answered
8 questions · data-driven answers · updated daily
01Is SISI or DBVT or ALKS or AGRI a better buy right now?
For growth investors, Shineco, Inc.
(SISI) is the stronger pick with 1681% revenue growth year-over-year, versus -5. 2% for Alkermes plc (ALKS). Alkermes plc (ALKS) offers the better valuation at 24. 5x trailing P/E, making it the more compelling value choice. Analysts rate DBV Technologies S. A. (DBVT) a "Buy" — based on 15 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — SISI or DBVT or ALKS or AGRI?
Over the past 5 years, Alkermes plc (ALKS) delivered a total return of +61.
7%, compared to -100. 0% for Shineco, Inc. (SISI). Over 10 years, the gap is even starker: ALKS returned -12. 0% versus SISI's -100. 0%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — SISI or DBVT or ALKS or AGRI?
By beta (market sensitivity over 5 years), Shineco, Inc.
(SISI) is the lower-risk stock at -0. 50β versus AgriFORCE Growing Systems Ltd. 's 2. 22β — meaning AGRI is approximately -548% more volatile than SISI relative to the S&P 500. On balance sheet safety, Alkermes plc (ALKS) carries a lower debt/equity ratio of 4% versus 81% for Shineco, Inc. — giving it more financial flexibility in a downturn.
04Which is growing faster — SISI or DBVT or ALKS or AGRI?
By revenue growth (latest reported year), Shineco, Inc.
(SISI) is pulling ahead at 1681% versus -5. 2% for Alkermes plc (ALKS). On earnings-per-share growth, the picture is similar: AgriFORCE Growing Systems Ltd. grew EPS 96. 0% year-over-year, compared to -347. 5% for DBV Technologies S. A.. Over a 3-year CAGR, SISI leads at 48. 0% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.
05Which has better profit margins — SISI or DBVT or ALKS or AGRI?
Alkermes plc (ALKS) is the more profitable company, earning 16.
4% net margin versus -239. 7% for AgriFORCE Growing Systems Ltd. — meaning it keeps 16. 4% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: ALKS leads at 17. 2% versus -153. 2% for AGRI. At the gross margin level — before operating expenses — ALKS leads at 86. 7%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
06Which pays a better dividend — SISI or DBVT or ALKS or AGRI?
None of the stocks in this comparison currently pay a material dividend.
All are effectively zero-yield and should be held for capital appreciation rather than income.
07Is SISI or DBVT or ALKS or AGRI better for a retirement portfolio?
For long-horizon retirement investors, Shineco, Inc.
(SISI) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β -0. 50)). AgriFORCE Growing Systems Ltd. (AGRI) carries a higher beta of 2. 22 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (SISI: -100. 0%, AGRI: -100. 0%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
08What are the main differences between SISI and DBVT and ALKS and AGRI?
These companies operate in different sectors (SISI (Healthcare) and DBVT (Healthcare) and ALKS (Healthcare) and AGRI (Consumer Defensive)), which means they face different economic cycles, regulatory environments, and macro sensitivities — making direct comparison nuanced.
In terms of investment character: SISI is a small-cap high-growth stock; DBVT is a mega-cap quality compounder stock; ALKS is a small-cap quality compounder stock; AGRI is a small-cap high-growth stock. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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