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SYRA vs TALK vs OPRX vs ACMR vs DOCS

Revenue, margins, valuation, and 5-year total return — side by side.

Live fundamentals10-year financials5-year price chart
SYRA
Syra Health Corp. Class A Common Stock

Medical - Care Facilities

HealthcareNASDAQ • US
Market Cap$6M
5Y Perf.-83.3%
TALK
Talkspace, Inc.

Medical - Care Facilities

HealthcareNASDAQ • US
Market Cap$868M
5Y Perf.+165.6%
OPRX
OptimizeRx Corporation

Medical - Healthcare Information Services

HealthcareNASDAQ • US
Market Cap$124M
5Y Perf.-14.8%
ACMR
ACM Research, Inc.

Semiconductors

TechnologyNASDAQ • US
Market Cap$3.92B
5Y Perf.+227.0%
DOCS
Doximity, Inc.

Medical - Healthcare Information Services

HealthcareNYSE • US
Market Cap$5.24B
5Y Perf.+22.7%

SYRA vs TALK vs OPRX vs ACMR vs DOCS — Key Financials

Market cap, revenue, margins, and valuation side-by-side.

Company Snapshot
SYRA logoSYRA
TALK logoTALK
OPRX logoOPRX
ACMR logoACMR
DOCS logoDOCS
IndustryMedical - Care FacilitiesMedical - Care FacilitiesMedical - Healthcare Information ServicesSemiconductorsMedical - Healthcare Information Services
Market Cap$6M$868M$124M$3.92B$5.24B
Revenue (TTM)$8M$229M$109M$901M$638M
Net Income (TTM)$-183K$8M$5M$94M$239M
Gross Margin33.2%43.0%67.3%44.4%89.7%
Operating Margin-3.1%1.4%10.7%12.1%37.4%
Forward P/E38.2x7.0x29.7x16.8x
Total Debt$144K$0.00$5M$303M$12M
Cash & Equiv.$2M$37M$23M$766M$210M

SYRA vs TALK vs OPRX vs ACMR vs DOCSLong-Term Stock Performance

Price return indexed to 100 at period start. Dividends excluded.

SYRA
TALK
OPRX
ACMR
DOCS
StockSep 23May 26Return
Syra Health Corp. C… (SYRA)10016.7-83.3%
Talkspace, Inc. (TALK)100265.6+165.6%
OptimizeRx Corporat… (OPRX)10085.2-14.8%
ACM Research, Inc. (ACMR)100327.0+227.0%
Doximity, Inc. (DOCS)100122.7+22.7%

Price return only. Dividends and distributions are not included.

Quick Verdict: SYRA vs TALK vs OPRX vs ACMR vs DOCS

Each card shows where this stock fits in a portfolio — not just who wins on paper.

Bottom line: SYRA and DOCS are tied at the top with 2 categories each (5-stock set) — the right choice depends on your priorities. Doximity, Inc. is the stronger pick specifically for profitability and margin quality and operational efficiency and capital deployment. TALK, OPRX, and ACMR also each lead in at least one category. This set spans 2 sectors — these stocks serve different portfolio roles, not just different price points.
SYRA
Syra Health Corp. Class A Common Stock
The Defensive Pick

SYRA has the current edge in this matchup, primarily because of its strength in defensive.

  • Beta 0.19, current ratio 4.06x
  • Beta 0.19 vs ACMR's 3.24, lower leverage
  • +5.2% vs DOCS's -55.4%
Best for: defensive
TALK
Talkspace, Inc.
The Growth Play

TALK ranks third and is worth considering specifically for growth exposure.

  • Rev growth 22.0%, EPS growth 6.5%, 3Y rev CAGR 24.2%
  • 22.0% revenue growth vs SYRA's -9.5%
Best for: growth exposure
OPRX
OptimizeRx Corporation
The Value Play

OPRX is the clearest fit if your priority is value.

  • Lower P/E (7.0x vs 29.7x)
Best for: value
ACMR
ACM Research, Inc.
The Income Pick

ACMR is the clearest fit if your priority is income & stability and long-term compounding.

  • Dividend streak 3 yrs, beta 3.24, yield 0.2%
  • 30.7% 10Y total return vs TALK's -48.7%
  • 0.2% yield; 3-year raise streak; the other 4 pay no meaningful dividend
Best for: income & stability and long-term compounding
DOCS
Doximity, Inc.
The Defensive Pick

DOCS is the #2 pick in this set and the best alternative if sleep-well-at-night and valuation efficiency is your priority.

  • Lower volatility, beta 1.03, Low D/E 1.1%, current ratio 6.97x
  • PEG 0.21 vs ACMR's 0.84
  • 37.5% margin vs SYRA's -2.4%
  • 20.7% ROA vs SYRA's -5.4%, ROIC 20.0% vs -86.8%
Best for: sleep-well-at-night and valuation efficiency
See the full category breakdown
CategoryWinnerWhy
GrowthTALK logoTALK22.0% revenue growth vs SYRA's -9.5%
ValueOPRX logoOPRXLower P/E (7.0x vs 29.7x)
Quality / MarginsDOCS logoDOCS37.5% margin vs SYRA's -2.4%
Stability / SafetySYRA logoSYRABeta 0.19 vs ACMR's 3.24, lower leverage
DividendsACMR logoACMR0.2% yield; 3-year raise streak; the other 4 pay no meaningful dividend
Momentum (1Y)SYRA logoSYRA+5.2% vs DOCS's -55.4%
Efficiency (ROA)DOCS logoDOCS20.7% ROA vs SYRA's -5.4%, ROIC 20.0% vs -86.8%

SYRA vs TALK vs OPRX vs ACMR vs DOCS — Revenue Breakdown by Segment

How each company's revenue is distributed across its business units

SYRASyra Health Corp. Class A Common Stock
FY 2025
Population Health
100.0%$5M
TALKTalkspace, Inc.

Segment breakdown not available.

OPRXOptimizeRx Corporation

Segment breakdown not available.

ACMRACM Research, Inc.
FY 2025
Total Single Wafer and Semi-Critical Cleaning Equipment
69.5%$626M
ECP Front End And Packaging Furnace And Other Technologies
22.1%$200M
Advanced Packaging (exclude ECP), Services & Spares
8.4%$76M
DOCSDoximity, Inc.
FY 2025
Subscription
95.3%$544M
Service, Other
4.7%$27M

SYRA vs TALK vs OPRX vs ACMR vs DOCS — Financial Metrics

Side-by-side numbers across 5 stocks — who leads on profitability, valuation, growth, and risk.

BEST OVERALLDOCSLAGGINGTALK

Income & Cash Flow (Last 12 Months)

DOCS leads this category, winning 4 of 6 comparable metrics.

ACMR is the larger business by revenue, generating $901M annually — 117.9x SYRA's $8M. DOCS is the more profitable business, keeping 37.5% of every revenue dollar as net income compared to SYRA's -2.4%. On growth, TALK holds the edge at +29.3% YoY revenue growth, suggesting stronger near-term business momentum.

MetricSYRA logoSYRASyra Health Corp.…TALK logoTALKTalkspace, Inc.OPRX logoOPRXOptimizeRx Corpor…ACMR logoACMRACM Research, Inc.DOCS logoDOCSDoximity, Inc.
RevenueTrailing 12 months$8M$229M$109M$901M$638M
EBITDAEarnings before interest/tax-$227,636$7M$16M$126M$250M
Net IncomeAfter-tax profit-$183,089$8M$5M$94M$239M
Free Cash FlowCash after capex$755,858-$2M$12M-$69M$314M
Gross MarginGross profit ÷ Revenue+33.2%+43.0%+67.3%+44.4%+89.7%
Operating MarginEBIT ÷ Revenue-3.1%+1.4%+10.7%+12.1%+37.4%
Net MarginNet income ÷ Revenue-2.4%+3.4%+4.7%+10.4%+37.5%
FCF MarginFCF ÷ Revenue+9.9%-0.9%+10.6%-7.6%+49.2%
Rev. Growth (YoY)Latest quarter vs prior year+22.4%+29.3%-0.2%+9.4%+9.8%
EPS Growth (YoY)Latest quarter vs prior year+130.8%-76.1%-16.2%
DOCS leads this category, winning 4 of 6 comparable metrics.

Valuation Metrics

OPRX leads this category, winning 4 of 7 comparable metrics.

At 23.5x trailing earnings, DOCS trades at a 82% valuation discount to TALK's 129.5x P/E. Adjusting for growth (PEG ratio), DOCS offers better value at 0.30x vs ACMR's 1.22x — a lower PEG means you pay less per unit of expected earnings growth.

MetricSYRA logoSYRASyra Health Corp.…TALK logoTALKTalkspace, Inc.OPRX logoOPRXOptimizeRx Corpor…ACMR logoACMRACM Research, Inc.DOCS logoDOCSDoximity, Inc.
Market CapShares × price$6M$868M$124M$3.9B$5.2B
Enterprise ValueMkt cap + debt − cash$4M$830M$105M$3.5B$5.0B
Trailing P/EPrice ÷ TTM EPS-6.62x129.50x24.56x43.21x23.45x
Forward P/EPrice ÷ next-FY EPS est.38.20x7.04x29.68x16.83x
PEG RatioP/E ÷ EPS growth rate1.22x0.30x
EV / EBITDAEnterprise value multiple137.77x6.55x27.49x21.14x
Price / SalesMarket cap ÷ Revenue0.79x3.79x1.13x4.35x9.18x
Price / BookPrice ÷ Book value/share2.83x7.69x0.98x2.06x4.84x
Price / FCFMarket cap ÷ FCF6.62x19.64x
OPRX leads this category, winning 4 of 7 comparable metrics.

Profitability & Efficiency

DOCS leads this category, winning 6 of 9 comparable metrics.

DOCS delivers a 24.4% return on equity — every $100 of shareholder capital generates $24 in annual profit, vs $-8 for SYRA. DOCS carries lower financial leverage with a 0.01x debt-to-equity ratio, signaling a more conservative balance sheet compared to ACMR's 0.16x. On the Piotroski fundamental quality scale (0–9), DOCS scores 9/9 vs ACMR's 2/9, reflecting strong financial health.

MetricSYRA logoSYRASyra Health Corp.…TALK logoTALKTalkspace, Inc.OPRX logoOPRXOptimizeRx Corpor…ACMR logoACMRACM Research, Inc.DOCS logoDOCSDoximity, Inc.
ROE (TTM)Return on equity-8.1%+6.9%+4.2%+6.1%+24.4%
ROA (TTM)Return on assets-5.4%+5.9%+3.0%+3.9%+20.7%
ROICReturn on invested capital-86.8%+3.9%+7.1%+7.0%+20.0%
ROCEReturn on capital employed-35.0%+2.7%+7.6%+6.6%+22.3%
Piotroski ScoreFundamental quality 0–956829
Debt / EquityFinancial leverage0.07x0.04x0.16x0.01x
Net DebtTotal debt minus cash-$1M-$37M-$19M-$463M-$197M
Cash & Equiv.Liquid assets$2M$37M$23M$766M$210M
Total DebtShort + long-term debt$143,787$0$5M$303M$12M
Interest CoverageEBIT ÷ Interest expense-55.59x1.26x20.44x
DOCS leads this category, winning 6 of 9 comparable metrics.

Total Returns (Dividends Reinvested)

Evenly matched — SYRA and TALK and ACMR each lead in 2 of 6 comparable metrics.

A $10,000 investment in ACMR five years ago would be worth $23,344 today (with dividends reinvested), compared to $1,266 for OPRX. Over the past 12 months, SYRA leads with a +517.7% total return vs DOCS's -55.4%. The 3-year compound annual growth rate (CAGR) favors TALK at 80.7% vs SYRA's -45.0% — a key indicator of consistent wealth creation.

MetricSYRA logoSYRASyra Health Corp.…TALK logoTALKTalkspace, Inc.OPRX logoOPRXOptimizeRx Corpor…ACMR logoACMRACM Research, Inc.DOCS logoDOCSDoximity, Inc.
YTD ReturnYear-to-date+475.1%+47.6%-46.6%+31.9%-39.9%
1-Year ReturnPast 12 months+517.7%+70.4%-30.1%+195.6%-55.4%
3-Year ReturnCumulative with dividends-83.3%+490.0%-54.4%+487.9%-24.2%
5-Year ReturnCumulative with dividends-83.3%-47.7%-87.3%+133.4%-50.9%
10-Year ReturnCumulative with dividends-83.3%-48.7%+110.5%+3065.8%-50.9%
CAGR (3Y)Annualised 3-year return-45.0%+80.7%-23.0%+80.5%-8.8%
Evenly matched — SYRA and TALK and ACMR each lead in 2 of 6 comparable metrics.

Risk & Volatility

Evenly matched — SYRA and TALK each lead in 1 of 2 comparable metrics.

SYRA is the less volatile stock with a 0.19 beta — it tends to amplify market swings less than ACMR's 3.24 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. TALK currently trades 99.6% from its 52-week high vs OPRX's 29.8% drawdown — a narrower gap to the peak suggests stronger recent price momentum.

MetricSYRA logoSYRASyra Health Corp.…TALK logoTALKTalkspace, Inc.OPRX logoOPRXOptimizeRx Corpor…ACMR logoACMRACM Research, Inc.DOCS logoDOCSDoximity, Inc.
Beta (5Y)Sensitivity to S&P 5000.19x0.86x2.28x3.24x1.03x
52-Week HighHighest price in past year$0.70$5.20$22.25$71.65$76.51
52-Week LowLowest price in past year$0.05$2.22$5.54$19.26$20.55
% of 52W HighCurrent price vs 52-week peak+71.5%+99.6%+29.8%+82.6%+34.0%
RSI (14)Momentum oscillator 0–10055.662.746.960.760.1
Avg Volume (50D)Average daily shares traded47K4.5M476K1.2M2.7M
Evenly matched — SYRA and TALK each lead in 1 of 2 comparable metrics.

Analyst Outlook

ACMR leads this category, winning 1 of 1 comparable metric.

Analyst consensus: TALK as "Hold", OPRX as "Buy", ACMR as "Buy", DOCS as "Buy". Consensus price targets imply 156.4% upside for OPRX (target: $17) vs -32.4% for ACMR (target: $40). ACMR is the only dividend payer here at 0.19% yield — a key consideration for income-focused portfolios.

MetricSYRA logoSYRASyra Health Corp.…TALK logoTALKTalkspace, Inc.OPRX logoOPRXOptimizeRx Corpor…ACMR logoACMRACM Research, Inc.DOCS logoDOCSDoximity, Inc.
Analyst RatingConsensus buy/hold/sellHoldBuyBuyBuy
Price TargetConsensus 12-month target$5.25$17.00$40.00$42.79
# AnalystsCovering analysts10151022
Dividend YieldAnnual dividend ÷ price+0.2%
Dividend StreakConsecutive years of raises13
Dividend / ShareAnnual DPS$0.11
Buyback YieldShare repurchases ÷ mkt cap0.0%+2.0%0.0%+0.2%+2.3%
ACMR leads this category, winning 1 of 1 comparable metric.
Key Takeaway

DOCS leads in 2 of 6 categories (Income & Cash Flow, Profitability & Efficiency). OPRX leads in 1 (Valuation Metrics). 2 tied.

Best OverallDoximity, Inc. (DOCS)Leads 2 of 6 categories
Loading custom metrics...

SYRA vs TALK vs OPRX vs ACMR vs DOCS: Key Questions Answered

10 questions · data-driven answers · updated daily

01

Is SYRA or TALK or OPRX or ACMR or DOCS a better buy right now?

For growth investors, Talkspace, Inc.

(TALK) is the stronger pick with 22. 0% revenue growth year-over-year, versus -9. 5% for Syra Health Corp. Class A Common Stock (SYRA). Doximity, Inc. (DOCS) offers the better valuation at 23. 5x trailing P/E (16. 8x forward), making it the more compelling value choice. Analysts rate OptimizeRx Corporation (OPRX) a "Buy" — based on 15 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.

02

Which has the better valuation — SYRA or TALK or OPRX or ACMR or DOCS?

On trailing P/E, Doximity, Inc.

(DOCS) is the cheapest at 23. 5x versus Talkspace, Inc. at 129. 5x. On forward P/E, OptimizeRx Corporation is actually cheaper at 7. 0x — notably different from the trailing picture, reflecting expected earnings growth. The PEG ratio (P/E divided by earnings growth rate) is the most growth-adjusted single valuation metric: Doximity, Inc. wins at 0. 21x versus ACM Research, Inc. 's 0. 84x — a PEG below 1. 0 traditionally signals the market is underpricing earnings growth.

03

Which is the better long-term investment — SYRA or TALK or OPRX or ACMR or DOCS?

Over the past 5 years, ACM Research, Inc.

(ACMR) delivered a total return of +133. 4%, compared to -87. 3% for OptimizeRx Corporation (OPRX). Over 10 years, the gap is even starker: ACMR returned +30. 7% versus SYRA's -83. 3%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.

04

Which is safer — SYRA or TALK or OPRX or ACMR or DOCS?

By beta (market sensitivity over 5 years), Syra Health Corp.

Class A Common Stock (SYRA) is the lower-risk stock at 0. 19β versus ACM Research, Inc. 's 3. 24β — meaning ACMR is approximately 1633% more volatile than SYRA relative to the S&P 500. On balance sheet safety, Doximity, Inc. (DOCS) carries a lower debt/equity ratio of 1% versus 16% for ACM Research, Inc. — giving it more financial flexibility in a downturn.

05

Which is growing faster — SYRA or TALK or OPRX or ACMR or DOCS?

By revenue growth (latest reported year), Talkspace, Inc.

(TALK) is pulling ahead at 22. 0% versus -9. 5% for Syra Health Corp. Class A Common Stock (SYRA). On earnings-per-share growth, the picture is similar: OptimizeRx Corporation grew EPS 124. 5% year-over-year, compared to -10. 5% for ACM Research, Inc.. Over a 3-year CAGR, ACMR leads at 32. 3% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.

06

Which has better profit margins — SYRA or TALK or OPRX or ACMR or DOCS?

Doximity, Inc.

(DOCS) is the more profitable company, earning 39. 1% net margin versus -12. 4% for Syra Health Corp. Class A Common Stock — meaning it keeps 39. 1% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: DOCS leads at 39. 9% versus -12. 5% for SYRA. At the gross margin level — before operating expenses — DOCS leads at 90. 2%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.

07

Is SYRA or TALK or OPRX or ACMR or DOCS more undervalued right now?

The PEG ratio (forward P/E divided by expected earnings growth rate) is the most precise measure of undervaluation relative to growth potential.

By this metric, Doximity, Inc. (DOCS) is the more undervalued stock at a PEG of 0. 21x versus ACM Research, Inc. 's 0. 84x. A PEG below 1. 0 is traditionally considered the threshold for growth-adjusted undervaluation. On forward earnings alone, OptimizeRx Corporation (OPRX) trades at 7. 0x forward P/E versus 38. 2x for Talkspace, Inc. — 31. 2x cheaper on a one-year earnings basis. Analyst consensus price targets imply the most upside for OPRX: 156. 4% to $17. 00.

08

Which pays a better dividend — SYRA or TALK or OPRX or ACMR or DOCS?

In this comparison, ACMR (0.

2% yield) pays a dividend. SYRA, TALK, OPRX, DOCS do not pay a meaningful dividend and should not be held primarily for income.

09

Is SYRA or TALK or OPRX or ACMR or DOCS better for a retirement portfolio?

For long-horizon retirement investors, Syra Health Corp.

Class A Common Stock (SYRA) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0. 19)). ACM Research, Inc. (ACMR) carries a higher beta of 3. 24 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (SYRA: -83. 3%, ACMR: +30. 7%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.

10

What are the main differences between SYRA and TALK and OPRX and ACMR and DOCS?

These companies operate in different sectors (SYRA (Healthcare) and TALK (Healthcare) and OPRX (Healthcare) and ACMR (Technology) and DOCS (Healthcare)), which means they face different economic cycles, regulatory environments, and macro sensitivities — making direct comparison nuanced.

In terms of investment character: SYRA is a small-cap quality compounder stock; TALK is a small-cap high-growth stock; OPRX is a small-cap high-growth stock; ACMR is a small-cap high-growth stock; DOCS is a small-cap high-growth stock. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.

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Quality Mega-Cap Compounder

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