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VTVT vs NRXP vs SAVA vs INMB
Revenue, margins, valuation, and 5-year total return — side by side.
Biotechnology
Biotechnology
Biotechnology
VTVT vs NRXP vs SAVA vs INMB — Key Financials
Market cap, revenue, margins, and valuation side-by-side.
| Company Snapshot | ||||
|---|---|---|---|---|
| Industry | Biotechnology | Biotechnology | Biotechnology | Biotechnology |
| Market Cap | $261M | $85M | $94M | $38M |
| Revenue (TTM) | $-24K | $242K | $0.00 | $0.00 |
| Net Income (TTM) | $-27M | $-38M | $-106M | $-42M |
| Gross Margin | — | 59.5% | — | 100.0% |
| Operating Margin | — | -63.0% | — | -617.4% |
| Total Debt | $0.00 | $631K | $0.00 | $1M |
| Cash & Equiv. | $89M | $8M | $129M | $25M |
VTVT vs NRXP vs SAVA vs INMB — Long-Term Stock Performance
Price return indexed to 100 at period start. Dividends excluded.
| Stock | May 20 | May 26 | Return |
|---|---|---|---|
| vTv Therapeutics In… (VTVT) | 100 | 26.9 | -73.1% |
| NRx Pharmaceuticals… (NRXP) | 100 | 2.8 | -97.2% |
| Cassava Sciences, I… (SAVA) | 100 | 745.8 | +645.8% |
| INmune Bio, Inc. (INMB) | 100 | 25.1 | -74.9% |
Price return only. Dividends and distributions are not included.
Quick Verdict: VTVT vs NRXP vs SAVA vs INMB
Each card shows where this stock fits in a portfolio — not just who wins on paper.
VTVT carries the broadest edge in this set and is the clearest fit for income & stability and sleep-well-at-night.
- beta 0.81
- Lower volatility, beta 0.81, current ratio 13.54x
- Beta 0.81, current ratio 13.54x
- Beta 0.81 vs INMB's 2.45
NRXP is the #2 pick in this set and the best alternative if momentum is your priority.
- +55.3% vs INMB's -80.0%
SAVA is the clearest fit if your priority is long-term compounding.
- -19.5% 10Y total return vs INMB's -82.1%
- 5.4% margin vs INMB's -918.7%
INMB is the clearest fit if your priority is growth exposure.
- Rev growth 257.1%, EPS growth 11.8%, 3Y rev CAGR -48.9%
- 257.1% revenue growth vs SAVA's -5.4%
See the full category breakdown
| Category | Winner | Why |
|---|---|---|
| Growth | 257.1% revenue growth vs SAVA's -5.4% | |
| Quality / Margins | 5.4% margin vs INMB's -918.7% | |
| Stability / Safety | Beta 0.81 vs INMB's 2.45 | |
| Dividends | Tie | None of these 4 stocks pay a meaningful dividend |
| Momentum (1Y) | +55.3% vs INMB's -80.0% | |
| Efficiency (ROA) | -43.5% ROA vs NRXP's -489.9% |
VTVT vs NRXP vs SAVA vs INMB — Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
Segment breakdown not available.
VTVT vs NRXP vs SAVA vs INMB — Financial Metrics
Side-by-side numbers across 4 stocks — who leads on profitability, valuation, growth, and risk.
Who Leads Where
NRXP leads in 1 of 6 categories
VTVT leads 1 • SAVA leads 0 • INMB leads 0 • 3 tied
Explore the data ↓Income & Cash Flow (Last 12 Months)
NRXP leads this category, winning 3 of 6 comparable metrics.
Income & Cash Flow (Last 12 Months)
NRXP and VTVT operate at a comparable scale, with $242,000 and -$24,000 in trailing revenue. NRXP is the more profitable business, keeping -157.3% of every revenue dollar as net income compared to INMB's -918.7%. On growth, INMB holds the edge at -100.0% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | ||||
|---|---|---|---|---|
| RevenueTrailing 12 months | -$24,000 | $242,000 | $0 | $0 |
| EBITDAEarnings before interest/tax | -$33M | -$31M | -$110M | -$27M |
| Net IncomeAfter-tax profit | -$27M | -$38M | -$106M | -$42M |
| Free Cash FlowCash after capex | -$25M | -$12M | -$84M | -$21M |
| Gross MarginGross profit ÷ Revenue | — | +59.5% | — | +100.0% |
| Operating MarginEBIT ÷ Revenue | — | -63.0% | — | -617.4% |
| Net MarginNet income ÷ Revenue | — | -157.3% | — | -918.7% |
| FCF MarginFCF ÷ Revenue | — | -49.0% | — | -472.5% |
| Rev. Growth (YoY)Latest quarter vs prior year | -2.4% | — | — | -100.0% |
| EPS Growth (YoY)Latest quarter vs prior year | +7.9% | -80.0% | +62.1% | +53.5% |
Valuation Metrics
Evenly matched — VTVT and NRXP and SAVA each lead in 1 of 3 comparable metrics.
Valuation Metrics
| Metric | ||||
|---|---|---|---|---|
| Market CapShares × price | $261M | $85M | $94M | $38M |
| Enterprise ValueMkt cap + debt − cash | $173M | $78M | -$34M | $14M |
| Trailing P/EPrice ÷ TTM EPS | -9.70x | -2.28x | -3.76x | -0.77x |
| Forward P/EPrice ÷ next-FY EPS est. | — | — | — | — |
| PEG RatioP/E ÷ EPS growth rate | — | — | — | — |
| EV / EBITDAEnterprise value multiple | — | — | — | — |
| Price / SalesMarket cap ÷ Revenue | — | 69.15x | — | 760.34x |
| Price / BookPrice ÷ Book value/share | 4.06x | — | 0.63x | 1.62x |
| Price / FCFMarket cap ÷ FCF | — | — | — | — |
Profitability & Efficiency
VTVT leads this category, winning 4 of 8 comparable metrics.
Profitability & Efficiency
VTVT delivers a -73.8% return on equity — every $100 of shareholder capital generates $-74 in annual profit, vs $-171 for INMB. On the Piotroski fundamental quality scale (0–9), NRXP scores 5/9 vs SAVA's 2/9, reflecting solid financial health.
| Metric | ||||
|---|---|---|---|---|
| ROE (TTM)Return on equity | -73.8% | — | -95.8% | -170.9% |
| ROA (TTM)Return on assets | -43.5% | -4.9% | -75.3% | -128.8% |
| ROICReturn on invested capital | — | — | -6.3% | -4.1% |
| ROCEReturn on capital employed | -56.4% | — | -99.9% | -109.7% |
| Piotroski ScoreFundamental quality 0–9 | 3 | 5 | 2 | 3 |
| Debt / EquityFinancial leverage | — | — | — | 0.04x |
| Net DebtTotal debt minus cash | -$89M | -$7M | -$129M | -$24M |
| Cash & Equiv.Liquid assets | $89M | $8M | $129M | $25M |
| Total DebtShort + long-term debt | $0 | $631,000 | $0 | $1M |
| Interest CoverageEBIT ÷ Interest expense | -5408.17x | -24.18x | — | — |
Total Returns (Dividends Reinvested)
Evenly matched — VTVT and NRXP and SAVA each lead in 2 of 6 comparable metrics.
Total Returns (Dividends Reinvested)
A $10,000 investment in SAVA five years ago would be worth $3,302 today (with dividends reinvested), compared to $92 for NRXP. Over the past 12 months, NRXP leads with a +55.3% total return vs INMB's -80.0%. The 3-year compound annual growth rate (CAGR) favors VTVT at -0.2% vs INMB's -44.5% — a key indicator of consistent wealth creation.
| Metric | ||||
|---|---|---|---|---|
| YTD ReturnYear-to-date | -21.6% | +16.8% | -6.5% | -7.1% |
| 1-Year ReturnPast 12 months | +52.5% | +55.3% | +25.3% | -80.0% |
| 3-Year ReturnCumulative with dividends | -0.5% | -50.6% | -40.8% | -82.9% |
| 5-Year ReturnCumulative with dividends | -68.6% | -99.1% | -67.0% | -86.6% |
| 10-Year ReturnCumulative with dividends | -87.0% | -96.8% | -19.5% | -82.1% |
| CAGR (3Y)Annualised 3-year return | -0.2% | -21.0% | -16.0% | -44.5% |
Risk & Volatility
Evenly matched — VTVT and NRXP each lead in 1 of 2 comparable metrics.
Risk & Volatility
VTVT is the less volatile stock with a 0.81 beta — it tends to amplify market swings less than INMB's 2.45 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. NRXP currently trades 79.7% from its 52-week high vs INMB's 12.3% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | ||||
|---|---|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 0.81x | 1.91x | 2.02x | 2.45x |
| 52-Week HighHighest price in past year | $44.00 | $3.84 | $4.98 | $11.64 |
| 52-Week LowLowest price in past year | $14.00 | $1.62 | $1.51 | $1.09 |
| % of 52W HighCurrent price vs 52-week peak | +70.5% | +79.7% | +39.3% | +12.3% |
| RSI (14)Momentum oscillator 0–100 | 41.1 | 64.7 | 46.8 | 59.2 |
| Avg Volume (50D)Average daily shares traded | 61K | 913K | 712K | 384K |
Analyst Outlook
Insufficient data to determine a leader in this category.
Analyst Outlook
Analyst consensus: VTVT as "Buy", SAVA as "Buy".
| Metric | ||||
|---|---|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | — | Buy | — |
| Price TargetConsensus 12-month target | $51.33 | — | — | — |
| # AnalystsCovering analysts | 14 | — | 12 | — |
| Dividend YieldAnnual dividend ÷ price | — | — | — | — |
| Dividend StreakConsecutive years of raises | — | — | 1 | — |
| Dividend / ShareAnnual DPS | — | — | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | 0.0% | 0.0% | 0.0% |
NRXP leads in 1 of 6 categories (Income & Cash Flow). VTVT leads in 1 (Profitability & Efficiency). 3 tied.
VTVT vs NRXP vs SAVA vs INMB: Key Questions Answered
8 questions · data-driven answers · updated daily
01Is VTVT or NRXP or SAVA or INMB a better buy right now?
For growth investors, INmune Bio, Inc.
(INMB) is the stronger pick with 257. 1% revenue growth year-over-year, versus -100. 0% for vTv Therapeutics Inc. (VTVT). Analysts rate vTv Therapeutics Inc. (VTVT) a "Buy" — based on 14 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — VTVT or NRXP or SAVA or INMB?
Over the past 5 years, Cassava Sciences, Inc.
(SAVA) delivered a total return of -67. 0%, compared to -99. 1% for NRx Pharmaceuticals, Inc. (NRXP). Over 10 years, the gap is even starker: SAVA returned -19. 5% versus NRXP's -96. 8%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — VTVT or NRXP or SAVA or INMB?
By beta (market sensitivity over 5 years), vTv Therapeutics Inc.
(VTVT) is the lower-risk stock at 0. 81β versus INmune Bio, Inc. 's 2. 45β — meaning INMB is approximately 204% more volatile than VTVT relative to the S&P 500.
04Which is growing faster — VTVT or NRXP or SAVA or INMB?
By revenue growth (latest reported year), INmune Bio, Inc.
(INMB) is pulling ahead at 257. 1% versus -100. 0% for vTv Therapeutics Inc. (VTVT). On earnings-per-share growth, the picture is similar: Cassava Sciences, Inc. grew EPS 77. 6% year-over-year, compared to 0. 0% for vTv Therapeutics Inc.. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.
05Which has better profit margins — VTVT or NRXP or SAVA or INMB?
vTv Therapeutics Inc.
(VTVT) is the more profitable company, earning 0. 0% net margin versus -918. 7% for INmune Bio, Inc. — meaning it keeps 0. 0% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: VTVT leads at 0. 0% versus -617. 4% for INMB. At the gross margin level — before operating expenses — INMB leads at 100. 0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
06Which pays a better dividend — VTVT or NRXP or SAVA or INMB?
None of the stocks in this comparison currently pay a material dividend.
All are effectively zero-yield and should be held for capital appreciation rather than income.
07Is VTVT or NRXP or SAVA or INMB better for a retirement portfolio?
For long-horizon retirement investors, vTv Therapeutics Inc.
(VTVT) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0. 81)). INmune Bio, Inc. (INMB) carries a higher beta of 2. 45 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (VTVT: -87. 0%, INMB: -82. 1%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
08What are the main differences between VTVT and NRXP and SAVA and INMB?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.
In terms of investment character: VTVT is a small-cap quality compounder stock; NRXP is a small-cap quality compounder stock; SAVA is a small-cap quality compounder stock; INMB is a small-cap high-growth stock. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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