Last 48 quarters of trend data · Healthcare · Biotechnology
Quarterly valuation ratios — annualised for comparability. YoY Δ shows same-quarter-prior-year change.
Alkermes plc's quarterly P/E stands at 24.1x, up 195.2% year-over-year — indicating the stock has re-rated higher or earnings have softened. EV/EBITDA has expanded 151.4% YoY to 17.0x, reflecting rising market expectations or slowing EBITDA growth.
| Metric | TTM | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 | Q1 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P/E Ratio → | 21.05 | 24.12 | 15.31 | 13.75 | 63.50 | 8.17 | 12.72 | 11.37 | 32.23 | 10.51 | 25.01 | 5.67 | — |
| — | +195.2% | +20.3% | +21.0% | +97.0% | -22.2% | -49.1% | +100.5% | — | — | — | — | — | |
| P/S Ratio | 3.38 | 3.07 | 3.21 | 3.08 | 4.54 | 2.79 | 3.09 | 2.58 | 3.34 | 3.13 | 3.16 | 2.17 | 4.05 |
| — | +10.2% | +3.7% | +19.4% | +36.0% | -10.9% | -2.2% | +18.7% | -17.4% | -11.3% | -13.0% | -50.8% | +5.4% | |
| P/B Ratio | 2.79 | 2.60 | 2.92 | 2.96 | 3.69 | 3.27 | 3.62 | 3.21 | 3.73 | 3.92 | 3.55 | 4.19 | 4.63 |
| — | -20.6% | -19.4% | -7.6% | -1.2% | -16.7% | +1.9% | -23.5% | -19.4% | -4.6% | +1.0% | -7.0% | +16.4% | |
| P/FCF | 9571.39 | — | 14.98 | 8.78 | 15.70 | 6.63 | 15.94 | 7.42 | 91.70 | 13.08 | 14.12 | 6.52 | — |
| — | — | -6.0% | +18.4% | -82.9% | -49.3% | +12.9% | +13.8% | — | — | — | — | — | |
| EV / EBITDA | 15.89 | 16.96 | 11.61 | 10.83 | 61.83 | 6.75 | 10.39 | 8.48 | 22.54 | 5.88 | 10.55 | 4.24 | 152.62 |
| — | +151.4% | +11.7% | +27.8% | +174.2% | +14.8% | -1.5% | +100.0% | -85.2% | — | — | — | — | |
| EV / EBIT | 17.59 | 18.08 | 11.19 | 10.42 | 51.45 | 6.55 | 9.99 | 8.06 | 21.89 | 6.15 | 11.53 | 4.43 | — |
| — | +176.0% | +12.0% | +29.3% | +135.0% | +6.5% | -13.3% | +81.9% | — | — | — | — | — |
Quarterly margins and returns. Watch for margin compression across consecutive quarters.
Alkermes plc's operating margin was 15.1% in Q4 2025, down 7.5 pp QoQ and down 22.7 pp YoY. This marks the 3rd consecutive quarter of margin compression, signaling a persistent pressure on profitability that investors should monitor. The trailing four-quarter average of 16.5% exceeds the current quarter, suggesting the latest result may reflect seasonal weakness or a one-off headwind.
| Metric | TTM | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 | Q1 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gross Margin | 86.3% | 86.5% | 86.9% | 87.3% | 83.9% | 85.6% | 83.3% | 84.6% | 83.3% | 81.4% | 83.9% | 89.8% | 79.8% |
| — | +1.1% | +4.3% | +3.2% | +0.8% | +5.1% | -0.6% | -5.7% | +4.4% | -1.0% | +4.9% | +13.8% | -0.5% | |
| Operating Margin | 17.2% | 15.1% | 22.6% | 23.8% | 4.5% | 37.8% | 27.7% | 27.5% | 12.4% | 47.3% | 23.4% | 45.6% | -3.8% |
| — | -60.1% | -18.4% | -13.5% | -63.6% | -20.0% | +18.3% | -39.6% | +424.0% | +800.3% | +197.4% | +465.2% | +60.0% | |
| Net Margin | 16.4% | 12.8% | 21.0% | 22.3% | 7.3% | 34.1% | 24.4% | 22.9% | 10.5% | 29.9% | 12.5% | 38.4% | -14.5% |
| — | -62.3% | -14.1% | -2.6% | -30.3% | +14.0% | +94.9% | -40.4% | +172.2% | +422.2% | +149.5% | +451.9% | -12.9% |
| Metric | TTM | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 | Q1 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ROE | 14.7% | 2.8% | 4.9% | 5.6% | 1.5% | 10.6% | 7.2% | 7.2% | 3.0% | 8.8% | 3.6% | 20.7% | -4.1% |
| — | -73.9% | -31.3% | -22.8% | -49.6% | +20.5% | +97.9% | -65.3% | +173.4% | +425.6% | +160.2% | +842.5% | -24.4% | |
| ROA | 10.6% | 2.0% | 3.6% | 4.0% | 1.1% | 7.0% | 4.2% | 4.2% | 1.7% | 5.1% | 2.1% | 11.5% | -2.2% |
| — | -70.6% | -14.7% | -4.7% | -37.2% | +36.2% | +98.1% | -63.4% | +180.3% | +453.1% | +165.2% | +853.2% | -20.0% | |
| ROIC | 14.9% | 3.5% | 5.7% | 5.9% | 0.8% | 9.7% | 6.6% | 7.1% | 2.8% | 12.1% | 6.4% | 20.3% | -0.7% |
| — | -64.0% | -14.5% | -16.9% | -69.6% | -19.8% | +3.5% | -64.9% | +475.6% | +1014.9% | +272.1% | +1071.4% | +54.9% |
Quarterly solvency trend — watch for debt spikes or covenant pressure.
Alkermes plc's Debt/EBITDA ratio is 1.1x, up from 0.7x last quarter — comfortably within a safe range. The current ratio has weakened 32.3% YoY to 2.06x, tightening the short-term liquidity position. Debt/Equity has declined for 9 consecutive quarters, reflecting a deleveraging trend.
| Metric | TTM | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 | Q1 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Debt / Equity | 0.04 | 0.04 | 0.04 | 0.04 | 0.05 | 0.05 | 0.28 | 0.29 | 0.29 | 0.31 | 0.28 | 0.30 | 0.39 |
| — | -25.4% | -85.4% | -84.4% | -83.4% | -83.3% | -0.3% | -5.8% | -24.7% | -14.9% | -29.7% | -22.8% | -2.3% | |
| Debt / EBITDA | 0.25 | 1.13 | 0.74 | 0.72 | 3.49 | 0.45 | 3.28 | 3.16 | 7.21 | 1.89 | 3.57 | 1.30 | 50.90 |
| — | +153.6% | -77.5% | -77.2% | -51.5% | -76.4% | -8.2% | +143.4% | -85.8% | — | — | — | — | |
| Current Ratio | 2.06 | 2.06 | 3.67 | 3.23 | 3.33 | 3.04 | 3.45 | 2.99 | 3.20 | 2.86 | 2.91 | 2.87 | 2.25 |
| — | -32.3% | +6.5% | +8.0% | +4.2% | +6.5% | +18.4% | +4.3% | +42.1% | +25.7% | +29.7% | +20.2% | +2.6% | |
| Quick Ratio | 1.70 | 1.70 | 3.27 | 2.85 | 2.92 | 2.65 | 3.03 | 2.61 | 2.77 | 2.50 | 2.53 | 2.48 | 1.88 |
| — | -35.9% | +8.0% | +9.1% | +5.5% | +6.1% | +19.6% | +5.4% | +47.5% | +31.0% | +33.8% | +22.1% | +0.9% | |
| Interest Coverage | 20.69 | 4.73 | — | — | — | 35.00 | 17.46 | 18.46 | 7.24 | 29.50 | 14.85 | 49.48 | -2.07 |
| — | — | — | — | — | — | — | — | — | — | — | — | — |
Includes 30+ ratios · 48 years · Updated daily
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Start ComparisonAlkermes plc's current P/E is 21.0x. The average P/E over the last 4 quarters is 29.2x. Quarterly P/E ratios can vary due to seasonal revenue patterns and one-time charges.
Alkermes plc's current operating margin is 17.2%. Margins have been expanding over recent quarters. Quarterly margins are particularly useful for identifying trend inflections that annual data smooths over.
Quarterly financial ratios reveal short-term trend shifts — margin compression, debt spikes, or valuation re-ratings — that annual figures smooth over. They're essential for active investors tracking Alkermes plc's business trajectory between earnings reports.