Last 30 quarters of trend data · Healthcare · Biotechnology
Quarterly valuation ratios — annualised for comparability. YoY Δ shows same-quarter-prior-year change.
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P/E Ratio → | -2.94 | — | — | — | — | — | 3.83 | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| P/S Ratio | 6.68 | — | 1.00 | 2.12 | 24.02 | 19.72 | 1.13 | 8.43 | — | — | — | — | — |
| — | — | -12.0% | -74.9% | — | — | — | — | — | — | — | — | — | |
| P/B Ratio | 1.14 | 0.96 | 0.45 | 0.78 | 1.04 | 0.73 | 0.93 | 0.80 | 0.66 | 0.80 | 0.73 | 0.65 | 1.83 |
| — | +31.9% | -51.3% | -2.6% | +58.6% | -9.5% | +26.2% | +23.4% | -64.0% | -83.3% | -73.1% | -69.9% | +104.0% | |
| P/FCF | — | — | — | — | — | — | 5.69 | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| EV / EBITDA | — | — | — | — | — | — | 2.47 | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| EV / EBIT | — | — | — | — | — | — | 2.47 | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — |
Quarterly margins and returns. Watch for margin compression across consecutive quarters.
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gross Margin | 100.0% | — | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% | — | — | — | — | — |
| — | — | 0.0% | 0.0% | — | — | — | — | — | — | — | — | — | |
| Operating Margin | -239.8% | — | -81.8% | -115.0% | -1797.8% | -1798.8% | 27.8% | -581.4% | — | — | — | — | — |
| — | — | -394.1% | +80.2% | — | — | — | — | — | — | — | — | — | |
| Net Margin | -170.1% | — | -78.0% | -111.5% | -348.4% | -1764.2% | 29.3% | -372.7% | — | — | — | — | — |
| — | — | -365.6% | +70.1% | — | — | — | — | — | — | — | — | — |
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ROE | -39.3% | -40.0% | -8.6% | -10.8% | -3.7% | -16.2% | 6.2% | -8.5% | -14.1% | -14.5% | -14.0% | 84.0% | -92.1% |
| — | -146.9% | -238.0% | -26.6% | +73.6% | -11.5% | +144.3% | -110.1% | +84.7% | +85.0% | +73.8% | +267.5% | -114.7% | |
| ROA | -36.1% | -34.4% | -7.8% | -9.9% | -3.4% | -14.7% | 5.7% | -7.6% | -12.3% | -12.5% | -11.9% | 59.8% | -38.8% |
| — | -133.5% | -236.5% | -29.4% | +72.7% | -18.0% | +148.4% | -112.8% | +68.2% | +73.5% | +64.6% | +271.6% | -18.4% | |
| ROIC | -65.1% | -49.1% | -11.6% | -14.3% | -23.4% | -20.3% | 6.9% | -17.8% | -24.6% | -30.6% | -36.0% | -275.6% | — |
| — | -141.5% | -268.9% | +19.4% | +5.0% | +33.5% | +119.1% | +93.6% | — | — | — | — | — |
Quarterly solvency trend — watch for debt spikes or covenant pressure.
The current ratio has weakened 57.2% YoY to 1.80x, tightening the short-term liquidity position.
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Debt / Equity | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| Debt / EBITDA | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| Current Ratio | 5.15 | 1.80 | 5.15 | 5.78 | 5.03 | 4.21 | 5.83 | 5.07 | 3.68 | 4.17 | 3.85 | 4.21 | 1.44 |
| — | -57.2% | -11.6% | +13.9% | +36.6% | +1.0% | +51.5% | +20.3% | +155.8% | +277.1% | +98.0% | +65.9% | -55.3% | |
| Quick Ratio | 5.15 | 1.80 | 5.15 | 5.78 | 5.03 | 4.21 | 5.83 | 5.07 | 3.68 | 4.17 | 3.85 | 4.21 | 1.44 |
| — | -57.2% | -11.6% | +13.9% | +36.6% | +1.0% | +51.5% | +20.3% | +155.8% | +277.1% | +98.0% | +65.9% | -55.3% | |
| Interest Coverage | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — |
Includes 30+ ratios · 30 years · Updated daily
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Quick answers to the most common questions about buying CYCN stock.
Cyclerion Therapeutics, Inc.'s current P/E is -2.9x. Quarterly P/E ratios can vary due to seasonal revenue patterns and one-time charges.
Cyclerion Therapeutics, Inc.'s current operating margin is -239.8%. Margins have been expanding over recent quarters. Quarterly margins are particularly useful for identifying trend inflections that annual data smooths over.
Quarterly financial ratios reveal short-term trend shifts — margin compression, debt spikes, or valuation re-ratings — that annual figures smooth over. They're essential for active investors tracking Cyclerion Therapeutics, Inc.'s business trajectory between earnings reports.