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SPROSpero Therapeutics, Inc.
$1.19$69M
Overview & Tools
OverviewChart Terminal ↗Visualize
Valuation & Forecasts
Valuation ModelsEstimatesDCF Model
Price & Analyst Data
Analyst TargetsPrice History
Financial Statements
Income StatementBalance SheetCash FlowRatios & Margins
Performance
P/E HistoryRevenue HistoryEarnings HistoryDividend HistoryTotal Return
Discovery & Screens
Live BreakoutsStock ScreenerOwnership
SPRO logo

Spero Therapeutics, Inc.

SPRO
NASDAQ · Biotechnology
$1.19
At close - Oct 2, 4:00 PM EDT - USD
Market Cap$69M
P/E7.9x
52W High$3.08
Volume906.91K
OverviewTerminalAnalysisFinancialsValuationEarningsBreakoutsOwnership
VCP Research Verdict2026Q1

Milestone Dependency Masks Underlying Clinical Pipeline Volatility

Spero Therapeutics faces a precarious financial outlook characterized by extreme revenue volatility, as evidenced by a 95.6% year-over-year revenue decline in 2026Q1. The company's reliance on non-recurring milestone payments rather than sustainable commercial...

GrowthMixed
ProfitabilityNegative
ValuationAttractive
TechnicalsWeak
Explore valuation models
MARKET ACTION

SPRO price & volume

Price trend, volume and key moving averages

Launch Terminal
Loading chart...
Decision Checklist4 Core Signals

What matters now

The signals most likely to change the investment case.

01

Earnings momentum

9/12 Beats

EPS beat 9 of last 12 quarters

02

Valuation risk

-58% Peers

P/E is 58% below peer median

03

Market leadership

RS 13 · Lag

Laggard (Underperforming 87% of market)

04

Weak Trend

Below 200DMA

Price < 200DMA

Next CatalystConfirmed earnings · Nov 12

Market performance

Price History →

Trailing total returns as of 10/3/2026, which may include dividends or other distributions. Benchmark is S&P 500 (^GSPC).

YTD Return
SPRO-49.36%
S&P 500 (^GSPC)+12.66%
1-Year Return
SPRO-41.38%
S&P 500 (^GSPC)+15.01%
3-Year Return
SPRO+0.00%
S&P 500 (^GSPC)+71.70%
5-Year Return
SPRO-93.42%
S&P 500 (^GSPC)+71.57%
02

Test the fundamentals

Check whether operating performance supports the current valuation.

VALUATION & INTRINSIC VALUE

Valuation Scenarios

Valuation Analysis
Trailing P/EMedian
7.9x
Forward P/E
N/A
EV/EBITDA50th %ile
3.6x
FCF YieldCash Flow
N/A

Valuation vs 5-Year History

Multiple Range
Metric
Current
5Y Median
Historical Range
Percentile
P/E
7.9x
15.5x
50th· Fair
EV/EBITDA
3.6x
11.3x
50th· Fair
Price/FCF
N/A
N/A
N/A
Current Multiple
5Y Median (50th %ile)

Intrinsic Value Scenarios

DCF Projection
No DCF Model AvailableIntrinsic value modeling is not supported for this equity.

Growth & profitability

Annual revenue & EPS trend
Revenue
$60M+24.3% YoY
Net income
$9M+112.5% YoY
Free cash flow
-$13M+46.2% YoY
Operating margin
-0%+152.9 pts YoY
ROIC (TTM)-0.2%
Avg ROIC 5Y-
ROE (TTM)16.3%
Piotroski Score5 / 9
Financial Statements →
03

Monitor what changed

Recent results and news deserve attention only when they alter the forward view.

OPERATING RESULTS

Recent Earnings

Earnings History
EPS Beat Rate9/12 (75%)
Revenue Beat Rate6/12 (55%)
QuarterEPS (Act vs Est)Revenue (Act vs Est)
Q3 2026Latest
Aug 12, 2026
-$0.16+5.9%
vs -$0.17
—
vs —
Q2 2026
May 13, 2026
-$0.13+27.8%
vs -$0.18
$258,000+0.0%
vs $258,000
Q2 2026
Mar 26, 2026
$0.53+365.0%
vs -$0.20
$41M+58.8%
vs $26M
Q4 2025
Nov 13, 2025
-$0.13+48.0%
vs -$0.25
$3M-74.6%
vs $12M
Historical baseline: 12 quarters analyzedGAAP / Adjusted
MARKET COVERAGE

Latest News

5 Stories
GlobeNewsWire·Sep 3, 2026
Spero Therapeutics Announces Inducement Grant Under Nasdaq Listing Rule 5635(c)(4)

CAMBRIDGE, Mass., Sept. 03, 2026 (GLOBE NEWSWIRE) -- Spero Therapeutics, Inc. (Nasdaq: SPRO), a clinical-stage biopharmaceutical company focused on advancing next-generation medicines in immunology and inflammation, today announced that the Compensation Committee of Spero's Board of Directors approved a grant, made on September 1, 2026, of an aggregate of 102,000 restricted stock unit awards (RSUs) and 67,600 stock options to new employees under the Spero Therapeutics, Inc. 2019 Inducement Equity Incentive Plan, as amended (2019 Inducement Plan).

GlobeNewsWire·Sep 2, 2026
Spero Therapeutics to Present at H.C. Wainwright 28th Annual Global Investment Conference

CAMBRIDGE, Mass., Sept. 02, 2026 (GLOBE NEWSWIRE) -- Spero Therapeutics, Inc. (Nasdaq: SPRO), a clinical-stage biopharmaceutical company focused on advancing next-generation medicines in immunology and inflammation, today announced that Esther Rajavelu, President and Chief Executive Officer, will present at the H.C.

Seeking Alpha·Aug 13, 2026
Spero Therapeutics, Inc. (SPRO) Q2 2026 Earnings Call Transcript

Spero Therapeutics, Inc. (SPRO) Q2 2026 Earnings Call Transcript

MarketBeat·Aug 13, 2026
Spero Therapeutics Q2 Earnings Call Highlights

Spero Therapeutics NASDAQ: SPRO used its second-quarter update to outline a strategic shift toward immune-mediated diseases, supported by the FDA approval of Utebzi and a new licensing agreement for SP001, an antibody candidate the company plans to develop initially for IgG4-related disease.

Filtered for Spero Therapeutics, Inc.More Headlines
04

Compare before deciding

Benchmark SPRO against direct peers instead of judging its metrics in isolation.

Peers Comparison

Key metrics vs top competitors for Spero Therapeutics, Inc. (SPRO)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
SPRO logoSPROSpero Therapeutics, Inc.Current
$1.19$68.9M7.9324.27%14.38%16.31%—
VNDA logoVNDAVanda Pharmaceuticals Inc.
$4.63$278.43M-1.248.72%-127.41%-84.95%—
PRAX logoPRAXPraxis Precision Medicines, Inc.
$295.51$8.24B-21.92-100%—-34.15%—
NAOV logoNAOVNanoVibronix, Inc.
$1.90$512.71K-0.14-0.2%-894.64%-52.57%—
AGEN logoAGENAgenus Inc.
$8.36$348.13M-2458.8210.37%69.76%——
TBPH logoTBPHTheravance Biopharma Inc
$17.03$882.64M8.2766.92%51.58%19.4%—

Compare SPRO vs Peers

Spero Therapeutics, Inc. (SPRO) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs VNDA

Most directly comparable listed peer for SPRO.

Scale Benchmark

vs ABBV

Larger-name benchmark to compare SPRO against a more recognizable public peer.

Peer Set

Compare Top 5

vs VNDA, PRAX, NAOV, AGEN

05

Keep researching

Verify the primary filings, follow material updates, and answer the remaining questions.

SPRO SEC Filings & Documents

Spero Therapeutics, Inc. (SPRO) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Aug 28, 2026·SEC

Material company update

Aug 12, 2026·SEC

Material company update

Jul 14, 2026·SEC

10-K Annual Reports

3
FY 2026

Mar 26, 2026·SEC

FY 2025

Mar 27, 2025·SEC

FY 2024

Mar 13, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

Aug 12, 2026·SEC

FY 2026

May 13, 2026·SEC

FY 2025

Nov 13, 2025·SEC

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SPRO Frequently Asked Questions

Spero Therapeutics, Inc. (SPRO) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
What is Spero Therapeutics, Inc.'s revenue?

Spero Therapeutics, Inc. (SPRO) reported $43.0M in revenue for fiscal year 2025.

How fast is Spero Therapeutics, Inc. growing?

Spero Therapeutics, Inc. (SPRO) grew revenue by 24.3% over the past year. This is strong growth.

Is SPRO profitable?

Yes, Spero Therapeutics, Inc. (SPRO) is profitable, generating $7.4M in net income for fiscal year 2025 (14.4% net margin).

Dividend & Returns
What is SPRO's return on equity?

Spero Therapeutics, Inc. (SPRO) has a return on equity (ROE) of 16.3%. This is reasonable for most industries.

What is Spero Therapeutics, Inc.'s free cash flow?

Spero Therapeutics, Inc. (SPRO) generated $19.6M in free cash flow for fiscal year 2025. Positive FCF indicates the company can fund dividends, buybacks, or reinvestment.

What if you invested $1,000 in SPRO back in 2015?

Total return calculator · dividends reinvested · 11+ years of data

See returns →